12
Views
55
CrossRef citations to date
0
Altmetric
Article

p18Ink4c, but Not p27Kip1, Collaborates with Men1 To Suppress Neuroendocrine Organ Tumors

, , , &
Pages 1495-1504 | Received 18 Sep 2006, Accepted 25 Nov 2006, Published online: 27 Mar 2023

REFERENCES

  • Bai, F., X. H. Pei, V. L. Godfrey, and Y. Xiong. 2003. Haploinsufficiency of p18INK4c sensitizes mice to carcinogen-induced tumorigenesis. Mol. Cell. Biol. 23:1269–1277.
  • Bertolino, P., W. M. Tong, D. Galendo, Z. Q. Wang, and C. X. Zhang. 2003. Heterozygous Men1 mutant mice develop a range of endocrine tumors mimicking multiple endocrine neoplasia type 1. Mol. Endocrinol. 17:1880–1892.
  • Buchwald, P. C., G. Akerstrom, and G. Westin. 2004. Reduced p18INK4c, p21CIP1/WAF1 and p27KIP1 mRNA levels in tumours of primary and secondary hyperparathyroidism. Clin. Endocrinol. 60:389–393.
  • Chandrasekharappa, S., S. C. Guru, P. Manickam, S. Olufemi, F. S. Collins, M. R. Emmert-Buck, L. V. Debelenko, Z. Zhuang, I. A. Lubensky, L. A. Liotta, J. S. Crabtree, Y. Wang, B. A. Roe, J. Weisemann, M. S. Boguski, S. K. Agawal, M. B. Kester, Y. S. Kim, C. Heppner, Q. Dong, A. M. Spiegel, A. L. Burns, and S. J. Marx. 1997. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 276:404–407.
  • Coxon, A. B., J. M. Ward, J. Geradts, G. A. Otterson, M. Zajac-Kaye, and F. J. Kaye. 1998. RET cooperates with RB/p53 inactivation in a somatic multi-step model for murine thyroid cancer. Oncogene 17:1625–1628.
  • Crabtree, J. S., P. C. Scacheri, J. M. Ward, L. Garrett-Beal, M. R. Emmert-Buck, K. A. Edgemon, D. Lorang, S. K. Libutti, S. C. Chandrasekharappa, S. J. Marx, A. M. Spiegel, and F. S. Collins. 2001. A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors. Proc. Natl. Acad. Sci. USA 98:1118–1123.
  • Fero, M. L., M. Rivkin, M. Tasch, P. Porter, C. E. Carow, E. Firpo, K. Polyak, L.-H. Tsai, V. Broudy, R. M. Perlmutter, K. Kaushansky, and J. M. Roberts. 1996. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27Kip1-deficient mice. Cell 85:733–744.
  • Franklin, D. S., V. L. Godfrey, H. Lee, G. I. Kovalev, R. Schoonhoven, S. Chen-Kiang, L. Su, and Y. Xiong. 1998. CDK inhibitors p18INK4c and p27KIP1 mediate two separate pathways to collaboratively suppress pituitary tumorigenesis. Genes Dev. 12:2899–2911.
  • Franklin, D. S., V. L. Godfrey, D. A. O'Brien, C. Deng, and Y. Xiong. 2000. Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity. Mol. Cell. Biol. 20:6147–6158.
  • Harvey, M., H. Vogel, E. Y.-H. P. Lee, A. Bradley, and L. A. Donehower. 1995. Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin. Oncogene 55:1146–1151.
  • Hughes, C. M., O. Rozenblatt-Rosen, T. A. Milne, T. D. Copeland, S. S. Levine, J. C. Lee, D. N. Hayes, K. S. Shanmugam, A. Bhattacharjee, C. A. Biondi, G. F. Kay, N. K. Hayward, J. L. Hess, and M. Meyerson. 2004. Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Mol. Cell 13:587–597.
  • Jacks, T., A. Fazeli, E. M. Schmitt, R. T. Bronson, M. A. Goodell, and R. A. Weinberg. 1992. Effects of an Rb mutation in the mouse. Nature 359:295–300.
  • Karnik, S. K., C. M. Hughes, X. Gu, O. Rozenblatt-Rosen, G. W. McLean, Y. Xiong, M. Meyerson, and S. K. Kim. 2005. Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. Proc. Natl. Acad. Sci. USA 102:14659–14664.
  • Kitagawa, M., H. Higashi, H. K. Jung, I. Suzuki-Takahashi, M. Ikeda, K. Tamai, J. Kato, K. Segawa, E. Yoshida, S. Nishimura, and Y. Taya. 1996. The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J. 15:7060–7069.
  • Kiyokawa, H., R. D. Kineman, K. O. Manova-Todorova, V. C. Soares, E. S. Hoffman, M. Ono, D. Khanam, A. C. Hayday, L. A. Frohman, and A. Koff. 1996. Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27Kip1. Cell 85:721–732.
  • Latres, E., M. Malumbres, R. Sotillo, J. Martin, S. Ortega, J. Martin-Caballero, J. M. Flores, C. Cordon-Cardo, and M. Barbacid. 2000. Limited overlapping roles of p15INK4b and p18INK4c cell cycle inhibitors in proliferation and tumorigenesis. EMBO J. 19:3496–3506.
  • Lee, Y.-H. P., C.-Y. Chang, N. Hu, Y.-C. J. Wang, C.-C. Lai, K. Herrup, W.-H. Lee, and A. Bradley. 1992. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature 359:288–294.
