2
Views
173
CrossRef citations to date
0
Altmetric
Research Article

The Cyclin-Dependent Kinase Inhibitor p21WAF1 Is Required for Survival of Differentiating Neuroblastoma Cells

, , , , , & show all
Pages 1335-1341 | Received 24 Jul 1995, Accepted 28 Dec 1995, Published online: 29 Mar 2023

REFERENCES

  • Armstrong, J. F., M. H. Kaufman, D. J. Harrison, and A. R. Clarke. 1995. High-frequency developmental abnormalities in p53-deficient mice. Curr. Biol. 5:931–936.
  • Baker, D. L., U. R. Reddy, D. Pleasure, C. L. Thorpe, A. E. Evans, P. S. Cohen, and A. H. Ross. 1989. Analysis of nerve growth factor receptor expression in human neuroblastoma and neuroepithelioma cell lines. Cancer Res. 49:4142–4146.
  • Biedler, J. L., S. R. Tarlow, M. Schachner, and L. S. Freedman. 1978. Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones. Cancer Res. 38:3751–3757.
  • Borner, M. M., C. E. Meyers, O. Sartor, Y. Sei, T. Toko, J. B. Trepel, and E. Schneider. 1995. Drug-induced apoptosis is not necessarily dependent on macromolecular synthesis or proliferation in the p53-negative human prostate cancer cell line PC-3. Cancer Res. 55:2122–2128.
  • Brugarolas, J., C. Chandrasekaran, J. I. Gordon, D. Beach, T. Jacks, and G. J. Hannon. 1995. Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature (London) 377:552–557.
  • Buchkovich, K. J., and E. B. Ziff. 1994. Nerve growth factor regulates the expression and activity of p33cdk2 and p34cdc2 kinases in PC12 pheochro-mocytoma cells. Mol. Biol. Cell 5:1225–1241.
  • Canman, C. E., T. M. Gilmer, S. B. Coutts, and M. B. Kastan. 1995. Growth factor modulation of p53-mediated growth arrest versus apoptosis. Genes Dev. 9:600–611.
  • Chen, J., B. Chattopadhyay, G. Venkatakrishnan, and A. H. Ross. 1990. Nerve growth factor-induced differentiation of human neuroblastoma and neuroepithelioma cell lines. Cell Growth Differ. 1:79–85.
  • Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156–159.
  • Davidoff, A. M., J. C. Pence, N. A. Shorter, J. D. Iglehart, and J. R. Marks. 1992. Expression of p53 in human neuroblastoma- and neuroepithelioma-derived cell lines. Oncogene 7:127–133.
  • Deng, C., P. Zhang, J. W. Harper, S. J. Elledge, and P. Leder. 1995. Mice lacking p21CIP1/WAF1 undergo normal development but are defective in G1 checkpoint control. Cell 82:675–684.
  • Donehower, L. A., M. Harvey, B. L. Slagle, M. J. McArthur, C. A. Montgomery, J. S. Butel, and A. Bradley. 1992. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature (London) 356:215–221.
  • Donovan, M. J., B. L. Hempstead, C. Horvath, M. V. Chao, and D. Schofield. 1993. Immunohistochemical localization of Trk receptor protein in pediatric small round blue cell tumors. Am. J. Pathol. 143:1560–1567.
  • Dulic, V., W. K. Kaufmann, S. J. Wilson, T. D. Tlsty, E. Lees, J. W. Harper, S. J. Elledge, and S. I. Reed. 1994. P53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 76:1013–1023.
  • Elbendary, A., A. Berchuck, P. Davis, L. Havrilesky, R. C. Bast, J. D. Iglehart, and J. R. Marks. 1994. Transforming growth factor β1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells. Cell Growth Differ. 5:1301–1307.
  • El-Deiry, W., T. Tokino, V. E. Velculescu, D. B. Levy, R. Parsons, J. M. Trent, D. Lin, W. E. Mercer, K. W. Kinzler, and B. Vogelstein. 1993. WAF1, a potential mediator of p53 tumor suppression. Cell 75:817–825.
  • El-Deiry, W. S., J. W. Harper, P. M. O’Connor, V. E. Velculescu, C. E. Canman, J. Jackman, J. A. Pietenpol, M. Burrell, D. E. Hill, Y. Wang, K. G. Wiman, W. E. Mercer, M. B. Kastan, K. W. Kohn, S. J. Elledge, K. W. Kinzler, and B. Vogelstein. 1994. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res. 54:1169–1174.
  • Freeman, R. S., S. Estus, and E. M. Johnson. 1994. Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of cyclin D1 during programmed cell death. Neuron 12:343–355.
  • Greenberg, M. E., and E. B. Ziff. 1984. Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature (London) 311:433–438.
  • Gregory, C. D., C. Dive, S. Henderson, C. A. Smith, G. T. Williams, J. Gordon, and A. B. Rickinson. 1991. Activation of Epstein-Barr virus latent genes protects human B cells from death by apoptosis. Nature (London) 349:612–614.
