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Research Article

A 5′ 2-Kilobase-Pair Region of the Imprinted Mouse H19 Gene Exhibits Exclusive Paternal Methylation throughout Development

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Pages 4322-4329 | Received 25 Mar 1997, Accepted 29 Apr 1997, Published online: 29 Mar 2023

REFERENCES

  • Barlow, D. P. 1995. Gametic imprinting in mammals. Science 270:1610–1613.
  • Bartolomei, M. S., A. L. Webber, M. E. Brunkow, and S. M. Tilghman. 1993. Epigenetic mechanisms underlying the imprinting of the mouse H19 gene. Genes Dev. 7:1663–1673.
  • Bartolomei, M. S., S. Zemel, and S. M. Tilghman. 1991. Parental imprinting of the mouse H19 gene. Nature 351:153–155.
  • Brandeis, M., T. Kafri, M. Ariel, J. R. Chaillet, J. McCarrey, A. Razin, and H. Cedar. 1993. The ontogeny of allele-specific methylation associated with imprinted genes in the mouse. EMBO J. 12:3669–3677.
  • Brannan, C. I., E. C. Dees, R. S. Ingram, and S. M. Tilghman. 1990. The product of the H19 gene may function as an RNA. Mol. Cell. Biol. 10:28–36.
  • DeChiara, T. M., A. Efstratiadis, and E. J. Robertson. 1990. A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature 345:78–80.
  • DeChiara, T. M., E. J. Robertson, and A. Efstratiadis. 1991. Parental imprinting of the mouse insulin-like growth factor II gene. Cell 64:849–859.
  • Efstratiadis, A. 1994. Parental imprinting of autosomal mammalian genes. Curr. Opin. Genet. Dev. 4:265–280.
  • Elson, D. A., and M. S. Bartolomei. 1997. A 5′ differentially methylated sequence and the 3′ flanking region are necessary for H19 transgene imprinting. Mol. Cell. Biol. 17:309–317.
  • Feil, R., J. Charlton, A. P. Bird, J. Walter, and W. Reik. 1994. Methylation analysis on individual chromosomes: improved protocol for bisulfite genomic sequencing. Nucleic Acids Res. 22:695–696.
  • Ferguson-Smith, A. S., H. Sasaki, B. M. Cattanach, and M. A. Surani. 1993. Parental-origin-specific epigenetic modification of the mouse H19 gene. Nature 362:751–754.
  • Frommer, M., L. E. McDonald, D. S. Millar, C. M. Collis, F. Watt, G. W. Grigg, P. L. Molloy, and C. L. Paul. 1992. A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc. Natl. Acad. Sci. USA 89:1827–1831.
  • Jinno, Y., K. Sengoku, M. Nakao, K. Tamate, T. Miyamoto, T. Matsuzaka, J. S. Sutcliffe, T. Anan, N. Takuma, K. Nishiwaki, Y. Ikeda, T. Ishimaru, M. Ishikawa, and N. Niikawa. 1996. Mouse/human sequence divergence in a region with a paternal-specific methylation imprint at the human H19 locus. Hum. Mol. Genet. 5:1155–1161.
  • Leighton, P. A., R. S. Ingram, J. Eggenschwiler, A. Efstratiadis, and S. M. Tilghman. 1995. Disruptionofimprintingcaused bydeletionoftheH19gene region in mice. Nature 375:34–39.
  • Li, E., C. Beard, and R. Jaenisch. 1993. Role for DNA methylation in genomic imprinting. Nature 366:362–365.
  • Li, E., T. H. Bestor, and R. Jaenisch. 1992. Targeted mutationofthe DNA methyltransferase gene results in embryonic lethality. Cell 69:915–926.
  • McGrath, J., and D. Solter. 1984. Completion of mouse embryogenesis requires both the maternal and paternal genomes. Cell 37:179–183.
  • Monk, M., M. Boubelik, and S. Lehnert. 1987. Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development. Development 99:371–382.
  • Neumann, B., P. Kubicka, and D. P. Barlow. 1995. Characteristics of imprinted genes. Nat. Genet. 9:12–13.
  • Poirier, F., C.-T. J. Chan, P. M. Timmons, E. J. Robertson, M. J. Evans, and P. W. J. Rigby. 1991. The murine H19 gene is activated during embryonic stem cell differentiation in vitro and at the time of implantation in the developing embryo. Development 113:1105–1114.
  • Razin, A., and H. Cedar. 1994. DNA methylation and genomic imprinting. Cell 77:473–476.
  • Rigby, P. W. J., M. Dieckmann, D. Rhodes, and P. Berg. 1977. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. J. Mol. Biol. 113:237–251.
  • Riggs, A. D., and G. P. Pfeifer. 1992. X-chromosome inactivation and cell memory. Trends Genet. 8:169–174.
  • Sanford, J. P., H. J. Clark, V. M. Chapman, and J. Rossant. 1987. Differences in DNA methylation during oogenesis and spermatogenesis and their persistence during early embryogenesis in the mouse. Genes Dev. 1:1039–1046.
  • Sasaki, H., A. C. Ferguson-Smith, A. S. W. Shum, S. C. Barton, and M. A. Surani. 1995. Temporal and spatial regulation of H19 imprinting in normal and uniparental mouse embryos. Development 121:4195–4202.
  • Shemer, R., Y. Birger, W. L. Dean, W. Reik, A. D. Riggs, and A. Razin. 1996. Dynamic methylation adjustments and counting as part of imprinting mechanisms. Proc. Natl. Acad. Sci. USA 93:6371–6376.
  • Solter, D. 1988. Differential imprinting and expression of maternal and paternal genomes. Annu. Rev. Genet. 22:127–146.
  • Southern, E. M. 1975. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98:503–517.
  • Stoger, R., P. Kubicka, C.-G. Liu, T. Kafri, A. Razin, H. Cedar, and D. P. Barlow. 1993. Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal. Cell 73:61–71.
  • Surani, M. A. H., S. C. Barton, and M. L. Norris. 1984. Development of reconstituted mouse eggs suggests imprinting of the genome during game-togenesis. Nature 308:548–550.
  • Szabo, P. E., and J. R. Mann. 1995. Allele-specific expression and total expression levels of imprinted genes during early mouse development: implications for imprinting mechanisms. Genes Dev. 9:3097–3108.
  • Tremblay, K. D., J. R. Saam, R. S. Ingram, S. M. Tilghman, and M. S. Bartolomei. 1995. A paternal-specific methylation imprint marks the alleles of the mouse H19 gene. Nat. Genet. 9:407–413.
  • Tremblay, K. D., M. S. Bartolomei, R. Schultz, and A. Doherty. Unpublished data.
  • Wahl, G. M., M. Stern, and G. R. Stark. 1979. Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. Proc. Natl. Acad. Sci. USA 76:3683–3687.
  • Yeivin, A., and A. Razin. 1993. Gene methylationpatterns and expression, p. 523–568. In J. P. Jost and H. P. Saluz (ed.), DNA methylation: molecular biology and biological significance. Birkhauser Verlag, Basel, Switzerland.
  • Zhang, Y., T. Shields, T. Crenshaw, Y. Hao, T. Moulton, and B. Tycko. 1993. Imprinting of human H19; allele-specific CpG methylation, loss of the active allele in Wilms tumor, and potential for somatic allele switching. Am. J. Hum. Genet. 53:113–124.

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