ELF-2, a New Member of the Eph Ligand Family, Is Segmentally Expressed in Mouse Embryos in the Region of the Hindbrain and Newly Forming Somites

REFERENCES

• Altschul, S. F., W. Gish, W. Miller, E. W. Myers, and D. J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403–410.
   PubMed Web of Science ®Google Scholar
• Aruffo, A., I. Stamenkovic, M. Melnick, C. B. Underhill, and B. Seed. 1990. CD44 is the principal cell surface receptor for hyaluronate. Cell 61:1303–1313.
   PubMed Web of Science ®Google Scholar
• Bartley, T. D., R. W. Hunt, A. A. Welcher, W. J. Boyle, V. P. Parker, R. A. Lindberg, H. S. Lu, A. M. Colombero, R. L. Elliott, B. A. Guthrie, P. L. Holst, J. D. Skrine, R. J. Toso, M. Zhang, E. Fernandez, G. Trail, B. Varnum, Y. Yarden, T. Hunter, and G. M. Fox. 1994. B61 is a ligand for the ECK receptor protein-tyrosine kinase. Nature (London) 368:558–560.
   PubMed Web of Science ®Google Scholar
• Becker, N., T. Seitanidou, P. Murphy, M.-G. Mattei, P. Topilko, M. A. Nieto, D. G. Wilkinson, P. Charnay, and P. Gilardi-Hebenstreit. 1994. Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain. Mech. Dev. 47:3–17.
   PubMedGoogle Scholar
• Beckmann, M. P., D. P. Cerretti, P. Baum, T. Vandenbos, L. James, T. Farrah, C. Kozlosky, T. Hollingsworth, H. Shilling, E. Maraskovsky, F. A. Fletcher, V. Lhotak, T. Pawson, and S. D. Lyman. 1994. Molecular charac-terization of a family of ligands for Ephrelated tyrosine kinase receptors. EMBO J. 13:3757–3762.
   PubMed Web of Science ®Google Scholar
• Bosenberg, M. W., A. Pandiella, and J. Massague. 1992. The cytoplasmic carboxy-terminal amino acid specifies cleavage of membrane TGFα into soluble growth factor. Cell 71:1157–1165.
   PubMedGoogle Scholar
• Brambilla, R., A. Schnapp, F. Casagranda, J. P. Labrador, A. D. Bergemann, J. G. Flanagan, E. B. Pasquale, and R. Klein. Membrane-bound LERK2 ligand can signal through three different Ephrelated receptor tyrosine kinases. EMBO J., in press.
   Google Scholar
• Cantley, L. C., K. R. Auger, C. Carpenter, B. Duckworth, A. Graziani, R. Kapeller, and S. Soltoff. 1991. Oncogenes and signal transduction. Cell 64:281–302.
   PubMed Web of Science ®Google Scholar
• Cheng, H.-J., and J. G. Flanagan. 1994. Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases. Cell 79:157–168.
   PubMed Web of Science ®Google Scholar
• Cheng, H.-J., and J. G. Flanagan. 1994. Transmembrane kit ligand cleavage does not require a signal in the cytoplasmic domain and occurs at a site dependent on spacing from the membrane. Mol. Biol. Cell 5:943–953.
   PubMedGoogle Scholar
• Cheng, H.-J., and J. G. Flanagan. Unpublished data.
   Google Scholar
• Cheng, H.-J., M. Nakamoto, A. D. Bergemann, and J. G. Flanagan. Unpublished data.
   Google Scholar
• Ciossek, T., B. Millauer, and A. Ullrich. 1995. Identification of alternatively spliced mRNAs encoding variants of MDK1, a novel receptor tyrosine kinase expressed in the murine nervous system. Oncogene 10:97–108.
   PubMedGoogle Scholar
• Davis, S., N. W. Gale, T. H. Aldrich, P. C. Maisonpierre, V. Lhotak, T. Pawson, M. Goldfarb, and G. D. Yancopoulos. 1994. Ligands for Ephrelated receptor tyrosine kinases that require membrane attachment or clustering for activity. Science 266:816–819.
   PubMed Web of Science ®Google Scholar
• Eisenberg, S. P., R. J. Evans, W. P. Arend, E. Verderber, M. T. Brewer, C. H. Hannum, and R. C. Thompson. 1990. Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist. Nature (London) 343:341–346.
   PubMed Web of Science ®Google Scholar
• Fantl, W. J., D. E. Johnson, and L. T. Williams. 1993. Signalling by receptor tyrosine kinases. Annu. Rev. Biochem. 62:453–481.
   PubMed Web of Science ®Google Scholar
• Flanagan, J. G., D. C. Chan, and P. Leder. 1991. Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant. Cell 64:1025–1035.
   PubMed Web of Science ®Google Scholar
• Flanagan, J. G., and P. Leder. 1990. The kit ligand: a cell surface molecule altered in Steel mutant fibroblasts. Cell 63:185–194.
   PubMed Web of Science ®Google Scholar
• Fletcher, F. A., B. Renshaw, T. Hollingsworth, P. Baum, S. D. Lyman, N. A. Jenkins, D. J. Gilbert, N. G. Copeland, and B. L. Davidson. 1994. Genomic organization and chromosomal localization of mouse elpg2, a gene encoding a binding protein for the receptor tyrosine kinase elk. Genomics 24:127–132.
