Constitutive Expression of Murine Sak-a Suppresses Cell Growth and Induces Multinucleation

REFERENCES

• Chirgwin, J. M., A. E. Przybyla, R. J. MacDonald, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294–5299.
   PubMed Web of Science ®Google Scholar
• Ciechanover, A. 1994. The ubiquitin-proteasome proteolytic pathway. Cell 79:13–21.
   PubMed Web of Science ®Google Scholar
• Clay, F. J., S. J. McEwen, I. Bertoncello, and A. F. Wilks. 1993. Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila. Proc. Natl. Acad. Sci. USA 90:4882–4886.
   PubMed Web of Science ®Google Scholar
• Donohue, P. J., G. F. Alberts, Y. Guo, and J. A. Winkles. 1995. Identification by targeted differential display of an immediate early gene encoding a putative serine/threonine kinase. J. Biol. Chem. 270:10351–10357.
   PubMed Web of Science ®Google Scholar
• Fenton, B., and D. M. Glover. 1993. A conserved mitotic kinase active at late anaphase-telophase in syncytial Drosophila embryos. Nature (London) 363:637–640.
   PubMed Web of Science ®Google Scholar
• Fode, C. Unpublished observations.
   Google Scholar
• Fode, C., B. Motro, S. Yousefi, M. Heffernan, and J. W. Dennis. 1994. Sak, a murine protein-serine/threonine kinase that is related to the Drosophila polo kinase and involved in cell proliferation. Proc. Natl. Acad. Sci. USA 91:6388–6392.
   PubMed Web of Science ®Google Scholar
• Fukasawa, K., T. Choi, R. Kuriyama, S. Rulong, and G. F. Vande Woude. 1996. Abnormal centrosome amplification in the absence of p53. Science 271:1744–1747.
   PubMed Web of Science ®Google Scholar
• Gaglio, T., A. Saredi, and D. A. Compton. 1995. NuMA is required for the organization of microtubules into aster-like mitotic arrays. J. Cell Biol. 131:693–708.
   PubMed Web of Science ®Google Scholar
• Glotzer, M., A. W. Murray, and M. W. Kirschner. 1991. Cyclin is degraded by the ubiquitin pathway. Nature (London) 349:132–138.
   PubMed Web of Science ®Google Scholar
• Golsteyn, R. M., K. E. Mundt, A. M. Fry, and E. A. Nigg. 1995. Cell cycle regulation of the activity and subcellular localization of PLK1, a human protein kinase implicated in mitotic spindle function. J. Cell. Biol. 129:1617–1628.
   PubMed Web of Science ®Google Scholar
• Golsteyn, R. M., S. J. Schultz, J. Bartek, A. Ziemiecki, T. Ried, and E. A. Nigg. 1994. Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharo-myces cerevisiae Cdc5. J. Cell Sci. 107:1509–1517.
   PubMed Web of Science ®Google Scholar
• Hamanaka, R., S. Maloid, M. R. Smith, C. D. O’Connell, D. L. Longo, and D. K. Ferris. 1994. Cloning and characterization of human and murine homologues of the Drosophila polo serine-threonine kinase. Cell Growth Differ. 5:249–257.
   PubMedGoogle Scholar
• Harlow, E., and D. Lane. 1988. Antibodies: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
   Google Scholar
• Hartwell, L. H., R. K. Mortimer, J. Culotti, and M. Culotti. 1973. Genetic control of the cell division cycle in yeast. V. Genetic analysis of cdc mutants. Genetics 74:267–286.
   PubMed Web of Science ®Google Scholar
• Hershko, A., and A. Ciechanover. 1992. The ubiquitin system for protein degradation. Annu. Rev. Biochem. 61:761–807.
   PubMed Web of Science ®Google Scholar
• Kitada, K., A. L. Johnson, L. H. Johnston, and A. Sugino. 1993. A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5. Mol. Cell. Biol. 13:4445–4457.
   PubMed Web of Science ®Google Scholar
• Kollajoki, M., J. Harborth, K. Weber, and M. Osborn. 1993. Microinjection of a monoclonal antibody against SPN antigen, now identified by peptide sequences as the NuMA protein, induces micronuclei in PtK2 cells. J. Cell Sci. 104:139–150.
