Single-Stranded-DNA Binding Alters Human Replication Protein A Structure and Facilitates Interaction with DNA-Dependent Protein Kinase

REFERENCES

• Adachi, Y., and U. K. Laemmli. 1992. Identification of nuclear pre-replica-tion centers poised for DNA synthesis in Xenopus egg extracts: immunolo-calization study of replication protein A. J. Cell Biol. 119:1–15.
   PubMedGoogle Scholar
• Alani, E., R. Thresher, J. Griffith, and R. D. Kolodner. 1992. Characterization of DNA-binding and strand-exchange stimulation properties of y-RPA, a yeast single-strand-DNA-binding protein. J. Mol. Biol. 227:54–71.
   PubMed Web of Science ®Google Scholar
• Atrazhev, A., S. Zhang, and F. Grosse. 1992. Single-stranded DNA binding protein from calf thymus. Purification, properties, and stimulation of the homologous DNA-polymerase-alpha-primase complex. Eur. J. Biochem. 210:855–865.
   PubMedGoogle Scholar
• Blackwell, L. J., and J. A. Borowiec. 1994. Human replication protein A binds single-stranded DNA in two distinct complexes. Mol. Cell. Biol. 14:3993–4001.
   PubMed Web of Science ®Google Scholar
• Blunt, T., N. J. Finnie, G. E. Taccioli, G. C. M. Smith, J. Demengeot, T. M. Gottlieb, R. Mizuta, A. J. Varghese, F. W. Alt, P. A. Jeggo, and S. P. Jackson. 1995. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 80:813–823.
   PubMed Web of Science ®Google Scholar
• Boubnov, N. V., and D. T. Weaver. 1995. scid cells are deficient in Ku and replication protein A phosphorylation by the DNA-dependent protein kinase. Mol. Cell. Biol. 15:5700–5706.
   PubMedGoogle Scholar
• Brill, S. J., and B. Stillman. 1989. Yeast replication factor-A functions in the unwinding of the SV40 origin of replication. Nature (London) 342:92–95.
   PubMed Web of Science ®Google Scholar
• Brush, G. S., C. W. Anderson, and T. J. Kelly. 1994. The DNA-activated protein kinase is required for the phosphorylation of replication protein A during simian virus 40 DNA replication. Proc. Natl. Acad. Sci. USA 91:12520–12524.
   PubMedGoogle Scholar
• Burke, R. L., B. M. Alberts, and J. Hosoda. 1980. Proteolytic removal of the COOH terminus of the T4 gene 32 helix-destabilizing protein alters the T4 in vitro replication complex. J. Biol. Chem. 255:11484–11493.
   PubMedGoogle Scholar
• Carty, M. P., M. Zernik-Kobak, S. McGrath, and K. Dixon. 1994. UV light-induced DNA synthesis arrest in HeLa cells is associated with changes in phosphorylation of human single-stranded DNA-binding protein. EMBO J. 13:2114–2123.
   PubMed Web of Science ®Google Scholar
• Coverley, D., M. K. Kenny, M. Munn, W. D. Rupp, D. P. Lane, and R. D. Wood. 1991. Requirement for the replication protein SSB in human DNA excision repair. Nature (London) 349:538–541.
   PubMed Web of Science ®Google Scholar
• Dean, F. B., P. Bullock, Y. Murakami, C. R. Wobbe, L. Weissbach, and J. Hurwitz. 1987. Simian virus 40 (SV40) DNA replication: SV40 large T antigen unwinds DNA containing the SV40 origin of replication. Proc. Natl. Acad. Sci. USA 84:16–20.
   PubMedGoogle Scholar
• Din, S., S. J. Brill, M. P. Fairman, and B. Stillman. 1990. Cell-cycle-regulated phosphorylation of DNA replication factor A from human and yeast cells. Genes Dev. 4:968–977.
   PubMed Web of Science ®Google Scholar
• Dornreiter, I., L. F. Erdile, I. U. Gilbert, D. von Winkler, T. J. Kelly, and E. Fanning. 1992. Interaction of DNA polymerase α-primase with cellular replication protein A and SV40 T antigen. EMBO J. 11:769–776.
