0
Views
17
CrossRef citations to date
0
Altmetric
Research Article

Protein and DNA Contact Surfaces That Mediate the Selective Action of the Phox1 Homeodomain at the c-fos Serum Response Element

, &
Pages 6653-6662 | Received 03 Jan 1997, Accepted 28 Jul 1997, Published online: 29 Mar 2023

REFERENCES

  • Ananthan, J., R. Baler, D. Morrissey, J. Zuo, Y. Lan, M. Weir, and R. Voellmy. 1993. Synergistic activation of transcription is mediated by the N-terminal domain of Drosophila fushi tarazu homeoprotein and can occur without DNA binding by the protein. Mol. Cell. Biol. 13:1599–1609.
  • Bender, A., and G. F. Sprague, Jr. 1986. Yeast peptide pheromones, a-factor and alpha-factor, activate a common response mechanism in their target cells. Cell 47:929–937.
  • Berkowitz, L. A., K. T. Riabowol, and M. Z. Gilman. 1989. Multiple sequence elements of a single functional class are required for cyclic AMP responsiveness of the mouse c-fos promoter. Mol. Cell. Biol. 9:4272–4281.
  • Bradford, A. P., K. E. Conrad, P. H. Tran, M. C. Ostrowski, and A. Gutierrez-Hartmann. 1996. GHF-1/Pit-1 functions as a cell-specific integrator of Ras signaling by targeting the Ras pathway to a composite Ets-1/GHF-1 response element. J. Biol. Chem. 271:24639–24648.
  • Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248.
  • Chan, S. K., and R. S. Mann. 1993. The segment identity functions of Ultrabithorax are contained within its homeo domain and carboxy-terminal sequences. Genes Dev. 7:796–811.
  • Chen, C. Y., and R. J. Schwartz. 1996. Recruitment of the tinman homolog Nkx-2.5 by serum response factor activates cardiac a-actin gene transcription. Mol. Cell. Biol. 16:6372–6384.
  • Cleary, M., S. Stern, M. Tanaka, and W. Herr. 1993. Differential positive control by Oct-1 and Oct-2: activation of a transcriptionally silent motif through Oct-1 and VP16 corecruitment. Genes Dev. 7:72–83.
  • Connolly, M. L. 1983. Solvent-accessible surfaces of proteins and nucleic acids. Science 221:709–713.
  • Duboule, D. (ed.). 1994. Guidebook to the homeobox genes. Oxford University Press, Oxford, United Kingdom.
  • Errede, B., and G. Ammerer. 1989. STE12, a protein involved in cell-type-specific transcription and signal transduction in yeast, is part of protein-DNA complexes. Genes Dev. 3:1349–1361.
  • Fitzpatrick, V. D., A. Percival-Smith, C. J. Ingles, and H. M. Krause. 1992. Homeodomain-independent activity of the fushi tarazu polypeptide in Drosophila embryos. Nature 356:610–612.
  • Gibson, G., A. Schier, P. LeMotte and W. J. Gehring. 1990. The specificities of Sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain. Cell 62:1087–1103.
  • Gilman, M. Z., R. N. Wilson, and R. A. Weinberg. 1986. Multiple proteinbinding sites in the 5′-flanking region regulate c-fos expression. Mol. Cell. Biol. 6:4305–4316.
  • Gorman, C. M., L. F. Moffat, and B. H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1044–1051.
  • Graham, R., and M. Gilman. 1991. Distinct protein targets for signals acting at the c-fos serum response element. Science 251:189–192.
  • Grueneberg, D. A., R. W. Henry, A. Brauer, C. D. Novina, V. Cheriyath, A. Roy, and M. Gilman. A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity of TFII-I. Genes Dev., in press.
  • Grueneberg, D. A., S. Natesan, C. Alexandre, and M. Z. Gilman. 1992. Human and Drosophila homeodomain proteins that enhance the DNA-binding activity of serum response factor. Science 257:1089–1095.
