REFERENCES
- Andrews, N., H. Erdjument-Bromage, M. Davidson, P. Tempst, and S. H. Orkin. 1993. Erythroid transcription factor NF-E2 is a hematopoietic-spe-cific basic-leucine zipper protein. Nature (London) 362:722–728.
- Beug, H., E. W. Müllner, and M. J. Hayman. 1994. Insights into erythroid differentiation obtained from studies on avian erythroblastosis virus. Curr. Opin. Cell Biol. 6:816–824.
- Blobel, G. A., C. A. Sieff, and S. H. Orkin. 1995. Ligand-dependent repression of the erythroid transcription factor GATA-1 by the estrogen receptor. Mol. Cell. Biol. 15:3147–3153.
- Blobel, G. A., M. C. Simon, and S. H. Orkin. 1995. Rescue of GATA-1-deficient embryonic stem cells by heterologous GATA-binding proteins. Mol. Cell. Biol. 15:626–633.
- Caron-Leslie, L.-A. M., R. B. Evans, and J. A. Cidlowski. 1994. Bcl-2 inhibits glucocorticoid-induced but not calcium ionophore- or cycloheximide-regulated apoptosis. FASEB J. 8:639–645.
- Chiba, T., Y. Ikawa, and K. Todokoro. 1991. GATA-1 activates erythropoietin receptor gene, and erythropoietin receptor-mediated signals enhance GATA-1 gene expression. Nucleic Acids Res. 19:3843–3848.
- Clarke, A. R., C. A. Purdie, D. J. Harrison, R. G. Morris, C. C. Bird, M. L. Hooper, and A. H. Wyllie. 1993. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature (London) 362:849–852.
- Crossley, M., M. Merika, and S. H. Orkin. 1995. Self-association of the erythroid transcription factor GATA-1 mediated by its zinc finger domains. Mol. Cell. Biol. 15:2448–2456.
- Crossley, M., A. Tsang, J. J. Bieker, and S. H. Orkin. 1994. Regulation of the erythroid Krüppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1. J. Biol. Chem. 269:15440–15444.
- Darzynkiewicz, Z., S. Bruno, G. Del Bino, W. Gorczyca, M. A. Hotz, P. Lassota, and F. Traganos. 1992. Features of apoptotic cells measured by flow cytometry. Cytometry 13:795–808.
- Diamond, M. I., J. N. Miner, S. K. Yoshinaga, and K. R. Yamamoto. 1990. Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science 249:1266–1271.
- Dieken, E. S., and R. L. Miesfeld. 1992. Transcriptional transactivation functions localized to the glucocorticoid receptor N terminus are necessary for steroid induction of lymphocyte apoptosis. Mol. Cell. Biol. 12:589–597.
- Dukes, P. P., and E. Goldwasser. 1961. Inhibition of erythropoiesis by estrogens. Endocrinology 69:21–29.
- Fisher, D. E. 1994. Apoptosis in cancer therapy: crossing the threshold. Cell 78:539–542.
- Fried, W., T. Tichler, I. Dennenberg, J. Barone, and F. Wang. 1974. Effects of estrogens on hematopoietic stem cells and on hematopoiesis of mice. J. Lab. Clin. Med. 83:807–815.
- Gavrieli, Y., Y. Sherman, and S. A. Ben-Sasson. 1992. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:493–501.
- Green, S., P. Walter, V. Kumar, A. Krust, J.-M. Bornert, P. Argos, and P. Chambon. 1986. Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature (London) 320:134–139.
- Helmberg, A., N. Auphan, C. Caelles, and M. Karin. 1995. Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor. EMBO J. 14:452–460.
- Ho, I.-C., P. Vorhees, N. Marin, B. K. Oakley, S.-F. Tsai, S. H. Orkin, and J. M. Leiden. 1991. A lineage-restricted transcription factor that regulates the expression of the T cell receptor α gene. EMBO J. 10:1187–1192.
