2
Views
28
CrossRef citations to date
0
Altmetric
Research Article

Mutations in the Conserved C-Terminal Sequence in Thyroid Hormone Receptor Dissociate Hormone-Dependent Activation from Interference with AP-1 Activity

, , , , , , , , , & show all
Pages 4687-4695 | Received 29 Jul 1996, Accepted 15 May 1997, Published online: 29 Mar 2023

REFERENCES

  • Angel, P., M. Imagawa, R. Chiu, B. Stein, R. J. Imbra, H. J. Rahmsdorf, C. Jonat, P. Herrlich, and M. Karin. 1987. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated transacting factor. Cell 49:729–739.
  • Angel, P., and M. Karin. 1991. The role of Jun, Fos, and the AP-1 complex in cell proliferation and transformation. Biochim. Biophys. Acta 1072:129–157.
  • Apriletti, J. W., J. D. Baxter, K. H. Lau, and B. L. West. 1995. Expression of the rat alpha 1 thyroid hormone receptor ligand binding domain in Escherichia coli and the use of a ligand-induced conformation change as a method for its purification to homogeneity. Protein Expr. Purif. 6:363–370.
  • Arias, J., A. S. Alberts, P. Brindle, F. X. Claret, T. Smeal, M. Karin, J. Feramisco, and M. Montminy. 1994. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature 370:226–229.
  • Baniahmad, A., A. C. Kohne, and R. Renkawitz. 1992. A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor. EMBO J. 11:1015–1023.
  • Baniahmad, A., X. Leng, T. P. Burris, Y. T. Tsai, M. J. Tsai, and B. W. O’Malley. 1995. The t4 activation domain of the thyroid hormone receptor is required for release of a putative corepressor(s) necessary for transcriptional silencing. Mol. Cell. Biol. 15:76–86.
  • Barettino, D., M. M. Vivanco Ruiz, and H. Stunnenberg. 1994. Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor. EMBO J. 13:3039–3049.
  • Beato, M. 1989. Gene regulation by steroid hormones. Cell 56:335–344.
  • Bugge, T. H., J. Pohl, O. Connoy, and H. G. Stunnenberg. 1992. RXRa, a promiscuous partner for retinoic acid and thyroid hormone receptors. EMBO J. 11:1409–1418.
  • Burris, T. P., Z. Nawaz, M. J. Tsai, and B. W. O’Malley. 1995. A nuclear hormone receptor-associated protein that inhibits transactivation by the thyroid hormone and retinoic acid receptors. Proc. Natl. Acad. Sci. USA 92:9525–9529.
  • Cavailles, V., S. Dauvois, F. L’Horset, G. Lopez, S. Hoare, P. J. Kushner, and M. G. Parker. 1995. Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. EMBO J. 14:3741–3751.
  • Chen, J. D., and R. M. Evans. 1995. A transcriptional corepressor that interacts with nuclear receptors. Nature 377:454–457.
  • Claret, F.-X., T. Antakly, M. Karin, and F. Saatcioglu. 1996. A shift in ligand responsiveness of thyroid hormone receptor alpha induced by heterodimerization with retinoid X receptor alpha. Mol. Cell. Biol. 16:219–227.
  • Claret, F.-X., and M. Karin. Unpublished data.
  • Damm, K., C. C. Thompson, and R. M. Evans. 1989. Protein encoded by v-erbA functions as a thyroid hormone receptor antagonist. Nature 339:593–597.
  • Danielian, P. S., R. White, J. A. Lees, and M. G. Parker. 1992. Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors. EMBO J. 11:1025–1033.
  • Deng, T., and M. Karin. 1994. C-Fos transcriptional activity stimulated by a H-ras activated protein kinase distinct from JNK and ERK. Nature 371:171–175.
  • Durand, B., M. Saunder, C. Gaudon, B. Roy, R. Losson, and P. Chambon. 1994. Activation function 2 (AF-2) of retinoic acid receptor and 9-cis-reti-noic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity. EMBO J. 13:5370–5382.
