Expression of NFAT-Family Proteins in Normal Human T Cells

REFERENCES

• Aramburu, J., L. Azzoni, A. Rao, and B. Perussia. 1995. Activation and expression of the nuclear factors of activated T cells, NFATp and NFATc, in human natural killer cells: regulation upon CD16 ligand binding. J. Exp. Med. 182:801–810.
   PubMedGoogle Scholar
• Choi, M. S. K., R. D. Brines, M. J. Holman, and G. G. B. Klaus. 1994. Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4. Immunity 1:179–187.
   PubMed Web of Science ®Google Scholar
• Chuvpilo, S., C. Schomberg, R. Gerwig, A. Heinfling, R. Reeves, F. Grummt, and E. Serfling. 1993. Multiple closely-linked NFAT/octamer and HMGI(Y) binding sites are part of the interleukin-4 promoter. Nucleic Acids Res. 21:5694–5704.
   PubMed Web of Science ®Google Scholar
• Cockerill, P. N., A. G. Bert, F. Jenkins, G. R. Ryan, M. F. Shannon, and M. A. Vadas. 1995. Human granulocyte-macrophage colony-stimulating factor enhancer function is associated with cooperative interactions between AP-1 and NFATp/c. Mol. Cell. Biol. 15:2071–2079.
   PubMed Web of Science ®Google Scholar
• Crabtree, G. R., and N. A. Clipstone. 1994. Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu. Rev. Biochem. 63:1045–1083.
   PubMed Web of Science ®Google Scholar
• Ghosh, P., A. Sica, M. Cippitelli, J. Subleski, R. Lahesmaa, H. A. Young, and N. R. Rice. 1996. Activation of nuclear factor of activated T cells in a cyclosporin A-resistant pathway. J. Biol. Chem. 271:7700–7704.
   PubMedGoogle Scholar
• Goldfeld, A. E., P. G. McCaffrey, J. L. Strominger, and A. Rao. 1993. Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor a gene promoter. J. Exp. Med. 178:1365–1379.
   PubMed Web of Science ®Google Scholar
• Ho, A. M., J. Jain, A. Rao, and P. G. Hogan. 1994. Expression of the transcription factor NFATp in a neuronal cell line and in the murine nervous system. J. Biol. Chem. 269:28181–28186.
   PubMedGoogle Scholar
• Ho, A. M., D. J. Thomas, L. A. Timmerman, X. Li, U. Francke, and G. R. Crabtree. 1995. NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity. J. Biol. Chem. 270:19898–19907.
   PubMedGoogle Scholar
• Hodge, M. R., A. M. Ranger, F. C. de la Brousse, T. Hoey, M. J. Grusby, and L. H. Glimcher. 1996. Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice. Immunity 4:397–405.
   PubMed Web of Science ®Google Scholar
• Hoey, T., Y.-L. Sun, K. Williamson, and X. Xu. 1995. Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. Immunity 2:461–472.
   PubMed Web of Science ®Google Scholar
• Jain, J., E. Burgeon, T. M. Badalian, P. G. Hogan, and A. Rao. 1995a. A similar DNA-binding motif in NFAT family proteins and the Rel homology region. J. Biol. Chem. 270:4138–4145.
   PubMedGoogle Scholar
• Jain, J., C. Loh, and A. Rao. 1995b. Transcriptional regulation of the IL-2 gene. Curr. Opin. Immunol. 7:333–342.
   PubMed Web of Science ®Google Scholar
• Kozak, M. 1987. An analysis of the 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res. 15:8125–8148.
   PubMed Web of Science ®Google Scholar
• Liu, F.-T., M. Zinnecker, T. Hamaoka, and D. H. Katz. 1979. New procedures for preparation and isolation of conjugates of proteins and a synthetic copolymer of D-amino acids and immunochemical characterization of such conjugates. Biochemistry. 18:690–697.
   PubMed Web of Science ®Google Scholar
• Loh, C., J. A. Carew, J. Kim, P. G. Hogan, and A. Rao. 1996. T-cell receptor stimulation elicits an early phase of activation and a later phase of deactivation of the transcription factor NFAT1. Mol. Cell. Biol. 16:3945–3954.