   PubMed Web of Science ®Google Scholar
• Ganju, P., K. Shigemoto, J. Brennan, A. Entwistle, and A. D. Reith. 1994. The eck receptor tyrosine kinase is implicated in pattern formation during gastrulation, hindbrain segmentation and limb development. Oncogene 9: 1613–1624.
   PubMedGoogle Scholar
• Hein, J. 1990. Unified approach to alignment and phylogenies. Methods Enzymol. 183:626–645.
   PubMed Web of Science ®Google Scholar
• Henkemeyer, M., L. Marengere, J. McGlade, J. P. Olivier, R. A. Conlon, D. P. Holmyard, K. Letwin, and T. Pawson. 1994. Immunolocalization of the nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis. Oncogene 9:1001–1014.
   PubMedGoogle Scholar
• Holzman, L. B., R. M. Marks, and V. M. Dixit. 1990. A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein. Mol. Cell. Biol. 10:5830–5838.
   PubMed Web of Science ®Google Scholar
• Kozak, M. 1987. An analysis of 59-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res. 15:8125–8148.
   PubMed Web of Science ®Google Scholar
• Kozlosky, C. J., E. Marakovsky, T. J. McGrew, T. VandedBos, M. Teepe, S. D. Lyman, S. Srinivasan, F. A. Fletcher, R. B. Gayle III, D. P. Cerretti, and M. P. Beckmann. 1995. Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins. Oncogene 10:299–306.
   PubMed Web of Science ®Google Scholar
• Lai, C., and G. Lemke. 1991. An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system. Neuron 6:691–704.
   PubMed Web of Science ®Google Scholar
• Lhotak, V., P. Greer, K. Letwin, and T. Pawson. 1991. Characterization of Elk, a brain-specific receptor tyrosine kinase. Mol. Cell. Biol. 11:2496–2502.
   PubMedGoogle Scholar
• Lumsden, A., and R. Keynes. 1989. Segmental patterns of neuronal development in the chick hindbrain. Nature (London) 337:424–428.
   PubMedGoogle Scholar
• Lumsden, A., N. Sprawson, and A. Graham. 1991. Segmental origin and migration of neural crest cells in the hindbrain region of the chick embryo. Development 113:1281–1291.
   PubMed Web of Science ®Google Scholar
• Maisonpierre, P. C., N. X. Barrezueta, and G. D. Yancopoulos. 1993. Ehk-1 and Ehk-2: two novel members of the Eph receptor-like tyrosine kinase family with distinctive structures and neuronal expression. Oncogene 8:3277–3288.
   PubMedGoogle Scholar
• Massague, J., and A. Pandiella. 1993. Membrane-anchored growth factors. Annu. Rev. Biochem. 62:515–541.
   PubMed Web of Science ®Google Scholar
• Nieto, M. A., P. Gilardi-Hebenstreit, P. Charnay, and D. G. Wilkinson. 1992. A receptor protein tyrosine kinase implicated in the segmental patterning of the hindbrain and mesoderm. Development 116:1137–1150.
   PubMed Web of Science ®Google Scholar
• Pasquale, E. B., T. J. Deerinck, S. J. Singer, and M. H. Ellisman. 1992. Cek5, a membrane receptor-type tyrosine kinase, is in neurons of the embryonic and postnatal avian brain. J. Neurosci. 12:3956–3967.
   PubMedGoogle Scholar
• Ruiz, J. C., and E. J. Robertson. 1994. The expression of the receptor-protein tyrosine kinase gene, eck, is highly restricted during early mouse development. Mech. Dev. 46:87–100.
   PubMedGoogle Scholar
• Sajjadi, F. G., and E. B. Pasquale. 1993. Five novel avian Ephrelated tyrosine kinases are differentially expressed. Oncogene 8:1807–1813.
   PubMed Web of Science ®Google Scholar
• Shao, H., L. Lou, A. Pandey, E. B. Pasquale, and V. M. Dixit. 1994. cDNA cloning and characterization of a ligand for the Cek5 receptor protein-tyrosine kinase. J. Biol. Chem. 269:26606–26609.
   PubMed Web of Science ®Google Scholar
• Soans, C., J. A. Holash, and E. B. Pasquale. 1994. Characterization of the expression of the Cek8 receptor-type tyrosine kinase during development and in tumor cell lines. Oncogene 9:3353–3361.
   PubMedGoogle Scholar
• Tuzi, N. L., and W. J. Gullick. 1994. eph, the largest known family of putative growth factor receptors. Br. J. Cancer 69:417–421.
   PubMed Web of Science ®Google Scholar
• van der Geer, P., T. Hunter, and R. A. Lindberg. 1994. Receptor protein-tyrosine kinases and their signal transduction pathways. Annu. Rev. Cell Biol. 10:251–337.
   PubMedGoogle Scholar
• von Heijne, G. 1984. How signal sequences maintain cleavage specificity. J. Mol. Biol. 173:243–251.
   PubMed Web of Science ®Google Scholar
• Wilkinson, D. G., and M. A. Nieto. 1993. Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts. Methods Enzymol. 225:361–373.
   PubMedGoogle Scholar
• Zhou, R., T. D. Copeland, L. F. Kromer, and N. T. Schulz. 1994. Isolation and characterization of bsk, a growth factor receptor-like tyrosine kinase associated with the limbic system. J. Neurosci. Res. 37:129–143.
   PubMedGoogle Scholar