Phosphorylation of MNAR Promotes Estrogen Activation of Phosphatidylinositol 3-Kinase

REFERENCES

• Balasenthil, S., and R. K. Vadlamudi. 2003. Functional interactions between the estrogen receptor coactivator PELP1/MNAR and retinoblastoma protein. J. Biol. Chem. 278:22119–22127.
   PubMedGoogle Scholar
• Barletta, F., C.-W. Wong, C. McNally, B. S. Komm, B. Katzenellenbogen, and B. J. Cheskis. 2004. Characterization of the interactions of estrogen receptor and MNAR in the activation of cSrc. Mol. Endocrinol. 18:1096–1108.
   PubMedGoogle Scholar
• Boonyaratanakornkit, V., and D. P. Edwards. 2004. Receptor mechanisms of rapid extranuclear signalling initiated by steroid hormones. Essays Biochem. 40:105–120.
   PubMedGoogle Scholar
• Boonyaratanakornkit, V., M. P. Scott, V. Ribon, L. Sherman, S. M. Anderson, J. L. Maller, W. T. Miller, and D. P. Edwards. 2001. Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases. Mol. Cell 8:269–280.
   PubMed Web of Science ®Google Scholar
• Burow, M. E., C. B. Weldon, Y. Tang, J. A. McLachlan, and B. S. Beckman. 2001. Oestrogen-mediated suppression of tumour necrosis factor alpha-induced apoptosis in MCF-7 cells: subversion of Bcl-2 by anti-oestrogens. J. Steroid Biochem. Mol. Biol. 78:409–418.
   PubMedGoogle Scholar
• Campbell, R. A., P. Bhat-Nakshatri, N. M. Patel, D. Constantinidou, S. Ali, and H. Nakshatri. 2001. Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance. J. Biol. Chem. 276:9817–9824.
   PubMed Web of Science ®Google Scholar
• Castoria, G., A. Migliaccio, A. Bilancio, M. Di Domenico, A. de Falco, M. Lombardi, R. Fiorentino, L. Varricchio, M. V. Barone, and F. Auricchio. 2001. PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells. EMBO J. 20:6050–6059.
   PubMed Web of Science ®Google Scholar
• Cato, A. C., A. Nestl, and S. Mink. 2002. Rapid actions of steroid receptors in cellular signaling pathways. Sci. STKE 2002:RE9.
   PubMedGoogle Scholar
• Cheskis, B. J. 2004. Regulation of cell signalling cascades by steroid hormones. J. Cell. Biochem. 93:20–27.
   PubMed Web of Science ®Google Scholar
• Edwards, D. P. 2005. Regulation of signal transduction pathways by estrogen and progesterone. Annu. Rev. Physiol. 67:335–376.
   PubMed Web of Science ®Google Scholar
• Falkenstein, E., H.-C. Tillmann, M. Christ, M. Feuring, and M. Wehling. 2000. Multiple actions of steroid hormones—a focus on rapid, nongenomic effects. Pharmacol. Rev. 52:513–556.
   PubMed Web of Science ®Google Scholar
• Falkenstein, E., and M. Wehling. 2000. Nongenomically initiated steroid actions. Eur. J. Clin. Investig. 30:51–54.
   PubMed Web of Science ®Google Scholar
• Greger, J. G., Y. Guo, R. Henderson, J. F. Ross, and B. J. Cheskis. 2006. Characterization of MNAR expression. Steroids. 71:317–322.
   PubMedGoogle Scholar
• Haas, D., S. N. White, L. B. Lutz, M. Rasar, and S. R. Hammes. 2005. The modulator of nongenomic actions of the estrogen receptor (MNAR) regulates transcription-independent androgen receptor-mediated signaling: evidence that MNAR participates in G protein-regulated meiosis in Xenopus laevis oocytes. Mol. Endocrinol. 19:2035–2046.
   PubMedGoogle Scholar
• Haynes, M. P., D. Sinha, K. S. Russell, M. Collinge, D. Fulton, M. Morales-Ruiz, W. C. Sessa, and J. R. Bender. 2000. Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cells. Circ. Res. 87:677–682.
   PubMed Web of Science ®Google Scholar
• Heery, D. M., E. Kalkhoven, S. Hoare, and M. G. Parker. 1997. A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387:733–736.
   PubMed Web of Science ®Google Scholar
• Joung, I., J. L. Strominger, and J. Shin. 1996. Molecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2 domain. Proc. Natl. Acad. Sci. USA 93:5991–5995.
   PubMed Web of Science ®Google Scholar
• Karas, R. H., H. Schulten, G. Pare, M. J. Aronovitz, C. Ohlsson, J. A. Gustafsson, and M. E. Mendelsohn. 2001. Effects of estrogen on the vascular injury response in estrogen receptor alpha, beta (double) knockout mice. Circ. Res. 89:534–539.
