A Targeted Mutation at the T-Cell Receptor α/δ Locus Impairs T-Cell Development and Reveals the Presence of the Nearby Antiapoptosis Gene Dad1

REFERENCES

• Apel, T., A. Schere, T. Adachi, D. Auch, M. Ayane, and M. Reth. 1995. The ribose 5-phosphate isomerase-encoding gene is located immediately downstream from that encoding murine immunoglobulin kappa. Gene 156:191–197.
   PubMedGoogle Scholar
• Apte, S. S., M.-G. Mattei, M. F. Seldin, and B. R. Olsen. 1995. The highly conserved defender against the death 1 (DAD1) gene maps to human chromosome 14q11-q12 and mouse chromosome 14 and has plant and nematode homologs. FEBS Lett. 323:304–306.
   Google Scholar
• Bennani-Baiti, I. M., B. K. Jones, S. A. Liebhaber, and N. E. Cooke. 1995. Physical linkage of the human growth hormone gene cluster and the skeletal muscle sodium channel α-subunit gene (SCN4A) on chromosome 17. Genomics 29:647–652.
   PubMedGoogle Scholar
• Bresnick, E. H., and G. Felsenfeld. 1994. Dual promoter activation by the human beta-globin locus control region. Proc. Natl. Acad. Sci. USA 91:1314–1317.
   PubMedGoogle Scholar
• Chen, J., F. Young, A. Bottaro, V. Stewart, R. K. Smith, and F. W. Alt. 1993. Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus. EMBO J. 12:4635–4645.
   PubMedGoogle Scholar
• Diaz, P., D. Cado, and A. Winoto. 1994. A locus control region in the T cell receptor α/δ locus. Immunity 1:207–217.
   PubMedGoogle Scholar
• Enver, T., A. Brewer, and R. Patient. 1985. Simian virus 40-mediated cis induction of the Xenopus β-globin DNase I hypersensitive site. Nature 318:680–683.
   PubMedGoogle Scholar
• Festenstein, R., M. Tolaini, P. Corbella, C. Mamalaki, J. Parrington, M. Fox, A. Miliou, M. Jones, and D. Kioussis. 1996. Locus control region function and heterochromatin-induced position effect variegation. Science 271:1123–1125.
   PubMedGoogle Scholar
• Fiering, S., E. Epner, K. Robinson, Y. Zhuang, A. Telling, M. Hu, D. I. K. Martin, T. Enver, T. J. Ley, and M. Groudine. 1995. Targeted deletion of 59HS2 of the murine beta-globin LCR reveals that is not essential for proper regulation of the beta-globin locus. Genes Dev. 9:2203–2213.
   PubMedGoogle Scholar
• Forrester, W. C., E. Epner, M. C. Driscoll, T. Enver, M. Brice, T. Papayannopoulou, and M. Groudine. 1990. A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus. Genes Dev. 4:1637–1649.
   PubMed Web of Science ®Google Scholar
• Fowlkes, B. J., and D. M. Pardoll. 1989. Molecular and cellular events of T cell development. Adv. Immunol. 44:207–264.
   PubMed Web of Science ®Google Scholar
• Gill, L. L., D. Zaninetta, and K. Karjalainen. 1991. A transcriptional enhancer of the mouse T cell receptor delta gene locus. Eur. J. Immunol. 21:807–810.
   PubMed Web of Science ®Google Scholar
• Hanscombe, O., D. Whyatt, P. Fraser, N. Yannoutsos, D. Greaves, N. Dillon, and F. Grosveld. 1991. Importance of globin gene order for correct developmental expression. Genes Dev. 5:1387–1394.
   PubMedGoogle Scholar
• Ho, I. C., and J. M. Leiden. 1990. Regulation of the human T-cell receptor alpha gene enhancer: ubiquitous and T-cell-specific nuclear proteins interactwith four hypomethylated enhancer elements. Mol. Cell. Biol. 10:4720–4727.
   PubMedGoogle Scholar
• Hug, B. A., R. L. Wesselschmidt, S. Fiering, M. A. Bender, E. Epner, M. Groudine, and T. J. Ley. 1996. Analysis of mice containing a targeted deletion of β-globin locus control region 5′ hypersensitive site 3. Mol. Cell. Biol. 16:2906–2912.
   PubMedGoogle Scholar
• Itohara, S., P. Mombaerts, J. Lafaille, J. Iacomini, A. Nelson, A. R. Clarke, M. L. Hooper, A. Farr, and S. Tonegawa. 1993. T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes. Cell 72:337–348.
   PubMed Web of Science ®Google Scholar
• Joulin, V., D. Bories, J. F. Eleouet, M. C. Labastie, S. Chretien, M. G. Mattei, and P. H. Romeo. 1991. A T-cell specific TCR delta DNA binding protein is a member of the human GATA family. EMBO J. 10:1809–1816.
   PubMed Web of Science ®Google Scholar
• Koop, B. F., and L. Hood. 1994. Striking sequence similarity over almost 100 kilobases of human and mouse T-cell receptor DNA. Nat. Genet. 7:48–53.
