A Role for c-myc in Chemically Induced Renal-Cell Death

REFERENCES

• Askew, D. S., R. A. Ashmun, B. C. Simmons, and J. L. Cleveland. 1991. Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene 6:1915–1922.
   PubMed Web of Science ®Google Scholar
• Ayer, D. E., L. Kretzner, and R. N. Eisenman. 1993. Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. Cell 72:211–222.
   PubMed Web of Science ®Google Scholar
• Ayer, D. E., Q. A. Lawrence, and R. N. Eisenman. 1995. Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. Cell 80:767–776.
   PubMed Web of Science ®Google Scholar
• Basu, A., and J. S. Cline. 1995. Oncogenic transformation alters cisplatin-induced apoptosis in rat embryo fibroblasts. Int. J. Cancer 63:597–603.
   PubMed Web of Science ®Google Scholar
• Beijersbergen, R. L., E. M. Hijmans, L. Shu, and R. Bernards. 1994. Interaction of c-Myc with the pRb-related protein p107 results in inhibition of c-Myc-mediated transactivation. EMBO J. 13:4080–4086.
   PubMedGoogle Scholar
• Bello-Fernandez, C., G. Packham, and J. L. Cleveland. 1993. The ornithine decarboxylase gene is a transcriptional target of c-myc. Proc. Natl. Acad. Sci. USA 90:7804–7808.
   PubMed Web of Science ®Google Scholar
• Berberich, S. J., and M. D. Cole. 1992. Casein kinase II inhibits the DNA-binding activity of Max homodimers but not Myc/Max heterodimers. Genes Dev. 6:166–176.
   PubMed Web of Science ®Google Scholar
• Bernards, R. 1995. Flipping the Myc switch. Curr. Biol. 5:859–861.
   PubMedGoogle Scholar
• Bissonnette, R. P., F. Echeverri, A. Mahboubi, and D. R. Green. 1992. Apoptotic cell death induced by c-myc is inhibited by bcl-2. Nature 359:552–554.
   PubMed Web of Science ®Google Scholar
• Blackwood, E. M., and R. N. Eisenman. 1991. Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science 251:1211–1217.
   PubMed Web of Science ®Google Scholar
• Chen, Q., T. W. Jones, P. C. Brown, and J. L. Stevens. 1990. The mechanism of cysteine conjugate cytotoxicity in renal epithelial cells. Covalent binding leads to thiol depletion and lipid peroxidation. J. Biol. Chem. 265:21603–21611.
   PubMed Web of Science ®Google Scholar
• Cherney, B. W., K. Bhatia, and G. Tosato. 1994. A role for deregulated c-Myc expression in apoptosis of Epstein-Barr virus-immortalized B cells. Proc. Natl. Acad. Sci. USA 91:12967–12971.
   PubMedGoogle Scholar
• Cowley, B. D., L. J. Chadwick, J. J. Grantham, and J. P. Calvet. 1989. Sequential protooncogene expression in regenerating kidney following acute renal injury. J. Biol. Chem. 264:8389–8393.
   PubMed Web of Science ®Google Scholar
• Crawford, D., I. Zbinden, P. Amstad, and P. Cerutti. 1988. Oxidant stress induces the proto-oncogenes c-fos and c-myc in mouse epidermal cells. Oncogene 3:27–32.
   Web of Science ®Google Scholar
• Davidoff, A. N., and B. V. Mendelow. 1993. Puromycin-elicited c-myc mRNA superinduction precedes apoptosis in HL-60 leukaemic cells. Anticancer Res. 13:2257–2260.
   PubMedGoogle Scholar
• Davis, R. H., D. R. Morris, and P. Coffino. 1992. Sequestered end products and enzyme regulation: the case of ornithine decarboxylase. Microbiol. Rev. 56:280–290.
   PubMedGoogle Scholar
• Dekant, W., S. Vamvakas, M. Koob, A. Kochling, W. Kanhai, D. Muller, and D. Henschler. 1990. A mechanisms of haloalkene-induced renal carcinogenesis. Environ. Health Perspect. 88:107–110.
   PubMed Web of Science ®Google Scholar
• Evan, G. I., and T. D. Littlewood. 1993. The role of c-myc in cell growth. Curr. Opin. Genet. Dev. 3:44–49.
   PubMed Web of Science ®Google Scholar
• Evan, G. I., A. H. Wyllie, C. S. Gilbert, T. D. Littlewood, H. Land, M. Brooks, C. M. Waters, L. Z. Penn, and D. C. Hancock. 1992. Induction of apoptosisin fibroblasts by c-myc protein. Cell 69:119–128.