  • Grueneberg, D. A., K. J. Simon, K. Brennan, and M. Gilman. 1995. Sequence specific targeting of nuclear signal transduction pathways by homeo-domain proteins. Mol. Cell. Biol. 15:3318–3326.
  • Halder, G., P. Callaerts, and W. J. Gehring. 1995. Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. Science 267:1788–1792.
  • Hayashi, S., and M. P. Scott. 1990. What determines the specificity of action of Drosophila homeodomain proteins. Cell 63:883–894.
  • Hill, C. S., R. Marais, S. John, J. Wynne, S. Dalton, and R. Treisman. 1993. Functional analysis of a growth factor-responsive transcription factor complex. Cell 73:395–406.
  • Hill, C. S., and R. Treisman. 1995. Differential activation of c-fos promoter elements by serum, lysophosphatidic acid, G proteins and polypeptide growth factors. EMBO J. 14:5037–5047.
  • Hoppler, S., and M. Bienz. 1994. Specification of a single cell type by a Drosophila homeotic gene. Cell 76:689–702.
  • Jack, T., G. L. Fox, and E. M. Meyerowitz. 1994. Arabidopsis homeotic gene APETALA3 ectopic expression: transcriptional and posttranscriptional regulation determine floral organ identity. Cell 76:703–716.
  • Kessel, M., and P. Gruss. 1990. Murine developmental control genes. Science 249:374–379.
  • Kissinger, C. R., B. S. Liu, E. Martin-Blanco, T. B. Kornberg, and C. O. Pabo. 1990. Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: a framework for understanding homeodomain-DNA interactions. Cell 63:579–590.
  • Klemm, J. D., M. A. Rould, R. Aurora, W. Herr, and C. O. Pabo. 1994. Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules. Cell 77:21–32.
  • Kornberg, T. B. 1993. Understanding the homeodomain. J. Biol. Chem. 268:26813–26816.
  • Kunkel, T. A. 1985. Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc. Natl. Acad. Sci. USA 82:488–492.
  • Kuziora, M. A., and W. McGinnis. 1989. A homeodomain substitution changes the regulatory specificity of the Deformed protein in Drosophila embryos. Cell 59:563–571.
  • Lai, J.-S., M. A. Cleary, and W. Herr. 1992. A single amino acid exchange transfers VP16-induced positive control from the Oct-1 to the Oct-2 homeo domain. Genes Dev. 6:2058–2065.
  • Lin, L., and W. McGinnis. 1992. Mapping functional specificity in the Dfd and Ubx homeodomains. Genes Dev. 6:1071–1081.
  • Ma, H. 1994. The unfolding drama of flower development: recent results from genetic and molecular analyses. Genes Dev. 8:745–756.
  • McGinnis, W., R. L. Garber, J. Wirz, A. Kuroiwa, and W. J. Gehring. 1984. A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans. Cell 37:403–408.
  • McGinnis, W., and R. Krumlauf. 1992. Homeobox genes and axial patterning. Cell 68:283–302.
  • Mohun, T. J., A. E. Chambers, N. Towers, and M. V. Taylor. 1991. Expression of genes encoding the transcription factor SRF during early development of Xenopus laevis: identification of a CArG box-binding activity as SRF. EMBO J. 10:933–940.
  • Nakayama, N., A. Miyajima, and K. Arai. 1987. Common signal transduction system shared by STE2 and STE3 in haploid cells of Saccharomyces cerevi-siae: autocrine cell-cycle arrest results from forced expression of STE2. EMBO J. 6:249–254.
  • Natesan, S., and M. Gilman. 1995. YY1 facilitates the association of serum response factor with the c-fos serum response element. Mol. Cell. Biol. 15:5975–5982.
  • Otting, G., Y. Q. Qian, M. Billeter, M. Müller, M. Affolter, W. J. Gehring, and K. Wüthrich. 1990. Protein-DNA contacts in the structure of a homeo-domain-DNA complex determined by nuclear magnetic resonance spectroscopy in solution. EMBO J. 9:3085–3092.