  • Gunning, P., P. Ponte, H. Okayama, J. Engel, H. Blau, and L. Kedes. 1983. Isolation and characterization of full-length cDNA clones for human α-, β-, and γ-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed. Mol. Cell. Biol. 3:787–795.
  • Halevy, O., B. G. Novitch, D. B. Spicer, S. X. Skapek, J. Rhee, G. J. Hannon, D. Beach, and A. B. Lassar. 1995. Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science 267:1018–1021.
  • Harper, J. W., G. R. Adami, N. Wei, K. Keyomarsi, and S. J. Elledge. 1993. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75:805–816.
  • Hayes, T. E., N. L. M. Valtz, and R. D. G. McKay. 1991. Downregulation of cdc2 upon terminal differentiation of neurons. New Biol. 3:259–269.
  • Jensen, L. M. 1987. Phenotypic differentiation of aphidicolin-selected human neuroblastoma cultures after long-term exposure to nerve growth factor. Dev. Biol. 120:56–64.
  • Jiang, H., J. Lin, Z.-Z. Su, F. R. Collart, E. Huberman, and P. B. Fisher. 1994. Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53. Oncogene 9:3397–3406.
  • Khanna, K. K., and M. F. Lavin. 1993. Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells. Oncogene 8:3307–3312.
  • Knudson, A. G., and A. T. Meadows. 1980. Regression of neuroblastoma IV-S: a genetic hypothesis. N. Engl. J. Med. 302:1254–1256.
  • Kogner, P., G. Barbany, C. Dominici, M. A. Castello, G. Raschella, and H. Persson. 1993. Coexpression of messenger RNA for TRK protooncogene and low affinity nerve growth factor receptor in neuroblastoma with favorable prognosis. Cancer Res. 53:2044–2050.
  • Komuro, H., Y. Hayashi, M. Kawamura, K. Hayashi, Y. Kaneko, S. Kamoshita, R. Hanada, K. Yamamoto, T. Hongo, M. Yamada, and Y. Tsuchida. 1993. Mutations of the p53 gene are involved in Ewing’s sarcomas but not in neuroblastomas. Cancer Res. 53:5284–5288.
  • Krek, W., and E. A. Nigg. 1989. Structure and developmental expression of the chicken CDC2 kinase. EMBO J. 8:3071–3078.
  • Lin, J., X. Wu, J. Chen, A. Chang, and A. J. Levine. 1995. Functions of the p53 protein in growth regulation and tumor suppression. Cold Spring Harbor Symp. Quant. Biol. 59:215–223.
  • LoPresti, P., W. Poluha, D. K. Poluha, E. Drinkwater, and A. H. Ross. 1992. Neuronal differentiation triggered by blocking cell proliferation. Cell Growth Differ. 3:627–635.
  • Matthews, J. A., A. Batki, C. Hynds, and L. J. Kricka. 1985. Enhanced chemiluminescent method for the detection of DNA dot-hybridization assays. Anal. Biochem. 151:205–209.
  • Meikrantz, W., S. Gisselbrecht, S. W. Tam, and R. Schlegel. 1994. Activation of cyclin A-dependent protein kinases during apoptosis. Proc. Natl. Acad. Sci. USA 91:3754–3758.
  • Michieli, P., M. Chedid, D. Lin, J. H. Pierce, W. E. Mercer, and D. Givol. 1994. Induction of WAF1/CIP1 by a p53-independent pathway. Cancer Res. 54:3391–3395.
  • Miyajima, M., H. O. Nornes, and T. Neuman. 1995. Cyclin E is expressed in neurons and forms complexes with cdk5. NeuroReport 6:1130–1132.
  • Moll, U. M., M. LaQuaglia, J. Benard, and G. Riou. 1995. Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors. Proc. Natl. Acad. Sci. USA 92:4407–4411.
  • Momand, J., G. P. Zambetti, D. C. Olson, D. George, and A. J. Levine. 1992. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69:1237–1245.
  • Murray, A., and T. Hunt. 1993. The cell cycle. W. H. Freeman, New York.
  • Nakagawara, A., M. Arima-Nakagawara, N. J. Scavard, C. G. Azar, A. B. Cantor, and G. M. Brodeur. 1993. Association between high levels of expression of the Trk gene and favorable outcome in human neuroblastoma. N. Engl. J. Med. 328:847–854.
  • Nakanishi, M., G. R. Adami, R. S. Robetorye, A. Noda, S. F. Venable, D. Dimitrov, O. M. Pereira-Smith, and J. R. Smith. 1995. Exit from G0 and entry into the cell cycle of cells expressing p21Sdi1 antisense RNA. Proc. Natl. Acad. Sci. USA 92:4352–4356.
  • Noda, A., Y. Ning, S. F. Venable, O. M. Pereira-Smith, and J. R. Smith. 1994. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res. 211:90–98.
  • Oberhammer, F., J. W. Wilson, C. Dive, I. D. Morris, J. A. Hickman, A. E. Wakeling, P. R. Walker, and M. Sikorska. 1993. Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO J. 12:3679–3684.