   PubMed Web of Science ®Google Scholar
• Fanidi, A., E. A. Harrington, and G. I. Evan. 1992. Cooperative interaction between c-myc and bcl-2 proto-oncogenes. Nature 359:554–556.
   PubMed Web of Science ®Google Scholar
• Galaktionov, K., X. Chen, and D. Beach. 1996. Cdc25 cell-cycle phosphatase as a target of c-myc. Nature 382:511–517.
   PubMed Web of Science ®Google Scholar
• Green, T., and J. Odum. 1985. Structure/activity studies of the nephrotoxic and mutagenic action of cysteine conjugates of chloro- and fluoroalkenes. Chem. Biol. Interact. 54:15–31.
   PubMed Web of Science ®Google Scholar
• Gu, W., K. Bhatia, I. T. Magrath, C. V. Dang, and R. Dalla-Favera. 1994. Binding and suppression of the Myc transcriptional activation domain by p107. Science 264:251–254.
   PubMedGoogle Scholar
• Gu, W., K. Cechova, V. Tassi, and R. Dalla-Favera. 1993. Opposite regulation of gene transcription and cell proliferation by c-Myc and Max. Proc. Natl. Acad. Sci. USA 90:2935–2939.
   PubMedGoogle Scholar
• Hahn, S. R., M. Dixit, R. C. Sears, and L. Sealy. 1994. The alternatively initiated c-Myc proteins differentially regulate transcription through a non-canonical DNA-binding site. Genes Dev. 8:2441–2452.
   PubMedGoogle Scholar
• Halleck, M. M., N. J. Holbrook, J. Skinner, H. Liu, and J. L. Stevens. 1997. The molecular response to reductive stress in the renal epithelial cell line LLC-PK1: coordinate transcriptional regulation of gadd153 and grp78 genes by thiols. Cell Stress Chaperones 2:31–40.
   PubMedGoogle Scholar
• Harrington, E. A., M. R. Bennett, A. Fanidi, and G. I. Evan. 1994. c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J. 13:3286–3295.
   PubMed Web of Science ®Google Scholar
• Hayden, P. J., and J. L. Stevens. 1990. Cysteine conjugate toxicity, metabolism, and binding to macromolecules in isolated rat kidney mitochondria. Mol. Pharmacol. 37:468–476.
   PubMedGoogle Scholar
• Hermeking, H., and D. Eick. 1994. Mediation of c-Myc-induced apoptosis by p53. Science 265:2091–2093.
   PubMed Web of Science ®Google Scholar
• Hockenbery, D., G. Nunez, C. Milliman, R. D. Schreiber, and S. J. Korsmeyer. 1990. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348:334–336.
   PubMed Web of Science ®Google Scholar
• Hurlin, P. J., C. Queva, P. J. Koskinen, E. Steingrimsson, D. E. Ayer, N. G. Copeland, N. A. Jenkins, and R. N. Eisenman. 1995. Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. EMBO J. 14:5646–5659.
   PubMed Web of Science ®Google Scholar
• Janicke, R., F. H. H. Lee, and A. G. Porter. 1994. Nuclear Myc plays an important role in the cytotoxicity of tumor necrosis factor alpha in tumor cells. Mol. Cell. Biol. 14:5661–5670.
   PubMedGoogle Scholar
• Kang, Y., R. Cortina, and R. R. Perry. 1996. Role of c-myc in tamoxifen-induced apoptosis estrogen-independent breast cancer cells. J. Natl. Cancer Inst. 88:279–284.
   PubMed Web of Science ®Google Scholar
• Kato, G. J., J. Barrett, M. Villa-Garcia, and C. V. Dang. 1990. An aminoterminal c-myc domain required for neoplastic transformation activates transcription. Mol. Cell. Biol. 10:5914–5920.
   PubMed Web of Science ®Google Scholar
• Kato, G. J., W. M. Lee, L. L. Chen, and C. V. Dang. 1992. Max: functional domains and interaction with c-Myc. Genes Dev. 6:81–92.
   PubMed Web of Science ®Google Scholar
• Klefstrom, J., I. Vastrik, E. Saksela, J. Valle, M. Eilers, and K. Alitalo. 1994. c-Myc induces cellular susceptibility to the cytotoxic action of TNF-alpha. EMBO J. 13:5442–5450.
   PubMed Web of Science ®Google Scholar
• Kretzner, L., E. M. Blackwood, and R. N. Eisenman. 1992. Myc and Max proteins possess distinct transcriptional activities. Nature 359:426–429.
