12
Views
210
CrossRef citations to date
0
Altmetric
Research Article

Deletion of the Carboxyl-Terminal Transactivation Domain of MGF-Stat5 Results in Sustained DNA Binding and a Dominant Negative Phenotype

, , , , , , , , & show all
Pages 5691-5700 | Received 12 Mar 1996, Accepted 02 Jul 1996, Published online: 29 Mar 2023

REFERENCES

  • Altiok, S., and B. Groner. 1993. Interaction of two sequence-specific singlestranded DNA-binding proteins with an essential region of the β-casein gene promoter is regulated by lactogenic hormones. Mol. Cell. Biol. 13:7303–7310.
  • Azam, M., H. Erdjument-Bromage, B. L. Kreider, M. Xia, F. Quelle, R. Basu, C. Saris, P. Tempst, J. N. Ihle, and C. Schindler. 1995. Interleukin-3 signals through multiple isoforms of Stat5. EMBO J. 14:1402–1411.
  • Beadling, C., J. Ng, J. W. Babbage, and D. A. Cantrell. 1996. Interleukin-2 activation of Stat5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Rafl/ERK2 MAP kinase pathway. EMBO J. 15:1902–1913.
  • Damen, J. E., H. Wakao, A. Miyajima, J. Krosl, R. K. Humphries, R. L. Cutler, and G. Krystal. 1995. Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin induced cell proliferation and Stat5 activation. EMBO J. 14:5557–5568.
  • David, M., I. E. Petricoin, C. Benjamin, R. Pine, M. J. Weber, and A. C. Larner. 1995. Requirement for MAP kinase (ERK2) activity in interferon-α and interferon-γ stimulated gene expression through Stat proteins. Science 269:1721–1723.
  • Dusanter-Fourt, I., O. Muller, A. Ziemiecki, P. Mayeux, B. Drucker, J. Djiane, A. Wilks, A. G. Harpur, S. Fisher, and S. Gisselbrecht. 1994. Identification of Jak protein tyrosine kinases as signaling molecules for PRL. Functional analysis of PRL receptor and PRL-erythropoietin receptor chimera expressed in lymphoid cells. EMBO J. 13:2583–2591.
  • Fuji, H., Y. Nakagawa, U. Schindler, A. Kawahara, H. Mori, F. Gouilleux, B. Groner, J. N. Ihle, Y. Minami, T. Miyazaki, and T. Taniguchi. 1995. Activation of Stat5 by interleukin 2 requires a carboxy-terminal region of the interleukin 2 receptor β chain but is not essential for the proliferative signal transmission. Proc. Natl. Acad. Sci. USA 92:5482–5486.
  • Gaffen, S. L., S. Y. Lai, W. Xu, F. Gouilleux, B. Groner, M. A. Goldsmith, and W. C. Greene. 1995. Signaling through the interleukin 2 receptor β chain activates a Stat5 like DNA binding activity. Proc. Natl. Acad. Sci. USA 92:7192–7196.
  • Garnier, J., D. J. Osguthorpe, and B. Robson. 1978. Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J. Mol. Biol. 120:97–120.
  • Gobert, S., S. Chretien, F. Gouilleux, O. Muller, C. Pallard, I. Dusanter-Fourt, B. Groner, C. Lacombe, S. Gisselbrecht, and P. Mayeux. 1996. Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for Stat5 activation. EMBO J. 15:2434–2441.
  • Gouilleux, F., D. Moritz, M. Humar, R. Moriggl, S. Berchtold, and B. Groner. 1995. Prolactin and interleukin 2 receptors in T lymphocytes signal through a MGF/Stat5-like transcription factor. Endocrinology. 136:5700–5708.
  • Gouilleux, F., C. Pallard, I. Dusanter-Fourt, H. Wakao, L.-A. Haldosen, G. Norstedt, D. Levy, and B. Groner. 1995. Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity. EMBO J. 14:2005–2013.
  • Gouilleux, F., H. Wakao, M. Mundt, and B. Groner. 1994. Prolactin induces phosphorylation of tyr694 of Stat5(MGF), a prerequisite for DNA binding and induction of transcription. EMBO J. 13: 4361–4369.
  • Greenlund, A. C., M. O. Morales, B. L. Viviano, H. Yan, J. Krolewski, and R. D. Schreiber. 1995. Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process. Immunity 2:677–687.
  • Groner, B., and F. Gouilleux. 1995. Prolactin-mediated gene activation in mammary epithelial cells. Curr. Opin. Gen. Dev. 5:587–594.