  • Evans, R. M. 1988. The steroid and thyroid hormone receptor superfamily. Science 240:889–895.
  • Forman, B. M., and H. H. Samuels. 1990. Interactions among a subfamily of nuclear hormone receptors: the regulatory zipper model. Mol. Endocrinol. 4:1293–1300.
  • Glass, C. K., S. M. Lipkin, O. V. Devary, and M. G. Rosenfeld. 1989. Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor heterodimer. Cell 59:697–708.
  • Heck, S., M. Kullmann, A. Gast, H. Ponta, H. J. Rahmsdorf, P. Herrlich, and A. C. B. Cabo. 1994. A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. EMBO J. 13:4087–4095.
  • Helmberg, A., N. Auphan, C. Caelles, and M. Karin. 1995. Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor. EMBO J. 14:452–460.
  • Hong, H., K. Kohli, A. Trivedi, D. L. Johnson, and M. R. Stallcup. 1996. GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors. Proc. Natl. Acad. Sci. USA 93:4948–4952.
  • Kamei, Y., L. Xu, T. Heinzel, J. Torchia, R. Kurokowa, P. Gloss, S.-C. Lin, R. A. Heyman, D. W. Rose, C. K. Glass, and M. G. Rosenfeld. 1996. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85:403–414.
  • Kliewer, S. A., K. Umesono, D. J. Mangelsdorf, and R. M. Evans. 1992. Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling. Nature 355:446–449.
  • Kurokawa, R., M. Soderstrom, A. Horlein, S. Halachmi, M. Brown, M. G. Rosenfeld, and C. K. Glass. 1995. Polarity-specific activities of retinoic acid receptors determined by a co-repressor. Nature 377:451–454.
  • LeDouarin, B., C. Zeckel, J. M. Garnier, Y. Lutz, L. Tora, P. Pierrat, D. Heery, H. Gronemeyer, P. Chambon, and R. Rosson. 1995. The N-terminal part of TIF-1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18. EMBO J. 14:2020–2033.
  • Lee, J. W., F. Ryan, J. C. Swaffield, S. A. Johnston, and D. D. Moore. 1995. Interaction of thyroid hormone receptor with a conserved transcriptional mediator. Nature 374:91–94.
  • Leid, M., P. Kastner, K. Lyons, H. Nakshatri, M. Saunders, T. Zocharewski, J.-Y. Chen, A. Staub, J.-M. Garnier, S. Mader, and P. Chambon. 1992. Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind to target sequences efficiently. Cell 68:377–396.
  • Leng, X., J. Blanco, S. Y. Tsai, K. Ozato, B. W. O’Malley, and M. J. Tsai. 1995. Mouse retinoid X receptor contains a separable ligand-binding and transactivation domain in its E region. Mol. Cell. Biol. 15:255–263.
  • Lopez, G., P. Kushner, and F. Saatcioglu. Unpublished data.
  • Lopez, G., and P. Kushner. Unpublished data.
  • Marks, M. S., P. L. Hallenbeck, T. Nagata, J. H. Segars, E. Appella, V. M. Nikodem, and K. Ozato. 1992. H-2RIIBP (RXRb) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes. EMBO J. 11:1419–1435.
  • Maxwell, I. H., G. S. Harrison, W. M. Wood, and F. Maxwell. 1989. A DNA cassette containing a trimerized SV40 polyadenylation signal which effi-ciently blocks spurious plasmid initiated transcription. BioTechniques 7:276–280.
  • Näär, A. M., J.-M. Boutin, S. M. Lipkin, V. C. Yu, J. M. Holloway, C. K. Glass, and M. G. Rosenfeld. 1991. The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors. Cell 65:1267–1299.
  • Onate, S. A., S. Y. Tsai, M. J. Tsai, and B. W. O’Malley. 1995. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270:1354–1358.
