58
Views
80
CrossRef citations to date
0
Altmetric
Article

Lipin 1 Represses NFATc4 Transcriptional Activity in Adipocytes To Inhibit Secretion of Inflammatory Factors

, , , , , , & show all
Pages 3126-3139 | Received 29 Dec 2009, Accepted 31 Mar 2010, Published online: 20 Mar 2023

REFERENCES

  • Aramburu, J., F. Garcia-Cozar, A. Raghavan, H. Okamura, A. Rao, and P. G. Hogan. 1998. Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT. Mol. Cell 1:627–637.
  • Baksh, S., H. R. Widlund, A. A. Frazer-Abel, J. Du, S. Fosmire, D. E. Fisher, J. A. DeCaprio, J. F. Modiano, and S. J. Burakoff. 2002. NFATc2-mediated repression of cyclin-dependent kinase 4 expression. Mol. Cell 10:1071–1081.
  • Brindley, D. N. 1984. Intracellular translocation of phosphatidate phosphohydrolase and its possible role in the control of glycerolipid synthesis. Prog. Lipid Res. 23:115–133.
  • Chang, C. P., J. R. Neilson, J. H. Bayle, J. E. Gestwicki, A. Kuo, K. Stankunas, I. A. Graef, and G. R. Crabtree. 2004. A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell 118:649–663.
  • Cinti, S., G. Mitchell, G. Barbatelli, I. Murano, E. Ceresi, E. Faloia, S. Wang, M. Fortier, A. S. Greenberg, and M. S. Obin. 2005. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J. Lipid Res. 46:2347–2355.
  • Coleman, R. A., and D. P. Lee. 2004. Enzymes of triacylglycerol synthesis and their regulation. Prog. Lipid Res. 43:134–176.
  • Croce, M. A., J. C. Eagon, L. L. LaRiviere, K. M. Korenblat, S. Klein, and B. N. Finck. 2007. Hepatic lipin 1beta expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight loss. Diabetes 56:2395–2399.
  • De Taeye, B. M., T. Novitskaya, O. P. McGuinness, L. Gleaves, M. Medda, J. W. Covington, and D. E. Vaughan. 2007. Macrophage TNF-alpha contributes to insulin resistance and hepatic steatosis in diet-induced obesity. Am. J. Physiol. Endocrinol. Metab. 293:E713–E725.
  • Donkor, J., M. Sariahmetoglu, J. Dewald, D. N. Brindley, and K. Reue. 2007. Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns. J. Biol. Chem. 282:3450–3457.
  • Falvo, J. V., C. H. Lin, A. V. Tsytsykova, P. K. Hwang, D. Thanos, A. E. Goldfeld, and T. Maniatis. 2008. A dimer-specific function of the transcription factor NFATp. Proc. Natl. Acad. Sci. U. S. A. 105:19637–19642.
  • Festuccia, W. T., P. G. Blanchard, V. Turcotte, M. Laplante, M. Sariahmetoglu, D. N. Brindley, and Y. Deshaies. 2009. Depot-specific effects of the PPARγ agonist rosiglitazone on adipose tissue glucose uptake and metabolism. J. Lipid Res. 50:1185–1194.
  • Finck, B. N., M. C. Gropler, Z. Chen, T. C. Leone, M. A. Croce, T. E. Harris, J. C. Lawrence, Jr., and D. P. Kelly. 2006. Lipin 1 is an inducible amplifier of the hepatic PGC-1α/PPARα regulatory pathway. Cell Metab. 4:199–210.
  • Garcia-Dominguez, M., and J. C. Reyes. 2009. SUMO association with repressor complexes, emerging routes for transcriptional control. Biochim. Biophys. Acta 1789:451–459.
  • Gropler, M. C., T. E. Harris, A. M. Hall, N. E. Wolins, R. W. Gross, X. Han, Z. Chen, and B. N. Finck. 2009. Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice. J. Biol. Chem. 284:6763–6772.
  • Han, G. S., S. Siniossoglou, and G. M. Carman. 2007. The cellular functions of the yeast lipin homolog PAH1p are dependent on its phosphatidate phosphatase activity. J. Biol. Chem. 282:37026–37035.
  • Han, G. S., W. I. Wu, and G. M. Carman. 2006. The Saccharomyces cerevisiae Lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme. J. Biol. Chem. 281:9210–9218.
  • Harkins, J. M., N. Moustaid-Moussa, Y. J. Chung, K. M. Penner, J. J. Pestka, C. M. North, and K. J. Claycombe. 2004. Expression of interleukin-6 is greater in preadipocytes than in adipocytes of 3T3-L1 cells and C57BL/6J and ob/ob mice. J. Nutr. 134:2673–2677.