  • Heim, M. H., I. M. Kerr, G. R. Stark, and J. E. Darnell. 1995. Contribution of Stat SH2 groups to specific interferon signaling by the Jak-Stat pathway. Science 267:1347–1349.
  • Horvarth, C. M., Z. Wen, and J. E. Darnell. 1995. A Stat protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. Genes Dev. 9:984–994.
  • Hou, X. S., M. B. Melnick, and N. Perrimon. 1996. Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs. Cell 84:411–441.
  • Ihle, J. N. 1995. Cytokine receptor signalling. Nature (London) 377:591–594.
  • Ihle, J. N. 1996. Stats: signal transducers and activators of transcription. Cell 84:331–334.
  • Johnston, J. A., C. M. Bacon, D. S. Finbloom, R. C. Rees, D. Kaplan, K. Shibuya, J. R. Ortaldo, S. Gupta, Y. Q. Chen, J. D. Giri, and J. J. O’Shea. 1995. Tyrosine phosphorylation and activation of Stat5, Stat3 and Janus kinases by interleukins 2 and 15. Proc. Natl. Acad. Sci. USA 92:8705–8709.
  • Kazansky, A. V., B. Raught, M. Lindsey, Y. Wang, and J. M. Rosen. 1995. Regulation of mammary gland factor/Stat5a during mammary gland development. Mol. Endocrinol. 9:1598–1609.
  • Lamb, P., H. M. Seidel, J. Haslam, L. Milocco, L. V. Kessler, R. B. Stein, and J. Rosen. 1995. Stat protein complexes activated by interferon-y and gpl30 signaling molecules differ in their sequence preferences and transcriptional induction properties. Nucleic Acids Res. 23:3283–3289.
  • Lin, J.-X., T.-S. Migone, M. Tsang, M. Friedmann, J. A. Wheatherbee, L. Zhou, A. Yamauchi, E. T. Bloom, J. Mietz, S. John, and W. J. Leonard. 1995. The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13 and IL-15. Immunity 2:331–339.
  • Liu, K. D., S. Y. Lai, M. A. Goldsmith, and W. C. Greene. 1995. Identification of a variable region within the cytoplasmic tail of the IL-2 receptor β chain that is required for growth signal transduction. J. Biol. Chem. 270:22176–22181.
  • Liu, X., G. W. Robinson, F. Gouilleux, B. Groner, and L. Hennighausen. 1995. Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. Proc. Natl. Acad. Sci. USA 92:8831–8835.
  • Meier, V., and B. Groner. 1994. The nuclear factor YY1 participates in repression of the β-casein gene promoter in mammary epithelial cells and is counteracted by mammary gland factor during lactogenic hormone induction. Mol. Cell. Biol. 14:128–137.
  • Mui, A. L.-F., H. Wakao, A.-M. O’Farrell, N. Harada, and A. Miyajima. 1995. Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two Stat5 homologs. EMBO J. 14: 1166–1175.
  • Pallard, C., F. Gouilleux, L. Benit, L. Cocault, M. Souyri, D. Levy, B. Groner, S. Gisselbrecht, and I. Dusanter-Fourt. 1995. Thrombopoietin activates a Stat5-like factor in hematopoietic cells. EMBO J. 14:2847–2856.
  • Pallard, C., F. Gouilleux, M. Charon, B. Groner, S. Gisselbrecht, and I. Dusanter-Fourt. 1995. Interleukin-3, erythropoietin and prolactin activate a Stat5-like factor in lymphoid cells. J. Biol. Chem. 270:15942–15945.
  • Qureshi, S. A., S. Leung, I. M. Kerr, G. R. Stark, and J. E. Darnell. 1996. Function of Stat2 protein in transcriptional activation by alpha interferon. Mol. Cell. Biol. 16:288–293.
  • Rippberger, J. A., S. Fritz, K. Richter, G. M. Hocke, F. Lottspeich, and G. H. Fey. 1995. Transcription factors Stat3 and Stat5b are present in rat liver nuclei in an acute phase response and bind interleukin 6 response elements. J. Biol. Chem. 270:29998–30006.
  • Ruff-Jamison, S., K. Chen, and S. Cohen. 1995. Epidermal growth factor induces the tyrosine phosphorylation and nuclear translocation of Stat5 in mouse liver. Proc. Natl. Acad. Sci. USA 92:4215–4218.
