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Article

A Role for Interferon Regulatory Factor 4 in Receptor Editing

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Pages 2815-2824 | Received 29 Oct 2007, Accepted 06 Feb 2008, Published online: 27 Mar 2023

REFERENCES

  • Allman, D., R. C. Lindsley, W. DeMuth, K. Rudd, S. A. Shinton, and R. R. Hardy. 2001. Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation. J. Immunol. 167:6834–6840.
  • Bai, L., Y. Chen, Y. He, X. Dai, X. Lin, R. Wen, and D. Wang. 2007. Phospholipase Cγ2 contributes to light-chain gene activation and receptor editing. Mol. Cell. Biol. 27:5957–5967.
  • Brass, A. L., E. Kehrli, C. F. Eisenbeis, U. Storb, and H. Singh. 1996. Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1. Genes Dev. 10:2335–2347.
  • Brass, A. L., A. Q. Zhu, and H. Singh. 1999. Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers. EMBO J. 18:977–991.
  • Cornall, R. J., A. M. Cheng, T. Pawson, and C. C. Goodnow. 2000. Role of Syk in B-cell development and antigen-receptor signaling. Proc. Natl. Acad. Sci. USA 97:1713–1718.
  • Desiderio, S., W. C. Lin, and Z. Li. 1996. The cell cycle and V(D)J. recombination. Curr. Top. Microbiol. Immunol. 217:45–59.
  • Durdik, J., M. W. Moore, and E. Selsing. 1984. Novel kappa light-chain gene rearrangements in mouse lambda light chain-producing B lymphocytes. Nature 307:749–752.
  • Fitzsimmons, S. P., R. M. Bernstein, E. E. Max, J. A. Skok, and M. A. Shapiro. 2007. Dynamic changes in accessibility, nuclear positioning, recombination, and transcription at the Igκ locus. J. Immunol. 179:5264–5273.
  • Gay, D., T. Saunders, S. Camper, and M. Weigert. 1993. Receptor editing: an approach by autoreactive B cells to escape tolerance. J. Exp. Med. 177:999–1008.
  • Goodnow, C. C., J. Crosbie, S. Adelstein, T. B. Lavoie, S. J. Smith-Gill, R. A. Brink, H. Pritchard-Briscoe, J. S. Wotherspoon, R. H. Loblay, K. Raphael, et al. 1988. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334:676–682.
  • Halverson, R., R. M. Torres, and R. Pelanda. 2004. Receptor editing is the main mechanism of B cell tolerance toward membrane antigens. Nat. Immunol. 5:645–650.
  • Hartley, S. B., J. Crosbie, R. Brink, A. B. Kantor, A. Basten, and C. C. Goodnow. 1991. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature 353:765–769.
  • Hayashi, K., T. Nojima, R. Goitsuka, and D. Kitamura. 2004. Impaired receptor editing in the primary B cell repertoire of BASH-deficient mice. J. Immunol. 173:5980–5988.
  • Hippen, K. L., B. R. Schram, L. E. Tze, K. A. Pape, M. K. Jenkins, and T. W. Behrens. 2005. In vivo assessment of the relative contributions of deletion, anergy, and editing to B cell self-tolerance. J. Immunol. 175:909–916.
  • Inlay, M., and Y. Xu. 2003. Epigenetic regulation of antigen receptor rearrangement. Clin. Immunol. 109:29–36.
  • Inlay, M. A., H. Tian, T. Lin, and Y. Xu. 2004. Important roles for E protein binding sites within the immunoglobulin kappa chain intronic enhancer in activating Vkappa Jkappa rearrangement. J. Exp. Med. 200:1205–1211.
  • Klein, U., S. Casola, G. Cattoretti, Q. Shen, M. Lia, T. Mo, T. Ludwig, K. Rajewsky, and R. Dalla-Favera. 2006. Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nat. Immunol. 7:773–782.
  • Kouskoff, V., G. Lacaud, K. Pape, M. Retter, and D. Nemazee. 2000. B cell receptor expression level determines the fate of developing B lymphocytes: receptor editing versus selection. Proc. Natl. Acad. Sci. USA 97:7435–7439.
  • Lang, J., B. Arnold, G. Hammerling, A. W. Harris, S. Korsmeyer, D. Russell, A. Strasser, and D. Nemazee. 1997. Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells. J. Exp. Med. 186:1513–1522.
  • Lazorchak, A. S., M. S. Schlissel, and Y. Zhuang. 2006. E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin κ locus in pre-B cells. Mol. Cell. Biol. 26:810–821.
