43
Views
215
CrossRef citations to date
0
Altmetric
Research Article

Human Eukaryotic Translation Initiation Factor 4G (eIF4G) Possesses Two Separate and Independent Binding Sites for eIF4A

&
Pages 6940-6947 | Received 04 Jun 1997, Accepted 10 Sep 1997, Published online: 29 Mar 2023

References

  • Allen, M., A. M. Metz, R. T. Timmer, R. E. Rhoads, and K. S. Browning. 1992. Isolation and sequence of the cDNAs encoding the subunits of the isozyme form of wheat protein synthesis initiation factor 4F. J. Biol. Chem. 267:23232–23236.
  • Altmann, M., S. Blum, J. Pelletier, N. Sonenberg, T. M. A. Wilson, and H. Trachsel. 1990. Translation factor-dependent extracts from Saccharomyces cerevisiae. Biochim. Biophys. Acta 1050:155–159.
  • Etchison, D. E., S. C. Milburn, L. Edery, N. Sonenberg, and J. W. B. Hershey. 1982. Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eukaryotic initiation factor 3 and a cap binding protein complex. J. Biol. Chem. 257:14806–14810.
  • Fuerst, T. R., E. G. Niles, F. W. Studier, and B. Moss. 1986. Eukaryotic transient expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase. Proc. Natl. Acad. Sci. USA 83:8122–8126.
  • Goyer, C., M. Altmann, H. S. Lee, A. Blanc, M. Deshmukh, J. L. Woolford, Jr., H. Trachsel, and N. Sonenberg. 1993. TIF4631 and TIF4632: two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and carry out an essential function. Mol. Cell. Biol. 13:4860–4874.
  • Haghighat, A., S. Mader, A. Pause, and N. Sonenberg. 1995. Repression of cap-dependent translation by 4E-binding protein-1: competition with p220 for binding to eukaryotic initiation factor-4E. EMBO J. 14:5701–5709.
  • Haghighat, A., Y. Svitkin, I. Novoa, E. Kuechler, T. Skern, and N. Sonenberg. 1996. The eIF4G-eIF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase. J. Virol. 70:8445–8450.
  • Imataka, H. Unpublished data.
  • Imataka, H., S. Olsen, and N. Sonenberg. 1997. A new translational regulator with homology to eukaryotic translation initiation factor 4G. EMBO J. 16:817–825.
  • Lamphear, B., R. Kirchweger, T. Skern, and R. Rhoads. 1995. Mapping of functional domains in eukaryotic protein synthesis initiation factor 4G (eIF4G) with picornaviral proteases: implications for cap-dependent nd cap-independent translational initiation. J. Biol. Chem. 270:21975–21983.
  • Lamphear, B., and R. Rhoads. 1996. A single amino acid change in protein synthesis initiation factor 4G renders cap-dependent translation resistant to picornaviral 2A proteases. Biochemistry 35:15726–15733.
  • Lazaris-Karatzas, A., M. R. Smith, M. L. Jaramillo, Y. L. Liu, H.-F. Kung, and N. Sonenberg. 1992. Ras mediates translation initiation factor 4E-in-duced malignant transformation. Genes Dev. 6:1631–1642.
  • Levy-Strumpf, N., L. P. Deiss, H. Berissi, and A. Kimchi. 1997. DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death. Mol. Cell. Biol. 17:1615–1625.
  • Liebig, H.-D., E. Ziegler, R. Yan, K. Hartmuth, H. Klump, H. Kowalski, D. Blaas, W. Sommergruber, L. Frasel, B. Lamphear, R. E. Rhoads, E. Kuechler, and T. Skern. 1993. Purification of two picornaviral 2A proteinases: interaction with eIF-4γ and influence on in vitro translation. Biochemistry 32:7581–7588.
  • Mader, S., H. Lee, A. Pause, and N. Sonenberg. 1995. The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4γ and the translational repressors 4E-binding proteins. Mol. Cell. Biol. 15:4990–4997.
  • Merrick, W. C., and J. W. B. Hershey. 1996. The pathway and mechanism of eukaryotic protein synthesis, p. 31–70. In J. Hershey, M. Mathews, and N. Sonenberg (ed.), Translational control. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
  • Metz, A. M., and K. S. Browning. 1996. Mutational analysis of the functional domains of the large subunit of the isozyme form of wheat initiation factor eIF4F. J. Biol. Chem. 271:31033–31036.
  • Nielsen, P., and H. Trachsel. 1988. The mouse protein synthesis initiation factor 4A gene family includes two related functional genes which are differentially expressed. EMBO J. 7:2097–2105.
  • Pain, V. M. 1996. Initiation of protein synthesis in eukaryotic cells. Eur. J. Biochem. 236:747–771.
  • Pause, A., N. Methot, Y. Svitkin, W. C. Merrick, and N. Sonenberg. 1994. Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation. EMBO J. 13:1205–1215.
  • Pestova, T. V., C. U. T. Hellen, and I. N. Shatsky. 1996. Functional dissection of eukaryotic initiation factor 4F: the 4A subunit and the central domain of the 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes. Mol. Cell. Biol. 16:6870–6878.
  • Rozen, F., I. Edery, K. Meerovitch, T. E. Dever, W. C. Merrick, and N. Sonenberg. 1990. Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F. Mol. Cell. Biol. 10:1134–1144.
  • Shaughnessy, J. D., Jr., N. A. Jenkins, and N. G. Copeland. 1997. cDNA cloning, expression analysis, and chromosomal localization of a gene with high homology to wheat eIF-(iso)4F and mammalian eIF-4G. Genomics 39:192–197.
  • Smith, R., and T. Smith. 1992. Pattern-induced multi-sequence alignment (PIMA) algorithm employing secondary structure-dependent gap penalties for comparative protein modelling. Protein Eng. 5:35–41.
  • Sonenberg, N. 1996. mRNA 5′ cap-binding protein eIF4E and control of cell growth, p. 271–294. In J. Hershey, M. Mathews, and N. Sonenberg (ed.), Translational control. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
  • Yamanaka, S., K. S. Poksay, K. S. Arnold, and T. L. Innerarity. 1997. A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme. Genes Dev. 11:321–333.
  • Yan, R., W. Rychlik, D. Etchison, and R. Rhoads. 1992. Amino acid sequence of the human protein synthesis initiation factor eIF-4γ. J. Biol. Chem. 267:23226–23231.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.