  • Harris, T. E., T. A. Huffman, A. Chi, J. Shabanowitz, D. F. Hunt, A. Kumar, and J. C. Lawrence, Jr. 2007. Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1. J. Biol. Chem. 282:277–286.
  • Ho, I. C., J. H. Kim, J. W. Rooney, B. M. Spiegelman, and L. H. Glimcher. 1998. A potential role for the nuclear factor of activated T cells family of transcriptional regulatory proteins in adipogenesis. Proc. Natl. Acad. Sci. U. S. A. 95:15537–15541.
  • Hogan, P. G., L. Chen, J. Nardone, and A. Rao. 2003. Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev. 17:2205–2232.
  • Hotamisligil, G. S., N. S. Shargill, and B. M. Spiegelman. 1993. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259:87–91.
  • Huffman, T. A., I. Mothe-Satney, and J. C. Lawrence, Jr. 2002. Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin. Proc. Natl. Acad. Sci. U. S. A. 99:1047–1052.
  • Huffman, T. A., I. Mothe-Satney, and J. C. Lawrence, Jr. 2002. Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin. Proc. Natl. Acad. Sci. U. S. A. 99:1047–1052.
  • Huffman, T. A., I. Mothe-Satney, and J. C. Lawrence, Jr. 2002. Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin. Proc. Natl. Acad. Sci. U. S. A. 99:1047–1052.
  • Jamdar, S. C., and L. J. Osborne. 1981. Glycerolipid biosynthesis in rat adipose tissue. 7. Effect of age, site of adipose tissue and cell size. Biochim. Biophys. Acta 665:145–153.
  • Kaplan, M. L., J. R. Trout, and G. A. Leveille. 1976. Adipocyte size distribution in ob/ob mice during preobese and obese phases of development. Proc. Soc. Exp. Biol. Med. 153:476–482.
  • Ke, Q., J. Li, J. Ding, M. Ding, L. Wang, B. Liu, M. Costa, and C. Huang. 2006. Essential role of ROS-mediated NFAT activation in TNF-alpha induction by crystalline silica exposure. Am. J. Physiol. Lung Cell Mol. Physiol. 291:L257–L264.
  • Koh, Y. K., M. Y. Lee, J. W. Kim, M. Kim, J. S. Moon, Y. J. Lee, Y. H. Ahn, and K. S. Kim. 2008. Lipin1 is a key factor for the maturation and maintenance of adipocytes in the regulatory network with CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma 2. J. Biol. Chem. 283:34896–34906.
  • Langner, C. A., E. H. Birkenmeier, O. Ben Zeev, M. C. Schotz, H. O. Sweet, M. T. Davisson, and J. I. Gordon. 1989. The fatty liver dystrophy (fld) mutation: a new mutant mouse with a developmental abnormality in triglyceride metabolism and associated tissue-specific defects in lipoprotein lipase and hepatic lipase activities. J. Biol. Chem. 264:7994–8003.
  • Lindegaard, B., L. F. Larsen, A. B. Hansen, J. Gerstoft, B. K. Pedersen, and K. Reue. 2007. Adipose tissue lipin expression levels distinguish HIV patients with and without lipodystrophy. Int. J. Obes. 31:449–456.
  • Liu, G. H., and L. Gerace. 2009. Sumoylation regulates nuclear localization of lipin-1α in neuronal cells. PLoS. One. 4:e7031.
  • Liu, G. H., J. Qu, and X. Shen. 2008. NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK. Biochim. Biophys. Acta 1783:713–727.
  • Lu, B., Y. Lu, A. H. Moser, J. K. Shigenaga, C. Grunfeld, and K. R. Feingold. 2008. LPS and proinflammatory cytokines decrease lipin-1 in mouse adipose tissue and 3T3-L1 adipocytes. Am. J. Physiol. Endocrinol. Metab. 295:E1502–E1509.
  • McCaffrey, P. G., A. E. Goldfeld, and A. Rao. 1994. The role of NFATp in cyclosporin A-sensitive tumor necrosis factor-alpha gene transcription. J. Biol. Chem. 269:30445–30450.
  • Miranda, M., M. R. Chacon, J. Gomez, A. Megia, V. Ceperuelo-Mallafre, S. Veloso, M. Saumoy, L. Gallart, C. Richart, J. M. Fernandez-Real, and J. Vendrell. 2007. Human subcutaneous adipose tissue LPIN1 expression in obesity, type 2 diabetes mellitus, and human immunodeficiency virus-associated lipodystrophy syndrome. Metabolism 56:1518–1526.