  • Lu, R., K. L. Medina, D. W. Lancki, and H. Singh. 2003. IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte development. Genes Dev. 17:1703–1708.
  • Ma, S., S. Pathak, L. Trinh, and R. Lu. 2008. Interferon regulatory factors 4 and 8 induce the expression of Ikaros and Aiolos to downregulate pre-B-cell receptor and promote cell-cycle withdrawal in pre-B-cell development. Blood 111:1396–1403.
  • Ma, S., A. Turetsky, L. Trinh, and R. Lu. 2006. IFN regulatory factor 4 and 8 promote Ig light chain kappa locus activation in pre-B cell development. J. Immunol. 177:7898–7904.
  • Mittrucker, H. W., T. Matsuyama, A. Grossman, T. M. Kundig, J. Potter, A. Shahinian, A. Wakeham, B. Patterson, P. S. Ohashi, and T. W. Mak. 1997. Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Science 275:540–543.
  • Moore, M. W., J. Durdik, D. M. Persiani, and E. Selsing. 1985. Deletions of kappa chain constant region genes in mouse lambda chain-producing B cells involve intrachromosomal DNA recombinations similar to V-J. joining. Proc. Natl. Acad. Sci. USA 82:6211–6215.
  • Muljo, S. A., and M. S. Schlissel. 2003. A small molecule Abl kinase inhibitor induces differentiation of Abelson virus-transformed pre-B cell lines. Nat. Immunol. 4:31–37.
  • Nagulapalli, S., and M. L. Atchison. 1998. Transcription factor Pip can enhance DNA binding by E47, leading to transcriptional synergy involving multiple protein domains. Mol. Cell. Biol. 18:4639–4650.
  • Nagulapalli, S., A. Goheer, L. Pitt, L. P. McIntosh, and M. L. Atchison. 2002. Mechanism of E47-Pip interaction on DNA resulting in transcriptional synergy and activation of immunoglobulin germ line sterile transcripts. Mol. Cell. Biol. 22:7337–7350.
  • Nemazee, D. 2006. Receptor editing in lymphocyte development and central tolerance. Nat. Rev. Immunol. 6:728–740.
  • Nemazee, D. A., and K. Burki. 1989. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature 337:562–566.
  • Pelanda, R., and R. M. Torres. 2006. Receptor editing for better or for worse. Curr. Opin. Immunol. 18:184–190.
  • Persiani, D. M., J. Durdik, and E. Selsing. 1987. Active lambda and kappa antibody gene rearrangement in Abelson murine leukemia virus-transformed pre-B cell lines. J. Exp. Med. 165:1655–1674.
  • Quong, M. W., A. Martensson, A. W. Langerak, R. R. Rivera, D. Nemazee, and C. Murre. 2004. Receptor editing and marginal zone B cell development are regulated by the helix-loop-helix protein, E2A. J. Exp. Med. 199:1101–1112.
  • Retter, M. W., and D. Nemazee. 1998. Receptor editing occurs frequently during normal B cell development. J. Exp. Med. 188:1231–1238.
  • Saito, M., J. Gao, K. Basso, Y. Kitagawa, P. M. Smith, G. Bhagat, A. Pernis, L. Pasqualucci, and R. Dalla-Favera. 2007. A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma. Cancer Cell 12:280–292.
  • Schlissel, M. S., and D. Baltimore. 1989. Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription. Cell 58:1001–1007.
  • Schweitzer, B. L., and R. P. DeKoter. 2004. Analysis of gene expression and Ig transcription in PU.1/Spi-B-deficient progenitor B cell lines. J. Immunol. 172:144–154.
  • Sciammas, R., A. L. Shaffer, J. H. Schatz, H. Zhao, L. M. Staudt, and H. Singh. 2006. Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation. Immunity 25:225–236.
  • Taniguchi, T., K. Ogasawara, A. Takaoka, and N. Tanaka. 2001. IRF family of transcription factors as regulators of host defense. Annu. Rev. Immunol. 19:623–655.
  • Tiegs, S. L., D. M. Russell, and D. Nemazee. 1993. Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177:1009–1020.
  • Vela, J. L., and D. Nemazee. 2007. Role of RS/kappaDE in B cell receptor editing. Adv. Exp. Med. Biol. 596:169–172.
  • Verkoczy, L., D. Ait-Azzouzene, P. Skog, A. Martensson, J. Lang, B. Duong, and D. Nemazee. 2005. A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes. Immunity 22:519–531.

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