9
Views
13
CrossRef citations to date
0
Altmetric
Article

Alternative Splicing within the elk-1 5′ Untranslated Region Serves To Modulate Initiation Events Downstream of the Highly Conserved Upstream Open Reading Frame 2

, , &
Pages 1745-1756 | Received 20 Dec 2011, Accepted 09 Feb 2012, Published online: 20 Mar 2023

REFERENCES

  • Andreev DE, et al. 2009. Differential contribution of the m7G-cap to the 5′ end-dependent translation initiation of mammalian mRNAs. Nucleic Acids Res. 37:6135–6147.
  • Araud T, Genolet R, Jaquier-Gubler P, Curran J. 2007. Alternatively spliced isoforms of the human elk-1 mRNA within the 5′ UTR: implications for ELK-1 expression. Nucleic Acids Res. 35:4649–4663.
  • Calkhoven CF, Muller C, Leutz A. 2000. Translational control of C/EBPalpha and C/EBPbeta isoform expression. Genes Dev. 14:1920–1932.
  • Churbanov A, Rogozin IB, Babenko VN, Ali H, Koonin EV. 2005. Evolutionary conservation suggests a regulatory function of AUG triplets in 5′-UTRs of eukaryotic genes. Nucleic Acids Res. 33:5512–5520.
  • Costa-Mattioli M, et al. 2007. eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell 129:195–206.
  • Costa-Mattioli M, Sossin WS, Klann E, Sonenberg N. 2009. Translational control of long-lasting synaptic plasticity and memory. Neuron 61:10–26.
  • Costa-Mattioli M, et al. 2005. Translational control of hippocampal synaptic plasticity and memory by the eIF2[alpha] kinase GCN2. Nature 436:1166–1173.
  • Davuluri RV, Suzuki Y, Sugano S, Zhang MQ. 2000. CART classification of human 5′ UTR sequences. Genome Res. 10:1807–1816.
  • Genolet R, Rahim G, Gubler-Jaquier P, Curran J. 2011. The translational response of the human mdm2 gene in HEK293T cells exposed to rapamycin: a role for the 5′-UTRs. Nucleic Acids Res. 39:989–1003.
  • Gjoerup O, Zaveri D, Roberts TM. 2001. Induction of p53-independent apoptosis by simian virus 40 small t antigen. J. Virol. 75:9142–9155.
  • Grant CM, Miller PF, Hinnebusch AG. 1995. Sequences 5′ of the first upstream open reading frame in GCN4 mRNA are required for efficient translational reinitiation. Nucleic Acids Res. 23:3980–3988.
  • Harding HP, et al. 2000. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol. Cell 6:1099–1108.
  • Hinnebusch AG. 2011. Molecular mechanism of scanning and start codon selection in eukaryotes. Microbiol. Mol. Biol. Rev. 75:434–467.
  • Iacono M, Mignone F, Pesole G. 2005. uAUG and uORFs in human and rodent 5′untranslated mRNAs. Gene 349:97–105.
  • Jordan M, Schallhorn A, Wurm FM. 1996. Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation. Nucleic Acids Res. 24:596–601.
  • Kaufman RJ, Davies MV, Pathak VK, Hershey JW. 1989. The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs. Mol. Cell. Biol. 9:946–958.
  • Kochetov AV, et al. 2008. uORFs, reinitiation and alternative translation start sites in human mRNAs. FEBS Lett. 582:1293–1297.
  • Kozak M. 1987. Effects of intercistronic length on the efficiency of reinitiation by eucaryotic ribosomes. Mol. Cell. Biol. 7:3438–3445.
  • Kozak M. 2001. Constraints on reinitiation of translation in mammals. Nucleic Acids Res. 29:5226–5232.
  • Lu PD, Harding HP, Ron D. 2004. Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response. J. Cell Biol. 167:27–33.
  • Merrick WC. 2010. Eukaryotic protein synthesis: still a mystery. J. Biol. Chem. 285:21197–21201.
