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Research Article

A New Member of the hsp90 Family of Molecular Chaperones Interacts with the Retinoblastoma Protein during Mitosis and after Heat Shock

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Pages 4691-4699 | Received 19 Mar 1996, Accepted 22 May 1996, Published online: 29 Mar 2023

REFERENCES

  • Abrams, H. D., L. R. Rohrschneider, and R. N. Eisenman. 1982. Nuclear location of the putative transforming protein of avian myelocytomatosis virus. Cell 29:427–439.
  • Alberts, A. S., A. M. Thorburn, S. Shenolikar, M. C. Mumby, and J. R. Feramisco. 1993. Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases. Proc. Natl. Acad. Sci. USA 90:388–392.
  • Bignon, Y.-J., Y. Chen, C.-Y. Chang, D. J. Riley, J. J. Windle, P. L. Melon, and W.-H. Lee. 1993. Expression of a retinoblastoma transgene results in dwarf mice. Genes Dev. 7:1654–1662.
  • Boeck, R., and D. Kolakofsky. 1994. Positions +5 and +6 can be major determinants of the efficiency of non AUG initiation codons for protein synthesis. EMBO J. 13:3608–3617.
  • Buchkovich, K., L. A. Duffy, and E. Harlow. 1989. The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell 58:1097–1105.
  • Chen, P.-L., and W.-H. Lee. Unpublished data.
  • Chen, P.-L., Y. Chen, B. Shan, R. Bookstein, and W.-H. Lee. 1992. Stability of retinoblastoma gene expression determines the tumorigenicity of reconstituted retinoblastoma cells. Cell Growth Differ. 3:119–125.
  • Chen, P.-L., D. J. Riley, S. Chen-Kiang, and W.-H. Lee. 1996. Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6. Proc. Natl. Acad. Sci. USA 93:465–469.
  • Chen, P.-L., D. J. Riley, and W.-H. Lee. 1995. The retinoblastoma protein as a fundamental mediator of growth and differentiation signals. Crit. Rev. Eukaryotic Gene Expression 5:79–95.
  • Chen, P.-L., P. Scully, J.-Y. Shew, J. Y. J. Wang, and W.-H. Lee. 1989. Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation. Cell 58:1193–1198.
  • Chen, P.-L., Y.-C. Ueng, T. Durfee, K.-C. Chen, T. Yang-Feng, and W.-H. Lee. 1995. Identification of a human homologue of yeast nuc2 which interacts with the retinoblastoma protein in a specific manner. Cell Growth Differ. 6:199–210.
  • Chen, Y., C.-F. Chen, D. J. Riley, D. C. Allred, P.-L. Chen, D. Van Hoff, C. K. Osborne, and W.-H. Lee. 1995. Aberrant subcellular localization of BRCA1 in breast cancer. Science 270:789–791.
  • Clarke, A. R., E. R. Maandag, M. van Roon, N. M. T. van der Lugt, M. van der Valk, M. L. Hooper, A. Berns, and H. te Riele. 1992. Requirement for a functional Rb-1 gene in murine development. Nature (London) 359:328–330.
  • DeCaprio, J. A., J. W. Ludlow, J. Figge, J.-Y. Shew, C.-M. Huang, W.-H. Lee, E. Marsillo, E. Pauch, and D. M. Livingston. 1988. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell 54:275–283.
  • DeCaprio, J. A., J. W. Ludlow, D. Lynch, Y. Furukawa, J. Griffin, H. Pinwica-Worms, C.-M. Huang, and D. M. Livingston. 1989. The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulating element. Cell 58:1085–1095.
  • Dowdy, S. F., P. W. Hinds, K. Louie, S. I. Reed, A. Arnold, and R. A. Weinberg. 1993. Physical interaction of the retinoblastoma protein with human D cyclins. Cell 73:499–511.
  • Durfee, T., K. Becherer, P.-L. Chen, S.-H. Yeh, Y. Yang, A. E. Kilburn, W.-H. Lee, and S. J. Elledge. 1993. The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev. 7:555–569.
  • Ellis, R. J., and S. M. van der Vies. 1991. Molecular chaperones. Annu. Rev. Biochem. 60:321–347.
