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Research Article

A Large Protein Complex Containing the Yeast Sin3p and Rpd3p Transcriptional Regulators

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Pages 4852-4858 | Received 03 Dec 1996, Accepted 06 May 1997, Published online: 29 Mar 2023

REFERENCES

  • Alland, L., R. Muhle, H. Hou, Jr., J. Potes, L. Chin, N. Schreiber-Agus, and R. A. DePinho. 1997. Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression. Nature 387:49–55.
  • Ayer, D. E., Q. A. Lawrence, and R. N. Eisenman. 1995. Mad-Max transcrip-tional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. Cell 80:767–776.
  • Berben, G., J. Dumont, V. Gilliquet, P. A. Bolle, and F. Hilger. 1991. The YDp plasmids: a uniform set of vectors bearing versatile gene disruption cassettes for Saccharomyces cerevisiae. Yeast 7:475–477.
  • Bowdish, K. S., and A. P. Mitchell. 1993. Bipartite structure of an early meiotic upstream activation sequence from Saccharomyces cerevisiae. Mol. Cell. Biol. 13:2172–2181.
  • Brownell, J. E., J. Zhou, T. Ranalli, R. Kobayashi, D. G. Edmondson, S. Y. Roth, and C. D. Allis. 1996. Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation. Cell 84:843–851.
  • Cairns, B. R., Y.-J. Kim, M. H. Sayre, B. C. Laurent, and R. D. Kornberg. 1994. A multisubunit complex containing the SWI1/ADR6, SWI2/SNF2, SWI3, SNF5, and SNF6 gene products isolated from yeast. Proc. Natl. Acad. Sci. USA 91:1950–1954.
  • Collart, M. A., and K. Struhl. 1994. NOT1/CDC39, NOT2/CDC36, NOT3 and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization. Genes Dev. 8:525–537.
  • Denis, C. Personal communication.
  • De Rubertis, F., D. Kadosh, S. Henchoz, D. Pauli, G. Reuter, K. Struhl, and P. Spierer. 1996. The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast. Nature 384:589–591.
  • Draper, M. P., H.-Y. Liu, A. H. Nelsbach, S. P. Mosley, and C. L. Denis. 1994. CCR4 is a glucose-regulated transcription factor whose leucine-rich repeat binds several proteins important for placing CCR4 in its proper promoter context. Mol. Cell. Biol. 14:4522–4531.
  • Field, J., J.-I. Nikawa, D. Broek, B. MacDonald, L. Rodgers, I. A. Wilson, R. A. Lerner, and M. Wigler. 1988. Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Mol. Cell. Biol. 8:2159–2165.
  • Hanes, S. D., and R. Brent. 1989. DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9. Cell 57:1275–1283.
  • Hassig, C. A., T. C. Fleischer, A. N. Billin, S. L. Schreiber, and D. E. Ayer. 1997. Histone deacetylase activity is required for full transcriptional repression by mSin3A. Cell 89:341–347.
  • Heinzel, T., R. M. Lavinsky, T. M. Mullen, M. Soderstrom, C. D. Laherty, J. Torchia, W. M. Yang, G. Brard, S. D. Ngo, J. R. Davie, E. Seto, R. N. Eisenman, D. W. Rose, C. K. Glass, and M. G. Rosenfeld. 1997. A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. Nature 387:43–48.
  • Hudak, K., J. Lopes, and S. Henry. 1994. A pleiotropic phospholipid bio-synthetic regulatory mutation in Saccharomyces cerevisiae is allelic to sin3 (sdi1, ume4, rpd1). Genetics 136:475–183.
  • Jiang, Y. W., P. R. Dohrmann, and D. J. Stillman. 1995. Genetic and physical interactions between yeast RGR1 and SIN4 in chromatin organization and transcriptional regulation. Genetics 140:47–54.
  • Kadosh, D., and K. Struhl. 1997. Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters. Cell 89:365–371.
  • Kasten, M. M., D. E. Ayer, and D. J. Stillman. 1996. SIN3-dependent transcriptional repression by interaction with the Mad1 DNA-binding protein. Mol. Cell. Biol. 16:4215–4221.
  • Kasten, M. M., and D. J. Stillman. Identification of the Saccharomyces cerevisiae STB1-STB5 genes encoding Sin3p binding proteins. Mol. Gen. Genet., in press.
  • Klekamp, M. S., and P. A. Weil. 1982. Specific transcription of homologous class III genes in yeast-soluble cell-free extracts. J. Biol. Chem. 257:8432–8441.
  • Koleske, A. J., and R. A. Young. 1995. The RNA polymerase II holoenzyme and its implications for gene regulation. Trends Biochem. Sci. 20:113–116.
  • Laherty, C., W. M. Yang, J. M. Sun, J. R. Davie, E. Seto, and R. N. Eisenman. 1997. Histone deacetylases associated with the mSIN3 corepressor mediate Mad:Max transcriptional repression. Cell 89:349–356.
