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Article

Cyclin-Dependent Kinase-Associated Proteins Cks1 and Cks2 Are Essential during Early Embryogenesis and for Cell Cycle Progression in Somatic Cells

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Pages 5698-5709 | Received 08 Oct 2007, Accepted 04 Jul 2008, Published online: 27 Mar 2023

REFERENCES

  • Berthet, C., E. Aleem, V. Coppola, L. Tessarollo, and P. Kaldis. 2003. Cdk2 knockout mice are viable. Curr. Biol. 13:1775–1785.
  • Bourne, Y., M. H. Watson, M. J. Hickey, W. Holmes, W. Rocque, S. I. Reed, and J. A. Tainer. 1996. Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1. Cell 84:863–874.
  • Brandeis, M., I. Rosewell, M. Carrington, T. Crompton, M. A. Jacobs, J. Kirk, J. Gannon, and T. Hunt. 1998. Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero. Proc. Natl. Acad. Sci. USA 95:4344–4349.
  • Broek, D., R. Bartlett, K. Crawford, and P. Nurse. 1991. Involvement of p34cdc2 in establishing the dependency of S phase on mitosis. Nature 349:388–393.
  • Caretti, G., V. Salsi, C. Vecchi, C. Imbriano, and R. Mantovani. 2003. Dynamic recruitment of NF-Y and histone acetyltransferases on cell-cycle promoters. J. Biol. Chem. 278:30435–30440.
  • Cerni, C., B. Binetruy, J. T. Schiller, D. R. Lowy, G. Meneguzzi, and F. Cuzin. 1989. Successive steps in the process of immortalization identified by transfer of separate bovine papillomavirus genes into rat fibroblasts. Proc. Natl. Acad. Sci. USA 86:3266–3270.
  • Chow, L. S., C. W. Lam, S. Y. Chan, S. W. Tsao, K. F. To, S. F. Tong, W. K. Hung, R. Dammann, D. P. Huang, and K. W. Lo. 2006. Identification of RASSF1A modulated genes in nasopharyngeal carcinoma. Oncogene 25:310–316.
  • Dahmann, C., J. F. Diffley, and K. A. Nasmyth. 1995. S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state. Curr. Biol. 5:1257–1269.
  • de Vos, S., U. Krug, W. K. Hofmann, G. S. Pinkus, S. H. Swerdlow, W. Wachsman, T. M. Grogan, J. W. Said, and H. P. Koeffler. 2003. Cell cycle alterations in the blastoid variant of mantle cell lymphoma (MCL-BV) as detected by gene expression profiling of mantle cell lymphoma (MCL) and MCL-BV. Diagn. Mol. Pathol. 12:35–43.
  • de Wit, N. J., J. Rijntjes, J. H. Diepstra, T. H. van Kuppevelt, U. H. Weidle, D. J. Ruiter, and G. N. van Muijen. 2005. Analysis of differential gene expression in human melanocytic tumour lesions by custom made oligonucleotide arrays. Br. J. Cancer 92:2249–2261.
  • Diffley, J. F. 2004. Regulation of early events in chromosome replication. Curr. Biol. 14:R778–R786.
  • Dobles, M., V. Liberal, M. L. Scott, R. Benezra, and P. K. Sorger. 2000. Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell 101:635–645.
  • Doree, M., and T. Hunt. 2002. From Cdc2 to Cdk1: when did the cell cycle kinase join its cyclin partner? J. Cell Sci. 115:2461–2464.
  • Dulic, V., E. Lees, and S. I. Reed. 1992. Association of human cyclin E with a periodic G1-S phase protein kinase. Science 257:1958–1961.
  • Elbashir, S. M., J. Harborth, W. Lendeckel, A. Yalcin, K. Weber, and T. Tuschl. 2001. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411:494–498.
  • Ganoth, D., G. Bornstein, T. K. Ko, B. Larsen, M. Tyers, M. Pagano, and A. Hershko. 2001. The cell-cycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27. Nat. Cell Biol. 3:321–324.
  • Geng, Y., Q. Yu, E. Sicinska, M. Das, J. E. Schneider, S. Bhattacharya, W. M. Rideout, R. T. Bronson, H. Gardner, and P. Sicinski. 2003. Cyclin E ablation in the mouse. Cell 114:431–443.
  • Gorr, I. H., D. Boos, and O. Stemmann. 2005. Mutual inhibition of separase and Cdk1 by two-step complex formation. Mol. Cell 19:135–141.
  • Hao, B., N. Zheng, B. A. Schulman, G. Wu, J. J. Miller, M. Pagano, and N. P. Pavletich. 2005. Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. Mol. Cell 20:9–19.