- Jonat, C., H. J. Rahmsdorf, K.-K. Park, A. C. B. Cato, S. Gebel, H. Ponta, and P. Herrlich. 1990. Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 62:1189–1204.
- Joulin, V., D. Bories, J.-F. Eleouet, M. C. Labastie, S. Chretien, M.-G. Mattei, and P.-H. Romeo. 1991. A T cell-specific TCR δ binding protein is a member of the human GATA family. EMBO J. 10:1809–1816.
- Katsumata, M., R. M. Siegel, D. C. Louie, T. Miyashita, Y. Tsujimoto, P. C. Nowell, M. I. Greene, and J. C. Reed. 1992. Differential effects of Bcl-2 on T and B cells in transgenic mice. Proc. Natl. Acad. Sci. USA 89:11376–11380.
- Ko, L. J., M. Yamamoto, M. W. Leonard, K. M. George, P. Ting, and J. D. Engel. 1991. Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor δ gene enhancer. Mol. Cell. Biol. 11:2778–2784.
- Korsmeyer, S. J. 1992. Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood 80:879–886.
- Korsmeyer, S. J. 1995. Regulators of cell death. Trends Genet. 11:101–105.
- Kotkow, K. J., and S. H. Orkin. 1995. Dependence of globingene expression in mouse erythroleukemia cells on the NF-E2 heterodimer. Mol. Cell. Biol. 15:4640–4647.
- Koury, M. J., and M. C. Bondurant. 1990. Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cells. Science 248:378–381.
- Kulessa, H., J. Frampton, and T. Graf. 1995. GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts. Genes Dev. 9:1250–1262.
- Li, J. P., A. D. D’Andrea, H. F. Lodish, and D. Baltimore. 1990. Activation of cell growth by binding of the Friend spleen focus-forming virus gp55 glycoprotein to the erythropoietin receptor. Nature (London) 343:762–764.
- Lowe, S. W., E. M. Schmitt, S. W. Smith, B. A. Osborne, and T. Jacks. 1993. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature (London) 362:847–849.
- Lucibello, F. C., E. P. Slater, K. U. Jooss, M. Beato, and R. Muller. 1990. Mutual transrepression of Fos and the glucocorticoid receptor: involvement of a functional domain in Fos which is absent in FosB. EMBO J. 9:2827–2834.
- Mader, S., V. Kumar, H. Verneuil, and P. Chambon. 1989. Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive element. Nature (London) 338:271–274.
- Merika, M., and S. H. Orkin. 1995. Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krüppel family proteins Sp1 and EKLF. Mol. Cell. Biol. 15:2437–2447.
- Mirand, E. A., and A. Gordon. 1966. Mechanism of estrogen action in erythropoiesis. Endocrinology 78:325–332.
- Miyashita, T., and J. C. Reed. 1992. bcl-2 gene transfer increases relative resistance of S49.1 WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs. Cancer Res. 52:5407–5411.
- Mizushima, S., and S. Nagata. 1990. pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res. 18:5322.
- Mowat, M. A., A. Cheng, N. Kimura, A. Bernstein, and S. Benchimol. 1985. Rearrangements of cellular p53 gene in erythroleukemic cells transformed by Friend virus. Nature (London) 314:633–636.
- Munroe, D. G., J. W. Peacock, and S. Benchimol. 1990. Inactivation of the cellular p53 gene is a common feature of Friend virus-induced erythroleukemia: relationship of inactivation to dominant transforming alleles. Mol. Cell. Biol. 10:3307–3313.
- Nazareth, L. V., D. V. Harbour, and E. B. Thompson. 1991. Mapping the human glucocorticoid receptor for leukemic cell death. J. Biol. Chem. 266:12976–12980.
- Perkins, A. C., A. H. Sharpe, and S. H. Orkin. 1995. Lethal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature (London) 375:318–322.