  • Ewen, M. E., H. K. Sluss, C. J. Sherr, H. Matsushima, J.-Y. Kato, and D. M. Livingston. 1993. Functional interaction of the retinoblastoma protein with mammalian D-type cyclins. Cell 73:487–497.
  • Furukawa, Y., J. A. DeCaprio, A. Freedman, Y. Kanakura, M. Nakamura, T. J. Ernst, D. M. Livingston, and J. D. Griffin. 1990. Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and non-cycling human hematopoietic cells. Proc. Natl. Acad. Sci. USA 87:2770–2774.
  • Goodrich, D. W., N.-P. Wang, Y.-W. Qian, E. Y.-H. P. Lee, and W.-H. Lee. 1991. The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle. Cell 67:293–302.
  • Gu, W., J. W. Schneider, G. Condorelli, S. Kaushal, V. Mahdavi, and B. Nadal-Ginard. 1993. Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell 72:309–324.
  • Hendrick, J. P., and F.-U. Hartl. 1993. Molecular chaperone functions of heat shock proteins. Annu. Rev. Biochem. 62:349–384.
  • Hensey, C. E., F. Hong, T. Durfee, Y.-W. Qian, E. Y.-H. P. Lee, and W.-H. Lee. 1994. Identification of discrete structural domains in the retinoblastoma protein: amino-terminal domain is required for its oligomerization. J. Biol. Chem. 269:1380–1387.
  • Higuchi, R., B. Krummel, and R. K. Saiki. 1988. A general method of in vitro preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions. Nucleic Acids Res. 16:7351–7367.
  • Hinds, P. W., S. Mittnacht, V. Dulic, A. Arnold, S. I. Reed, and R. A. Weinberg. 1992. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70:993–1006.
  • Hu, Q. J., N. Dyson, and E. Harlow. 1990. The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations. EMBO J. 9:1147–1155.
  • Huang, H.-J. S., J.-K. Yee, J.-Y. Shew, P.-L. Chen, R. Bookstein, T. Fried-mann, E. Y.-H. P. Lee, and W.-H. Lee. 1988. Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. Science 242:1563–1566.
  • Huang, S., N. P. Wang, B. Y. Tseng, W.-H. Lee, and E. Y.-H. P. Lee. 1990. Two distinct and frequently mutated regions of the retinoblastoma protein are required for binding to SV40 T antigen. EMBO J. 9:1815–1822.
  • Inoue, A., T. Torigoe, K. Sogahata, K. Kamiguchi, S. Takahashi, Y. Sawada, M. Saijo, Y. Taya, S. Ishii, N. Sato, and K. Kikuchi. 1995. 70-kDa heat shock cognate protein interacts directly with the N-terminal region of the retino-blastoma gene product pRb. J. Biol. Chem. 270:22571–22576.
  • Jacks, T., A. Fazeli, E. M. Schmitt, R. T. Bronson, M. A. Goodell, and R. A. Weinberg. 1992. Effects of an Rb mutation in the mouse. Nature (London) 359:295–300.
  • Kang, K. I., J. Devin, F. Cadepard, N. Jibard, A. Guichon-Mantel, E. E. Baulieu, and M.-G. Catelli. 1994. In vivo functional protein-protein interaction: nuclear targeted hsp90 shifts cytoplasmic steroid receptor mutants into the nucleus. Proc. Natl. Acad. Sci. USA 91:340–344.
  • Kato, J.-Y., H. Matsushime, S. W. Hiebert, M. E. Ewen, and C. J. Sherr. 1993. Direct binding of cyclin D to the retinoblastoma gene product (Rb) and Rb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev. 7:331–342.
  • Lee, E. Y.-H. P., C.-Y. Chang, N. Hu, Y.-C. J. Wang, C.-C. Lai, K. Herrup, W.-H. Lee, and A. Bradley. 1992. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature (London) 359:288–294.
  • Lee, E. Y.-H. P., N. Hu, S.-S. F. Yuan, L. A. Cox, A. Bradley, W.-H. Lee, and K. Herrup. 1994. Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. Genes Dev. 8:2008–2021.