  • Hayles, J., D. Beach, B. Durkacz, and P. Nurse. 1986. The fission yeast cell cycle control gene cdc2: isolation of a sequence suc1 that suppresses cdc2 mutant function. Mol. Gen. Genet. 202:291–293.
  • Hayles, J., D. Fisher, A. Woollard, and P. Nurse. 1994. Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex. Cell 78:813–822.
  • Hengst, L., V. Dulic, J. M. Slingerland, E. Lees, and S. I. Reed. 1994. A cell cycle-regulated inhibitor of cyclin-dependent kinases. Proc. Natl. Acad. Sci. USA 91:5291–5295.
  • Hogan, B., R. Beddington, F. Costantini, and E. Lacy. 1994. Manipulating the mouse embryo: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Plainview, NY.
  • Inui, N., K. Kitagawa, S. Miwa, T. Hattori, K. Chida, H. Nakamura, and M. Kitagawa. 2003. High expression of Cks1 in human non-small cell lung carcinomas. Biochem. Biophys. Res. Commun. 303:978–984.
  • Itzhaki, J. E., C. S. Gilbert, and A. C. Porter. 1997. Construction by gene targeting in human cells of a “conditional” CDC2 mutant that rereplicates its DNA. Nat. Genet. 15:258–265.
  • Ji, J. Y., J. Crest, and G. Schubiger. 2005. Genetic interactions between Cdk1-cyclinB and the separase complex in Drosophila. Development 132:1875–1884.
  • Jin, P., S. Hardy, and D. O. Morgan. 1998. Nuclear localization of cyclin B1 controls mitotic entry after DNA damage. J. Cell Biol. 141:875–885.
  • Kawakami, K., H. Enokida, T. Tachiwada, T. Gotanda, K. Tsuneyoshi, H. Kubo, K. Nishiyama, M. Takiguchi, M. Nakagawa, and N. Seki. 2006. Identification of differentially expressed genes in human bladder cancer through genome-wide gene expression profiling. Oncol. Rep. 16:521–531.
  • Keck, J. M., M. K. Summers, D. Tedesco, S. Ekholm-Reed, L. C. Chuang, P. K. Jackson, and S. I. Reed. 2007. Cyclin E overexpression impairs progression through mitosis by inhibiting APC(Cdh1). J. Cell Biol. 178:371–385.
  • Kinsella, T. M., and G. P. Nolan. 1996. Episomal vectors rapidly and stably produce high-titer recombinant retrovirus. Hum. Gene Ther. 7:1405–1413.
  • Kitajima, S., Y. Kudo, I. Ogawa, T. Bashir, M. Kitagawa, M. Miyauchi, M. Pagano, and T. Takata. 2004. Role of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradation. Am. J. Pathol. 165:2147–2155.
  • Kozar, K., M. A. Ciemerych, V. I. Rebel, H. Shigematsu, A. Zagozdzon, E. Sicinska, Y. Geng, Q. Yu, S. Bhattacharya, R. T. Bronson, K. Akashi, and P. Sicinski. 2004. Mouse development and cell proliferation in the absence of D-cyclins. Cell 118:477–491.
  • Li, M., Y. M. Lin, S. Hasegawa, T. Shimokawa, K. Murata, M. Kameyama, O. Ishikawa, T. Katagiri, T. Tsunoda, Y. Nakamura, and Y. Furukawa. 2004. Genes associated with liver metastasis of colon cancer, identified by genome-wide cDNA microarray. Int. J. Oncol. 24:305–312.
  • Liu, N., F. C. Lucibello, K. Korner, L. A. Wolfraim, J. Zwicker, and R. Muller. 1997. CDF-1, a novel E2F-unrelated factor, interacts with cell cycle-regulated repressor elements in multiple promoters. Nucleic Acids Res. 25:4915–4920.
  • Mantovani, R. 1999. The molecular biology of the CCAAT-binding factor NF-Y. Gene 239:15–27.
  • Masuda, T. A., H. Inoue, K. Nishida, H. Sonoda, Y. Yoshikawa, Y. Kakeji, T. Utsunomiya, and M. Mori. 2003. Cyclin-dependent kinase 1 gene expression is associated with poor prognosis in gastric carcinoma. Clin. Cancer Res. 9:5693–5698.
  • McGowan, C. H., P. Russell, and S. I. Reed. 1990. Periodic biosynthesis of the human M-phase promoting factor catalytic subunit p34 during the cell cycle. Mol. Cell. Biol. 10:3847–3851.
  • Morris, M. C., P. Kaiser, S. Rudyak, C. Baskerville, M. H. Watson, and S. I. Reed. 2003. Cks1-dependent proteasome recruitment and activation of CDC20 transcription in budding yeast. Nature 423:1009–1013.