   PubMedGoogle Scholar
• Lake, R. J., and W. R. Jelinek. 1993. Cell cycle- and terminal differentiation-associated regulation of the mouse mRNA encoding a conserved mitotic protein kinase. Mol. Cell. Biol. 13:7793–7801.
   PubMed Web of Science ®Google Scholar
• Landt, O., H.-P. Grunert, and U. Hahn. 1990. A general method for rapid site-directed mutagenesis using the polymerase chain reaction. Gene 96:125–128.
   PubMed Web of Science ®Google Scholar
• Llamazares, S., A. Moreira, A. Tavares, C. Girdham, B. A. Spruce, C. Gonzalez, R. E. Karess, D. M. Glover, and C. E. Sunkel. 1991. polo encodes a protein kinase homolog required for mitosis in Drosophila. Genes Dev. 5:2153–2165.
   PubMed Web of Science ®Google Scholar
• Majone, F., S. Tonetto, C. Soligo, and M. Panozzo. 1992. Identification of kinetochores and DNA synthesis in micronuclei induced by mitomycin C and colchicine in Chinese hamster ovary cells. Teratog. Carcinog. Mutagen. 12:155–166.
   PubMedGoogle Scholar
• Morgan, D. O. 1995. Principles of CDK regulation. Nature (London) 374:131–134.
   PubMed Web of Science ®Google Scholar
• Ohkura, H., I. M. Hagan, and D. M. Glover. 1995. The conserved Schizo-saccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells. Genes Dev. 9:1059–1073.
   PubMed Web of Science ®Google Scholar
• Rogers, S., R. Wells, and M. Rechsteiner. 1986. Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis. Science 234:364–368.
   PubMed Web of Science ®Google Scholar
• Schild, D., and B. Byers. 1980. Diploid spore formation and other meiotic effects of two cell-division-cycle mutations of Saccharomyces cerevisiae. Genetics 96:859–876.
   PubMedGoogle Scholar
• Seufert, W., B. Futcher, and S. Jentsch. 1995. Role of a ubiquitin-conjugating enzyme in degradation of S- and M-phase cyclins. Nature (London) 373:78–83.
   PubMed Web of Science ®Google Scholar
• Sharon, G., and G. Simchen. 1990. Mixed segregation of chromosomes during single division meiosis of Saccharomyces cerevisiae. Genetics 125:475–485.
   PubMedGoogle Scholar
• Simmons, D. L., B. G. Neel, R. Stevens, G. Evett, and R. L. Erikson. 1992. Identification of an early-growth response gene encoding a novel putative protein kinase. Mol. Cell. Biol. 12:4164–4169.
   PubMed Web of Science ®Google Scholar
• Sunkel, C. E., and D. M. Glover. 1988. polo, a mitotic mutant of Drosophila displaying abnormal spindle poles. J. Cell Sci. 89:25–38.
   PubMed Web of Science ®Google Scholar
• Takanari, H., H. Yamanaka, H. Mitani, and K. Izutsu. 1994. Replication sites as revealed by double label immunofluorescence against proliferating cell nuclear antigen (PCNA) and bromodeoxyuridine (BrdU) in synchronized CHO cells and vincristine-induced multinucleate cells. Biol. Cell 82:23–31.
   PubMed Web of Science ®Google Scholar
• Treier, M., L. M. Staszewski, and D. Bohmann. 1994. Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain. Cell 78:787–798.
   PubMed Web of Science ®Google Scholar
• van den Heuvel, S., and E. Harlow. 1993. Distinct roles for cyclin-dependent kinases in cell cycle control. Science 262:2050–2054.
   PubMed Web of Science ®Google Scholar
• Warren, K. S., J. L. Lin, J. P. McDermott, and J. J. Lin. 1995. Forced expression of chimeric human fibroblast tropomyosin mutants affects cytokinesis. J. Cell Biol. 129:697–708.
   PubMed Web of Science ®Google Scholar