   PubMed Web of Science ®Google Scholar
• Dutta, A., J. M. Ruppert, J. C. Aster, and E. Winchester. 1993. Inhibition of DNA replication factor RPA by p53. Nature (London) 365:79–82.
   PubMed Web of Science ®Google Scholar
• Dutta, A., and B. Stillman. 1992. cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication. EMBO J. 11:2189–2199.
   PubMedGoogle Scholar
• Erdile, L. F., W. D. Heyer, R. Kolodner, and T. J. Kelly. 1991. Characterization of a cDNA encoding the 70-kDa single-stranded DNA-binding sub-unit of human replication protein A and the role of the protein in DNA replication. J. Biol. Chem. 266:12090–12098.
   PubMedGoogle Scholar
• Fairman, M. P., and B. Stillman. 1988. Cellular factors required for multiple stages of SV40 DNA replication in vitro. EMBO J. 7:1211–1218.
   PubMedGoogle Scholar
• Fotedar, R., and J. M. Roberts. 1992. Cell cycle regulated phosphorylation of RPA-32 occurs within the replication initiation complex. EMBO J. 11:2177–2187.
   PubMedGoogle Scholar
• Gottlieb, T. M., and S. P. Jackson. 1993. The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell 72:131–142.
   PubMed Web of Science ®Google Scholar
• He, Z., L. A. Henricksen, M. S. Wold, and J. C. Ingles. 1995. RPA involvement in the damage-recognition and incision steps of nucleotide excision repair. Nature (London) 374:566–569.
   PubMed Web of Science ®Google Scholar
• Henricksen, L. A., C. B. Umbricht, and M. S. Wold. 1994. Recombinant replication protein A: expression, complex formation, and functional characterization. J. Biol. Chem. 269:11121–11132.
   PubMed Web of Science ®Google Scholar
• Henricksen, L. A., and M. S. Wold. 1994. Replication protein A mutants lacking phosphorylation sites for p34cdc2 kinase support DNA replication. J. Biol. Chem. 269:24203–24208.
   PubMedGoogle Scholar
• Heyer, W.-D., M. R. S. Rao, L. F. Erdile, T. J. Kelly, and R. D. Kolodner. 1990. An essential Saccharomyces cerevisiae single-stranded DNA binding protein is homologous to the large subunit of human RP-A. EMBO J. 9:2321–2329.
   PubMedGoogle Scholar
• Hosoda, J., and H. Moise. 1978. Purification and physicochemical properties of limited proteolysis products of T4 helix destabilizing protein (gene 32 protein). J. Biol. Chem. 253:7547–7558.
   PubMed Web of Science ®Google Scholar
• Jackson, S. P., J. J. MacDonald, S. Lees-Miller, and R. Tjian. 1990. GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase. Cell 63:155–165.
   PubMed Web of Science ®Google Scholar
• Kenny, M. K., S.-H. Lee, and J. Hurwitz. 1989. Multiple functions of human single-stranded-DNA binding protein in simian virus 40 DNA replication: single-strand stabilization and stimulation of DNA polymerases α and δ. Proc. Natl. Acad. Sci. USA 86:9757–9761.
   PubMedGoogle Scholar
• Kenny, M. K., U. Schlegel, H. Furneaux, and J. Hurwitz. 1990. The role of human single-stranded DNA binding protein and its individual subunits in simian virus 40 DNA replication. J. Biol. Chem. 265:7693–7700.
   PubMedGoogle Scholar
• Kim, C., B. F. Paulus, and M. S. Wold. 1994. Interactions of human replication protein A with oligonucleotides. Biochemistry 33:14197–14206.
   PubMed Web of Science ®Google Scholar
• Kim, C., R. O. Snyder, and M. S. Wold. 1992. Binding properties of replication protein A from human and yeast cells. Mol. Cell. Biol. 12:3050–3059.
   PubMed Web of Science ®Google Scholar
• Kirchgessner, C. U., C. K. Patil, J. W. Evans, C. A. Cuomo, L. M. Fried, T. Carter, M. A. Oettinger, and J. M. Brown. 1995. DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect. Science 267:1178–1183.
   PubMed Web of Science ®Google Scholar
• Lee, S.-H., and D.-K. Kim. 1995. The role of the 34-kDa subunit of human replication protein A in simian virus 40 DNA replication in vitro. J. Biol. Chem. 270:12801–12807.