  • Qi, J.-S., V. Desai-Yajnik, M. E. Greene, B. M. Raaka, and H. H. Samuels. 1995. The ligand-binding domains of the thyroid hormone/retinoid receptor gene subfamily function in vivo to mediate heterodimerization, gene silencing, and transactivation. Mol. Cell. Biol. 15:1817–1825.
  • Renaud, J.-P., N. Rochel, M. Ruff, V. Vivat, P. Chambon, H. Gronemeyer, and D. Moras. 1995. Crystal structure of the RAR-g ligand binding domain bound to all-trans retinoic acid. Nature 378:681–689.
  • Saatcioglu, F., P. Bartunek, T. Deng, M. Zenke, and M. Karin. 1993. A conserved C-terminal sequence that is deleted in v-ErbA is essential for the biological activities of the T3R (the thyroid hormone receptor). Mol. Cell. Biol. 13:3675–3685.
  • Saatcioglu, F., T. Deng, and M. Karin. 1993. A novel cis element mediating ligand-independent activation by T3R: implications for hormonal regulation. Cell 75:1095–1105.
  • Saatcioglu, F., F.-X. Claret, and M. Karin. 1994. Negative transcriptional regulation by nuclear receptors. Semin. Cancer Biol. 5:347–359.
  • Saatcioglu, F. Unpublished data.
  • Sadowski, I., and M. Ptashne. 1989. A vector for expressing GAL4(1-147) fusions in mammalian cells. Nucleic Acids Res. 17:7539.
  • Sande, S., and M. L. Privalsky. 1996. Identification of TRACs (T3 receptorassociating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors. Mol. Endocrinol. 10:813–825.
  • Sap, J., A. Munoz, K. Damm, Y. Goldberg, J. Ghysdael, A. Leutz, H. Berg, and B. Vennstrom. 1986. The c-erb-A protein is a high affinity receptor for thyroid hormone. Nature 324:635–640.
  • Sap, J., A. Munoz, J. Schmitt, H. Stunnenberg, and B. Vennstrom. 1989. Repression of transcription mediated by a thyroid hormone response element by the v-erb-A oncogene product. Nature 340:242–244.
  • Tone, Y., T. N. Collingwood, M. Adams, and V. K. Chatterjee. 1994. Functional analysis of a transactivation domain in the thyroid hormone b receptor. J. Biol. Chem. 269:31157–31161.
  • Umesono, K., V. Giguere, C. K. Glass, M. G. Rosenfeld, and R. M. Evans. 1988. Retinoic acid and thyroid hormone induce gene expression through a common responsive element. Nature 336:262–265.
  • Umesono, K., K. K. Murakami, C. C. Thompson, and R. M. Evans. 1991. Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors. Cell 65:1255–1266.
  • Wagner, R. L., J. W. Apriletti, M. E. McGrath, B. West, J. D. Baxter, and R. J. Fletterick. 1995. A structural role for hormone in the thyroid hormone receptor. Nature 378:690–697.
  • Webb, P., G. N. Lopez, G. L. Greene, J. D. Baxter, and P. J. Kushner. 1992. The limits of the cellular capacity to mediate an estrogen response. Mol. Endocrinol. 6:157–167.
  • Weinberger, C., C. Thompson, E. S. Ong, R. Lebo, D. J. Grvol, and R. M. Evans. 1986. The c-erbA gene encodes a thyroid hormone receptor. Nature 324:641–646.
  • Yu, V. C., C. Delsert, B. Andersen, J. M. Holloway, O. V. Devary, A. M. Näär, S. Y. Kim, J.-M. Boutin, C. Glass, and M. G. Rosenfeld. 1991. RXRb: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell 67:1251–1266.
  • Zhang, X., B. Hoffman, P. B.-V. Tran, G. Graupner, and M. Pfahl. 1992. Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors. Nature 355:441–446.
  • Zhang, X.-K., K. N. Wills, M. Husmann, T. Hermann, and M. Pfahl. 1991. Novel pathway for thyroid hormone receptor action through interaction with jun and fos oncogene activities. Mol. Cell. Biol. 11:6016–6025.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.