   PubMed Web of Science ®Google Scholar
• Littlewood, T. D., D. C. Hancock, P. S. Danielian, M. G. Parker, and G. I. Evan. 1995. A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res. 23:1686–1690.
   PubMed Web of Science ®Google Scholar
• Liu, H., and J. L. Stevens. Unpublished data.
   Google Scholar
• Lotem, J., and L. Sachs. 1993. Regulation by bcl-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiation-competent and differentiation-defective myeloid leukemic Cells. Cell Growth Differ. 4:41–47.
   PubMedGoogle Scholar
• Lotem, J., and L. Sachs. 1995. A mutant p53 antagonizes the deregulated c-myc-mediated enhancement of apoptosis and decrease in leukemogenicity. Proc. Natl. Acad. Sci. USA 92:9672–9676.
   PubMedGoogle Scholar
• Lowe, S. W., H. E. Ruley, T. Jacks, and D. E. Housman. 1993. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74:957–967.
   PubMed Web of Science ®Google Scholar
• Majno, G., and I. Joris. 1995. Apoptosis, oncosis and necrosis. An overview of cell death. Am. J. Pathol. 146:3–15.
   PubMed Web of Science ®Google Scholar
• Maki, A., I. K. Berezesky, J. Fargnoli, N. J. Holbrook, and B. F. Trump. 1992. Role of [Ca21] induction of c-fos, c-jun and c-myc mRNA in rat PTE after oxidative stress. FASEB J. 6:919–924.
   PubMed Web of Science ®Google Scholar
• Marcu, K. B., S. A. Bossone, and A. J. Patel. 1992. myc function and regulation. Annu. Rev. Biochem. 61:809–860.
   PubMed Web of Science ®Google Scholar
• Matsuoka, M., and K. M. Call. 1995. Cadmium-induced expression of immediate early genes in LLC-PK1 cells. Kidney Int. 48:383–389.
   PubMedGoogle Scholar
• McCarthy, N. J., M. K. B. Whyte, C. S. Gilbert, and G. I. Evan. 1997. Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak. J. Cell Biol. 136:215–227.
   PubMed Web of Science ®Google Scholar
• Nunez, G., L. London, D. Hockenberry, M. Alexander, J. P. McKearn, and S. J. Korsmeyer. 1990. Deregulated bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. J. Immunol. 144:3602–3610.
   PubMed Web of Science ®Google Scholar
• Packham, G., R. A. Ashmun, and J. L. Cleveland. 1996. Cytokines suppress apoptosis independent of increases in reactive oxygen levels. J. Immunol. 156:2792–2800.
   PubMedGoogle Scholar
• Packham, G., and J. L. Cleveland. 1994. Ornithine decarboxylase is a mediator of c-Myc-induced apoptosis. Mol. Cell. Biol. 14:5741–5747.
   PubMed Web of Science ®Google Scholar
• Packham, G., and J. L. Cleveland. 1995. c-Myc and apoptosis. Biochim. Biophys. Acta 1242:11–28.
   PubMed Web of Science ®Google Scholar
• Packham, G., and J. L. Cleveland. Induction of ornithine decarboxylase by IL-3 is mediated by sequential c-Myc-independent and c-Myc dependent pathways. Oncogene, in press.
   Google Scholar
• Packham, G., C. W. Porter, and J. L. Cleveland. 1996. c-Myc induces apoptosis and cell cycle progression by separable, yet overlapping, pathways. Oncogene 13:461–469.
   PubMed Web of Science ®Google Scholar
• Pena, A., C. D. Reddy, S. J. Wu, N. J. Hickok, E. P. Reddy, G. Yumet, D. R. Soprano, and K. J. Soprano. 1993. Regulation of human ornithine decarboxylase expression by the c-MyczMax protein complex. J. Biol. Chem. 268:27277–27285.
   PubMedGoogle Scholar
• Reisman, D., N. B. Elkind, B. Roy, J. Beamon, and V. Rotter. 1993. c-Myc trans-activates the p53 promoter through a required downstream CACGTG motif. Cell Growth Differ. 4:57–65.
   PubMedGoogle Scholar
• Sakamuro, D., V. Eviner, K. J. Elliott, L. Showe, E. White, and G. C. Prendergast. 1995. c-Myc induces apoptosis in epithelial cells by both p53-dependent and p53-independent mechanisms. Oncogene 11:2411–2418.
   PubMed Web of Science ®Google Scholar
• Schreiber-Agus, N., L. Chin, K. Chen, R. Torres, G. Rao, P. Guida, A. I. Skoultchi, and R. A. DePinho. 1995. An amino-terminal domain of Mxi1 mediates anti-myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3. Cell 80:777–786.