   PubMed Web of Science ®Google Scholar
• Koga, M., K. Hirano, M. Hirano, J. Nishimura, H. Nakano, and H. Kanaide. 2004. Akt plays a central role in the anti-apoptotic effect of estrogen in endothelial cells. Biochem. Biophys. Res. Commun. 324:321–325.
   PubMedGoogle Scholar
• Leevers, S. J., B. Vanhaesebroeck, and M. D. Waterfield. 1999. Signalling through phosphoinositide 3-kinases: the lipids take centre stage. Curr. Opin. Cell Biol. 11:219–225.
   PubMed Web of Science ®Google Scholar
• Leist, M., B. Single, G. Kunstle, C. Volbracht, H. Hentze, and P. Nicotera. 1997. Apoptosis in the absence of poly-(ADP-ribose) polymerase. Biochem. Biophys. Res. Commun. 233:518–522.
   PubMed Web of Science ®Google Scholar
• Levin, E. R. 2005. Integration of the extranuclear and nuclear actions of estrogen. Mol. Endocrinol. 19:1951–1959.
   PubMed Web of Science ®Google Scholar
• Mangelsdorf, D. J., C. Thummel, M. Beato, P. Herrlich, G. Schutz, K. Umesono, B. Blumberg, P. Kastner, M. Mark, P. Chambon, and R. M. Evans. 1995. The nuclear receptor superfamily: the second decade. Cell 83:835–839.
   PubMed Web of Science ®Google Scholar
• Migliaccio, A., G. Castoria, M. Di Domenico, A. De Falco, A. Bilancio, and F. Auricchio. 2002. Src is an initial target of sex steroid hormone action. Ann. N. Y. Acad. Sci. 963:185–190.
   PubMedGoogle Scholar
• Migliaccio, A., M. Di Domenico, G. Castoria, A. de Falco, P. Bontempo, E. Nola, and F. Auricchio. 1996. Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells. EMBO J. 15:1292–1300.
   PubMed Web of Science ®Google Scholar
• Migliaccio, A., M. Di Domenico, G. Castoria, M. Nanayakkara, M. Lombardi, A. de Falco, A. Bilancio, L. Varricchio, A. Ciociola, and F. Auricchio. 2005. Steroid receptor regulation of epidermal growth factor signaling through Src in breast and prostate cancer cells: steroid antagonist action. Cancer Res. 65:10585–10593.
   PubMed Web of Science ®Google Scholar
• Norman, A. W., M. T. Mizwicki, and D. P. G. Norman. 2004. Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model. Nat. Rev. Drug Discov. 3:27–41.
   PubMed Web of Science ®Google Scholar
• Santen, R. J., R. X. Song, Z. Zhang, R. Kumar, M. H. Jeng, S. Masamura, J. J. Lawrence, L. P. MacMahon, W. Yue, and L. Berstein. 2005. Adaptive hypersensitivity to estrogen: mechanisms and clinical relevance to aromatase inhibitor therapy in breast cancer treatment. J. Steroid Biochem. Mol. Biol. 95:155–165.
   PubMed Web of Science ®Google Scholar
• Shupnik, M. A. 2004. Crosstalk between steroid receptors and the c-Src-receptor tyrosine kinase pathways: implications for cell proliferation. Oncogene 23:7979–7989.
   PubMed Web of Science ®Google Scholar
• Simoncini, T., A. Hafezl-Moghadam, D. P. Brazil, K. Ley, W. W. Chin, and J. K. Liao. 2000. Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase. Nature 407:538–541.
   PubMed Web of Science ®Google Scholar
• Unni, E., S. Sun, B. Nan, M. J. McPhaul, B. Cheskis, M. A. Mancini, and M. Marcelli. 2004. Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence. Cancer Res. 64:7156–7168.
   PubMed Web of Science ®Google Scholar
• Vadlamudi, R. K., B. Manavathi, S. Balasenthil, S. S. Nair, Z. Yang, A. A. Sahin, and R. Kumar. 2005. Functional implications of altered subcellular localization of PELP1 in breast cancer cells. Cancer Res. 65:7724–7732.
   PubMed Web of Science ®Google Scholar
• Vadlamudi, R. K., R. A. Wang, A. Mazumdar, Y. Kim, J. Shin, A. Sahin, and R. Kumar. 2001. Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha. J. Biol. Chem. 276:38272–38279.
   PubMed Web of Science ®Google Scholar
• Watson, C. S., and B. Gametchu. 2003. Proteins of multiple classes may participate in nongenomic steroid actions. Exp. Biol. Med. 228:1272–1281.
   PubMed Web of Science ®Google Scholar
• Wong, C. W., C. McNally, E. Nickbarg, B. S. Komm, and B. J. Cheskis. 2002. Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade. Proc. Natl. Acad. Sci. USA 99:14783–14788.
   PubMed Web of Science ®Google Scholar