229
Views
362
CrossRef citations to date
0
Altmetric
Article

The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane

, , &
Pages 5747-5763 | Received 18 Nov 2007, Accepted 02 Jul 2008, Published online: 27 Mar 2023

REFERENCES

  • Agarraberes, F., and J. F. Dice. 2001. A molecular chaperone complex at the lysosomal membrane is required for protein translocation. J. Cell Sci. 114:2491–2499.
  • Agarraberes, F., S. Terlecky, and J. Dice. 1997. An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation. J. Cell Biol. 137:825–834.
  • Aniento, F., E. Roche, A. M. Cuervo, and E. Knecht. 1993. Uptake and degradation of glyceraldehyde-3-phosphate dehydrogenase by rat liver lysosomes. J. Biol. Chem. 268:10463–10470.
  • Auteri, J. S., A. Okada, V. Bochaki, and J. F. Dice. 1983. Regulation of intracellular protein degradation in IMR-90 human diploid fibroblasts. J. Cell. Physiol. 115:167–174.
  • Bandhyopadhyay, U., and A. M. Cuervo. 2006. Chaperone-mediated autophagy in aging and neurodegeneration: lessons from alpha-synuclein. Exp. Gerontol. 42:120–128.
  • Chiang, H., S. Terlecky, C. Plant, and J. Dice. 1989. A role for a 70 kDa heat shock protein in lysosomal degradation of intracellular protein. Science 246:382–385.
  • Cuervo, A., and J. Dice. 1996. A receptor for the selective uptake and degradation of proteins by lysosomes. Science 273:501–503.
  • Cuervo, A., and J. Dice. 2000. Regulation of lamp2a levels in the lysosomal membrane. Traffic 1:570–583.
  • Cuervo, A., and J. Dice. 2000. Unique properties of lamp2a compared to other lamp2 isoforms. J. Cell Sci. 113:4441–4450.
  • Cuervo, A., J. Dice, and E. Knecht. 1997. A lysosomal population responsible for the hsc73-mediated degradation of cytosolic proteins in lysosomes. J. Biol. Chem. 272:5606–5615.
  • Cuervo, A., E. Knecht, S. Terlecky, and J. Dice. 1995. Activation of a selective pathway of lysosomal proteolysis in rat liver by prolonged starvation. Am. J. Physiol. 269:C1200–C1208.
  • Cuervo, A., S. Terlecky, J. Dice, and E. Knecht. 1994. Selective binding and uptake of ribonuclease A and glyceraldehyde-3-phosphate dehydrogenase by isolated rat liver lysosomes. J. Biol. Chem. 269:26374–26380.
  • Cuervo, A. M. 2004. Autophagy: many pathways to the same end. Mol. Cell. Biochem. 263:55–72.
  • Cuervo, A. M., and J. F. Dice. 2000. Age-related decline in chaperone-mediated autophagy. J. Biol. Chem. 275:31505–31513.
  • Cuervo, A. M., L. Mann, E. Bonten, A. d'Azzo, and J. Dice. 2003. Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor. EMBO J. 22:12–19.
  • Eskelinen, E., C. Schmidt, S. Neu, M. Willenborg, G. Fuertes, N. Salvador, Y. Tanaka, R. Lullmann-Rauch, D. Hartmann, J. Heeren, K. von Figura, E. Knecht, and P. Saftig. 2004. Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double-deficient fibroblasts. Mol. Biol. Cell 15:3132–3145.
  • Eskelinen, E. L., Y. Tanaka, and P. Saftig. 2003. At the acidic edge: emerging functions for lysosomal membrane proteins. Trends Cell Biol. 13:137–145.
  • Finn, P., N. Mesires, M. Vine, and J. F. Dice. 2005. Effects of small molecules on chaperone-mediated autophagy. Autophagy 1:141–145.
  • Huynh, K., E. Eskelinen, C. Scott, A. Malevanets, P. Saftig, and S. Grinstein. 2007. LAMP proteins are required for fusion of lysosomes with phagosomes. EMBO J. 26:313–324.
  • Jadot, M., R. Wattiaux, F. Mainferme, F. Dubois, A. Claessens, and S. Wattiaux-De Coninck. 1996. Soluble form of Lamp II in purified rat liver lysosomes. Biochem. Biophys. Res. Commun. 223:353–359.
  • Jentoft, N., and D. Dearborn. 1983. Protein labeling by reductive alkylation. Methods Enzymol. 91:570–579.
  • Kaushik, S., A. C. Massey, and A. M. Cuervo. 2006. Lysosome membrane lipid microdomains: novel regulators of chaperone-mediated autophagy. EMBO J. 25:3921–3933.
  • Kiffin, R., C. Christian, E. Knecht, and A. Cuervo. 2004. Activation of chaperone-mediated autophagy during oxidative stress. Mol. Biol. Cell 15:4829–4840.
  • Laemmli, U. 1970. Cleavage of structural proteins during the assembly of the head of the bacteriophage T4. Nature 227:680–685.
  • Lowry, O., N. Rosebrough, A. Farr, and R. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265–275.
  • Massey, A., C. Zhang, and A. Cuervo. 2006. Chaperone-mediated autophagy in aging and disease. Curr. Top. Dev. Biol. 73:205–235.
  • Massey, A. C., S. Kaushik, G. Sovak, R. Kiffin, and A. M. Cuervo. 2006. Consequences of the selective blockage of chaperone-mediated autophagy. Proc. Natl. Acad. Sci. USA 103:5805–5810.
  • Ohsumi, Y., T. Ishikawa, and K. Kato. 1983. A rapid and simplified method for the preparation of lysosomal membranes from rat liver. J. Biochem. 93:547–556.
  • Russ, W. P., and D. M. Engelman. 2000. The GxxxG motif: a framework for transmembrane helix-helix association. J. Mol. Biol. 296:911–919.
  • Sharp, S., and P. Workman. 2006. Inhibitors of the HSP90 molecular chaperones: current status. Adv. Cancer Res. 95:323–348.
  • Storrie, B., and E. Madden. 1990. Isolation of subcellular organelles. Methods Enzymol. 182:203–225.
  • Tanaka, Y., G. Guhde, A. Suter, E.-L. Eskelinen, D. Hartmann, R. Lullmann-Rauch, P. Janssen, J. Blanz, K. von Figura, and P. Saftig. 2000. Accumulation of autophagic vacuoles and cardiomyopathy in Lamp-2-deficient mice. Nature 406:902–906.
  • Terlecky, S., and J. Dice. 1993. Polypeptide import and degradation by isolated lysosomes. J. Biol. Chem. 268:23490–23495.
  • Towbin, H., T. Staehelin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. 76:4350–4354.
  • Waki, H., T. Yamauchi, J. Kamon, Y. Ito, S. Uchida, S. Kita, K. Hara, Y. Hada, F. Vasseur, P. Froguel, S. Kimura, R. Nagai, and T. Kadowaki. 2003. Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. J. Biol. Chem. 278:40352–40363.
  • Young, J. C., V. R. Agashe, K. Siegers, and F. U. Hartl. 2004. Pathways of chaperone-mediated protein folding in the cytosol. Nat. Rev. Mol. Cell Biol. 5:781–791.
  • Zhou, D., P. Li, Y. Lin, J. M. Lott, A. D. Hislop, D. H. Canaday, R. R. Brutkiewicz, and J. S. Blum. 2005. Lamp-2a facilitates MHC class II presentation of cytoplasmic antigens. Immunity 22:571–581.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.