Vac7p, a Novel Vacuolar Protein, Is Required for Normal Vacuole Inheritance and Morphology

References

• Acharya, U., R. Jacobs, J.-M. Peters, N. Watson, M. G. Farquhar, and V. Malhotra. 1995. The formation of Golgi stacks from vesiculated Golgi membranes requires two distinct fusion events. Cell 82:859–904.
   Google Scholar
• Banta, L. M., J. S. Robinson, D. J. Klionsky, and S. D. Emr. 1988. Organelle assembly in yeast: characterization of yeast mutants defective in vacuolar biogenesis and protein sorting. J. Cell Biol. 107:1369–1383.
   PubMed Web of Science ®Google Scholar
• Baudin, A., O. Ozier-Kalogeropoulos, A. Denouel, F. Lacroute, and C. Cullin. 1993. A simple and ef(r)cient method for direct gene deletion in Saccharomyces cerevisiae. Nucleic Acids Res. 21:3329–3330.
   PubMed Web of Science ®Google Scholar
• Belde, P. J. M., J. H. Vossen, G. H. F. H. Borst-Pauwels, and A. P. R. Theuvenet. 1993. Inositol 1,4,5-triphosphate releases Ca2+from vacuolar membrane vesicles of Saccharomyces cerevisiae. FEBS Lett. 323:113–118.
   PubMedGoogle Scholar
• Bergez, P., F. Doignon, and M. Crouzet. 1995. The sequence of a 44,420 bp fragment located on the left arm of the chromosome XIV from Saccharomyces cerevisiae. Yeast 11:967–974.
   PubMedGoogle Scholar
• Berkower, C., D. Loayza, and S. Michaelis. 1994. Metabolic instability and constitutive endocytosis of STE6, the a-factor transporter of Saccharomyces cerevisiae. Mol. Biol. Cell 5:1185–1198.
   PubMedGoogle Scholar
• Cardenas, M. E., and J. Heitman. 1995. FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity. EMBO J. 14:5892–5907.
   PubMedGoogle Scholar
• Conibear, E., and T. H. Stevens. 1995. Vacuolar biogenesis in yeast: sorting out the sorting proteins. Cell 83:513–516.
   PubMedGoogle Scholar
• Davis, R. W., M. Thomas, J. Cameron, T. P. St. John, S. Scherer, and R. A. Padgett. 1980. Rapid DNA isolation for enzymatic and hybridization analysis. Methods Enzymol. 65:404–411.
   PubMedGoogle Scholar
• De Camilli, P. 1995. Molecular mechanisms in synaptic vesicle recycling. FEBS Lett. 369:3–12.
   PubMedGoogle Scholar
• Duzgunes, N., J. Wilschut, R. Fraley, and D. Papahadjopoulos. 1981. Studies on the mechanism of fusion: role of head-group composition in calcium- and magnesium-induced fusion of mixed phospholipid vesicles. Biochim. Biophys. Acta 642:182–195.
   PubMed Web of Science ®Google Scholar
• Gammie, A. E., L. J. Kurihara, R. B. Vallee, and M. D. Rose. 1995. DNM1, a dynamin-related gene, participates in endosomal trafficking in yeast. J. Cell Biol. 130:553–566.
   PubMedGoogle Scholar
• Gietz, R. D., A. Jean, R. A. Woods, and R. H. Schiestl. 1992. Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res. 8:1425.
   Google Scholar
• Gomes de Mesquita, D. S., R. ten Hoopen, and C. L. Woldringh. 1991. Vacuolar segregation to the bud of S. cerevisiae: an analysis of the morphology and timing in the cell cycle. J. Gen. Microbiol. 137:2447–2454.
   PubMedGoogle Scholar
• Gomes de Mesquita, D. S., B. van den Haazel, J. Bouwman, and C. L. Woldringh. 1996. Characterization of new vacuolar segregation mutants, isolated by screening for loss of proteinase B self-activation. Eur. J. Cell Biol. 71:237–247.
   PubMed Web of Science ®Google Scholar
• Guan, K., L. Farh, T. K. Marshall, and R. J. Deschenes. 1993. Normal mitochondrial structure and genome maintenance in yeast requires the dynamin-like product of the MGM1 gene. Curr. Genet. 24:141–148.
   PubMedGoogle Scholar
• Haas, A., and W. Wickner. 1996. Homotypic vacuole fusion requires Sec17p (yeast alpha-SNAP) and Sec18p (yeast NSF). EMBO J. 15:3296–3305.
   PubMedGoogle Scholar
• Hay, J. C., P. L. Fisette, G. H. Jenkins, K. Fukami, T. Takenawa, R. A. Anderson, and T. F. J. Martin. 1995. ATP-dependent inositide phosphorylation required for Ca2+-activated secretion. Nature 374:173–177.
   PubMedGoogle Scholar
• Heitman, J., N. R. Movva, and M. N. Hall. 1991. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253:905–909.