  • Lemmens, I., W. J. Van de Ven, K. Kas, C. X. Zhang, S. Giraud, V. Wautot, N. Buisson, K. De Witte, J. Salandre, G. Lenoir, M. Pugeat, A. Calender, F. Parente, D. Quincey, P. Gaudray, M. J. De Wit, C. J. Lips, J. W. Hoppener, S. Khodaei, A. L. Grant, G. Weber, S. Kytola, B. T. Teh, F. Farnebo, R. V. Thakker, et al. 1997. Identification of the multiple endocrine neoplasia type 1 (MEN1) gene. Hum. Mol. Genet. 6:1177–1183.
  • Maandag, E. C., M. Van Der Valk, M. Vlaar, C. Feltkamp, J. O'Brien, M. Van Roon, N. Van Der Lugt, A. Berns, and H. Te Riele. 1994. Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice. EMBO J. 13:4260–4268.
  • Martin, J., S. L. Hunt, P. Dubus, R. Sotillo, F. Nehme-Pelluard, M. A. Magnuson, A. F. Parlow, M. Malumbres, S. Ortega, and M. Barbacid. 2003. Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number. Oncogene 22:5261–5269.
  • Marx, S. J. 1998. Multiple endocrine neoplasia type 1, p. 489–506. In B. Vogelstein and K. W. Kinzler (ed.), The genetic basis of human cancer. McGraw-Hill, New York, NY.
  • Milne, T. A., C. M. Hughes, R. Lloyd, Z. Yang, O. Rozenblatt-Rosen, Y. Dou, R. W. Schnepp, C. Krankel, V. A. Livolsi, D. Gibbs, X. Hua, R. G. Roeder, M. Meyerson, and J. L. Hess. 2005. Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proc. Natl. Acad. Sci. USA 102:749–754.
  • Morishita, A., T. Masaki, H. Yoshiji, S. Nakai, T. Ogi, Y. Miyauchi, S. Yoshida, T. Funaki, N. Uchida, Y. Kita, F. Funakoshi, H. Usuki, S. Okada, K. Izuishi, S. Watanabe, K. Kurokohchi, and S. Kuriyama. 2004. Reduced expression of cell cycle regulator p18INK4C in human hepatocellular carcinoma. Hepatology 40:677–686.
  • Nakayama, K., N. Ishida, M. Shirane, A. Inomata, T. Inoue, N. Shishido, I. Horii, D. Y. Loh, and K.-i. Nakayama. 1996. Mice lacking p27Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85:707–720.
  • Nikitin, A. Y., M. I. Juarez-Perez, S. Li, L. Huang, and W. H. Lee. 1999. RB-mediated suppression of spontaneous multiple neuroendocrine neoplasia and lung metastases in Rb+/− mice. Proc. Natl. Acad. Sci. USA 96:3916–3921.
  • Pei, X. H., F. Bai, T. Tsutsui, H. Kiyokawa, and Y. Xiong. 2004. Genetic evidence for functional dependency of p18Ink4c on Cdk4. Mol. Cell. Biol. 24:6653–6664.
  • Sanchez-Aguilera, A., J. Delgado, F. I. Camacho, M. Sanchez-Beato, L. Sanchez, C. Montalban, M. F. Fresno, C. Martin, M. A. Piris, and J. F. Garcia. 2004. Silencing of the p18INK4c gene by promoter hypermethylation in Reed-Sternberg cells in Hodgkin lymphomas. Blood 103:2351–2357.
  • Scacheri, P. C., S. Davis, D. T. Odom, G. E. Crawford, S. Perkins, M. J. Halawi, S. K. Agarwal, S. J. Marx, A. M. Spiegel, P. S. Meltzer, and F. S. Collins. 2006. Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis. PLOS Genet. 2:e51.
  • Sherr, C. J. 1996. Cancer cell cycle. Science 274:1672–1677.
  • Sotillo, R., P. Dubus, J. Martin, E. de La Cueva, S. Ortega, M. Malumbres, and M. Barbacid. 2001. Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors. EMBO J. 20:6637–6647.
  • Spiegel, A. M. 2004. Focus on hereditary endocrine neoplasia. Cancer Cell 6:327–332.
  • Stewart, C., F. Parente, F. Piehl, F. Farnebo, D. Quincey, G. Silins, L. Bergman, G. F. Carle, I. Lemmens, S. Grimmond, C. Z. Xian, S. Khodei, B. T. Teh, J. Lagercrantz, P. Siggers, A. Calender, V. V. de Vem, K. Kas, G. Weber, N. Hayward, P. Gaudray, and C. Larsson. 1998. Characterization of the mouse Men1 gene and its expression during development. Oncogene 17:2485–2493.
  • Uziel, T., F. Zindy, S. Xie, Y. Lee, A. Forget, S. Magdaleno, J. E. Rehg, C. Calabrese, D. Solecki, C. G. Eberhart, S. E. Sherr, S. Plimmer, S. C. Clifford, M. E. Hatten, P. J. McKinnon, R. J. Gilbertson, T. Curran, C. J. Sherr, and M. F. Roussel. 2005. The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Genes Dev. 19:2656–2667.
  • Weinberg, R. A. 1995. The retinoblastoma protein and cell cycle control. Cell 81:323–330.
  • Williams, B. O., L. Remington, D. M. Albert, S. Mukai, R. T. Bronson, and T. Jacks. 1994. Cooperative tumorigenic effects of germline mitations in Rb and p53. Nat. Genet. 7:480–484.
  • Yokoyama, A., Z. Wang, J. Wysocka, M. Sanyal, D. J. Aufiero, I. Kitabayashi, W. Herr, and M. L. Cleary. 2004. Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Mol. Cell. Biol. 24:5639–5649.
  • Zarkowska, T., S. U, E. Harlow, and S. Mittnacht. 1997. Monoclonal antibodies specific for underphosphorylated retinoblastoma protein identify a cell cycle regulated phosphorylation site targeted by CDKs. Oncogene 14:249–254.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.