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Article

Biphasic Response of Pancreatic β-Cell Mass to Ablation of Tuberous Sclerosis Complex 2 in Mice

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Pages 2971-2979 | Received 14 Sep 2007, Accepted 15 Feb 2008, Published online: 27 Mar 2023

REFERENCES

  • Bernal-Mizrachi, E., W. Wen, S. Stahlhut, C. M. Welling, and M. A. Permutt. 2001. Islet β cell expression of constitutively active Akt1/PKBα induces striking hypertrophy, hyperplasia, and hyperinsulinemia. J. Clin. Investig. 108:1631–1638.
  • Bonawitz, N. D., M. Chatenay-Lapointe, Y. Pan, and G. S. Shadel. 2007. Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression. Cell Metab. 5:265–277.
  • Briaud, I., L. M. Dickson, M. K. Lingohr, J. F. McCuaig, J. C. Lawrence, and C. J. Rhodes. 2005. Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in β-cells. J. Biol. Chem. 280:2282–2293.
  • Butler, A. E., J. Janson, S. B. Weir, R. Ritzel, R. A. Rizza, and P. C. Butler. 2003. β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes. Diabetes 52:102–110.
  • Garami, A., F. J. Zwartkruis, T. Nobukuni, M. Joaquin, M. Roccio, H. Stocker, S. C. Kozma, E. Hafen, J. L. Bos, and G. Thomas. 2003. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol. Cell 11:1457–1466.
  • Giordano, E., V. Cirulli, D. Bosco, D. Rouiller, P. Halban, and P. Meda. 1993. B-cell size influences glucose-stimulated insulin secretion. Am. J. Physiol. 265:C358–C364.
  • Harrington, L. S., G. M. Findlay, A. Gray, T. Tolkacheva, S. Wigfield, H. Rebholz, J. Barnett, N. R. Leslie, S. Cheng, P. R. Shepherd, I. Gout, C. P. Downes, and R. F. Lamb. 2004. The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J. Cell Biol. 166:213–223.
  • Hashimoto, N., Y. Kido, T. Uchida, S. Asahara, Y. Shigeyama, T. Matsuda, A. Takeda, D. Tsuchihashi, A. Nishizawa, W. Ogawa, Y. Fujimoto, H. Okamura, K. C. Arden, P. L. Herrera, T. Noda, and M. Kasuga. 2006. Ablation of PDK1 in pancreatic β cells induces diabetes as a result of loss of β cell mass. Nat. Genet. 38:589–593.
  • Hashimoto, N., Y. Kido, T. Uchida, T. Matsuda, K. Suzuki, H. Inoue, M. Matsumoto, W. Ogawa, S. Maeda, H. Fujihara, Y. Ueta, Y. Uchiyama, K. Akimoto, S. Ohno, T. Noda, and M. Kasuga. 2005. PKCλ regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic β cells. J. Clin. Investig. 115:138–145.
  • Herrera, P. L. 2000. Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. Development 127:2317–2322.
  • Inoki, K., Y. Li, T. Zhu, J. Wu, and K. L. Guan. 2002. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling. Nat. Cell Biol. 4:648–657.
  • Inoki, K., Y. Li, T. Xu, and K. L. Guan. 2003. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 17:1829–1834.
  • Kandt, R. S., J. L. Haines, M. Smith, H. Northrup, R. J. M. Gardner, M. P. Short, K. Dumars, E. S. Roach, S. Steingold, S. Wall, S. H. Blanton, P. Flodman, D. J. Kwiatkowski, A. Jewell, J. L. Weber, A. D. Roses, and M. A. Pericak-Vance. 1992. Linkage of an important gene locus for tuberous sclerosis to a chromosome 16 marker for polycystic kidney disease. Nat. Genet. 2:37–41.
  • Kido, Y., D. J. Burks, D. Withers, J. C. Bruning, C. R. Kahn, M. F. White, and D. Accili. 2000. Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J. Clin. Investig. 105:199–205.
  • Kitamura, T., J. Nakae, Y. Kitamura, Y. Kido, W. H. Biggs, C. V. Wright, M. F. White, K. C. Arden, and D. Accili. 2002. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth. J. Clin. Investig. 110:1839–1847.
  • Kobayashi, T., O. Minowa, J. Kuno, H. Mitani, O. Hino, and T. Noda. 1999. Renal carcinogenesis, hepatic hematogiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice. Cancer Res. 59:1206–1211.
  • Kubota, N., K. Tobe, Y. Terauchi, K. Eto, T. Yamauchi, R. Suzuki, Y. Tsubamoto, K. Komeda, R. Nakano, H. Miki, S. Satoh, H. Sekihara, S. Sciacchitano, M. Lesniak, S. Aizawa, R. Nagai, S. Kimura, Y. Akanuma, S. I. Taylor, and T. Kadowaki. 2000. Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. Diabetes 49:1880–1889.