   PubMedGoogle Scholar
• Loh, C., K. T.-Y. Shaw, J. Carew, J. P. B. Viola, C. Luo, B. A. Perrino, and A. Rao. 1996. Calcineurin binds the transcription factor NFAT1 and revers-ibly regulates its activity. J. Biol. Chem. 271:10884–10891.
   PubMedGoogle Scholar
• Luo, C., E. Burgeon, J. A. Carew, P. G. McCaffrey, T. M. Badalian, W. S. Lane, P. G. Hogan, and A. Rao. 1996. Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes. Mol. Cell. Biol. 16:3955–3966.
   PubMed Web of Science ®Google Scholar
• Luo, C., E. Burgeon, and A. Rao. 1996. Mechanisms of transactivation by nuclear factor of activated T cells-1. J. Exp. Med. 184:141–147.
   PubMed Web of Science ®Google Scholar
• Luo, C., K. T.-Y. Shaw, A. Raghavan, J. Aramburu, F. Garcia-Cozar, B. A. Perrino, P. G. Hogan, and A. Rao. 1996. Interaction of calcineurin with a domain of the transcription factor NFAT1 that controls nuclear import. Proc. Natl. Acad. Sci. USA 93:8907–8912.
   PubMed Web of Science ®Google Scholar
• Masuda, E. S., Y. Naito, H. Tokumitsu, D. Campbell, F. Saito, C. Hannum, K.-I. Arai, and N. Arai. 1995. NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus. Mol. Cell. Biol. 15:2697–2706.
   PubMed Web of Science ®Google Scholar
• Masuda, E. S., H. Tokumitsu, A. Tsuboi, J. Shlomai, P. Hung, K.-I. Arai, and N. Arai. 1993. The granulocyte-macrophage colony-stimulating factor promoter cis-acting element CLE0 mediates induction signals in T cells and is recognized by factors related to AP1 and NFAT. Mol. Cell. Biol. 13:7399–7407.
   PubMed Web of Science ®Google Scholar
• McCaffrey, P. G., A. E. Goldfeld, and A. Rao. 1994. The role of NFATp in cyclosporin A-sensitive tumor necrosis factor-a gene transcription. J. Biol. Chem. 269:30445–30450.
   PubMed Web of Science ®Google Scholar
• McCaffrey, P. G., C. Luo, T. K. Kerppola, J. Jain, T. M. Badalian, A. M. Ho, E. Burgeon, W. S. Lane, J. N. Lambert, T. Curran, G. L. Verdine, A. Rao, and P. G. Hogan. 1993. Isolation of the cyclosporin-sensitive T cell transcription factor NFATp. Science 262:750–754.
   PubMed Web of Science ®Google Scholar
• McCaffrey, P. G., B. A. Perrino, T. R. Soderling, and A. Rao. 1993. NFATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs. J. Biol. Chem. 268:3747–3752.
   PubMed Web of Science ®Google Scholar
• Northrop, J. P., S. N. Ho, L. Chen, D. J. Thomas, L. A. Timmerman, G. P. Nolan, A. Admon, and G. R. Crabtree. 1994. NF-AT components define a family of transcription factors targeted in T-cell activation. Nature 369:497–502.
   PubMed Web of Science ®Google Scholar
• Park, J., A. Takeuchi, and S. Sharma. 1996. Characterization of a new isoform of the NFAT (nuclear factor of activated T cells) gene family member NFATc. J. Biol. Chem. 271:20914–20921.
   PubMedGoogle Scholar
• Park, J., N. R. Yaseen, P. G. Hogan, A. Rao, and S. Sharma. 1995. Phosphorylation of the transcription factor NFATp inhibits its DNA binding activity in cyclosporin A-treated human B and T cells. J. Biol. Chem. 270:20653–20659.
   PubMed Web of Science ®Google Scholar
• Prieschl, E. E., V. Gouilleux-Gruart, C. Walker, N. E. Harrer, and T. Baum-ruker. 1995. A nuclear factor of activated T cell-like transcription factor in mast cells is involved in IL-5 gene regulation after IgE plus antigen stimulation. J. Immunol. 154:6112–6119.
