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Article

Murine Pif1 Interacts with Telomerase and Is Dispensable for Telomere Function In Vivo

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Pages 1017-1026 | Received 02 Oct 2006, Accepted 10 Nov 2006, Published online: 27 Mar 2023

REFERENCES

  • Aroya, S. B., and M. Kupiec. 2005. The Elg1 replication factor C-like complex: a novel guardian of genome stability. DNA Repair (Amsterdam) 4:409–417.
  • Azam, M., J. Y. Lee, V. Abraham, R. Chanoux, K. A. Schoenly, and F. B. Johnson. 2006. Evidence that the S.cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence. Nucleic Acids Res. 34:506–516.
  • Baerlocher, G. M., J. Mak, T. Tien, and P. M. Lansdorp. 2002. Telomere length measurement by fluorescence in situ hybridization and flow cytometry: tips and pitfalls. Cytometry 47:89–99.
  • Bayani, J., M. Zielenska, P. Marrano, Y. Kwan Ng, M. D. Taylor, V. Jay, J. T. Rutka, and J. A. Squire. 2000. Molecular cytogenetic analysis of medulloblastomas and supratentorial primitive neuroectodermal tumors by using conventional banding, comparative genomic hybridization, and spectral karyotyping. J. Neurosurg. 93:437–448.
  • Beattie, T. L., W. Zhou, M. O. Robinson, and L. Harrington. 2001. Functional multimerization of the human telomerase reverse transcriptase. Mol. Cell. Biol. 21:6151–6160.
  • Beattie, T. L., W. Zhou, M. O. Robinson, and L. Harrington. 2000. Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding. Mol. Biol. Cell 11:3329–3340.
  • Beattie, T. L., W. Zhou, M. O. Robinson, and L. Harrington. 1998. Reconstitution of human telomerase activity in vitro. Curr. Biol. 8:177–180.
  • Bennett, R. J., and J. L. Keck. 2004. Structure and function of RecQ DNA helicases. Crit. Rev. Biochem. Mol. Biol. 39:79–97.
  • Bertuch, A. A., and V. Lundblad. 2003. Which end: dissecting Ku's function at telomeres and double-strand breaks. Genes Dev. 17:2347–2350.
  • Bessler, J. B., J. Z. Torredagger, and V. A. Zakian. 2001. The Pif1p subfamily of helicases: region-specific DNA helicases? Trends Cell Biol. 11:60–65.
  • Bessler, J. B., and V. A. Zakian. 2004. The amino terminus of the Saccharomyces cerevisiae DNA helicase Rrm3p modulates protein function altering replication and checkpoint activity. Genetics 168:1205–1218.
  • Bhattacharyya, M. K., and A. J. Lustig. 2006. Telomere dynamics in genome stability. Trends Biochem. Sci. 31:114–122.
  • Biek, D. P., and S. N. Cohen. 1986. Identification and characterization of recD, a gene affecting plasmid maintenance and recombination in Escherichia coli. J. Bacteriol. 167:594–603.
  • Blasco, M. A., H. W. Lee, M. P. Hande, E. Samper, P. M. Lansdorp, R. A. DePinho, and C. W. Greider. 1997. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91:25–34.
  • Boule, J. B., L. R. Vega, and V. A. Zakian. 2005. The yeast Pif1p helicase removes telomerase from telomeric DNA. Nature 438:57–61.
  • Bridge, W. L., C. J. Vandenberg, R. J. Franklin, and K. Hiom. 2005. The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair. Nat. Genet. 37:953–957.
  • Budd, M. E., C. C. Reis, S. Smith, K. Myung, and J. L. Campbell. 2006. Evidence suggesting that Pif1 helicase functions in DNA replication with the Dna2 helicase/nuclease and DNA polymerase delta. Mol. Cell. Biol. 26:2490–2500.
  • Chen, Y. B., C. P. Yang, R. X. Li, R. Zeng, and J. Q. Zhou. 2005. Def1p is involved in telomere maintenance in budding yeast. J. Biol. Chem. 280:24784–24791.
  • Cohn, M., and E. H. Blackburn. 1995. Telomerase in yeast. Science 269:396–400.
  • Ding, H., M. Schertzer, X. Wu, M. Gertsenstein, S. Selig, M. Kammori, R. Pourvali, S. Poon, I. Vulto, E. Chavez, P. P. Tam, A. Nagy, and P. M. Lansdorp. 2004. Regulation of murine telomere length by Rtel: an essential gene encoding a helicase-like protein. Cell 117:873–886.
  • Doudican, N. A., B. Song, G. S. Shadel, and P. W. Doetsch. 2005. Oxidative DNA damage causes mitochondrial genomic instability in Saccharomyces cerevisiae. Mol. Cell. Biol. 25:5196–5204.