  • Kubota, N., Y. Terauchi, K. Tobe, W. Yano, R. Suzuki, K. Ueki, I. Takamoto, H. Satoh, T. Maki, T. Kubota, M. Moroi, M. Okada-Iwabu, O. Ezaki, R. Nagai, Y. Ueta, T. Kadowaki, and T. Noda. 2004. Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus. J. Clin. Investig. 114:917–927.
  • Kulkarni, R. N., J. C. Bruning, J. N. Winnay, C. Postic, M. A. Magnuson, and C. R. Kahn. 1999. Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96:329–339.
  • Le Bacquer, O., E. Petroulakis, S. Paglialunga, F. Poulin, D. Richard, K. Cianflone, and N. Sonenberg. 2007. Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. J. Clin. Investig. 117:387–396.
  • Lin, X., A. Taguchi, S. Park, J. A. Kushner, F. Li, Y. Li, and M. F. White. 2004. Dysregulation of insulin receptor substrate 2 in β cells and brain causes obesity and diabetes. J. Clin. Investig. 114:908–916.
  • Postic, C., M. Shiota, K. D. Niswender, T. L. Jetton, Y. Chen, J. M. Moates, K. D. Shelton, J. Lindner, A. D. Cherrington, and M. A. Magnuson. 1999. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic β cell-specific gene knock-outs using Cre recombinase. J. Biol. Chem. 274:305–315.
  • Potter, C. J., H. Huang, and T. Xu. 2001. Drosophila TSC1 functions with TSC2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Cell 105:357–368.
  • Ravikumar, B., C. Vacher, Z. Berger, J. E. Davies, S. Luo, L. G. Oroz, F. Scaravilli, D. F. Easton, R. Duden, C. J. O'Kane, and D. C. Rubinsztein. 2004. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat. Genet. 36:585–595.
  • Shah, O. J., Z. Wang, and T. Hunter. 2004. Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr. Biol. 14:1650–1656.
  • Tuttle, R. L., N. S. Gill, W. Pugh, J. P. Lee, B. Koeberlein, E. E. Furth, K. S. Polonsky, A. Naji, and M. J. Birnbaum. 2001. Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα. Nat. Med. 7:1133–1137.
  • Uchida, T., T. Nakamura, N. Hashimoto, T. Matsuda, K. Kotani, H. Sakaue, Y. Kido, Y. Hayashi, K. I. Nakayama, M. F. White, and M. Kasuga. 2005. Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. Nat. Med. 11:175–182.
  • Ueki, K., T. Okada, J. Hu, C. W. Liew, A. Assmann, G. M. Dahlgren, J. L. Peters, J. G. Shackman, M. Zhang, I. Artner, L. S. Satin, R. Stein, M. Holzenberger, R. T. Kennedy, C. R. Kahn, and R. N. Kulkarni. 2006. Total insulin and IGF-1 resistance in pancreatic β cells causes overt diabetes. Nat. Genet. 38:583–588.
  • Um, S. H., F. Frigerio, M. Watanabe, F. Picard, M. Joaquin, M. Sticker, S. Fumagalli, P. R. Allegrini, S. C. Kozma, J. Auwerx, and G. Thomas. 2004. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 431:200–205.
  • van Slegtenhorst, M., R. de Hoogt, C. Hermans, M. Nellist, B. Janssen, S. Verhoef, D. Lindhout, A. van den Ouweland, D. Halley, J. Young, M. Burley, S. Jeremian, K. Woodward, J. Nahmias, M. Fox, R. Ekong, J. Osborne, J. Wolfe, S. Povey, R. G. Snell, J. P. Cheadle, A. C. Jones, M. Tachataki, D. Ravine, J. R. Sampson, M. P. Reeve, P. Richardson, F. Wilmer, C. Munro, T. L. Hawkins, T. Sepp, J. B. M. Ali, S. Ward, A. J. Green, J. R. W. Yates, J. Kwiatkowska, E. P. Henske, M. P. Short, E. P. Haines, M. P. Short, J. H. Haines, S. Jozwiak, and D. J. Kwiatkowski. 1997. Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science 277:805–808.
  • Withers, D. J., J. S. Gutierrez, H. Towery, D. J. Burks, J. M. Ren, S. Previs, Y. Zhang, D. Bernal, S. Pons, G. I. Shulman, S. B. Weir, and M. F. White. 1998. Disruption of IRS-2 causes type 2 diabetes in mice. Nature 391:900–904.
  • Wu, H., X. Liu, and R. Jaenisch. 1994. Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic sytem cells. Proc. Natl. Acad. Sci. USA 91:2819–2823.

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