   PubMed Web of Science ®Google Scholar
• Rao, A. 1994. NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes. Immunol. Today 15:274–281.
   PubMedGoogle Scholar
• Rice, N. R., and M. K. Ernst. 1993. In vivo control of NF-κB activation by IκBα. EMBO J. 12:4685–4695.
   PubMedGoogle Scholar
• Rice, N. R., M. L. MacKichan, and A. Israel. 1992. The precursor of NF-κB p50 has IκB-like functions. Cell 71:243–252.
   PubMedGoogle Scholar
• Rooney, J. W., T. Hoey, and L. H. Glimcher. 1995. Coordinate and cooperative roles for NFAT and AP-1 in the regulation of the murine IL-4 gene. Immunity 2:473–483.
   PubMed Web of Science ®Google Scholar
• Ruff, V. A., and K. L. Leach. 1995. Direct demonstration of NFATp dephos-phorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibody. J. Biol. Chem. 270:22602–22607.
   PubMedGoogle Scholar
• Serfling, E., A. Avots, and M. Neumann. 1995. The architecture of the interleukin-2 promoter: a reflection of T lymphocyte activation. Biochim. Biophys. Acta 1263:181–200.
   PubMed Web of Science ®Google Scholar
• Shaw, K. T.-Y., A. M. Ho, A. Raghavan, J. Kim, J. Jain, J. Park, S. Sharma, A. Rao, and P. G. Hogan. 1995. Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells. Proc. Natl. Acad. Sci. USA 92:11205–11209.
   PubMed Web of Science ®Google Scholar
• Shibasaki, F., E. R. Price, D. Milan, and F. McKeon. 1996. Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4. Nature 382:370–373.
   PubMed Web of Science ®Google Scholar
• Szabo, S. J., J. S. Gold, T. L. Murphy, and K. M. Murphy. 1993. Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc. Mol. Cell. Biol. 13:4793–4805.
   PubMed Web of Science ®Google Scholar
• Thompson, C. B., T. Lindsten, J. A. Ledbetter, S. L. Kunkel, H. A. Young, S. G. Emerson, J. M. Leiden, and C. H. June. 1989. CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proc. Natl. Acad. Sci. USA 86:1333–1337.
   PubMed Web of Science ®Google Scholar
• Venkataraman, L., D. A. Francis, Z. Wang, J. Liu, T. L. Rothstein, and R. Sen. 1994. Cyclosporin A-sensitive induction of NF-AT in murine B cells. Immunity 1:189–196.
   PubMed Web of Science ®Google Scholar
• Verweij, C. L., C. Guidos, and G. R. Crabtree. 1990. Cell type specificity and activation requirements for NFAT-1 (nuclear factor of activated T-cells) transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual nuclear factor. J. Biol. Chem. 265:15788–15795.
   PubMedGoogle Scholar
• Wang, D. Z., P. G. McCaffrey, and A. Rao. 1995. The cyclosporin-sensitive transcription factor NFATp is expressed in several classes of cells in the immune system. Ann. N. Y. Acad. Sci. 766:182–195.
   PubMed Web of Science ®Google Scholar
• Wesselborg, S., D. A. Fruman, J. K. Sagoo, B. E. Bierer, and S. J. Burakoff. 1996. Identification of a physical interaction between calcineurin and nuclear factor of activated T cells (NFATp). J. Biol. Chem. 271:1274–1277.
   PubMedGoogle Scholar
• Xanthoudakis, S., J. P. B. Viola, K. T. Y. Shaw, C. Luo, J. D. Wallace, P. T. Bozza, T. Curran, and A. Rao. 1996. An enhanced immune response in mice lacking the transcription factor NFAT1. Science 272:892–895.
   PubMed Web of Science ®Google Scholar
• Yaseen, N. R., A. L. Maizel, F. Wang, and S. Sharma. 1993. Comparative analysis of NFAT (nuclear factor of activated T cells) complex in human T and B lymphocytes. J. Biol. Chem. 268:14285–14293.
   PubMedGoogle Scholar