  • Okano, H. J., D. W. Pfaff, and R. B. Gibbs. 1993. RB and cdc2 expression in brain: correlations with 3H-thymidine incorporation and neurogenesis. J. Neurosci. 13:2930–2938.
  • Ormerod, M. G., C. F. O’Neill, D. Robertson, and K. R. Harrap. 1994. Cisplatin induces apoptosis in a human ovarian carcinoma cell line without concomitant internucleosomal degradation of DNA. Exp. Cell Res. 211:231–237.
  • Parker, S. B., G. Eichele, P. Zhang, A. Rawls, A. T. Sands, A. Bradley, E. N. Olson, J. W. Harper, and S. J. Elledge. 1995. p53-independent expression of p21 Cip1 in muscle and other terminally differentiating cells. Science 267:1024–1027.
  • Poluha, W., D. K. Poluha, and A. H. Ross. 1995. TrkA neurogenic receptor regulates differentiation of neuroblastoma cells. Oncogene 10:185–189.
  • Quattrone, A., G. Di Pasquale, and S. Capaccioli. 1995. Enhancing antisense oligonucleotide intracellular levels by means of cationic lipids as vectors. Biochemica 1:25–29.
  • Rudkin, B. B., P. Lazarovici, B.-Z. Levi, Y. Abe, K. Fujita, and G. Guroff. 1989. Cell cycle-specific action of nerve growth factor in PC12 cells: differentiation without proliferation. EMBO J. 8:3319–3325.
  • Schwartz, L. M., S. W. Smith, M. E. E. Jones, and B. A. Osborne. 1993. Do all programmed cell deaths occur via apoptosis? Proc. Natl. Acad. Sci. USA 90:980–984.
  • Sheikh, M. S., X.-S. Li, J.-C. Chen, Z.-M. Shao, J. V. Ordonez, and J. A. Fontana. 1994. Mechanisms of regulation of WAF1/Cip1 gene expression in human breast carcinoma: role of p53-dependent and independent signal transduction pathways. Oncogene 9:3407–3415.
  • Shi, L., W. K. Nishioka, J. Th’ng, E. M. Bradbury, D. W. Litchfield, and A. H. Greenberg. 1994. Premature p34cdc2 activation required for apoptosis. Science 263:1143–1145.
  • Skapek, S. X., J. Rhee, D. B. Spicer, and A. B. Lassar. 1995. Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase. Science 267:1022–1024.
  • Sonnenfeld, K. H., and D. H. Ishii. 1982. Nerve growth factor effects and receptors in cultured human neuroblastoma cell lines. J. Neurosci. Res. 8:375–391.
  • Steinman, R. A., B. Hoffman, A. Iro, C. Guillouf, D. A. Liebermann, and M. E. El-Houseini. 1994. Induction of p21 (WAF-1/CIP1) during differentiation. Oncogene 9:3389–3396.
  • Suzuki, T., E. Bogenmann, H. Shimada, D. Stram, and R. C. Seeger. 1993. Lack of high-affinity nerve growth factor receptors in aggressive neuroblastomas. J. Natl. Cancer Inst. 85:377–384.
  • Tamaru, T., M. Okada, and H. Nakagawa. 1994. Differential expression of D type cyclins during neuronal maturation. Neurosci. Lett. 168:229–232.
  • Tsai, L.-H., T. Takahashi, V. S. Caviness, and E. Harlow. 1993. Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. Development 119:1029–1040.
  • Tso, J. Y., X. H. Sun, T. H. Kao, K. S. Reece, and R. Wu. 1985. Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene. Nucleic Acids Res. 13:2485–2502.
  • Verdi, J. M., and D. J. Anderson. 1994. Neurotrophins regulate sequential changes in neurotrophin receptor expression by sympathetic neuroblasts. Neuron 13:1359–1372.
  • Vogan, K., M. Bernstein, J.-M. Leclerc, L. Brisson, J. Brossar, G. M. Brodeur, J. Pelletier, and P. Gros. 1993. Absence of p53 mutations in primary neuroblastomas. Cancer Res. 53:5269–5273.
  • Vogel, K. S., C. I. Brannan, N. A. Jenkins, N. G. Copeland, and L. F. Parada. 1995. Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons. Cell 82:733–742.
  • Vogelstein, B., and K. W. Kinzler. 1992. p53 function and dysfunction. Cell 70:523–526.
  • Wagner, R. W. 1994. Gene inhibition using antisense oligodeoxynucleotides. Nature (London) 372:333–335.
  • Weintraub, H. 1993. The MyoD family and myogenesis: redundancy, networks, and thresholds. Cell 75:1241–1244.
  • Yan, G.-Z., and E. B. Ziff. 1995. NGF regulates the PC12 cell cycle machinery through specific inhibition of the cdk kinases and induction of cyclin D1. J. Neurosci. 15:6200–6212.
  • Zhang, H., G. J. Hannon, and D. Beach. 1994. p21-containing cyclin kinases exist in both active and inactive states. Genes Dev. 8:1750–1758.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.