   PubMed Web of Science ®Google Scholar
• Lauzurica, P., and M. S. Krangel. 1994. Enhancer-dependent and -independent steps in the rearrangement of a human T cell receptor delta transgene. J. Exp. Med. 179:43–55.
   PubMed Web of Science ®Google Scholar
• Lerner, A., L. D’Adamio, A. C. Diener, L. K. Clayton, and E. L. Reinherz. 1993. CD3 zeta/eta/theta locus is colinear with and transcribed antisense to the gene encoding the transcription factor Oct-1. J. Immunol. 151:3152–3162.
   PubMedGoogle Scholar
• Martin, D. I., S. Fiering, and M. Groudine. 1996. Regulation of β-globin gene expression: straightening out the locus. Curr. Opin. Genet. Dev. 6:488–495.
   PubMed Web of Science ®Google Scholar
• Mombaerts, P., A. R. Clarke, M. L. Hooper, and S. Tonegawa. 1991. Creation of a large genomic deletion at the T-cell antigen receptor beta-subunit locus in mouse embryonic stem cells by gene targeting. Proc. Natl. Acad. Sci. USA 88:3084–3087.
   PubMedGoogle Scholar
• Mombaerts, P., A. R. Clarke, M. A. Rudnicki, J. Iacomini, S. Itohara, J. J. Lafaille, L. Wang, Y. Ichikawa, R. Jaenisch, and M. L. Hooper. 1992. Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages. Nature 360:225–231.
   PubMed Web of Science ®Google Scholar
• Nakashima, T., T. Sekiguchi, A. Kuraoka, K. Fukushima, Y. Shibata, S. Komiyama, and T. Nishimoto. 1993. Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells. Mol. Cell. Biol. 13:6367–6374.
   PubMed Web of Science ®Google Scholar
• Oettinger, M. A., D. G. Schatz, C. Gorka, and D. Baltimore. 1990. RAG-1 and RAG-2, adjacent genes that synergistically activate recombination. Science 248:1517–1523.
   PubMed Web of Science ®Google Scholar
• Olson, E. N., H. H. Arnold, P. W. Rigby, and B. J. Wold. 1996. Know your neighbors: three phenotypes in null mutants of the myogenic bHLH gene MRF4. Cell 85:1–4.
   PubMed Web of Science ®Google Scholar
• Ortiz, B. D., D. Cado, and A. Winoto. Unpublished data.
   Google Scholar
• Ramirez-Solis, R., A. Davis, and A. Bradley. 1993. Gene targeting in embryonic stem cells. Methods Enzymol. 225:855–878.
   PubMedGoogle Scholar
• Redondo, J. M., S. Hata, C. Brocklehurst, and M. S. Krangel. 1990. A T cell-specific transcriptional enhancer within the human T receptor delta locus. Science 247:1225–1229.
   PubMed Web of Science ®Google Scholar
• Siebenlist, U., L. Henninghausen, J. Battey, and P. Leder. 1984. Chromatin structure and protein binding in the putative regulatory region of the c-myc gene in Burkitt lymphoma. Cell 37:381–391.
   PubMed Web of Science ®Google Scholar
• Silberstein, S., P. G. Collins, D. J. Kelleher, and R. Gilmore. 1995. The essential OST2 gene encodes the 16-kD subunit of the yeast oligosaccharyl- transferase, a highly conserved protein expressed in diverse eukaryotic organisms. J. Cell Biol. 131(2):371–383.
   PubMedGoogle Scholar
• Sugimoto, A., R. R. Hozak, T. Nakashima, T. Nishimoto, and J. H. Rothman. 1995. dad-1, an endogenous programmed cell death suppressor in Caeno- rhabditis elegans and vertebrates. EMBO J. 14:4434–4441.
   PubMedGoogle Scholar
• Tybulewicz, V., C. Crawford, P. Jackson, R. Bronson, and R. Mulligan. 1991. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65:1153–1163.
   PubMed Web of Science ®Google Scholar
• Vyas, P., M. A. Vickers, D. J. Picketts, and D. R. Higgs. 1995. Conservation of position and sequence of a novel, widely expressed gene containing the major human α-globin regulatory element. Genomics 29:679–689.
   PubMedGoogle Scholar
• Walters, M. C., W. Magis, S. Fiering, J. Eidemiller, D. Scalzo, M. Groudine, and D. I. K. Martin. 1996. Transcriptional enhancers act in cis to suppress position-effect variegation. Genes Dev. 10:185–195.
   PubMedGoogle Scholar
• Winoto, A., and D. Baltimore. 1989. Alpha-beta lineage-specific expression of the alpha T cell receptor gene by nearby silencers. Cell 59:649–655.
   PubMedGoogle Scholar
• Wu, C. 1989. Analysis of hypersensitive sites in chromatin. Methods Enzy- mol. 170:269–289.
   PubMedGoogle Scholar
• Xie, W. Q., and L. I. Rothblum. 1991. Rapid, small-scale RNA isolation from tissue culture cells. BioTechniques 11:324, 326–327.
   PubMedGoogle Scholar
• Ylug, I. G., C. G. See, and E. M. C. Fisher. 1995. The DAD1 protein, whose defect causes apoptotic cell death, maps to human chromosome 14. Genomics 26:433–435.
   PubMedGoogle Scholar