   PubMed Web of Science ®Google Scholar
• Sentman, C. L., J. R. Shutter, D. Hockenberry, O. Kanagawa, and S. J. Korsmeyer. 1991. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67:879–888.
   PubMed Web of Science ®Google Scholar
• Shi, Y., J. M. Glynn, L. J. Guilbert, T. G. Cotter, R. P. Bissonnette, and D. R. Green. 1992. Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas. Science 257:212–214.
   PubMed Web of Science ®Google Scholar
• Shibanuma, M., T. Kuroki, and K. Nose. 1990. Stimulation by hydrogen peroxide of DNA synthesis, competence family gene expression and phosphorylation of a specific protein in quiescent Balb/3T3 cells. Oncogene 5:1025–1032.
   PubMed Web of Science ®Google Scholar
• Stevens, J., P. Hayden, and G. Taylor. 1986. The role of glutathione conjugate metabolism and cysteine conjugate beta-lyase in the mechanism of S-cysteine conjugate toxicity in LLC-PK1 cells. J. Biol. Chem. 261:3325–3332.
   PubMed Web of Science ®Google Scholar
• Tang, N., and M. D. Enger. 1993. Cd21-Induced c-myc messenger RNA accumulation in NRK-49F cells is blocked by the protein kinase inhibitor H7 but not by HA1004, indicating that protein kinase C is a mediator of the response. Toxicology 81:155–164.
   PubMedGoogle Scholar
• Tsujimoto, Y. 1989. Stress-resistance conferred by high level bcl-2 protein in human B lymphoblastoid cell. Oncogene 4:1331–1336.
   PubMed Web of Science ®Google Scholar
• Vamvakas, S., and U. Koster. 1993. The nephrotoxin dichlorovinylcysteine induces expression of the protooncogenes c-fos and c-myc in LLC-PK(1) cells—a comparative investigation with growth factors and 12- O-tetrade-canoylphorbolacetate. Cell Biol. Toxicol. 9:1–13.
   PubMed Web of Science ®Google Scholar
• van de Water, B., M. Kruidering, and J. F. Nagelkerke. 1996. Role of F-actin damage and cell detachment in apoptotic cell death of cultured proximal tubular cells. Am. J. Physiol. 270:F593–F603.
   PubMedGoogle Scholar
• van de Water, B., J. P. Zoeteweij, H. J. G. M. de Bont, G. J. Mulder, and J. F. Nagelkerke. 1994. Role of mitochondrial calcium in the oxidative stress-induced dissipation of the mitochondrial membrane potential: studies in isolated proximal tubular cells using the nephrotoxin 1,2-dichlorovinyl-cys-teine. J. Biol. Chem. 269:14546–14552.
   PubMedGoogle Scholar
• Vaux, D. L., S. Cory, and J. M. Adams. 1988. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335:440–442.
   PubMed Web of Science ®Google Scholar
• Wagner, A. J., J. M. Kokontis, and N. Hay. 1994. Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1. Genes Dev. 8:2817–2830.
   PubMed Web of Science ®Google Scholar
• Wagner, A. J., C. Meyers, L. A. Laimins, and N. Hay. 1993. c-Myc induces the expression and activity of ornithine decarboxylase. Cell Growth Differ. 4:879–883.
   PubMedGoogle Scholar
• Wagner, A. J., M. B. Small, and N. Hay. 1993. Myc-Mediated apoptosis is blocked by ectopic expression of Bcl-2. Mol. Cell Biol. 13:2432–2440.
   PubMed Web of Science ®Google Scholar
• Weiss, J. M., K. J. Lembach, and R. J. Boucek. 1981. A comparison of ornithine decarboxylase from normal and SV40-transformed 3T3 mouse fibroblasts. Biochem. J. 194:229–239.
   PubMedGoogle Scholar
• Yu, K., Q. Chen, H. Liu, Y. Zhan, and J. L. Stevens. 1994. Signaling the molecular stress response to nephrotoxic and mutagenic cysteine conjugates: differential roles for protein synthesis and calcium in the induction of c-fos and c-myc mRNA in LLC-PK1 cells. J. Cell Physiol. 161:303–311.
   PubMedGoogle Scholar
• Zervos, A. S., J. Gyuris, and R. Brent. 1993. Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. Cell 72:223–232.
   PubMed Web of Science ®Google Scholar
• Zhan, Y., and J. L. Stevens. Unpublished results.
   Google Scholar
• Zhan, Y., B. van de Water, and J. L. Stevens. Unpublished results.
   Google Scholar