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Research Article

ch-IAP1, a Member of the Inhibitor-of-Apoptosis Protein Family, Is a Mediator of the Antiapoptotic Activity of the v-Rel Oncoprotein

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Pages 7328-7341 | Received 03 Jul 1997, Accepted 01 Sep 1997, Published online: 29 Mar 2023

References

  • Abbadie, C., N. Kabrun, F. Bouali, J. Smardova, D. Stehelin, B. Vandenbunder, and P. J. Enrietto. 1993. High levels of c-rel expression are associated with programmed cell death in the developing avian embryo and in bone marrow cells in vitro. Cell 75:899–912.
  • Alnemri, E. S., D. J. Livingston, D. W. Nicholson, G. Salvesen, N. A. Thornberry, W. W. Wong, and J. Yuan. 1996. Human ICE/CED-3 protease nomenclature. Cell 87:171.
  • Andrews, N. C., and D. V. Faller. 1991. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 19:2499.
  • Arsura, M., M. Wu, and G. E. Sonenshein. 1996. TGF β 1 inhibits NF-κB/ Rel activity inducing apoptosis of B cells: transcriptional activation of IκBα. Immunity 5:31–40.
  • Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl. 1992. Current protocols in molecular biology. Greene Publishing Associates and Wiley-Interscience, New York, N.Y.
  • Baeuerle, P. A., and D. Baltimore. 1996. NF-κB: ten years after. Cell 87:13–20.
  • Baldwin, A. S., Jr. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649–683.
  • Ballard, D. W., W. H. Walker, S. Doerre, P. Sista, J. A. Molitor, E. P. Dixon, N. J. Peffer, M. Hannink, and W. C. Greene. 1990. The v-rel oncogene encodes a κB enhancer binding protein that inhibits NF-κB function. Cell 63:803–814.
  • Beg, A. A., and D. Baltimore. 1996. An essential role for NF-κB in preventing TNF-α-induced cell death. Science 274:782–784.
  • Birnbaum, M. J., R. J. Clem, and L. K. Miller. 1994. An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs. J. Virol. 68:2521–2528.
  • Bose, H. R., Jr. 1992. The Rel family: models for transcriptional regulation and oncogenic transformation. Biochim. Biophys. Acta 1114:1–17.
  • Carrasco, D., C. A. Rizzo, K. Dorfman, and R. Bravo. 1996. The v-rel oncogene promotes malignant T-cell leukemia/lymphoma in transgenic mice. EMBO J. 15:3640–3650.
  • Carthew, R. W., and G. M. Rubin. 1990. seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye. Cell 63:561–577.
  • Clem, R. J., M. Fechheimer, and L. K. Miller. 1991. Prevention of apoptosis by a baculovirus gene during infection of insect cells. Science 254:1388–1390.
  • Clem, R. J., and L. K. Miller. 1994. Induction and inhibition of apoptosis by insect viruses, p. 89–110. In D. L. Tomei and F. O. Cope (ed.), Apoptosis II: the molecular basis of apoptosis in disease. Cold Spring Laboratory Press, Plainview, N.Y.
  • Clem, R. J., and L. K. Miller. 1994. Control of programmed cell death by the baculovirus genes p35 and iap. Mol. Cell. Biol. 14:5212–5222.
  • Crook, N. E., R. J. Clem, and L. K. Miller. 1993. An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif. J. Virol. 67:2168–2174.
  • Davis, N., S. Ghosh, D. L. Simmons, P. Tempst, H. C. Liou, D. Baltimore, and H. R. Bose, Jr. 1991. Rel-associated pp40: an inhibitor of the rel family of transcription factors. Science 253:1268–1271.
  • Della, N. G., P. V. Senior, and D. D. Bowtell. 1993. Isolation and characterization of murine homologues of the Drosophila seven in absentia gene (sina). Development 117:1333–1343.
  • Digby, M. R., W. G. Kimpton, J. J. York, T. E. Connick, and J. W. Lowenthal. 1996. ITA, a vertebrate homologue of IAP that is expressed in T lymphocytes. DNA Cell Biol. 15:981–988.