  • Pellegrini, L., S. Tan, and T. J. Richmond. 1995. Structure of serum response factor core bound to DNA. Nature 376:490–498.
  • Qian, Y. Q., M. Billeter, G. Otting, M. Muller, W. J. Gehring, and K. Wuthrich. 1989. The structure of the Antennapedia homeodomain determined by NMR spectroscopy in solution: comparison with prokaryotic repressors. Cell 59:573–580.
  • Rubin, G. M. 1991. Signal transduction and the fate of the R7 photoreceptor in Drosophila. Trends Genet. 7:372–377.
  • Schier, A. F., and W. J. Gehring. 1993. Functional specificity of the homeo-domain protein fushi tarazu: the role of DNA-binding specificity in vivo. Proc. Natl. Acad. Sci. USA 90:1450–1454.
  • Scott, M. P., and S. B. Carroll. 1987. The segmentation and homeotic gene network in early Drosophila development. Cell 51:689–698.
  • Scott, M. P., J. W. Tamkun, and G. W. Hartzell III. 1989. The structure and function of the homeodomain. Biochim. Biophys. Acta 989:25–48.
  • Scott, M. P., and A. J. Weiner. 1984. Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila. Proc. Natl. Acad. Sci. USA 81:4115–4119.
  • Smith, D. L., and A. D. Johnson. 1992. A molecular mechanism for combinatorial control in yeast: MCM1 protein sets the spacing and orientation of the homeodomains of an a2 dimer. Cell 68:133–142.
  • Stern, S., M. Tanaka, and W. Herr. 1989. The Oct-1 homeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16. Nature 341:624–630.
  • Sternberg, P. W., and H. R. Horvitz. 1991. Signal transduction during C. elegans vulval induction. Trends Genet. 7:366–371.
  • Tanaka, M., and W. Herr. 1990. Differential transcriptional activation by oct-1 and oct-2: interdependent activation domains induce oct-2 phosphorylation. Cell 60:375–386.
  • Treisman, J., P. Gönczy, M. Vashishtha, E. Harris, and C. Desplan. 1989. A single amino acid can determine the DNA binding specificity of homeodo-main proteins. Cell 59:553–562.
  • Treisman, R. 1990. The SRE: a growth factor responsive transcriptional regulator, p. 47–58. In N. Jones (ed.), Seminars in cancer biology transcription factors, differentiation and cancer. Saunders Scientific Publications, London, United Kingdom.
  • Treisman, R., and G. Ammerer. 1992. The SRF and MCM1 transcription factors. Curr. Opin. Genet. Dev. 2:221–226.
  • Vershon, A. K., Y. Jin, and A. D. Johnson. 1995. A homeo domain protein lacking specific side chains of helix 3 can still bind DNA and direct transcriptional repression. Genes Dev. 9:182–192.
  • Weigel, D., and E. M. Meyerowitz. 1994. The ABCs of floral homeotic genes. Cell 78:203–209.
  • Wilson, A. C., K. LaMarco, M. G. Peterson, and W. Herr. 1993. The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein. Cell 74:115–125.
  • Wilson, D. S., B. Guenther, C. Desplan, and J. Kuriyan. 1995. High resolution crystal structure of a paired (Pax) class cooperative homeodomain dimer on DNA. Cell 82:709–719.
  • Wolberger, C., A. K. Vershon, B. Liu, A. D. Johnson, and C. O. Pabo. 1991. Crystal structure of a MAT alpha 2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions. Cell 67:517–528.
  • Zeng, W., D. J. Andrew, L. D. Mathies, M. A. Horner, and M. P. Scott. 1993. Ectopic expression and function of the Antp and Scr homeotic genes: the N terminus of the homeodomain is critical to functional specificity. Development 118:339–352.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.