3
Views
46
CrossRef citations to date
0
Altmetric
Research Article

The MEF2A 3′ Untranslated Region Functions as a cis-Acting Translational Repressor

, &
Pages 2756-2763 | Received 29 Aug 1996, Accepted 12 Feb 1997, Published online: 29 Mar 2023

REFERENCES

  • Black, B. L., and D. S. Lyles. 1992. Vesicular stomatitis virus matrix protein inhibits host cell-directed transcription of target genes in vivo. J. Virol. 66:4058–4064.
  • Black, B. L., J. F. Martin, and E. N. Olson. 1995. The mouseMRF4 promoter is trans-activated directly and indirectly by muscle-specific transcription factors. J. Biol. Chem. 270:2889–2892.
  • Black, B. L., K. L. Ligon, Y. Zhang, and E. N. Olson. 1996. Cooperative transcriptional activation by the neurogenic bHLH protein MASH1 and members of the MEF2 family. J. Biol. Chem. 271:26659–26663.
  • Black, B. L., and E. N. Olson. Unpublished observations.
  • Breibart, R., C. Liang, L. B. Smoot, D. Laheru, V. Mahdavi, and B. Nadal-Ginard. 1993. A fourth human MEF-2 transcription factor, hMEF2D, is an early marker of the myogenic lineage. Development 118:1095–1106.
  • Buchberger, A., K. Ragge, and H. H. Arnold. 1994. The myogenin gene is activated during myocyte differentiation by pre-existing, not newly synthesized transcription factor MEF-2. J. Biol. Chem. 269:17289–17296.
  • Chambers, A. E., S. Kotecha, N. Towers, and T. J. Mohun. 1992. Muscle-specific expression of SRF-related genes in the early embryo of Xenopus laevis. EMBO J. 11:4981–4991.
  • Davis, S., and J. C. Watson. 1996. In vitro activation of the interferon-induced, double-stranded RNA-dependent protein kinase PKR by RNA from the 3′ untranslated regions of human a-tropomyosin. Proc. Natl. Acad. Sci. USA 93:508–513.
  • Decker, C. J., and R. Parker. 1995. Diversity of cytoplasmic functions for the 3′ untranslated region of eukaryotic transcripts. Curr. Opin. Cell Biol. 7:386–392.
  • Dodou, E., D. B. Sparrow, T. Mohun, and R. Treisman. 1996. MEF2 proteins, including MEF2A, are expressed in both muscle and non-muscle cells. Nucleic Acids Res. 23:4267–4274.
  • Edmondson, D. G., G. E. Lyons, J. F. Martin, and E. N. Olson. 1994. MEF2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis. Development 120:1251–1263.
  • Gossett, L. A., D. J. Kelvin, E. A. Sternberg, and E. N. Olson. 1989. A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes. Mol. Cell. Biol. 9:5022–5033.
  • Horton, R. M. 1993. In vitro recombination and mutagenesis of DNA, p. 251–261. In B. A. White (ed.), PCR protocols: current methods and applications, vol. 15. Humana Press, Inc., Totowa, NJ.
  • Kaushal, S., J. W. Schneider, B. Nadal-Ginard, and V. Mahdavi. 1994. Activation of the myogenic lineage by MEF2A, a factor that induces and cooperates with MyoD. Science 266:1236–1240.
  • Krieg, P. A., and D. A. Melton. 1984. Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs. Nucleic Acids Res. 12:7057–7070.
  • Kruys, V., and G. Huez. 1994. Translational control of cytokine expression by 3′ UA-rich sequences. Biochimie 76:862–866.
  • L’Ecuyer, T. J., P. C. Tompach, E. Morris, and A. B. Fulton. 1995. Trans-differentiation of chicken embryonic cells into muscle cells by the 3′ untranslated region of muscle tropomyosin. Proc. Natl. Acad. Sci. USA 92:7520–7524.
  • Leifer, D., J. Golden, and N. W. Kowall. 1994. Myocyte-specific enhancer binding factor 2C expression in human brain development. Neuroscience 63:1067–1079.
