37
Views
58
CrossRef citations to date
0
Altmetric
Article

The LYR Protein Mzm1 Functions in the Insertion of the Rieske Fe/S Protein in Yeast Mitochondria

, , , , &
Pages 3988-3996 | Received 20 May 2011, Accepted 19 Jul 2011, Published online: 20 Mar 2023

REFERENCES

  • Atkinson, A., et al. 2010. Mzm1 influences a labile pool of mitochondrial zinc important for respiratory function. J. Biol. Chem. 285:19450–19459.
  • Brandt, U., S. Uribe, H. Schagger, and B. L. Trumpower. 1994. Isolation and characterization of QCR10, the nuclear gene encoding the 8.5-kDa subunit 10 of the Saccharomyces cerevisiae cytochrome bc1 complex. J. Biol. Chem. 269:12947–12953.
  • Crivellone, M. D., M. A. Wu, and A. Tzagoloff. 1988. Assembly of the mitochondrial membrane system. Analysis of structural mutants of the yeast coenzyme QH2-cytochrome c reductase complex. J. Biol. Chem. 263:14323–14333.
  • Cruciat, C. M., S. Brunner, F. Baumann, W. Neupert, and R. A. Stuart. 2000. The cytochrome bc1 and cytochrome c oxidase complexes associate to form a single supracomplex in yeast mitochondria. J. Biol. Chem. 275:18093–18098.
  • Cruciat, C. M., K. Hell, H. Folsch, W. Neupert, and R. A. Stuart. 1999. Bcs1, an AAA-family member, is a chaperone for the assembly of the cytochrome bc1 complex. EMBO J. 18:5226–5233.
  • Diekert, K., A. I. De Kroon, G. Kispal, and R. Lill. 2001. Isolation and subfractionation of mitochondria from the yeast Saccharomyces cerevisiae. Methods Cell Biol. 65:37–51.
  • Edwards, C. A., and B. L. Trumpower. 1986. Resolution and reconstitution of the iron-sulfur protein of the cytochrome bc1 segment of the mitochondrial respiratory chain. Methods Enzymol. 126:211–224.
  • Esser, L., et al. 2008. Inhibitor-complexed structures of the cytochrome bc1 from the photosynthetic bacterium Rhodobacter sphaeroides. J. Biol. Chem. 283:2846–2857.
  • Ghezzi, D., et al. 2011. Mutations in TTC19 cause mitochondrial complex III deficiency and neurological impairment in humans and flies. Nat. Genet. 43:259–263.
  • Ghezzi, D., et al. 2011. SDHAF1, encoding a LYR complex-II specific assembly factor, is mutated in SDH-defective infantile leukoencephalopathy. Nat. Genet. 43:259–265.
  • Graham, L. A., U. Brandt, and B. L. Trumpower. 1994. Protease maturation of the Rieske iron-sulphur protein after its insertion into the mitochondrial cytochrome bc1 complex of Saccharomyces cerevisiae. Biochem. Soc. Trans. 22:188–191.
  • Graham, L. A., J. D. Phillips, and B. L. Trumpower. 1992. Deletion of subunit 9 of the Saccharomyces cerevisiae cytochrome bc1 complex specifically impairs electron transfer at the ubiquinol oxidase site (center P) in the bc1 complex. FEBS Lett. 313:251–254.
  • Graham, L. A., and B. L. Trumpower. 1991. Mutational analysis of the mitochondrial Rieske iron-sulfur protein of Saccharomyces cerevisiae. III. Import, protease processing, and assembly into the cytochrome bc1 complex of iron-sulfur protein lacking the iron-sulfur cluster. J. Biol. Chem. 266:22485–22492.
  • Gruschke, S., et al. 2011. Cbp3-Cbp6 interacts with the yeast mitochondrial ribosomal tunnel exit and promotes cytochrome b synthesis and assembly. J. Cell Biol. 193:1101–1114.
  • Hartl, F. U., B. Schmidt, E. Wachter, H. Weiss, and W. Neupert. 1986. Transport into mitochondria and intramitochondrial sorting of the Fe/S protein of ubiquinol-cytochrome c reductase. Cell 47:939–951.
  • Heinemeyer, J., H. P. Braun, E. J. Boekema, and R. Kouril. 2007. A structural model of the cytochrome c reductase/oxidase supercomplex from yeast mitochondria. J. Biol. Chem. 282:12240–12248.
  • Hu, J., L. Dong, and C. E. Outten. 2008. The redox environment in the mitochondrial intermembrane space is maintained separately from the cytosol and matrix. J. Biol. Chem. 283:29126–29134.
  • Iwata, S., et al. 1998. Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex. Science 281:64–71.
  • Kronekova, Z., and G. Rodel. 2005. Organization of assembly factors Cbp3 and Cbp4 and their effect on bc1 complex assembly in Saccharomyces cerevisiae. Curr. Genet. 47:203–212.