  • McKenzie, E. A., N. A. Kent, S. J. Dowell, F. Moreno, L. E. Bird, and J. Mellor. 1993. The centromere and promoter factor, 1, CPF1, of Sac-charomyces cerevisiae modulates gene activity through a family of factors including SPT21, RPD1 (SIN3), RPD3 and CCR4. Mol. Gen. Genet. 240:374–386.
  • Nagy, L., H. Y. Kao, D. Chakravarti, R. J. Lin, C. A. Hassig, D. E. Ayer, S. L. Schreiber, and R. M. Evans. 1997. Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell 89:373–380.
  • Park, H. O., J. Chant, and I. Herskowitz. 1993. BUD2 encodes a GTPase-activating protein for Bud1/Rsr1 necessary for proper bud-site selection in yeast. Nature 365:269–274.
  • Peterson, C. L., A. Dingwall, and M. P. Scott. 1994. Five SWIISNF gene products are components of a large multisubunit complex required for tran-scriptional enhancement. Proc. Natl. Acad. Sci. USA 91:2905–2908.
  • Ruden, D. M., J. Ma, K. Li, K. Wood, and M. Ptashne. 1992. Generating yeast transcriptional activators containing no yeast protein sequences. Nature 350:250–252.
  • Rundlett, S. E., A. A. Carmen, R. Kobayashi, S. Bavykin, B. M. Turner, and M. Grunstein. 1996. HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc. Natl. Acad. Sci. USA 93:14503–14508.
  • Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
  • Sherman, F. 1991. Getting started with yeast. Methods Enzymol. 194:1–21.
  • Sikorski, R. S., and P. Hieter. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122:19–27.
  • Stillman, D. J. Unpublished data.
  • Stillman, D. J., S. Dorland, and Y. Yu. 1994. Epistasis analysis of suppressor mutations that allow HO expression in the absence of the yeast SWI5 tran-scriptional activator. Genetics 136:781–788.
  • Strich, R., M. R. Slater, and R. E. Esposito. 1989. Identification of negative regulatory genes that govern the expression of early meiotic genes in yeast. Proc. Natl. Acad. Sci. USA 86:10018–10022.
  • Swanson, M. S., and F. Winston. 1992. SPT4, SPT5, and SPT6 interactions: effects on transcription and viability in Saccharomyces cerevisiae. Genetics 132:325–336.
  • Taunton, J., C. A. Hassig, and S. L. Schreiber. 1996. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272:408–411.
  • Thomas, B. J., and R. Rothstein. 1989. Elevated recombination rates in transcriptionally active DNA. Cell 56:619–630.
  • Treich, I., B. R. Cairns, T. de los Santos, E. Brewster, and M. Carlson. 1995. SNF11, anew component of the yeast SNF-SWI complex that interacts with a conserved region of SNF2. Mol. Cell. Biol. 15:4240–4248.
  • Turner, B. M., and L. P. O’Neill. 1995. Histone acetylation and chromosomes. Semin. Cell. Biol. 6:229–236.
  • Vannier, D., D. Balderes, and D. Shore. 1996. Evidence that the transcrip-tional regulators SIN3 and RPD3, and a novel gene (SDS3) with similar functions, are involved in transcriptional silencing in Saccharomyces cerevisiae. Genetics 144:1343–1353.
  • Vidal, M., and R. F. Gaber. 1991. RPD3 encodes a second factor required to achieve maximum positive and negative transcriptional states in Saccharo-myces cerevisiae. Mol. Cell. Biol. 11:6317–6327.
  • Vidal, M., R. Strich, R. E. Esposito, and R. F. Gaber. 1991. RPD1 (SIN3I UME4) is required for maximal activation and repression of diverse yeast genes. Mol. Cell. Biol. 11:6306–6316.
  • Wang, H., I. Clark, P. R. Nicholson, I. Herskowitz, and D. J. Stillman. 1990. The Saccharomyces cerevisiae SIN3 gene, a negative regulator of HO, contains four paired amphipathic helix motifs. Mol. Cell. Biol. 10:5927–5936.
  • Wang, H., and D. J. Stillman. 1990. In vitro regulation of a SIN3-dependent DNA-binding activity by stimulatory and inhibitory factors. Proc. Natl. Acad. Sci. USA 87:9761–9765.
  • Wang, H., and D. J. Stillman. 1993. Transcriptional repression in Saccharomyces cerevisiae by a SIN3-LexA fusion protein. Mol. Cell. Biol. 13:1805–1814.
  • Williams, F. E., U. Varanasi, and R. J. Trumbly. 1991. The CYC8 and TUP1 proteins involved in glucose repression in Saccharomyces cerevisiae are associated in a protein complex. Mol. Cell. Biol. 11:3307–3316.
  • Wolffe, A. P. 1996. Histone deacetylase: a regulator of transcription. Science 272:371–372.
  • Yoshimoto, H., M. Ohmae, and I. Yamashita. 1992. The Saccharomyces cerevisiae GAM2ISIN3 protein plays a role in both activation and repression of transcription. Mol. Gen. Genet. 233:327–330.
  • Zhang, Y., R. Iratni, H. Erdjument-Bromage, P. Tempst, and D. Reinberg. 1997. Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. Cell 89:357–364.

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