  • Erdmann, N., Y. Liu, and L. Harrington. 2004. Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice. Proc. Natl. Acad. Sci. USA 101:6080–6085.
  • Eugster, A., C. Lanzuolo, M. Bonneton, P. Luciano, A. Pollice, J. F. Pulitzer, E. Stegberg, A. S. Berthiau, K. Forstemann, Y. Corda, J. Lingner, V. Geli, and E. Gilson. 2006. The finger subdomain of yeast telomerase cooperates with Pif1p to limit telomere elongation. Nat. Struct. Mol. Biol. 13:734–739.
  • Evans, S. K., and V. Lundblad. 2000. Positive and negative regulation of telomerase access to the telomere. J. Cell Sci. 113:3357–3364.
  • Fisher, T. S., and V. A. Zakian. 2005. Ku: a multifunctional protein involved in telomere maintenance. DNA Repair (Amsterdam) 4:1215–1226.
  • Gorbalenya, A. E., and E. V. Koonin. 1993. Helicases: amino acid sequence comparisons and structure-function relationships. Curr. Opin. Struct. Biol. 3:419–429.
  • Grandin, N., C. Damon, and M. Charbonneau. 2001. Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13. EMBO J. 20:1173–1183.
  • Hakem, R., J. L. de la Pompa, C. Sirard, R. Mo, M. Woo, A. Hakem, A. Wakeham, J. Potter, A. Reitmair, F. Billia, E. Firpo, C. C. Hui, J. Roberts, J. Rossant, and T. W. Mak. 1996. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell 85:1009–1023.
  • Huang, Y., D. H. Zhang, and J. Q. Zhou. 2006. Characterization of ATPase activity of recombinant human Pif1. Acta Biochim. Biophys. Sin. (Shanghai) 38:335–341.
  • Hug, N., and J. Lingner. 2006. Telomere length homeostasis. Chromosoma 115:413–425.
  • Ivessa, A. S., B. A. Lenzmeier, J. B. Bessler, L. K. Goudsouzian, S. L. Schnakenberg, and V. A. Zakian. 2003. The Saccharomyces cerevisiae helicase Rrm3p facilitates replication past nonhistone protein-DNA complexes. Mol. Cell 12:1525–1536.
  • Ivessa, A. S., J. Q. Zhou, V. P. Schulz, E. K. Monson, and V. A. Zakian. 2002. Saccharomyces Rrm3p, a 5′ to 3′ DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA. Genes Dev. 16:1383–1396.
  • Ivessa, A. S., J. Q. Zhou, and V. A. Zakian. 2000. The Saccharomyces Pif1p DNA helicase and the highly related Rrm3p have opposite effects on replication fork progression in ribosomal DNA. Cell 100:479–489.
  • Khakhar, R. R., J. A. Cobb, L. Bjergbaek, I. D. Hickson, and S. M. Gasser. 2003. RecQ helicases: multiple roles in genome maintenance. Trends Cell Biol. 13:493–501.
  • Kim, N. W., M. A. Piatyszek, K. R. Prowse, C. B. Harley, M. D. West, P. L. Ho, G. M. Coviello, W. E. Wright, S. L. Weinrich, and J. W. Shay. 1994. Specific association of human telomerase activity with immortal cells and cancer. Science 266:2011–2015.
  • Korolev, S., J. Hsieh, G. H. Gauss, T. M. Lohman, and G. Waksman. 1997. Major domain swiveling revealed by the crystal structures of complexes of E. coli Rep helicase bound to single-stranded DNA and ADP. Cell 90:635–647.
  • Lahaye, A., H. Stahl, D. Thines-Sempoux, and F. Foury. 1991. PIF1: a DNA helicase in yeast mitochondria. EMBO J. 10:997–1007.
  • Liu, Y., H. Kha, M. Ungrin, M. O. Robinson, and L. Harrington. 2002. Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert. Proc. Natl. Acad. Sci. USA 99:3597–3602.
  • Lo, A. W., C. N. Sprung, B. Fouladi, M. Pedram, L. Sabatier, M. Ricoul, G. E. Reynolds, and J. P. Murnane. 2002. Chromosome instability as a result of double-strand breaks near telomeres in mouse embryonic stem cells. Mol. Cell. Biol. 22:4836–4850.
  • Lustig, A. J. 2003. Clues to catastrophic telomere loss in mammals from yeast telomere rapid deletion. Nat. Rev. Genet. 4:916–923.
  • Lydall, D. 2003. Hiding at the ends of yeast chromosomes: telomeres, nucleases and checkpoint pathways. J. Cell Sci. 116:4057–4065.
