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Research Article

C/EBP, c-Myb, and PU.1 Cooperate To Regulate the Neutrophil Elastase Promoter

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Pages 4717-4725 | Received 25 Apr 1996, Accepted 06 Jun 1996, Published online: 29 Mar 2023

REFERENCES

  • Berliner, N., A. Hsing, T. Graubert, F. Sigurdsson, M. Zain, E. Bruno, and R. Hoffman. 1995. Granulocyte-colony stimulating factor induction of normal human bone marrow progenitors results in neutrophil-specific gene expression. Blood 85:799–803.
  • Britos-Bray, M., N. Sacchi, and A. D. Friedman. 1996. DNA-binding domain of AML1, expressed in t(8;21) and t(3;21) myeloid leukemias, inhibits PEBP2/CBF DNA-binding but is not sufficient to transform 32D cl3 myeloid cells. Leukemia 10:984–990.
  • Burk, O., S. Mink, M. Ringwald, and K.-H. Klempnauer. 1993. Synergistic activation of the chicken mim-1 gene by v-myb and C/EBP transcription factors. EMBO J. 12:2027–2038.
  • Cao, Z., R. M. Umek, and S. L. McKnight. 1991. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 5:1538–1552.
  • Chen, C., and H. Okayama. 1987. High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7:2745–2752.
  • Dai, P., H. Akimaru, Y. Tanaka, D.-X. Hou, T. Yasukawa, C. Kanei-Ishii, T. Takahashi, and S. Ishii. 1996. CBP as a transcriptional coactivator with c-Myb. Genes Dev. 10:528–540.
  • Dudek, H., R. V. Tantravahi, V. N. Rao, E. S. P. Reddy, and E. P. Reddy. 1992. Myb and Ets proteins cooperate in the transcriptional activation of the mim-1 promoter. Proc. Natl. Acad. Sci. USA 89:1291–1295.
  • Firzlaff, J. M., B. Lüscher, and R. N. Eisenman. 1991. Negative charge at the casein kinase II phosphorylation site is important for transformation but not for Rb binding by the E7 protein of human papillomavirus type 16. Proc. Natl. Acad. Sci. USA 88:5187–5191.
  • Ford, T. Personal communication.
  • Fouret, P., R. M. duBois, J.-F. Bernaudin, H. Takahashi, V. J. Ferrans, and R. G. Crystal. 1989. Expression of the neutrophil elastase gene during human bone marrow cell differentiation. J. Exp. Med. 169:833–845.
  • Friedman, A. D. 1996. Regulation of immature myeloid cell differentiation by PEBP2/CBF, Myb, C/EBP, and Ets family members. Curr. Top. Microbiol. Immunol. 211:149–157.
  • Friedman, A. D. GADD153/CHOP, a DNA damage-inducible protein, reduced CAAT/enhancer binding protein activities and increased apoptosis in 32D cl3 myeloid cells. Cancer Res., in press.
  • Friedman, A. D., M. Britos-Bray, and J. Suzow. The murine myeloperoxidase gene contains a bipartite distal enhancer, including a novel region regulated by PEBP2/CBF. Leuk. Res., in press.
  • Friedman, A. D., B. L. Krieder, D. Venturelli, and G. Rovera. 1991. Transcriptional regulation of two myeloid-specific genes, myeloperoxidase and lactoferrin, during differentiation of the murine cell line 32D Cl3. Blood 78:2426–2432.
  • Friedman, A. D., W. H. Landschulz, and S. L. McKnight. 1989. CCAAT/ enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells. Genes Dev. 3:1314–1322.
  • Friedman, A. D., and S. L. McKnight. 1990. Identification of two polypeptide segments of CCAAT/enhancer-binding protein required for transcriptional activation of the serum albumin gene. Genes Dev. 4:1416–1426.
  • Friedman, A. D., I. Nuchprayoon, M. Britos-Bray, and J. Suzow. 1995. The myeloperoxidase and neutrophil elastase genes have distal 5′ enhancers which contain PEBP2/CBF-binding sites. Blood 86:663a.
  • Haas, J. G., M. Strobel, A. Leutz, P. Wendelgaβ, C. Muller, E. Sterneck, G. Riethmuller, and H. W. L. Ziegler-Heitbrock. 1992. Constitutive monocyte-restricted activity of NF-M, a nuclear factor that binds to a C/EBP motif. J. Immunol. 149:237–243.