  • Lee, W.-H., J.-Y. Shew, F. D. Hong, T. W. Sery, L. A. Donoso, L.-J. Young, R. Bookstein, and E. Y.-H. P. Lee. 1987. The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity. Nature (London) 329:642–645.
  • Lee, W.-H., Y. Xu, F. Hong, T. Durfee, M. A. Mancini, Y.-C. Ueng, P.-L. Chen, and D. Riley. 1994. The corral hypothesis: a novel regulatory mode for retinoblastoma protein function. Cold Spring Harbor Symp. Quant. Biol. 60:97–107.
  • Lin, B. T.-Y., S. Gruenwald, A. O. Morla, W.-H. Lee, and J. Y. J. Wang. 1991. Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase. EMBO J. 10:857–864.
  • Ludlow, J. W., C. L. Glendening, D. M. Livingston, and J. A. DeCaprio. 1993. Specific enzymatic dephosphorylation of the retinoblastoma protein. Mol. Cell. Biol. 13:367–372.
  • Ludlow, J. W., J. Shen, J. M. Pipas, D. M. Livingston, and J. A. DeCaprio. 1990. The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T. Cell 60:387–396.
  • Mancini, M. A., B. Shan, J. Nickerson, S. Penman, and W.-H. Lee. 1994. The retinoblastoma gene product is a cell-cycle dependent, nuclear-matrix associated protein. Proc. Natl. Acad. Sci. USA 91:418–422.
  • Nevins, J. R. 1992. E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424–429.
  • Nihei, T., S. Takahashi, S. Sagae, N. Sato, and K. Kikiuchi. 1993. Protein interaction of retinoblastoma gene product pRb110 with Mr 73,000 heat shock cognate protein. Cancer Res. 53:1702–1705.
  • Parsell, D. A., and S. Lindquist. 1993. The function of heat-shock proteins in stress tolerance: degradation and reactivation of damaged proteins. Annu. Rev. Genet. 27:437–496.
  • Rebbe, N. F., W. S. Hackman, T. J. Ley, D. W. Stafford, and S. Hickman. 1989. Nucleotide sequence and regulation of a human 90-kDa heat shock protein gene. J. Biol. Chem. 264:15006–15011.
  • Riley, D. J., E. Y.-H. P. Lee, and W.-H. Lee. 1994. The retinoblastoma protein: more than a tumor suppressor. Annu. Rev. Cell Biol. 10:1–29.
  • Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463–5467.
  • Schneider, J. W., W. Gu, L. Zhu, V. Mahdavi, and B. Nadal-Ginard. 1994. Reversal of terminal differentiation mediated by p107 in RB−/− mouse cells. Science 264:1467–1471.
  • Shan, B., and W.-H. Lee. 1994. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol. Cell. Biol. 14:8166–8173.
  • Shan, B., X. Zhu, P.-L. Chen, T. Durfee, Y. Yang, D. Sharp, and W.-H. Lee. 1992. Molecular cloning of the cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F. Mol. Cell. Biol. 12:5620–5631.
  • Singh, P., J. Coe, and W. Hong. 1995. A role of retinoblastoma protein in potentiating transcriptional activation by the glucocorticoid receptor. Nature (London) 374:562–565.
  • Smith, D. B., and K. S. Johnson. 1988. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67:31–40.
  • Song, H. Y., J. D. Dunbar, Y. X. Zhang, D. Guo, and D. B. Donner. 1995. Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor. J. Biol. Chem. 270:3574–3581.
  • Weich, H., J. Buchner, R. Zimmermann, and U. Jakob. 1992. Hsp90 chap-erones protein folding in vitro. Nature (London) 358:169–170.
  • Whyte, P., K. J. Buchkovich, J. M. Horowitz, S. H. Friend, M. Raybuck, R. A. Weinberg, and E. Harlow. 1988. Association between an oncogene and an anti-oncogene: the adenovirus E1A protein binds to the retinoblastoma gene product. Nature (London) 334:124–129.
  • Xu, Y., and S. Lindquist. 1993. Heat shock protein hsp90 governs the activity of pp60v-src kinase. Proc. Natl. Acad. Sci. USA 90:7074–7078.

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