  • Mangahas, J. L., M. K. Alexander, L. L. Sandell, and V. A. Zakian. 2001. Repair of chromosome ends after telomere loss in Saccharomyces. Mol. Biol. Cell 12:4078–4089.
  • Marchler-Bauer, A., J. B. Anderson, P. F. Cherukuri, C. DeWeese-Scott, L. Y. Geer, M. Gwadz, S. He, D. I. Hurwitz, J. D. Jackson, Z. Ke, C. J. Lanczycki, C. A. Liebert, C. Liu, F. Lu, G. H. Marchler, M. Mullokandov, B. A. Shoemaker, V. Simonyan, J. S. Song, P. A. Thiessen, R. A. Yamashita, J. J. Yin, D. Zhang, and S. H. Bryant. 2005. CDD: a Conserved Domain Database for protein classification. Nucleic Acids Res. 33:D192–D196.
  • Mateyak, M. K., and V. A. Zakian. 2006. Human PIF1 helicase is cell cycle regulated and associates with telomerase. Cell Cycle 5:2796–2804.
  • Mitelman, F. 1995. An international system for human cytogenetic nomenclature. S. Karger, Basel, Switzerland.
  • Mohanty, B. K., N. K. Bairwa, and D. Bastia. 2006. The Tof1p-Csm3p protein complex counteracts the Rrm3p helicase to control replication termination of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 103:897–902.
  • Myers, R. S., and F. W. Stahl. 1994. Chi and the RecBC D enzyme of Escherichia coli. Annu. Rev. Genet. 28:49–70.
  • Myung, K., C. Chen, and R. D. Kolodner. 2001. Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae. Nature 411:1073–1076.
  • Myung, K., V. Pennaneach, E. S. Kats, and R. D. Kolodner. 2003. Saccharomyces cerevisiae chromatin-assembly factors that act during DNA replication function in the maintenance of genome stability. Proc. Natl. Acad. Sci. USA 100:6640–6645.
  • Oh, K. S., S. G. Khan, N. G. Jaspers, A. Raams, T. Ueda, A. Lehmann, P. S. Friedmann, S. Emmert, A. Gratchev, K. Lachlan, A. Lucassan, C. C. Baker, and K. H. Kraemer. 2006. Phenotypic heterogeneity in the XPB DNA helicase gene (ERCC3): xeroderma pigmentosum without and with Cockayne syndrome. Hum. Mutat. 27:1092–1103
  • Ooi, S. L., D. D. Shoemaker, and J. D. Boeke. 2003. DNA helicase gene interaction network defined using synthetic lethality analyzed by microarray. Nat. Genet. 35:277–286.
  • O'Rourke, T. W., N. A. Doudican, M. D. Mackereth, P. W. Doetsch, and G. S. Shadel. 2002. Mitochondrial dysfunction due to oxidative mitochondrial DNA damage is reduced through cooperative actions of diverse proteins. Mol. Cell. Biol. 22:4086–4093.
  • O'Rourke, T. W., N. A. Doudican, H. Zhang, J. S. Eaton, P. W. Doetsch, and G. S. Shadel. 2005. Differential involvement of the related DNA helicases Pif1p and Rrm3p in mtDNA point mutagenesis and stability. Gene 354:86–92.
  • Peng, M., R. Litman, Z. Jin, G. Fong, and S. B. Cantor. 2006. BACH1 is a DNA repair protein supporting BRCA1 damage response. Oncogene 25:2245–2253.
  • Pennaneach, V., C. D. Putnam, and R. D. Kolodner. 2006. Chromosome healing by de novo telomere addition in Saccharomyces cerevisiae. Mol. Microbiol. 59:1357–1368.
  • Prescott, J., and E. H. Blackburn. 1997. Functionally interacting telomerase RNAs in the yeast telomerase complex. Genes Dev. 11:2790–2800.
  • Prowse, K. R., A. A. Avilion, and C. W. Greider. 1993. Identification of a nonprocessive telomerase activity from mouse cells. Proc. Natl. Acad. Sci. USA 90:1493–1497.
  • Rufer, N., W. Dragowska, G. Thornbury, E. Roosnek, and P. M. Lansdorp. 1998. Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry. Nat. Biotechnol. 16:743–747.
  • Ryu, G. H., H. Tanaka, D. H. Kim, J. H. Kim, S. H. Bae, Y. N. Kwon, J. S. Rhee, S. A. MacNeill, and Y. S. Seo. 2004. Genetic and biochemical analyses of Pfh1 DNA helicase function in fission yeast. Nucleic Acids Res. 32:4205–4216.
  • Schmidt, K. H., and R. D. Kolodner. 2004. Requirement of Rrm3 helicase for repair of spontaneous DNA lesions in cells lacking Srs2 or Sgs1 helicase. Mol. Cell. Biol. 24:3213–3226.