   PubMedGoogle Scholar
• Lee, S.-H., D.-K. Kim, and R. Drissi. 1995. Human xeroderma pigmentosum group A protein interacts with human replication protein A and inhibits DNA replication. J. Biol. Chem. 270:21800–21805.
   PubMedGoogle Scholar
• Lee, S.-H., Z. Q. Pan, A. D. Kwong, P. M. J. Burgers, and J. Hurwitz. 1991. Synthesis of DNA by DNA polymerase ɛ in vitro. J. Biol. Chem. 266:22707–22717.
   PubMedGoogle Scholar
• Lees-Miller, S. P., Y.-R. Chen, and C. W. Anderson. 1990. Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen. Mol. Cell. Biol. 10:6472–6481.
   PubMed Web of Science ®Google Scholar
• Lees-Miller, S. P., R. Godbout, D. W. Chan, M. Weinfeld, R. S. Day, G. M. Barron, and J. Allalunis-Turner. 1995. Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line. Science 267:1183–1185.
   PubMed Web of Science ®Google Scholar
• Liu, V. F., and D. T. Weaver. 1993. The ionizing radiation-induced replication protein A phosphorylation response differs between ataxia telangiectasia and normal human cells. Mol. Cell. Biol. 13:7222–7231.
   PubMed Web of Science ®Google Scholar
• Lohman, T. M., and M. E. Ferrari. 1994. Escherichia coli single-stranded DNA-binding protein: multiple DNA binding modes and cooperativities. Annu. Rev. Biochem. 63:527–570.
   PubMed Web of Science ®Google Scholar
• Mastrangelo, I. A., A. J. Courey, J. S. Wall, S. P. Jackson, and P. V. C. Hough. 1991. DNA looping and Sp1 multimer links: a mechanism for transcriptional synergism and enhancement. Proc. Natl. Acad. Sci. USA 88:5670–5674.
   PubMed Web of Science ®Google Scholar
• Mastrangelo, I. A., P. V. C. Hough, J. S. Wall, M. Dodson, F. B. Dean, and J. Hurwitz. 1989. ATP-dependent assembly of double hexamers of SV40 T antigen at the viral origin of DNA replication. Nature (London) 338:658–662.
   PubMed Web of Science ®Google Scholar
• Matsuda, T., M. Saijo, I. Kuraoka, T. Kobayashi, Y. Nakatsu, A. Nagai, T. Enjoji, C. Masutani, K. Sugasawa, F. Hanaoka, A. Yasui, and K. Tanaka. 1995. DNA repair protein XPA binds replication protein A (RPA). J. Biol. Chem. 270:4152–4157.
   PubMedGoogle Scholar
• Melendy, T., and B. Stillman. 1993. An interaction between replication protein A and SV40 T antigen appears essential for primosome assembly during SV40 DNA replication. J. Biol. Chem. 268:3389–3395.
   PubMedGoogle Scholar
• Mitsis, P. G., S. C. Kowalczykowski, and I. R. Lehman. 1993. A single-stranded DNA binding protein from Drosophila melanogaster: characterization of the heterotrimeric protein and its interaction with single-stranded DNA. Biochemistry 32:5257–5266.
   PubMed Web of Science ®Google Scholar
• Moore, S. P., L. Erdile, T. Kelly, and R. Fishel. 1991. The human homologous pairing protein HPP-1 is specifically stimulated by the cognate single-stranded binding protein hRP-A. Proc. Natl. Acad. Sci. USA 88:9067–9071.
   PubMedGoogle Scholar
• Morozov, V. E., M. Falzon, C. W. Anderson, and E. L. Kuff. 1994. DNA-dependent protein kinase is activated by nicks and larger single-stranded gaps. J. Biol. Chem. 269:16684–16688.
   PubMed Web of Science ®Google Scholar
• Pan, Z.-Q., A. A. Amin, E. Gibbs, H. Niu, and J. Hurwitz. 1994. Phosphor-ylation of the p34 subunit of human single-stranded-DNA-binding protein in cyclin A-activated G1 extracts is catalyzed by cdk-cyclin A complex and DNA-dependent protein kinase. Proc. Natl. Acad. Sci. USA 91:8343–8347.