  • Sadowski, I., and M. Ptashne. 1989. A vector for expressing GAL4( 1–147) fusions in mammalian cells. Nucleic Acids Res. 18:7593–7599.
  • Schaefer, T. S., L. K. Sanders, and D. Nathans. 1995. Cooperative transcriptional activity of Jun and Stat3β, a short form of Stat3. Proc. Natl. Acad. Sci. USA 92:9097–9101.
  • Schindler, C., and J. E. Darnell. 1995. Transcriptional responses to polypeptide ligands: the Jak-Stat pathway. Annu. Rev. Biochem. 64:621–651.
  • Schindler, C., X.-Y. Fu, T. Improta, R. Aebersold, and J. E. Darnell. 1992. Proteins of transcription factor ISGF-3: one gene encodes the 91- and 84-kDa ISGF-3 proteins that are activated by interferon-α. Proc. Natl. Acad. Sci. USA 89:7836–7839.
  • Schindler, U., P. Wu, M. Rothe, M. Brasseur, and S. L. McKnight. 1995. Components of a Stat recognition code: evidence for two layers of molecular selectivity. Immunity 2:689–697.
  • Schmitt-Ney, M., W. Doppler, R. K. Ball, and B. Groner. 1991. Beta-casein gene promoter activity is regulated by the hormone-mediated relief of transcriptional repression and a mammary-specific nuclear factor. Mol. Cell. Biol. 11:3745–3755.
  • Schmitt-Ney, M., B. Happ, R. K. Ball, and B. Groner. 1992. Developmental and environmental regulation of a mammary gland specific nuclear factor essential for transcription of the gene encoding beta-casein. Proc. Natl. Acad. Sci. USA 89:3130–3134.
  • Schmitz, M. L., and P. Baeuerle. 1991. The p65 subunit is responsible for the strong transcription activating potential of NF-kB. EMBO J. 10:3805–3817.
  • Seidel, M. H., L. H. Milocco, P. Lamb, J. E. Darnell, R. B. Stein, and J. Rosen. 1995. Spacing of palindromic half sites as a determinant of selective Stat (signal transducers and activators of transcription) DNA binding and transcriptional activity. Proc. Natl. Acad. Sci. USA 92:3041–3045.
  • Shuai, K., C. M. Horvath, L. H. T. Huang, S. A. Qureshi, D. Cowburn, and J. E. Darnell. 1994. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell 76:821–828.
  • Shuai, K., G. R. Stark, I. M. Kerr, and J. E. Darnell. 1993. A single phosphotyrosine residue of Stat91 required for gene activation by interferon-y. Science 261:1808–1812.
  • Stahl, N., T. J. Farruggella, T. G. Boulton, Z. Zhong, J. E. Darnell, and G. D. Yancopoulos. 1995. Choice of Stats and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science 267:1349–1352.
  • Wakao, H., F. Gouilleux, and B. Groner. 1994. Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the PRL response. EMBO J. 13:2182–2191.
  • Wakao, H., N. Harada, T. Kitamura, A. L.-F. Mui, and A. Miyajima. 1995. Interleukin 2 and erythropoietin activate Stat5/MGF via distinct pathways. EMBO J. 14:2527–2535.
  • Wakao, H., M. Schmitt-Ney, and B. Groner. 1992. Mammary gland-specific nuclear factor is present in lactating rodent and bovine mammary tissue and composed of a single polypeptide of 89 kDa. J. Biol. Chem. 267:16365–16370.
  • Yan, R., S. Small, C. Desplan, C. R. Dearolf, and J. E. Darnell. 1996. Identification of a Stat gene that functions in Drosophila development. Cell 84:421–430.
  • Wen, Z., Z. Zhong, and J. E. Darnell. 1995. Maximal activation of transcription by Statl and Stat3 requires both tyrosine and serine phosphorylation. Cell 82:241–250.
  • Wood, T. J. J., D. Sliva, T. Pircher, P. E. Lobie, F. Gouilleux, H. Wakao, J.-A. Gustafsson, B. Groner, G. Norstedt, and L.-A. Haldosen. 1995. Mediation of growth hormone-dependent transcriptional activation by mammary gland factor/Stat5. J. Biol. Chem. 16:9448–9453.
  • Zhang, X., J. Blenis, H.-C. Li, C. Schindler, and S. Chen-Kiang. 1995. Requirement of serine phosphorylation for formation of Stat-promoter complexes. Science 267:1990–1994.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.