   PubMed Web of Science ®Google Scholar
• Hill, K. L., N. L. Catlett, and L. S. Weisman. 1996. Actin and myosin function in directed vacuole movement during yeast cell division in Saccharomyces cerevisiae. J. Cell Biol. 135:1535–1549.
   PubMedGoogle Scholar
• Jones, B. A., and W. L. Fangman. 1992. Mitochondrial DNA maintenance in yeast requires a protein containing a region related to the GTP-binding domain of dynamin. Genes Dev. 6:380–389.
   PubMedGoogle Scholar
• Kaiser, C., S. Michaelis, and A. Mitchell. 1994. Methods in yeast genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
   Google Scholar
• Kane, P. M., M. C. Kuehn, I. Howald-Stevenson, and T. H. Stevens. 1992. Assembly and targeting of peripheral and integral membrane subunits of the yeast vacuolar H+-ATPase. J. Biol. Chem. 267:447–454.
   PubMedGoogle Scholar
• Klionsky, D. J., H. Nelson, and N. Nelson. 1992. Compartment acidification is required for efficient sorting of proteins to the vacuole in Saccharomyces cerevisiae. J. Biol. Chem. 267:3416–3422.
   PubMedGoogle Scholar
• Koenig, J. H., and K. Ikeda. 1989. Disappearance and reformation of synaptic vesicle membrane upon transmitter release observed under reversible blockage of membrane retrieval. J. Neurosci. 9:3844–3860.
   PubMed Web of Science ®Google Scholar
• Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680–685.
   PubMed Web of Science ®Google Scholar
• Latterich, M., K.-U. Frohlich, and R. Schekman. 1995. Membrane fusion and the cell cycle: Cdc48p participates in the fusion of ER membranes. Cell 82:885–893.
   PubMed Web of Science ®Google Scholar
• Liscovitch, M., V. Chalifa, P. Pertile, C.-S. Chen, and L. C. Cantley. 1994. Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D. J. Biol. Chem. 269:21403–21406.
   PubMedGoogle Scholar
• Mellman, I. 1994. Membranes and sorting. Curr. Opin. Cell Biol. 6:497–498.
   Google Scholar
• Michaelis, S. (Johns Hopkins University). Personal communication.
   Google Scholar
• Ohashi, M., K. Jan de Vries, R. Frank, G. Snoek, V. Bankaitis, K. Wirtz, and W. B. Huttner. 1995. A role for phosphatidylinositol transfer protein in secretory vesicle formation. Nature 377:544–547.
   PubMedGoogle Scholar
• Rabouille, C., T. P. Levine, J.-M. Peters, and G. Warren. 1995. An NSF-like ATPase, p97, and NSF mediate cisternal regrowth from mitotic Golgi fragments. Cell 82:905–914.
   PubMedGoogle Scholar
• Raymond, C. K., I. Howald-Stevenson, C. A. Vater, and T. H. Stevens. 1992. Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants. Mol. Biol. Cell 3:1389–1402.
   PubMed Web of Science ®Google Scholar
• Robinson, J. S., D. J. Klionsky, L. M. Banta, and S. D. Emr. 1988. Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases. Mol. Cell. Biol. 8:4936–4948.
   PubMed Web of Science ®Google Scholar
• Roeder, A. D., D. Otsuga, and J. M. Shaw (University of Utah). Personal communication.
   Google Scholar
• Rothman, J. E., C. K. Raymond, T. Gilbert, P. J. O’Hara, and T. H. Stevens. 1990. A putative GTP binding protein homologous to interferon-inducible Mx proteins performs an essential function in yeast protein sorting. Cell 61:1063–1074.
   PubMed Web of Science ®Google Scholar
• Rothman, J. E., and F. T. Wieland. 1996. Protein sorting by transport vesicles. Science 272:227–234.
   PubMed Web of Science ®Google Scholar
• Schneider, B. L., W. Seufert, B. Steiner, Q. H. Yang, and A. B. Futcher. 1995. Use of polymerase chain reaction epitope tagging for protein tagging in Saccharomyces cerevisiae. Yeast 11:1265–1274.
   PubMedGoogle Scholar
• Sears, L. E., L. S. Moran, C. Kissinger, T. Creasey, H. Perry-O’Keefe, M. Roskey, E. Sutherland, and B. S. Slatko. 1992. Circum Vent thermal cycle sequencing and alternative manual and automated DNA sequencing protocols using highly thermostable VentR (exo-) DNA polymerase. BioTechniques 13:626–633.
   PubMedGoogle Scholar
• Sikorski, R. S., and P. Hieter. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122:19–27.
   PubMed Web of Science ®Google Scholar
• Simon, J., I. E. Ivanov, M. Adesnik, and D. D. Sabatini. 1996. The production of post-Golgi vesicles requires a protein kinase C-like molecule, but not its phosphorylating activity. J. Cell Biol. 135:355–370.