- Pevny, L., C.-S. Lin, V. D. Agati, M. C. Simon, S. H. Orkin, and F. Costantini. 1995. Development of hematopoietic cells lacking transcription factor GATA-1. Development 121:163–172.
- Pevny, L., M. C. Simon, E. Robertson, W. H. Klein, S.-F. Tsai, V. D’Agati, S. H. Orkin, and F. Costantini. 1991. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature (London) 349:257–260.
- Ruscetti, S. K., N. J. Janesch, A. Chakraborti, S. T. Sawyer, and W. D. Hankins. 1990. Friend spleen focus-forming virus induces factor independence in an erythropoietin-dependent erythroleukemia cell line. J. Virol. 64:1057–1062.
- Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
- Schroeder, C., L. Gibson, C. Nordstrom, and H. Beug. 1993. The estrogen receptor cooperates with the TGFa receptor (c-erbB) in regulation of chicken erythroid progenitor self renewal. EMBO J. 12:951–960.
- Schüle, R., P. Rangarajan, S. Kliewer, L. J. Ransone, J. Bolado, N. Yang, I. M. Verma, and R. M. Evans. 1990. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell 62:1217–1226.
- Schwartzman, R. A., and J. A. Cidlowski. 1994. Glucocorticoid-induced apoptosis of lymphoid cells. Int. Arch. Allergy Immunol. 105:347–354.
- Sentman, C. L., J. R. Shutter, D. Hockenbery, O. Kanagawa, and S. J. Korsmeyer. 1991. Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67:879–888.
- Seto, M., U. Jagger, R. D. Hockett, W. Graninger, S. Bennett, P. Goldman, and S. J. Korsmeyer. 1988. Alternative promoters and exons, somatic mutation and deregulation of the bcl-2-Ig fusion gene in lymphoma. EMBO J. 7:123–131.
- Simon, M. C., L. Pevny, M. V. Wiles, G. Keller, F. Costantini, and S. H. Orkin. 1992. Rescue of erythroid development in gene targeted GATA-1- mouse embryonic stem cells. Nat. Genet. 1:92–98.
- Strasser, A., A. W. Harris, and S. Cory. 1991. bcl-2 transgene inhibits T-cell death and perturbs thymic self-censorship. Cell 67:889–899.
- Tsai, S. F., E. Strauss, and S. H. Orkin. 1991. Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter. Genes Dev. 5:919–931.
- Tyslowitz, R., and E. Dingemanse. 1941. Effect of large doses of estrogens on the blood picture of dogs. Endocrinology 29:817–827.
- Visvader, J. E., and J. M. Adams. 1993. Megakaryocytic differentiation induced in 416B myeloid cells by GATA-2 and GATA-3 transgenes or 5-azacytidine is tightly coupled to GATA-1 expression. Blood 82:1493–1501.
- Weiss, M. J., G. Keller, and S. H. Orkin. 1994. Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 — embryonic stem cells. Genes Dev. 8:1184–1197.
- Weiss, M. J., and S. Orkin. 1995. Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis. Proc. Natl. Acad. Sci. USA 92:9623–9627.
- Weiss, M. J., and S. H. Orkin. 1995. GATA transcription factors: key regulators of hematopoiesis. Exp. Hematol. 23:99–107.
- Yamamoto, M., L. J. Ko, M. W. Leonard, H. Beug, S. H. Orkin, and J. D. Engel. 1990. Activity and tissue-specific expression of the transcription factor NF-E1 multigene family. Genes Dev. 4:1650–1662.
- Yang-Yen, H.-F., J.-C. Chambard, Y.-L. Sun, T. Smeal, T. J. Schmidt, J. Drouin, and M. Karin. 1990. Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 62:1205–1215.
- Zon, L. I., H. Youssoufian, C. Mather, H. F. Lodish, and S. H. Orkin. 1991. Activation of the erythropoietin receptor promoter by transcription factor GATA-1. Proc. Natl. Acad. Sci. USA 88:10638–10641.