  • Morris DR, Geballe AP. 2000. Upstream open reading frames as regulators of mRNA translation. Mol. Cell. Biol. 20:8635–8642.
  • Munzarova V, et al. 2011. Translation reinitiation relies on the interaction between eIF3a/TIF32 and progressively folded cis-acting mRNA elements preceding short uORFs. PLoS Genet. 7:e1002137.
  • Oikawa T, Yamada T. 2003. Molecular biology of the Ets family of transcription factors. Gene 303:11–34.
  • Parsyan A, et al. 2011. mRNA helicases: the tacticians of translational control. Nat. Rev. Mol. Cell Biol. 12:235–245.
  • Peabody DS, Berg P. 1986. Termination-reinitiation occurs in the translation of mammalian cell mRNAs. Mol. Cell. Biol. 6:2695–2703.
  • Poyry TAA, Kaminski A, Connell EJ, Fraser CS, Jackson RJ. 2007. The mechanism of an exceptional case of reinitiation after translation of a long ORF reveals why such events do not generally occur in mammalian mRNA translation. Genes Dev. 21:3149–3162.
  • Rajkowitsch L, Vilela C, Berthelot K, Ramirez CV, McCarthy JE. 2004. Reinitiation and recycling are distinct processes occurring downstream of translation termination in yeast. J. Mol. Biol. 335:71–85.
  • Resch A, Ogurtsov A, Rogozin I, Shabalina S, Koonin E. 2009. Evolution of alternative and constitutive regions of mammalian 5′ UTRs. BMC Genomics 10:162.
  • Suzuki Y, et al. 2000. Statistical analysis of the 5′ untranslated region of human mRNA using “oligo-capped” cDNA libraries. Genomics 64:286–297.
  • Szamecz B, et al. 2008. eIF3a cooperates with sequences 5′ of uORF1 to promote resumption of scanning by post-termination ribosomes for reinitiation on GCN4 mRNA. Genes Dev. 22:2414–2425.
  • Twiss JL, Shooter EM. 1995. Nerve growth factor promotes neurite regeneration in PC12 cells by translational control. J. Neurochem. 64:550–557.
  • Twiss JL, Smith DS, Chang B, Shooter EM. 2000. Translational control of ribosomal protein L4 mRNA is required for rapid neurite regeneration. Neurobiol. Dis. 7:416–428.
  • Vanhoutte P, Caboche J. 2002. Elk-1: an important regulator of immediate early gene expression in the brain, p 287–308.Kaczmarck L, Robertson HJ (ed), Handbook of chemical neuroanatomy, vol. 19. Elsevier, New York, NY.
  • Vanhoutte P, et al. 2001. Opposing roles of Elk-1 and its brain-specific isoform, short Elk-1, in nerve growth factor-induced PC12 differentiation. J. Biol. Chem. 276:5189–5196.
  • Vattem KM, Wek RC. 2004. Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proc. Natl. Acad. Sci. U. S. A. 101:11269–11274.
  • Wang XQ, Rothnagel JA. 2004. 5′-Untranslated regions with multiple upstream AUG codons can support low-level translation via leaky scanning and reinitiation. Nucleic Acids Res. 32:1382–1391.
  • Wethmar K, et al. 2010. C/EBPbetaDeltauORF mice—a genetic model for uORF-mediated translational control in mammals. Genes Dev. 24:15–20.
  • Wiesenthal V, Leutz A, Calkhoven CF. 2006. A translation control reporter system (TCRS) for the analysis of translationally controlled processes in the vertebrate cell. Nucleic Acids Res. 34:e23.
  • Wiesenthal V, Leutz A, Calkhoven CF. 2006. Analysis of translation initiation using a translation control reporter system. Nat. Protoc. 1:1531–1537.
  • Zhou D, et al. 2008. Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions. J. Biol. Chem. 283:7064–7073.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.