Transformation by the Bmi-1 Oncoprotein Correlates with Its Subnuclear Localization but Not Its Transcriptional Suppression Activity

REFERENCES

• Alkema, M. J., N. M. T. van der Lugt, R. C. Bobeldijk, A. Berns, and M. van Lohuizen. 1995. Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice. Nature (London) 374: 724–727.
   PubMedGoogle Scholar
• Alkema, M. J., J. Wiegant, A. K. Raap, A. Berns, and M. van Lohuizen. 1993. Characterization and chromosomal localization of the human proto-oncogene BMI-1. Hum. Mol. Genet. 2: 1597–1603.
   PubMed Web of Science ®Google Scholar
• Berger, R., L. Baranger, A. Bernheim, F. Valensi, and G. Flandrin. 1987. Cytogenetics of T-cell malignant lymphoma. Report of 17 cases and review of the chromosomal breakpoints. Cancer Genet. Cytogenet. 36: 123–130.
   Google Scholar
• Bunker, C. A., and R. E. Kingston. 1994. Transcriptional repression by drosophila and mammalian polycomb group proteins in transfected mammalian cells. Mol. Cell. Biol. 14: 1721–1732.
   PubMedGoogle Scholar
• Cohen, K. J., and C. V. Dang. Unpublished data.
   Google Scholar
• D’Alessandro, E., P. Paterlini, M. Lo Re, M. Di Cola, C. Ligas, D. Quaglino, and G. Del Porto. 1990. Cytogenetic follow-up in a case of Sezary syndrome. Cancer Genet. Cytogenet. 45: 231–236.
   PubMedGoogle Scholar
• Dang, C. V., J. Barrett, M. Villa-Garcia, L. M. S. Resar, G. J. Kato, and E. R. Fearon. 1991. Intracellular leucine zipper interactions suggest c-Myc heterooligomerization. Mol. Cell. Biol. 11: 954–962.
   PubMedGoogle Scholar
• Dang, C. V., and W. M. F. Lee. 1989. Nuclear and nucleolar targeting sequences of c-erb-A, c-myb, N-myc, p53, HSP70 and HIV tat proteins. J. Biol. Chem. 264: 18019–18023.
   PubMed Web of Science ®Google Scholar
• Dyck, J. A., G. G. Maul, W. H. Miller Jr., J. D. Chen, A. Kakizuka, and R. M. Evans. 1994. A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein. Cell 76: 333–343.
   PubMed Web of Science ®Google Scholar
• Freemont, P. S., I. M. Hanson, and J. Trowsdale. 1991. A novel cysteine-rich sequence motif. Cell 64: 483–484.
   PubMed Web of Science ®Google Scholar
• Haupt, Y., W. S. Alexander, G. Barri, S. P. Klinken, and J. M. Adams. 1991. Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in Eµ-myc transgenic mice. Cell 65: 753–763.
   PubMed Web of Science ®Google Scholar
• Haupt, Y., M. L. Bath, A. W. Harris, and J. M. Adams. 1993. bmi-1 transgene induces lymphomas and collaborates with myc in tumorigenesis. Oncogene 8: 3161–3164.
   PubMed Web of Science ®Google Scholar
• Hoang, A. T., K. J. Cohen, J. F. Barrett, D. A. Bergstrom, and C. V. Dang. 1994. Participation of cyclin A in myc-induced apoptosis. Proc. Natl. Acad. Sci. USA 91: 6875–6879.
   PubMedGoogle Scholar
• Ishida, A., H. Asano, M. Hasegawa, H. Koseki, T. Ono, M. C. Yoshida, M. Taniguchi, and M. Kanno. 1993. Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new ‘RING-finger’ motif. Gene 129: 249–255.
   PubMedGoogle Scholar
• Kalderon, D., B. L. Roberts, W. D. Richardson, and A. E. Smith. 1984. A short amino acid sequence able to specify nuclear location. Cell 39: 499–509.
   PubMed Web of Science ®Google Scholar
• Kanno, M., M. Hasegawa, A. Ishida, K. Isono, and M. Taniguchi. 1995. mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity. EMBO J. 14: 5672–5678.
   PubMedGoogle Scholar
• Kato, G. J., J. Barrett, M. Villa-Garcia, and C. V. Dang. 1990. An aminoterminal c-myc domain required for neoplastic transformation activates transcription. Mol. Cell. Biol. 10: 5914–5920.
   PubMed Web of Science ®Google Scholar
• Kennison, J. A. 1995. The polycomb and trithorax group proteins of Drosophila: trans-regulators of homeotic gene function. Annu. Rev. Genet. 29: 289–303.
   PubMed Web of Science ®Google Scholar
• Klemsz, M. J., S. R. McKercher, A. Celada, C. Van Beveren, and R. A. Maki. 1990. The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. Cell 61: 113–124.
   PubMed Web of Science ®Google Scholar
• Krumlauf, R. 1994. Hox genes in vertebrate development. Cell 78: 191–201.
   PubMed Web of Science ®Google Scholar
• Land, H., L. F. Parada, and R. A. Weinberg. 1983. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature (London) 304: 596–602.
   PubMed Web of Science ®Google Scholar
• Lawrence, H. J., and C. Largman. 1992. Homeobox genes in normal hematopoiesis and leukemia. Blood. 80: 2445–2453.
