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Research Article

Cyclin-Binding Motifs Are Essential for the Function of p21CIP1

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Pages 4673-4682 | Received 01 Mar 1996, Accepted 01 Jun 1996, Published online: 29 Mar 2023

REFERENCES

  • Brugarolas, J., C. Chandrasekaran, J. I. Gordon, D. Beach, T. Jacks, and G. J. Hannon. 1995. Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature (London) 377:552–556.
  • Chen, I.-T., M. Akamatsu, M. L. Smith, F.-D. T. Lung, D. Duba, P. P. Roller, A. J. Fornace, Jr., and P. M. O’Connor. 1996. Characterization of p21 (Cip1/Waf1) peptide domains required for cyclin E/cdk2 and PCNA interaction. Oncogene 12:595–607.
  • Chen, J., P. K. Jackson, M. W. Kirschner, and A. Dutta. 1995. Separate domains of p21 involved in the inhibition of cdk kinase and PCNA. Nature (London) 374:386–388.
  • Deng, C. X., P. M. Zhang, J. W. Harper, S. J. Elledge, and P. Leder. 1995. Mice lacking p21(cip1/waf1) undergo normal development, but are defective in g1 checkpoint control. Cell 82:675–684.
  • Dutta, A., J. M. Ruppert, J. C. Aster, and E. Winchester. 1993. Inhibition of DNA replication factor RPA by p53. Nature (London) 365:79–82.
  • el Deiry, W. S., J. W. Harper, P. M. O’Connor, V. E. Velculescu, C. E. Canman, J. Jackman, J. A. Pietenpol, M. Burrell, D. E. Hill, Y. S. Wang, K. G. Wiman, W. E. Mercer, M. B. Kastan, K. W. Kohn, S. J. Elledge, K. W. Kinzler, and B. Vogelstein. 1994. Waf1/cip1 is induced in p53-mediated g(1) arrest and apoptosis. Cancer Res. 54:1169–1174.
  • el Deiry, W. S., T. Tokino, V. E. Velculescu, D. B. Levy, R. Parsons, J. M. Trent, D. Lin, W. E. Mercer, K. W. Kinzler, and B. Vogelstein. 1993. WAF1, a potential mediator of p53 tumor suppression. Cell 75:817–825.
  • Flores-Rozas, H., Z. Kelman, F. B. Dean, Z.-Q. Pan, J. W. Harper, S. J. Elledge, M. O’Donnell, and J. Hurwitz. 1994. Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme. Proc. Natl. Acad. Sci. USA 91:8655–8659.
  • Goubin, F., and B. Ducommun. 1995. Identification of binding domains on the p21 cyclin-dependent kinase inhibitor. Oncogene 10:2281–2287.
  • Gu, Y., C. W. Turck, and D. O. Morgan. 1993. Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature (London) 366:707–710.
  • Guan, K. L., C. W. Jenkins, Y. Li, M. A. Nichols, X. Wu, C. L. O’Keefe, A. G. Matera, and Y. Xiong. 1994. Growth suppression by p18, a p16- and p14-related CDK6 inhibitor, correlates with wild-type pRB function. Genes Dev. 8:2939–2952.
  • Halevy, O., B. G. Novitch, D. B. Spicer, S. X. Skapek, J. Rhee, G. J. Hannon, D. Beach, and A. B. Lassar. 1995. Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by myod. Science 267:1018–1021.
  • Hannon, G. J., and D. Beach. 1994. P15(ink4b) is a potential effector of TGF-(3-induced cell cycle arrest. Nature (London) 371:257–261.
  • Harper, J. W., G. R. Adami, N. Wei, K. Keyomarsi, and S. J. Elledge. 1993. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75:805–816.
  • Harper, J. W., S. J. Elledge, K. Keyomarsi, B. Dynlacht, L. H. Tsai, P. M. Zhang, S. Dobrowolski, C. Bai, L. Connell-Crowley, E. Swindell, M. P. Fox, and N. Wei. 1995. Inhibition of cyclin-dependent kinases by p21. Mol. Biol. Cell 6:387–400.
  • Hengst, L., V. Dulic, J. M. Slingerland, E. Lees, and S. I. Reed. 1994. A cell cycle-regulated inhibitor of cyclin-dependent kinases. Proc. Natl. Acad. Sci. USA 91:5291–5295.
  • Jackson, P. K., S. Chevalier, M. Philippe, and M. W. Kirschner. 1995. Early events in DNA replication require cyclin E and are blocked by p21/CIP1. J. Cell Biol. 130:755–769.
  • Jeffrey, P. D., A. A. Russo, K. Polyak, E. Gibbs, J. Hurwitz, J. Massague, and N. P. Pavletich. 1995. Mechanism of cdk activation revealed by the structure of a cyclin A-cdk2 complex. Nature (London) 376:313–320.
  • Kamb, A., N. A. Gruis, J. Weaver-Feldhaus, Q. Liu, K. Harshman, S. V. Tavitgian, E. Stockert, R. S. Day, B. E. Johson, and M. H. Skolnick. 1994. A cell cycle regulator potentially involved in genesis of many tumor types. Science 264:436–440.
  • Koh, J., G. H. Enders, B. D. Dynlacht, and E. Harlow. 1995. Tumor-derived p16 alleles encoding proteins defective in cell-cycle inhibition. Nature (London) 375:506–510.
  • Kornbluth, S., C. Smythe, and J. W. Newport. 1992. In vitro cell cycle arrest induced by using artificial DNA templates. Mol. Cell. Biol. 12:3216–3223.