   PubMed Web of Science ®Google Scholar
• Skinner, H. B., T. P. McGee, C. R. McMaster, M. R. Fry, R. M. Bell, and V. A. Bankaitis. 1995. The Saccharomyces cerevisiae phosphatidylinositol-transfer protein effects a ligand-dependent inhibition of choline-phosphate cytidylyltransferase activity. Proc. Natl. Acad. Sci. USA 92:112–116.
   PubMedGoogle Scholar
• Stack, J. H., B. Horazdovsky, and S. D. Emr. 1995. Receptor-mediated protein sorting to the vacuole in yeast: roles for a protein kinase, a lipid kinase and GTP-binding proteins. Annu. Rev. Cell Dev. Biol. 11:1–33.
   PubMedGoogle Scholar
• Sullivan, K. M. C., W. B. Busa, and K. L. Wilson. 1993. Calcium mobilization is required for nuclear vesicle fusion in vitro: implications for membrane traffic and IP3 receptor function. Cell 73:1411–1422.
   PubMed Web of Science ®Google Scholar
• Sundler, R., N. Duzgunes, and D. Papahadjopoulos. 1981. Control of membrane fusion by phospholipid head groups. The role of phosphatidylethanolamine in mixtures with phosphatidate and phosphatidylinositol. Biochim. Biophys. Acta 649:751–758.
   PubMedGoogle Scholar
• Sundler, R., and D. Papahadjopoulos. 1981. Control of membrane fusion by phospholipid head groups. Phosphatidate/phosphatidylinositol specificity. Biochim. Biophys. Acta 649:743–750.
   PubMedGoogle Scholar
• Takei, K., P. S. McPherson, S. L. Schmid, and P. De Camilli. 1995. Tubular membrane invaginations coated by dynamin rings are induced by GTP-?S in nerve terminals. Nature 374:186–190.
   PubMed Web of Science ®Google Scholar
• Takei, K., O. Mundigl, L. Daniell, and P. De Camilli. 1996. The synaptic vesicle cycle: a single vesicle budding step involving clathrin and dynamin. J. Cell Biol. 133:1237–1250.
   PubMedGoogle Scholar
• Towbin, H., T. Staehelin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76:4350–4354.
   PubMed Web of Science ®Google Scholar
• Uchida, E., Y. Ohsumi, and Y. Anraku. 1988. Purification of yeast vacuolar membrane H+-ATPase and enzymological discrimination of three ATP- driven proton pumps in Saccharomyces cerevisiae. Methods Enzymol. 157:544–563.
   PubMedGoogle Scholar
• Vida, T. A., and S. D. Emr. 1995. A new vital stain for visualizing vacuolar membrane dynamics and endocytosis in yeast. J. Cell Biol. 128:779–792.
   PubMed Web of Science ®Google Scholar
• Wang, Y.-X., N. L. Catlett, and L. S. Weisman. Submitted for publication.
   Google Scholar
• Wang, Y.-X., H. Zhao, T. Harding, D. S. Gomes de Mesquita, C. L. Woldringh, D. J. Klionsky, A. L. Munn, and L. S. Weisman. 1996. Multiple classes of yeast mutants are defective in vacuole partitioning yet target vacuole proteins correctly. Mol. Biol. Cell 7:1375–1389.
   PubMed Web of Science ®Google Scholar
• Warren, G., and W. Wickner. 1996. Organelle inheritance. Cell 84:395–400.
   PubMedGoogle Scholar
• Weisman, L. S., R. Bacallao, and W. Wickner. 1987. Multiple methods of visualizing the yeast vacuole permit evaluation of its morphology and inheritance during the cell cycle. J. Cell Biol. 105:1539–1547.
   PubMed Web of Science ®Google Scholar
• Weisman L. S., S. D. Emr, and W. Wickner. 1990. Mutants of Saccharomyces cerevisiae that block intervacuole vesicular traffic and vacuole division and segregation. Proc. Natl. Acad. Sci. USA 87:1067–1080.
   Google Scholar
• Weisman, L. S., and W. Wickner. 1988. Intervacuole exchange in the yeast zygote: a new pathway in organelle communication. Science 241:589–591.
   PubMed Web of Science ®Google Scholar
• Weisman, L. S., and W. Wickner. 1992. Molecular characterization of VAC1, a gene required for vacuole inheritance and vacuole protein sorting. J. Cell Biol. 267:618–623.
   Google Scholar
• Xu, Z., A. Mayer, E. Muller, and W. Wickner. 1997. A heterodimer of thioredoxin and IB2 cooperates with Sec18p (NSF) to promote yeast vacuole inheritance. J. Cell Biol. 136:299–306.
   PubMedGoogle Scholar
• Yamamoto, A., D. B. DeWald, I. V. Boronenkov, R. A. Anderson, S. D. Emr, and D. Koshland. 1995. Novel PI(4)P 5-kinase homologue, Fab1p, essential for normal vacuole function and morphology in yeast. Mol. Biol. Cell 6:525–539.
   PubMed Web of Science ®Google Scholar