   PubMed Web of Science ®Google Scholar
• Le, X. F., P. Yang, and K. S. Chang. 1996. Analysis of the growth and transformation suppressor domains of promyelocytic leukemia gene, pml. J. Biol. Chem. 271: 130–135.
   PubMed Web of Science ®Google Scholar
• Levy, L. S., P. A. Lobelle-Rich, and J. Overbaugh. 1993. flvi-2, a target of retroviral insertional mutagenesis in feline thymic lymphosarcomas, encodes bmi-1. Oncogene 8: 1833–1838.
   PubMedGoogle Scholar
• Lillie, J. W., and M. R. Green. 1989. Transcription activation by the adenovirus E1A protein. Nature (London) 388: 39–44.
   Google Scholar
• Lovering, R., I. M. Hanson, K. L. B. Borden, S. Martin, N. J. O’Reilly, G. I. Evan, D. Rahman, D. J. C. Pappin, J. Trowsdale, and P. S. Freemont. 1993. Identification and preliminary characterization of a protein motif related to the zinc finger. Proc. Natl. Acad. Sci. USA 90: 2112–2116.
   PubMed Web of Science ®Google Scholar
• Madden, S. L., D. M. Cook, and F. J. Rauscher. 1993. A structure-function analysis of transcriptional repression mediated by the WT1, Wilms’ tumor suppressor protein. Oncogene 8: 1713–1720.
   PubMed Web of Science ®Google Scholar
• Müller, J. 1995. Transcriptional silencing by the Polycomb protein in Drosophila embryos. EMBO J. 14: 1209–1220.
   PubMedGoogle Scholar
• Reijen, M. J., K. M. Hamer, J. L. den Blaauwen, C. Lambrechts, I. Schoneveld, R. van Driel, and A. P. Otte. 1995. Polycomb and bmi-1 homologs are expressed in overlapping patterns in Xenopus embryos and are able to interact with each other. Mech. Dev. 53: 35–46.
   PubMedGoogle Scholar
• Resar, L. M. S., C. Dolde, J. F. Barrett, and C. V. Dang. 1993. B-Myc inhibits neoplastic transformation and transcriptional activation by c-Myc. Mol. Cell. Biol. 13: 1130–1136.
   PubMedGoogle Scholar
• Rogers, S., R. Wells, and M. Rechsteiner. 1986. Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis. Science 234: 364–368.
   PubMed Web of Science ®Google Scholar
• Sanger, F., S. Nicklen, and A. Coulson. 1977. DNA sequencing with chainterminating inhibitors. Proc. Natl. Acad. Sci. USA 74: 5463–5467.
   PubMed Web of Science ®Google Scholar
• Seed, B., and J. Y. Sheen. 1988. A simple phase-extraction assay for chloramphenicol acetyltransferase activity. Gene 67: 271.
   PubMed Web of Science ®Google Scholar
• Simon, J., A. Chiang, W. Bender, M. J. Shimell, and M. O’Connor. 1993. Elements of the Drosophila bithorax complex that mediate repression by Polycomb group products. Dev. Biol. 158: 131–144.
   PubMed Web of Science ®Google Scholar
• Small, M. B., N. Hay, M. Schwab, and J. M. Bishop. 1987. Neoplastic transformation by the human gene N-myc. Mol. Cell. Biol. 7: 1638–1645.
   PubMed Web of Science ®Google Scholar
• Stone, J., T. de Lange, G. Ramsay, E. Jokobovits, J. M. Bishop, H. E. Varmus, and W. M. F. Lee. 1987. Definition of regions in human c-myc that are involved in transformation and nuclear localization. Mol. Cell. Biol. 7: 1697–1709.
   PubMed Web of Science ®Google Scholar
• Sugden, B., K. Marsh, and J. Yates. 1985. A vector that replicated as a plasmid can be efficiently selected in B-lymphoblasts transformed by Epstein-Barr virus. Mol. Cell. Biol. 5: 410–413.
   PubMedGoogle Scholar
• Tagawa, M., T. Sakamoto, K. Shigemoto, H. Matsubara, Y. Tamura, T. Ito, I. Nakamura, A. Okitsu, K. Imai, and M. Taniguchi. 1990. Expression of novel DNA-binding protein with zinc finger structure in various tumor cells. J. Biol. Chem. 265: 20021–20026.
   PubMedGoogle Scholar
• van der Lugt, N. M. T., J. Domsen, K. Linders, M. van Roon, E. Robanus-Maandag, H. te Riele, M. van der Valk, J. Deschamps, M. Sofroniew, M. van Lohuizen, and A. Berns. 1994. Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev. 8: 757–769.
   PubMed Web of Science ®Google Scholar
• van Lohuizen, M., S. Verbeek, B. Scheijen, E. Wientjens, H. van der Gulden, and A. Berns. 1991. Identification of cooperating oncogenes in Eµ-myc transgenic mice by provirus tagging. Cell 65: 737–752.
   PubMed Web of Science ®Google Scholar
• Yu, B. D., J. L. Hess, S. E. Horning, G. A. J. Brown, and S. J. Korsmeyer. 1995. Altered Hox expression and segmental identity in MLL-mutant mice. Nature (London) 378: 505–508.
   PubMed Web of Science ®Google Scholar