  • Duckett, C. S., V. E. Nava, R. W. Gedrich, R. J. Clem, J. L. Van Dongen, M. C. Gilfillan, H. Shiels, and J. M. Hardwick. 1996. A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. EMBO J. 15:2685–2694.
  • Evan, G. I., A. H. Wyllie, C. S. Gilbert, T. D. Littlewood, H. Land, M. Brooks, C. M. Waters, L. Z. Penn, and D. C. Hancock. 1992. Induction of apoptosis in fibroblasts by c-myc protein. Cell 69:119–128.
  • Fraser, A., and G. Evan. 1996. A license to kill. Cell 85:781–784.
  • Freemont, P. S. 1993. The RING finger. A novel protein sequence motif related to the zinc finger. Ann. N. Y. Acad. Sci. 684:174–192.
  • Fujii, M., T. Minamino, M. Nomura, K. L. Miyamoto, J. Tanaka, and M. Seiki. 1996. Selective activation of the proto-oncogene c-jun promoter by the transforming protein v-Rel. Oncogene 12:2193–2202.
  • Gavrieli, Y., Y. Sherman, and S. A. Ben-Sasson. 1992. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:493–501.
  • Gelinas, C., and H. M. Temin. 1988. The v-rel oncogene encodes a cell-specific transcriptional activator of certain promoters. Oncogene 3:349–355.
  • Gilmore, T. D., M. Koedood, K. A. Piffat, and D. W. White. 1996. Rel/NF-κB/IκB proteins and cancer. Oncogene 13:1367–1378.
  • Grilli, M., J. J. Chiu, and M. J. Lenardo. 1993. NF-kappa B and Rel: participants in a multiform transcriptional regulatory system. Int. Rev. Cytol. 143:1–62.
  • Harvey, A. J., A. P. Bidwai, and L. K. Miller. 1997. Doom, a product of the Drosophila mod(mdg4) gene, induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. Mol. Cell. Biol. 17:2835–2843.
  • Hawkins, C. J., A. G. Uren, G. Hacker, R. L. Medcalf, and D. L. Vaux. 1996. Inhibition of interleukin 1 β-converting enzyme-mediated apoptosis of mammalian cells by baculovirus IAP. Proc. Natl. Acad. Sci. USA 93:13786–13790.
  • Hay, B. A., D. A. Wassarman, and G. M. Rubin. 1995. Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death. Cell 83:1253–1262.
  • Herzog, N. K., and H. R. Bose, Jr. 1986. Expression of the oncogene of avian reticuloendotheliosis virus in Escherichia coli and identification of the transforming protein in reticuloendotheliosis virus T-transformed cells. Proc. Natl. Acad. Sci. USA 83:812–816.
  • Hrdličková, R., J. Nehyba, and E. H. Humphries. 1994. v-rel induces expression of three avian immunoregulatory surface receptors more efficiently than c-rel. J. Virol. 68:308–319.
  • Hrdličková, R., J. Nehyba, and H. R. Bose, Jr. 1995. Mutations in the DNA-binding and dimerization domains of v-Rel are responsible for altered κB DNA-binding complexes in transformed cells. J. Virol. 69:3369–3380.
  • Hughes, S. H., J. J. Greenhouse, C. J. Petropoulos, and P. Sutrave. 1987. Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors. J. Virol. 61:3004–3012.
  • Ishida, T., S. Mizushima, S. Azuma, N. Kobayashi, T. Tojo, K. Suzuki, S. Aizawa, T. Watanabe, G. Mosialos, E. Kieff, T. Yamamoto, and J. Inoue. 1996. Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region. J. Biol. Chem. 271:28745–28748.
  • Ishikawa, H., M. Asano, T. Kanda, S. Kumar, C. Gelinas, and Y. Ito. 1993. Two novel functions associated with the Rel oncoproteins: DNA replication and cell-specific transcriptional activation. Oncogene 8:2889–2896.
  • Kanno, M., M. Hasegawa, A. Ishida, K. Isono, and M. Taniguchi. 1995. mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity. EMBO J. 14:5672–5678.