  • Herschlag, D., and F. B. Johnson. 1993. Synergism in transcriptional activation: a kinetic view. Genes Dev. 7:173–179.
  • Hohaus, S., M. S. Petrovick, M. T. Voso, Z. Sun, D.-E. Zhang, and D. G. Tenen. 1995. PU.1 (Spi-1) and C/EBPα regulate expression of the granulocyte-macrophage colony-stimulating factor receptor a gene. Mol. Cell. Biol. 15:5830–5845.
  • Holloway, J. M., D. P. Szeto, K. M. Scully, C. K. Glass, and M. G. Rosenfeld. 1995. Pit-1 binding to specific DNA sites as a monomer or dimer determines gene-specific use of a tyrosine-dependent synergy domain. Genes Dev. 9:1992–2006.
  • Landschulz, W. H., P. F. Johnson, and S. L. McKnight. 1989. The DNA binding domain of the rat liver protein C/EBP is bipartite. Science 246:1681–1688.
  • Luscher, B., and R. N. Eisenman. 1990. New light on Myc and Myb. Part II. Myb. Genes Dev. 4:2235–2241.
  • Melotti, P., and B. Calabretta. 1994. Ets-2 and c-Myb act independently in regulating expression of the hematopoietic stem cell antigen CD34. J. Biol. Chem. 269:25303–25309.
  • Metz, R., and E. Ziff. 1991. cAMP stimulates the C/EBP-related transcription factor NFIL-6 to trans-locate to the nucleus and induce c-fos transcription. Genes Dev. 5:1754–1766.
  • Mink, S., U. Kerber, and K.-H. Klempnauer. 1996. Interaction of C/EBPβ and v-Myb is required for synergistic activation of the mim-1 gene. Mol. Cell. Biol. 16:1316–1325.
  • Mucenski, M. L., K. McClain, A. B. Kier, S. H. Swerdlow, C. M. Schreiner, T. A. Miller, D. W. Pietryga, W. J. Scott, and S. S. Potter. 1991. A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell 65:677–689.
  • Nakajima, T., S. Kinoshita, T. Sasagawa, K. Sasaki, M. Naruto, T. Kishi-moto, and S. Akira. 1993. Phosphorylation at threonine-235 by ras-depen-dent mitogen-activated protein kinase cascade is essential for transcription factor NFIL-6. Proc. Natl. Acad. Sci. USA 90:2207–2211.
  • Ness, S. A., E. Kowenz-Leutz, T. Casini, T. Graf, and A. Leutz. 1993. Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types. Genes Dev. 7:749–759.
  • Nuchprayoon, I., and A. D. Friedman. Unpublished observation.
  • Nuchprayoon, I., S. Meyers, L. M. Scott, J. Suzow, S. Hiebert, and A. D. Friedman. 1994. PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2β/CBFβ oncoproteins, regulates the murine MPO and neutrophil elastase genes in immature myeloid cells. Mol. Cell. Biol. 14:5558–5568.
  • Oelgeschläger, M., R. Janknecht, J. Krieg, S. Schreek, and B. Lüscher. 1996. Interaction of the coactivator CBP with Myb proteins: effects on Myb-specific transactivation on the cooperativity with NF-M. EMBO J. 15:2771–2780.
  • Oelgeschläger, M., J. Krieg, J. M. Lüscher-Firzlaff, and B. Lüscher. 1995. Casein kinase II phosphorylation site mutations in c-Myb affect DNA binding and transcriptional cooperativity with NF-M. Mol. Cell. Biol. 15:5966–5974.
  • Oelgeschläger, M., and B. Lüscher. Unpublished observation.
  • Okuda, T., J. van Deursen, S. W. Hiebert, G. Grosveld, and J. R. Downing. 1996. AML-1, the target of multiple chromosomal translocations in human leukemia, is essential for normal murine fetal liver hematopoiesis. Cell 84:321–330.
  • Pahl, H. L., R. J. Scheibe, H.-M. Chen, D.-E. Zhang, D. L. Galson, R. A. Maki, and D. G. Tenen. 1993. The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter. J. Biol. Chem. 61:1053–1095.
  • Patel, G., B. Krieder, G. Rovera, and E. P. Reddy. 1993. v-myb blocks granulocyte colony-stimulating factor-induced myeloid cell differentiation but not proliferation. Mol. Cell. Biol. 13:2269–2276.
  • Sauer, F., S. K. Hansen, and R. Tjian. 1995. Multiple TAFIIs directing synergistic activation of transcription. Science 270:1783–1788.
  • Scott, E. W., M. C. Simon, J. Anastasi, and H. Singh. 1994. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 265:1573–1577.