  • Krek, W., G. Xu, and D. M. Livingston. 1995. Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint. Cell 83:1149–1158.
  • Lee, M. H., I. Reynisdottir, and J. Massague. 1995. Cloning of p57-Kip2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes Dev. 9:639–649.
  • Lees, E. M., and E. Harlow. 1993. Sequences within the conserved cyclin box of human cyclin A are sufficient for binding to and activation of cdc2 kinase. Mol. Cell. Biol. 13:1194–1201.
  • Li, R., S. Waga, G. J. Hannon, D. Beach, and B. Stillman. 1994. Differential effects by the p21 cdk inhibitor on PCNA-dependent DNA replication and repair. Nature (London) 371:534–537.
  • Lin, J., C. Reichner, X. Wu, and A. J. Levine. 1996. Analysis of wild-type and mutant p21WAF-1 gene activities. Mol. Cell. Biol. 16:1786–1793.
  • Luo, Y., J. Hurwitz, and J. Massague. 1995. Cell-cycle inhibition by independent cdk and PCNA binding domains in p21-Cip1. Nature (London) 375:159–161.
  • Matsuoka, S., M. C. Edwards, C. Bai, S. Parker, P. Zhang, A. Baldini, J. W. Harper, and S. J. Elledge. 1995. p57Kip2, a structurally distinct member of the p21Cip1 Cdk inhibitor family, is a candidate tumor suppressor gene. Genes Dev. 9:650–662.
  • Morgan, D. O. 1995. Principles of CDK regulation. Nature (London) 374:131–134.
  • Nakanishi, M., R. S. Robetorye, G. R. Adami, O. M. Pereira-Smith, and J. R. Smith. 1995. Identification of the active region of the DNA synthesis inhibitory gene p21Sdi1/CIP1/WAF1. EMBO J. 14:555–563.
  • Nobori, T., K. Miura, D. J. Wu, A. Lois, K. Takabayashi, and D. A. Carson. 1994. Deletion of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature (London) 368:753–756.
  • Noda, A., Y. Ning, S. F. Venable, S. O. Pereira, and J. R. Smith. 1994. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res. 211:90–98.
  • Pan, Z. Q., J. T. Reardon, L. Li, H. Flores-Rozas, R. Legerski, A. Sancar, and J. Hurwitz. 1995. Inhibition of nucleotide excision repair by the cyclin-dependent kinase inhibitor p21. J. Biol. Chem. 270:22008–22016.
  • Parker, S. B., G. Eichele, P. M. Zhang, A. Rawls, A. T. Sands, A. Bradley, E. N. Olson, J. W. Harper, and S. J. Elledge. 1995. P53-independent expression of p21(cip)1 in muscle and other terminally differentiating cells. Science 267:1024–1027.
  • Polyak, K., J. Y. Kato, M. J. Solomon, C. J. Sherr, J. Massague, J. M. Roberts, and A. Koff. 1994. p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev. 8:9–22.
  • Polyak, K., M. H. Lee, H. Erdjument-Bromage, A. Koff, J. M. Roberts, P. Tempst, and J. Massague. 1994. Cloning of p27(kip1), a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78:59–66.
  • Serrano, M., G. J. Hannon, and D. Beach. 1993. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature (London) 366:704–707.
  • Sewing, A., V. Rönicke, C. Bürger, M. Funk, and R. Müller. 1994. Alternative splicing of human cyclin e. J. Cell Sci. 107:581–588.
  • Sherr, C. 1994. G1 phase progression: cycling on cue. Cell 79:551–555.
  • Shivji, M. K., S. T. Grey, U. P. Strausfeld, R. D. Wood, and J. J. Blow. 1994. Cip1 inhibits DNA replication but not PCNA-dependent nucleotide excision-repair. Curr. Biol. 4:1062–1068.
  • Steinman, R. A., B. Hoffman, A. Iro, C. Guillouf, D. A. Liebermann, and M. E. Elhouseini. 1994. Induction of p21 (waf-1/cip1) during differentiation. Oncogene 9:3389–3396.
  • Strausfeld, U. P., M. Howell, R. Rempel, J. L. Maller, T. Hunt, and J. J. Blow. 1994. Cip1 blocks the initiation of DNA replication in xenopus extracts by inhibition of cyclin-dependent kinases. Curr. Biol. 4:876–883.
  • Toyoshima, H., and T. Hunter. 1994. P27, a novel inhibitor of g1 cyclin-cdk protein kinase activity, is related to p21. Cell 78:67–74.
  • Waga, S., G. J. Hannon, D. Beach, and B. Stillman. 1994. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature (London) 369:574–578.
  • Xiong, Y., G. J. Hannon, H. Zhang, D. Casso, R. Kobayashi, and D. Beach. 1993. p21 is a universal inhibitor of cyclin kinases. Nature (London) 366:701–704.
  • Zhang, H., G. J. Hannon, and D. Beach. 1994. P21-containing cyclin kinases exist in both active and inactive states. Genes Dev. 8:1750–1758.
  • Zhu, L., E. Harlow, and B. D. Dynlacht. 1995. p107 uses a p21-related domain to bind cyclin/cdk2 and regulate interactions with E2F. Genes Dev. 9:1740–1752.

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