  • Lange, H., A. Kaut, G. Kispal, and R. Lill. 2000. A mitochondrial ferredoxin is essential for biogenesis of cellular iron-sulfur proteins. Proc. Natl. Acad. Sci. U. S. A. 97:1050–1055.
  • Lill, R., and U. Muhlenhoff. 2008. Maturation of iron-sulfur proteins in eukaryotes: mechanisms, connected processes, and diseases. Annu. Rev. Biochem. 77:669–700.
  • Mathieu, L., S. Marsy, Y. Saint-Georges, C. Jacq, and G. Dujardin. 2011. A transcriptome screen in yeast identifies a novel assembly factor for the mitochondrial complex III. Mitochondrion 11:391–396.
  • Merbitz-Zahradnik, T., K. Zwicker, J. H. Nett, T. A. Link, and B. L. Trumpower. 2003. Elimination of the disulfide bridge in the Rieske iron-sulfur protein allows assembly of the [2Fe-2S] cluster into the Rieske protein but damages the ubiquinol oxidation site in the cytochrome bc1 complex. Biochemistry 42:13637–13645.
  • Mumberg, D., R. Muller, and M. Funk. 1994. Regulatable promoters of Saccharomyces cerevisiae: Comparison of transcriptional activity and their use of heterologous expression. Nucleic Acids Res. 22:5767–5768.
  • Nett, J. H., and B. L. Trumpower. 1996. Dissociation of import of the Rieske iron-sulfur protein into Saccharomyces cerevisiae mitochondria from proteolytic processing of the presequence. J. Biol. Chem. 271:26713–26716.
  • Nett, J. H., and B. L. Trumpower. 1999. Intermediate length Rieske iron-sulfur protein is present and functionally active in the cytochrome bc1 complex of Saccharomyces cerevisiae. J. Biol. Chem. 274:9253–9257.
  • Nobrega, F. G., M. P. Nobrega, and A. Tzagoloff. 1992. BCS1, a novel gene required for the expression of functional Rieske iron-sulfur protein in Saccharomyces cerevisiae. EMBO J. 11:3821–3829.
  • Phillips, J. D., L. A. Graham, and B. L. Trumpower. 1993. Subunit 9 of the Saccharomyces cerevisiae cytochrome bc1 complex is required for insertion of EPR-detectable iron-sulfur cluster into the Rieske iron-sulfur protein. J. Biol. Chem. 268:11727–11736.
  • Pierrel, F., O. Khalimonchuk, P. A. Cobine, M. Bestwick, and D. R. Winge. 2008. Coa2 is an assembly factor for yeast cytochrome c oxidase biogenesis facilitating the maturation of Cox1. Mol. Cell. Biol. 28:4927–4939.
  • Stuart, R. A. 2008. Supercomplex organization of the oxidative phosphorylation enzymes in yeast mitochondria. J. Bioenerg. Biomembr. 40:411–417.
  • Vonck, J., and E. Schafer. 2009. Supramolecular organization of protein complexes in the mitochondrial inner membrane. Biochim. Biophys. Acta 1793:117–124.
  • Wach, A., A. Brachat, C. Alberti-Segui, C. Rebischung, and P. Philippsen. 1997. Heterologous HIS3 marker and GFP reporter modules for PCR-targeting in Saccharomyces cerevisiae. Yeast 13:1065–1075.
  • Wiedemann, N., et al. 2006. Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins. EMBO J. 25:184–195.
  • Wittig, I., H. P. Braun, and H. Schagger. 2006. Blue native PAGE. Nat. Protoc. 1:418–428.
  • Xia, D., et al. 1997. Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria. Science 277:60–66.
  • Zara, V., L. Conte, and B. L. Trumpower. 2009. Biogenesis of the yeast cytochrome bc1 complex. Biochim. Biophys. Acta 1793:89–96.
  • Zara, V., L. Conte, and B. L. Trumpower. 2009. Evidence that the assembly of the yeast cytochrome bc1 complex involves the formation of a large core structure in the inner mitochondrial membrane. FEBS J. 276:1900–1914.
  • Zara, V., L. Conte, and B. L. Trumpower. 2007. Identification and characterization of cytochrome bc1 subcomplexes in mitochondria from yeast with single and double deletions of genes encoding cytochrome bc1 subunits. FEBS J. 274:4526–4539.
  • Zollner, A., G. Rodel, and A. Haid. 1994. Expression of the Saccharomyces cerevisiae CYT2 gene, encoding cytochrome c1 heme lyase. Curr. Genet. 25:291–298.
  • Zollner, A., G. Rodel, and A. Haid. 1992. Molecular cloning and characterization of the Saccharomyces cerevisiae CYT2 gene encoding cytochrome-c1-heme lyase. Eur. J. Biochem. 207:1093–1100.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.