  • Murphy, M., M. G. Stinnakre, C. Senamaud-Beaufort, N. J. Winston, C. Sweeney, M. Kubelka, M. Carrington, C. Brechot, and J. Sobczak-Thepot. 1997. Delayed early embryonic lethality following disruption of the murine cyclin A2 gene. Nat. Genet. 15:83–86.
  • Musat, M., V. V. Vax, N. Borboli, M. Gueorguiev, S. Bonner, M. Korbonits, and A. B. Grossman. 2004. Cell cycle dysregulation in pituitary oncogenesis. Front. Horm. Res. 32:34–62.
  • Nakayama, K., H. Nagahama, Y. A. Minamishima, S. Miyake, N. Ishida, S. Hatakeyama, M. Kitagawa, S. Iemura, T. Natsume, and K. I. Nakayama. 2004. Skp2-mediated degradation of p27 regulates progression into mitosis. Dev. Cell 6:661–672.
  • Nurse, P., P. Thuriaux, and K. Nasmyth. 1976. Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe. Mol. Gen. Genet. 146:167–178.
  • Ortega, S., I. Prieto, J. Odajima, A. Martin, P. Dubus, R. Sotillo, J. L. Barbero, M. Malumbres, and M. Barbacid. 2003. Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nat. Genet. 35:25–31.
  • Ouellet, V., M. C. Guyot, C. Le Page, A. Filali-Mouhim, C. Lussier, P. N. Tonin, D. M. Provencher, and A. M. Mes-Masson. 2006. Tissue array analysis of expression microarray candidates identifies markers associated with tumor grade and outcome in serous epithelial ovarian cancer. Int. J. Cancer 119:599–607.
  • Ouellet, V., D. M. Provencher, C. M. Maugard, C. Le Page, F. Ren, C. Lussier, J. Novak, B. Ge, T. J. Hudson, P. N. Tonin, and A. M. Mes-Masson. 2005. Discrimination between serous low malignant potential and invasive epithelial ovarian tumors using molecular profiling. Oncogene 24:4672–4687.
  • Paddison, P. J., J. M. Silva, D. S. Conklin, M. Schlabach, M. Li, S. Aruleba, V. Balija, A. O'Shaughnessy, L. Gnoj, K. Scobie, K. Chang, T. Westbrook, M. Cleary, R. Sachidanandam, W. R. McCombie, S. J. Elledge, and G. J. *Hannon. 2004. A resource for large-scale RNA-interference-based screens in mammals. Nature 428:427–431.
  • Parisi, T., A. R. Beck, N. Rougier, T. McNeil, L. Lucian, Z. Werb, and B. Amati. 2003. Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells. EMBO J. 22:4794–4803.
  • Patra, D., and W. G. Dunphy. 1996. Xe-p9, a Xenopus Suc1/Cks homolog, has multiple essential roles in cell cycle control. Genes Dev. 10:1503–1515.
  • Patra, D., and W. G. Dunphy. 1998. Xe-p9, a Xenopus Suc1/Cks protein, is essential for the Cdc2-dependent phosphorylation of the anaphase-promoting complex at mitosis. Genes Dev. 12:2549–2559.
  • Patra, D., S. X. Wang, A. Kumagai, and W. G. Dunphy. 1999. The xenopus Suc1/Cks protein promotes the phosphorylation of G2/M regulators. J. Biol. Chem. 274:36839–36842.
  • Philips, A., S. Chambeyron, N. Lamb, A. Vie, and J. M. Blanchard. 1999. CHF: a novel factor binding to cyclin A CHR corepressor element. Oncogene 18:6222–6232.
  • Pines, J., and T. Hunter. 1992. Cyclins A and B1 in the human cell cycle. Ciba Found. Symp. 170:187–196.
  • Polinko, E. S., and S. Strome. 2000. Depletion of a Cks homolog in C. elegans embryos uncovers a post-metaphase role in both meiosis and mitosis. Curr. Biol. 10:1471–1474.
  • Reed, S. I., and C. Wittenberg. 1990. Mitotic role for the Cdc28 protein kinase of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 87:5697–5701.
  • Richardson, H. E., C. S. Stueland, J. Thomas, P. Russell, and S. I. Reed. 1990. Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe. Genes Dev. 4:1332–1344.
  • Shapira, M., O. Ben-Izhak, B. Bishara, B. Futerman, I. Minkov, M. M. Krausz, M. Pagano, and D. D. Hershko. 2004. Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma. Cancer 100:1615–1621.
  • Shapira, M., O. Ben-Izhak, S. Linn, B. Futerman, I. Minkov, and D. D. Hershko. 2005. The prognostic impact of the ubiquitin ligase subunits Skp2 and Cks1 in colorectal carcinoma. Cancer 103:1336–1346.