   PubMedGoogle Scholar
• Pan, Z.-Q., C. H. Park, A. A. Amin, J. Hurwitz, and A. Sancar. 1995. Phosphorylated and unphosphorylated forms of human single-stranded DNA-binding protein are equally active in simian virus 40 DNA replication and in nucleotide excision repair. Proc. Natl. Acad. Sci. USA 92:4636–4640.
   PubMedGoogle Scholar
• Peterson, S. R., A. Kurimasa, M. Oshimura, W. S. Dynan, E. M. Bradbury, and D. J. Chen. 1995. Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells. Proc. Natl. Acad. Sci. USA 92:3171–3174.
   PubMed Web of Science ®Google Scholar
• Smider, V., W. K. Rathmell, M. R. Lieber, and G. Chu. 1994. Restoration of x-ray resistance and V(D)J recombination in mutant cells by the Ku cDNA. Science 266:288–291.
   PubMed Web of Science ®Google Scholar
• Taccioli, G. E., T. M. Gottlieb, T. Blunt, A. Priestley, J. Demengeot, R. Mizuta, A. R. Lehmann, F. W. Alt, S. P. Jackson, and P. A. Jeggo. 1994. Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science 265:1442–1445.
   PubMed Web of Science ®Google Scholar
• Tsurimoto, T., M. P. Fairman, and B. Stillman. 1989. Simian virus 40 DNA replication in vitro: identification of multiple stages of initiation. Mol. Cell. Biol. 9:3839–3849.
   PubMedGoogle Scholar
• Tsurimoto, T., and B. Stillman. 1989. Multiple replication factors augment DNA synthesis by the two eukaryotic DNA polymerases, α and δ. EMBO J. 8:3883–3889.
   PubMed Web of Science ®Google Scholar
• Tucker, P. A., D. Tsernoglou, A. D. Tucker, F. E. Coenjaerts, H. Leenders, and P. C. van der Vliet. 1994. Crystal structure of the adenovirus DNA binding protein reveals a hook-on model for cooperative DNA binding. EMBO J. 13:2994–3002.
   PubMedGoogle Scholar
• Wall, J. S. 1979. Biological scanning transmission electron microscopy, p. 333–342. In J. Hren, J. Goldstein, and D. Joy (ed.), Analytical electron microscopy. Plenum Press, New York.
   Google Scholar
• Williams, K. R., and W. Konigsberg. 1978. Structural changes in the T4 gene 32 protein induced by DNA polynucleotides. J. Biol. Chem. 253:2463–2470.
   PubMed Web of Science ®Google Scholar
• Williams, K. R., E. K. Spicer, M. B. LoPresti, R. A. Guggenheimer, and J. W. Chase. 1983. Limited proteolysis studies on the Escherichia coli single-stranded DNA binding protein. Evidence for a functionally homologous domain in both the Escherichia coli and T4 DNA binding proteins. J. Biol. Chem. 258:3346–3355.
   PubMed Web of Science ®Google Scholar
• Wobbe, C. R., L. Weissbach, J. A. Borowiec, F. B. Dean, Y. Murakami, P. Bullock, and J. Hurwitz. 1987. Replication of simian virus 40 origin-containing DNA in vitro with purified proteins. Proc. Natl. Acad. Sci. USA 84:1834–1838.
   PubMedGoogle Scholar
• Wold, M. S., and T. J. Kelly. 1988. Purification and characterization of replication protein A, a cellular protein required for in vitro replication of simian virus 40 DNA. Proc. Natl. Acad. Sci. USA 85:2523–2527.
   PubMed Web of Science ®Google Scholar
• Wold, M. S., J. J. Li, and T. J. Kelly. 1987. Initiation of simian virus 40 DNA replication in vitro: large-tumor-antigen- and origin-dependent unwinding of the template. Proc. Natl. Acad. Sci. USA 84:3643–3647.
   PubMedGoogle Scholar
• Wold, M. S., D. H. Weinberg, D. M. Virshup, J. J. Li, and T. J. Kelly. 1989. Identification of cellular proteins required for simian virus 40 DNA replication. J. Biol. Chem. 264:2801–2809.
   PubMedGoogle Scholar