  • Schrock, E., T. Veldman, H. Padilla-Nash, Y. Ning, J. Spurbeck, S. Jalal, L. G. Shaffer, P. Papenhausen, C. Kozma, M. C. Phelan, E. Kjeldsen, S. A. Schonberg, P. O'Brien, L. Biesecker, S. du Manoir, and T. Ried. 1997. Spectral karyotyping refines cytogenetic diagnostics of constitutional chromosomal abnormalities. Hum. Genet. 101:255–262.
  • Schulz, V. P., and V. A. Zakian. 1994. The saccharomyces PIF1 DNA helicase inhibits telomere elongation and de novo telomere formation. Cell 76:145–155.
  • Sharma, S., K. M. Doherty, and R. M. Brosh, Jr. 2006. Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability. Biochem. J. 398:319–337.
  • Spillare, E. A., X. W. Wang, C. von Kobbe, V. A. Bohr, I. D. Hickson, and C. C. Harris. 2006. Redundancy of DNA helicases in p53-mediated apoptosis. Oncogene 25:2119–2123.
  • Sprung, C. N., G. Afshar, E. A. Chavez, P. Lansdorp, L. Sabatier, and J. P. Murnane. 1999. Telomere instability in a human cancer cell line. Mutat. Res. 429:209–223.
  • Stellwagen, A. E., Z. W. Haimberger, J. R. Veatch, and D. E. Gottschling. 2003. Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends. Genes Dev. 17:2384–2395.
  • Taggart, A. K., and V. A. Zakian. 2003. Telomerase: what are the Est proteins doing? Curr. Opin. Cell Biol. 15:275–280.
  • Taylor, S. D., H. Zhang, J. S. Eaton, M. S. Rodeheffer, M. A. Lebedeva, W. O'Rourke, T. W. Siede, and G. S. Shadel. 2005. The conserved Mec1/Rad53 nuclear checkpoint pathway regulates mitochondrial DNA copy number in Saccharomyces cerevisiae. Mol. Biol. Cell 16:3010–3018.
  • Torres, J. Z., J. B. Bessler, and V. A. Zakian. 2004. Local chromatin structure at the ribosomal DNA causes replication fork pausing and genome instability in the absence of the S. cerevisiae DNA helicase Rrm3p. Genes Dev. 18:498–503.
  • Torres, J. Z., S. L. Schnakenberg, and V. A. Zakian. 2004. Saccharomyces cerevisiae Rrm3p DNA helicase promotes genome integrity by preventing replication fork stalling: viability of rrm3 cells requires the intra-S-phase checkpoint and fork restart activities. Mol. Cell. Biol. 24:3198–3212.
  • Van Dyck, E., F. Foury, B. Stillman, and S. J. Brill. 1992. A single-stranded DNA binding protein required for mitochondrial DNA replication in S. cerevisiae is homologous to E. coli SSB. EMBO J. 11:3421–3430.
  • Wagner, M., G. Price, and R. Rothstein. 2006. The absence of Top3 reveals an interaction between the Sgs1 and Pif1 DNA helicases in Saccharomyces cerevisiae. Genetics 174:555–573
  • Wahle, E., and W. Keller. 1996. The biochemistry of polyadenylation. Trends Biochem. Sci. 21:247–250.
  • Wang, R. C., A. Smogorzewska, and T. de Lange. 2004. Homologous recombination generates T-loop-sized deletions at human telomeres. Cell 119:355–368.
  • Williams, B., and A. J. Lustig. 2003. The paradoxical relationship between NHEJ and telomeric fusion. Mol. Cell 11:1125–1126.
  • Zhang, D. H., B. Zhou, Y. Huang, L. X. Xu, and J. Q. Zhou. 2006. The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity. Nucleic Acids Res. 34:1393–1404.
  • Zhou, J., E. K. Monson, S. C. Teng, V. P. Schulz, and V. A. Zakian. 2000. Pif1p helicase, a catalytic inhibitor of telomerase in yeast. Science 289:771–774.
  • Zhou, J. Q., H. Qi, V. P. Schulz, M. K. Mateyak, E. K. Monson, and V. A. Zakian. 2002. Schizosaccharomyces pombe pfh1+ encodes an essential 5′ to 3′ DNA helicase that is a member of the PIF1 subfamily of DNA helicases. Mol. Biol. Cell 13:2180–2191.
  • Zijlmans, J. M., U. M. Martens, S. S. Poon, A. K. Raap, H. J. Tanke, R. K. Ward, and P. M. Lansdorp. 1997. Telomeres in the mouse have large interchromosomal variations in the number of T2AG3 repeats. Proc. Natl. Acad. Sci. USA 94:7423–7428.

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