  • Slotky, M., M. Shapira, O. Ben-Izhak, S. Linn, B. Futerman, M. Tsalic, and D. D. Hershko. 2005. The expression of the ubiquitin ligase subunit Cks1 in human breast cancer. Breast Cancer Res. 7:R737–R744.
  • Spruck, C., H. Strohmaier, M. Watson, A. P. Smith, A. Ryan, T. W. Krek, and S. I. Reed. 2001. A CDK-independent function of mammalian Cks1: targeting of SCFSkp2 to the CDK inhibitor p27Kip1. Mol. Cell 7:639–650.
  • Spruck, C. H., M. P. de Miguel, A. P. Smith, A. Ryan, P. Stein, R. M. Schultz, A. J. Lincoln, P. J. Donovan, and S. I. Reed. 2003. Requirement of Cks2 for the first metaphase/anaphase transition of mammalian meiosis. Science 300:647–650.
  • Stanbrough, M., G. J. Bubley, K. Ross, T. R. Golub, M. A. Rubin, T. M. Penning, P. G. Febbo, and S. P. Balk. 2006. Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer. Cancer Res. 66:2815–2825.
  • Tan, B. C., C. T. Chien, S. Hirose, and S. C. Lee. 2006. Functional cooperation between FACT and MCM helicase facilitates initiation of chromatin DNA replication. EMBO J. 25:3975–3985.
  • Tang, Y., and S. I. Reed. 1993. The Cdk-associated protein Cks1 functions both in G1 and G2 in Saccharomyces cerevisiae. Genes Dev. 7:822–832.
  • Th'ng, J. P., P. S. Wright, J. Hamaguchi, M. G. Lee, C. J. Norbury, P. Nurse, and E. M. Bradbury. 1990. The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product. Cell 63:313–324.
  • Urbanowicz-Kachnowicz, I., N. Baghdassarian, C. Nakache, D. Gracia, Y. Mekki, P. A. Bryon, and M. Ffrench. 1999. ckshs expression is linked to cell proliferation in normal and malignant human lymphoid cells. Int. J. Cancer 82:98–104.
  • van't Veer, L. J., H. Dai, M. J. van de Vijver, Y. D. He, A. A. Hart, M. Mao, H. L. Peterse, K. van der Kooy, M. J. Marton, A. T. Witteveen, G. J. Schreiber, R. M. Kerkhoven, C. Roberts, P. S. Linsley, R. Bernards, and S. H. Friend. 2002. Gene expression profiling predicts clinical outcome of breast cancer. Nature 415:530–536.
  • Vassilev, L. T., C. Tovar, S. Chen, D. Knezevic, X. Zhao, H. Sun, D. C. Heimbrook, and L. Chen. 2006. Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proc. Natl. Acad. Sci. USA 103:10660–10665.
  • Visintin, R., S. Prinz, and A. Amon. 1997. CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science 278:460–463.
  • Wolthuis, R., L. Clay-Farrace, W. van Zon, M. Yekezare, L. Koop, J. Ogink, R. Medema, and J. Pines. 2008. Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A. Mol. Cell 30:290–302.
  • Wong, Y. F., T. H. Cheung, G. S. Tsao, K. W. Lo, S. F. Yim, V. W. Wang, M. M. Heung, S. C. Chan, L. K. Chan, T. W. Ho, K. W. Wong, C. Li, Y. Guo, T. K. Chung, and D. I. Smith. 2006. Genome-wide gene expression profiling of cervical cancer in Hong Kong women by oligonucleotide microarray. Int. J. Cancer 118:2461–2469.
  • Yamashita, M., S. Fukada, M. Yoshikuni, P. Bulet, T. Hirai, A. Yamaguchi, Y. H. Lou, Z. Zhao, and Y. Nagahama. 1992. Purification and characterization of maturation-promoting factor in fish. Dev. Biol. 149:8–15.
  • Yu, V. P., C. Baskerville, B. Grunenfelder, and S. I. Reed. 2005. A kinase-independent function of Cks1 and Cdk1 in regulation of transcription. Mol. Cell 17:145–151.
  • Zwicker, J., F. C. Lucibello, V. Jerome, S. Brusselbach, and R. Muller. 1997. CDF-1-mediated repression of cell cycle genes targets a specific subset of transactivators. Nucleic Acids Res. 25:4926–4932.
  • Zwicker, J., F. C. Lucibello, L. A. Wolfraim, C. Gross, M. Truss, K. Engeland, and R. Muller. 1995. Cell cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression. EMBO J. 14:4514–4522.

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