  • Keane, M. M., O. M. Rivero-Lezcano, J. A. Mitchell, K. C. Robbins, and S. Lipkowitz. 1995. Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene. Oncogene 10:2367–2377.
  • Kralova, J., J. D. Schatzle, W. Bargmann, and H. R. Bose, Jr. 1994. Transformation of avian fibroblasts overexpressing the c-rel proto-oncogene and a variant of c-rel lacking 40 C-terminal amino acids. J. Virol. 68:2073–2083.
  • Kralova, J., J. D. Schatzle, A. S. Liss, W. Bargmann, and H. R. Bose, Jr. 1996. Synergistic stimulation of avian IκBa transcription by rel and fos/jun factors. Oncogene 12:2595–2604.
  • Levine, A. J. 1997. p53, the cellular gatekeeper for growth and division. Cell 88:323–331.
  • Lewis, R. B., J. McClure, B. Rup, D. W. Niesel, R. F. Garry, J. D. Hoelzer, K. Nazerian, and H. R. Bose, Jr. 1981. Avian reticuloendotheliosis virus: identification of the hematopoietic target cell for transformation. Cell 25:421–431.
  • Liang, P., and A. B. Pardee. 1992. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science 257:967–971.
  • Liston, P., N. Roy, K. Tamai, C. Lefebvre, S. Baird, G. Cherton-Horvat, R. Farahani, M. McLean, J. E. Ikeda, A. MacKenzie, and R. G. Korneluk. 1996. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. Nature 379:349–353.
  • Madden, S. L., E. A. Galella, D. Riley, A. H. Bertelsen, and G. A. Beaudry. 1996. Induction of cell growth regulatory genes by p53. Cancer Res. 56:5384–5390.
  • Meisner, H., A. Daga, J. Buxton, B. Fernandez, A. Chawla, U. Banerjee, and M. P. Czech. 1997. Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development. Mol. Cell. Biol. 17:2217–2225.
  • Miller, S. A., D. D. Dykes, and H. F. Polesky. 1988. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16:1215.
  • Miura, M., H. Zhu, R. Rotello, E. A. Hartwieg, and J. Yuan. 1993. Induction of apoptosis in fibroblasts by IL-1 β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 75:653–660.
  • Mosialos, G., and T. D. Gilmore. 1993. v-Rel and c-Rel are differentially affected by mutations at a consensus protein kinase recognition sequence. Oncogene 8:721–730.
  • Nehyba, J., R. Hrdličková, and E. H. Humphries. 1994. Evolution of the oncogenic potential of v-rel: rel-induced expression of immunoregulatory receptors correlates with tumor development and in vitro transformation. J. Virol. 68:2039–2050.
  • Neiman, P. E., S. J. Thomas, and G. Loring. 1991. Induction of apoptosis during normal and neoplastic B-cell development in the bursa of Fabricius. Proc. Natl. Acad. Sci. USA 88:5857–5861.
  • Nemani, M., G. Linares-Cruz, H. Bruzzoni-Giovanelli, J. P. Roperch, M. Tuynder, L. Bougueleret, D. Cherif, M. Medhioub, P. Pasturaud, V. Alvaro, H. der Sarkissan, L. Cazes, D. Le Paslier, I. Le Gall, D. Israeli, J. Dausset, F. Sigaux, I. Chumakov, M. Oren, F. Calvo, R. B. Amson, D. Cohen, and A. Telerman. 1996. Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression. Proc. Natl. Acad. Sci. USA 93:9039–9042.
  • Oliner, J. D., K. W. Kinzler, P. S. Meltzer, D. L. George, and B. Volgelstein. 1992. Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 358:80–83.
  • Ota, Y., and L. E. Samelson. 1997. The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinase. Science 276:418–420.
  • Rao, A., K. Kline, and B. G. Sanders. 1990. Immune abnormalities in avian erythroblastosis virus-infected chickens. Cancer Res. 50:4764–4770.
  • Ray, C. A., R. A. Black, S. R. Kronheim, T. A. Greenstreet, P. R. Sleath, G. S. Salvesen, and D. J. Pickup. 1992. Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme. Cell 69:598–604.
  • Reed, J. C. 1997. Double identity for proteins of the Bcl-2 family. Nature 387:773–776.