  • Leifer, D., D. Krainc, Y. T. Yu, J. C. McDermott, R. Breibart, J. Heng, R. L. Neve, B. Kosofsky, B. Nadal-Ginard, and S. A. Lipton. 1993. MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex. Proc. Natl. Acad. Sci. USA 90:1546–1550.
  • Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265–275.
  • Lyons, G. E., B. K. Micales, J. J. Schwarz, J. F. Martin, and E. N. Olson. 1995. Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturation. J. Neurosci. 15:5727–5738.
  • Mao, Z., and B. Nadal-Ginard. 1996. Functional and physical interactions between mammalian achaete-scute homolog 1 and myocyte enhancer factor 2A. J. Biol. Chem. 271:14371–14375.
  • Martin, J. F., J. M. Miano, C. M. Hustad, N. G. Copeland, N. A. Jenkins, and E. N. Olson. 1994. A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing. Mol. Cell. Biol. 14:1647–1656.
  • Martin, J. F., J. J. Schwarz, and E. N. Olson. 1993. Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors. Proc. Natl. Acad. Sci. USA 90:5282–5286.
  • McCarthy, J. E. G., and H. Kollmus. 1995. Cytoplasmic mRNA-protein interactions in eukaryotic gene expression. Trends Biochem. Sci. 20:191–197.
  • McDermott, J. C., M. C. Cardoso, Y. T. Yu, V. Andres, D. Leifer, D. Krainc, S. A. Lipton, and B. Nadal-Ginard. 1993. hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors. Mol. Cell. Biol. 13:2564–2577.
  • Molkentin, J. D., B. L. Black, J. F. Martin, and E. N. Olson. 1995. Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. Cell 83:1125–1136.
  • Olson, E. N., M. Perry, and R. A. Schulz. 1995. Regulation of muscle differentiation by the MEF2 family of MADS box transcription factors. Dev. Biol. 172:2–14.
  • Pollock, R., and R. Treisman. 1991. Human SRF-related proteins: DNA-binding properties and potential regulatory targets. Genes Dev. 5:2327–2341.
  • Rastinejad, F., and H. M. Blau. 1993. Genetic complementation reveals a novel regulatory role for 3′ untranslated regions in growth and differentiation. Cell 72:903–917.
  • Rastinejad, F., M. J. Conboy, T. A. Rando, and H. M. Blau. 1993. Tumor suppression by RNA from the 3′ untranslated region of a-tropomyosin. Cell 75:1107–1117.
  • Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Sonenberg, N. 1994. mRNA translation: influence of the 5′ and 3′ untranslated regions. Curr. Opin. Genet. Dev. 4:310–315.
  • Standart, N., and R. J. Jackson. 1994. Regulation of translation by specific protein/mRNA interactions. Biochimie 76:867–879.
  • Subramanian, S. V., and B. Nadal-Ginard. 1996. Early expression of the different isoforms of the myocyte enhancer factor-2 (MEF2) protein in myogenic as well as non-myogenic cell lineages during mouse embryogenesis. Mech. Dev. 57:103–112.
  • Suzuki, E., K. Guo, M. Kolman, Y. T. Yu, and K. Walsh. 1995. Serum induction of MEF2/RSRF expression in vascular myocytes is mediated at the level of translation. Mol. Cell. Biol. 15:3415–3423.
  • Suzuki, E., J. Lowry, G. Sonoda, J. R. Testa, and K. Walsh. 1996. Structure and chromosomal locations of the human MEF2A gene and a pseudogene MEF2AP. Cytogenet. Cell. Genet. 73:244–249.
  • Wahle, E. 1995. 3′-end cleavage and polyadenylation of mRNA precursors. Biochim. Biophys. Acta 1261:183–194.
  • Wahle, E., and W. Keller. 1992. The biochemistry of 3′-end cleavage and polyadenylation of messenger RNA precursors. Annu. Rev. Biochem. 61:419–440.
  • Yu, Y. T., R. E. Breibart, L. B. Smoot, Y. Lee, V. Mahdavi, and B. Nadal-Ginard. 1992. Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors. Genes Dev. 6:1783–1798.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.