  • Neal, J. W., and N. A. Clipstone. 2002. Calcineurin mediates the calcium-dependent inhibition of adipocyte differentiation in 3T3-L1 cells. J. Biol. Chem. 277:49776–49781.
  • Neal, J. W., and N. A. Clipstone. 2003. A constitutively active NFATc1 mutant induces a transformed phenotype in 3T3-L1 fibroblasts. J. Biol. Chem. 278:17246–17254.
  • Peterfy, M., T. E. Harris, N. Fujita, and K. Reue. 2010. Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes. J. Biol. Chem. 285:3857–3864.
  • Peterfy, M., J. Phan, and K. Reue. 2005. Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis. J. Biol. Chem. 280:32883–32889.
  • Peterfy, M., J. Phan, P. Xu, and K. Reue. 2001. Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. Nat. Genet. 27:121–124.
  • Pfaffl, M. W. 2001. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29:e45.
  • Phan, J., M. Peterfy, and K. Reue. 2004. Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro. J. Biol. Chem. 279:29558–29564.
  • Phan, J., and K. Reue. 2005. Lipin, a lipodystrophy and obesity gene. Cell Metab. 1:73–83.
  • Rao, A., C. Luo, and P. G. Hogan. 1997. Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol. 15:707–747.
  • Reue, K. 2009. The lipin family: mutations and metabolism. Curr. Opin. Lipidol. 20:165–170.
  • Reue, K., and D. N. Brindley. 2008. Thematic review series: glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism. J. Lipid Res. 49:2493–2503.
  • Reue, K., P. Xu, X. P. Wang, and B. G. Slavin. 2000. Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene. J. Lipid Res. 41:1067–1076.
  • Reue, K., and P. Zhang. 2008. The lipin protein family: dual roles in lipid biosynthesis and gene expression. FEBS Lett. 582:90–96.
  • Roehrl, M. H., S. Kang, J. Aramburu, G. Wagner, A. Rao, and P. G. Hogan. 2004. Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc. Natl. Acad. Sci. U. S. A. 101:7554–7559.
  • Santos-Rosa, H., J. Leung, N. Grimsey, S. Peak-Chew, and S. Siniossoglou. 2005. The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth. EMBO J. 24:1931–1941.
  • Schenk, S., M. Saberi, and J. M. Olefsky. 2008. Insulin sensitivity: modulation by nutrients and inflammation. J. Clin. Invest. 118:2992–3002.
  • van Harmelen, V., M. Ryden, E. Sjolin, and J. Hoffstedt. 2007. A role of lipin in human obesity and insulin resistance: relation to adipocyte glucose transport and GLUT4 expression. J. Lipid Res. 48:201–206.
  • Westman, S. 1968. Development of the obese-hyperglycaemic syndrome in mice. Diabetologia 4:141–149.
  • Yang, T. T., and C. W. Chow. 2003. Transcription cooperation by NFAT.C/EBP composite enhancer complex. J. Biol. Chem. 278:15874–15885.
  • Yang, T. T., H. Y. Suk, X. Yang, O. Olabisi, R. Y. Yu, J. Durand, L. A. Jelicks, J. Y. Kim, P. E. Scherer, Y. Wang, Y. Feng, L. Rossetti, I. A. Graef, G. R. Crabtree, and C. W. Chow. 2006. Role of transcription factor NFAT in glucose and insulin homeostasis. Mol. Cell. Biol. 26:7372–7387.
  • Yang, T. T., Q. Xiong, H. Enslen, R. J. Davis, and C. W. Chow. 2002. Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases. Mol. Cell. Biol. 22:3892–3904.
  • Yang, T. T., R. Y. Yu, A. Agadir, G. J. Gao, R. Campos-Gonzalez, C. Tournier, and C. W. Chow. 2008. Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4. Mol. Cell. Biol. 28:3489–3501.
  • Yao-Borengasser, A., N. Rasouli, V. Varma, L. M. Miles, B. Phanavanh, T. N. Starks, J. Phan, H. J. Spencer III, R. E. McGehee, Jr., K. Reue, and P. A. Kern. 2006. Lipin expression is attenuated in adipose tissue of insulin-resistant human subjects and increases with peroxisome proliferator-activated receptor gamma activation. Diabetes 55:2811–2818.
  • Zhang, P., L. O'Loughlin, D. N. Brindley, and K. Reue. 2008. Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis. J. Lipid Res. 49:1519–1528.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.