  • Scott, L. M., C. I. Civin, P. Rorth, and A. D. Friedman. 1992. A novel expression pattern of three C/EBP family members in differentiating my-elomonocytic cells. Blood 80:1725–1735.
  • Screpanti, I., L. Romani, P. Musiani, A. Modesti, E. Fattori, et al. 1995. Lymphoproliferative disorder and imbalanced T-helper response in C/EBPβ-deficient mice. EMBO J. 14:1932–1941.
  • Smith, L. T., D. A. Gonzalez, and D. G. Tenen. 1994. The myeloid specific granulocyte colony stimulating factor (G-CSF) receptor promoter contains a functional site for the myeloid transcription factor PU.1 (Spi-1). Blood 84:372a.
  • Sterneck, E., C. Muller, S. Katz, and A. Leutz. 1992. Autocrine growth induced by kinase type oncogenes in myeloid cells requires AP-1 and NF-M, a myeloid specific, C/EBP-like factor. EMBO J. 11:115–126.
  • Suzow, J., and A. D. Friedman. 1993. The murine myeloperoxidase promoter contains several functional elements, one which binds a cell type-restricted transcription factor, myeloid nuclear factor 1 (MyNF1). Mol. Cell. Biol. 13:2141–2151.
  • Takahashi, H., T. Nukiwa, P. Basset, and R. G. Crystal. 1988. Myelomono-cytic cell lineage expression of the neutrophil elastase gene. J. Biol. Chem. 263:2543–2547.
  • Takahashi, H., T. Nukiwa, K. Yoshimura, C. D. Quick, D. J. States, M. D. Holmes, J. Whang-Peng, T. Knutsen, and R. G. Crystal. 1988. Structure of the human neutrophil elastase gene. J. Biol. Chem. 263:14739–14747.
  • Tanaka, T., S. Akira, M. Yoshida, Y. Umemoto, N. Yoneda, H. Shirafuji, S. Suematsu, N. Yoshida, and T. Kishimoto. 1995. Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell 80:353–361.
  • Trautwein, C., C. Caelles, P. van der Greer, T. Hunter, M. Karin, and M. Chojkier. 1993. Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain. Nature (London) 364:544–547.
  • Umek, R. M., A. D. Friedman, and S. L. McKnight. 1991. CCAAT/enhancer binding protein: a component of a differentiation switch. Science 251:288–292.
  • Valtieri, M., D. J. Tweardy, D. Caracciolo, K. Johnson, F. Mavilio, S. Alt-man, D. Snatoli, and G. Rovera. 1987. Regulation of proliferative and dif-ferentiative responses in a murine progenitor cell line. J. Immunol. 138:3829–3835.
  • Warner, N. L., M. A. S. Moore, and D. Metcalf. 1969. A transplantable myelomonocytic leukemia in Balb/c mice: cytology, karyotype, and murimi-dase content. J. Natl. Cancer Inst. 43:963–982.
  • Wegner, M., Z. Cao, and M. G. Rosenfeld. 1992. Calcium-regulated phosphorylation within the leucine zipper of C/EBPβ. Science 256:370–373.
  • Yeh, W.-C., Z. Cao, M. Classon, and S. L. McKnight. 1995. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev. 9:168–181.
  • Yoshimura, K., and R. G. Crystal. 1992. Transcriptional and posttranscrip-tional modulation of human neutrophil elastase gene expression. Blood 79:2733–2740.
  • Zhang, D.-E., C. J. Hetherington, H.-M. Chen, and D. G. Tenen. 1994. The macrophage transcription factor PU.1 directs tissue-specific expression of the M-CSF receptor. Mol. Cell. Biol. 14:373–381.
  • Zhang, D.-E., C. J. Hetherington, S. Meyers, K. L. Rhoades, C. J. Larson, H.-M. Chen, S. W. Hiebert, and D. G. Tenen. 1996. CCAAT/enhancer-binding protein (C/EBP) and AML1 (CBFα2) synergistically activate the macrophage colony-stimulating factor receptor promoter. Mol. Cell. Biol. 16:1231–1240.
  • Zhu, J., C. A. Bennett, A. D. MacGregor, M. F. Greaves, G. H. Goodwin, and A. M. Ford. 1994. A myeloid-lineage-specific enhancer upstream of the mouse myeloperoxidase (MPO) gene. Leukemia 8:717–724.
  • Zimmer, M., R. L. Medcalf, T. M. Fink, C. Mattmann, P. Lichter, and D. E. Jenne. 1992. Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter. Proc. Natl. Acad. Sci. USA 89:8215–8219.

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