  • Rothe, M., M. G. Pan, W. J. Henzel, T. M. Ayres, and D. V. Goeddel. 1995. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell 83:1243–1252.
  • Roy, N., M. S. Mahadevan, M. McLean, G. Shutler, Z. Yaraghi, R. Farahani, S. Baird, A. Besner-Johnston, C. Lefebvre, X. Kang, M. Salih, H. Aubry, K. Tamai, X. Guan, P. Loannou, T. Crawford, P. J. de Jong, L. Surh, J. Ikeda, R. G. Korneluk, and A. Mackenzie. 1995. The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. Cell 80:167–178.
  • Sarkar, S., and T. D. Gilmore. 1993. Transformation by the v-Rel oncoprotein requires sequences carboxy-terminal to the Rel homology domain. Oncogene 8:2245–2252.
  • Schatzle, J. D., J. Kralova, and H. R. Bose, Jr. 1995. Avian IκBα is transcriptionally induced by c-Rel and v-Rel with different kinetics. J. Virol. 69:5383–5390.
  • Schnitzler, P., M. Hug, M. Handermann, W. Janssen, E. V. Koonin, H. Delius, and C. Darai. 1994. Identification of genes encoding zinc finger proteins, non-histone chromosomal HMG protein homologue, and a putative GTP phosphohydrolase in the genome of Chilo iridescent virus. Nucleic Acids Res. 22:158–166.
  • Shu, H. B., M. Takeuchi, and D. V. Goeddel. 1996. The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex. Proc. Natl. Acad. Sci. USA 93:13973–13978.
  • Siebenlist, U. 1997. NF-κB/IκB proteins. Their role in cell growth, differentiation and development. Biochim. Biophys. Acta 1332:R7–R13.
  • Steller, H. 1995. Mechanisms and genes of cellular suicide. Science 267:1445–1449.
  • Teodoro, J. G., and P. E. Branton. 1997. Regulation of apoptosis by viral gene products. J. Virol. 71:1739–1746.
  • Tewari, M., and V. M. Dixit. 1995. Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. J. Biol. Chem. 270:3255–3260.
  • Thompson, C. B. 1995. Apoptosis in the pathogenesis and treatment of disease. Science 267:1456–1462.
  • Uren, A. G., M. Pakusch, C. J. Hawkins, K. L. Puls, and D. L. Vaux. 1996. Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. Proc. Natl. Acad. Sci. USA 93:4974–4978.
  • Van Antwerp, D. J., S. J. Martin, T. Kafri, D. R. Green, and I. M. Verma. 1996. Suppression of TNF-α-induced apoptosis by NF-κB. Science 274:787–789.
  • Walker, A. K., and P. J. Enrietto. 1996. Analysis of the role of v-rel in transcriptional regulation of high mobility group 14. Oncogene 12:2515–2525.
  • Wang, C. Y., M. W. Mayo, and A. S. Baldwin, Jr. 1996. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappa B. Science 274:784–787.
  • White, D. W., and T. D. Gilmore. 1993. Temperature-sensitive transforming mutants of the v-rel oncogene. J. Virol. 67:6876–6881.
  • White, D. W., A. Roy, and T. D. Gilmore. 1995. The v-Rel oncoprotein blocks apoptosis and proteolysis of IκB-α in transformed chicken spleen cells. Oncogene 10:857–868.
  • White, D. W., and T. D. Gilmore. 1996. Bcl-2 and CrmA have different effects on transformation, apoptosis and the stability of IκB-α in chicken spleen cells transformed by temperature-sensitive v-Rel oncoproteins. Oncogene 13:891–899.
  • White, E. 1996. Life, death, and the pursuit of apoptosis. Genes Dev. 10:1–15.
  • Zhang, G., C. Slaughter, and E. H. Humphries. 1995. v-rel induces ectopic expression of an adhesion molecule, DM-GRASP, during B-lymphoma development. Mol. Cell. Biol. 15:1806–1816.
  • Zhang, G., and E. H. Humphries. 1996. v-rel and c-rel induce a membrane protein, p75, on avian hematopoietic cells. Oncogene 12:1153–1157.

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