Opposite Effects of the Acute Promyelocytic Leukemia PML-Retinoic Acid Receptor α (RARα) and PLZF-RARα Fusion Proteins on Retinoic Acid Signalling

REFERENCES

• Bardwell, V. J., and R. Treisman. 1994. The POZ domain: a conserved protein-protein interaction motif. Genes Dev. 8:1664–1677.
   PubMed Web of Science ®Google Scholar
• Benedetti, L., F. Grignani, B. M. Scicchitano, A. M. Jetten, D. Diverio, F. Lo Coco, C. Gambacorti-Passerini, S. Adamo, A. A. Levin, P. G. Pelicci, and C. Nervi. 1996. Retinoid-induced differentiationofacute promyelocytic leukaemia involves PML/RARα-mediated increase of type II transglutaminase. Blood 87:1939–1950.
   PubMed Web of Science ®Google Scholar
• Brown, D., S. Kogan, E. Lagasse, I. Weissman, M. Alcalay, P. G. Pelicci, S. Atwater, and M. J. Bishop. 1997. A PML/RARa transgene initiates murine acute promyelocytic leukemia. Proc. Natl. Acad. Sci. USA 94:2551–2556.
   PubMed Web of Science ®Google Scholar
• Chambon, P. 1994. The retinoid signalling pathway: molecular and genetic analyses. Semin. Cell Biol. 5:115–125.
   PubMedGoogle Scholar
• Chen, D., and R. M. Evans. 1995. A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377:454–457.
   PubMed Web of Science ®Google Scholar
• Chen, Z., N. J. Brand, A. Chen, S. J. Chen, J. H. Tong, Z. Y. Wang, S. Waxman, and A. Zelent. 1993. Fusion between a novel Kruppel-like zinc finger gene and retinoic acid receptor-α locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia. EMBO J. 12:1161–1167.
   PubMed Web of Science ®Google Scholar
• Chen, Z., F. Guidez, P. Rousselot, A. Agadir, S. J. Chen, Z. Y. Wang, L. Degos, A. Zelent, S. Waxman, and C. Chomienne. 1994. PLZF/RARa fusion proteins generated from the variant t(11;17) (q23;q21) translocation in acute promyelocytic leukaemia inhibit ligand-dependent transactivation of wildtype retinoic acid receptors. Proc. Natl. Acad. Sci. USA 91:1178–1182.
   PubMed Web of Science ®Google Scholar
• Collins, S. J. 1987. The HL-60 promyelocytic leukaemia cell line: proliferation, differentiation, and cellular oncogene expression Blood 70:1233–1244.
   PubMed Web of Science ®Google Scholar
• Collins, S. J., K. Robertson, and L. Mueller. 1990. Retinoic-acid induced granulocytic differentiation of HL-60 cells is mediated directly through the retinoic acid receptor (RARa). Mol. Cell. Biol. 10:2154.
   PubMed Web of Science ®Google Scholar
• Degos, L., C. Chomienne, M. T. Daniel, R. Berger, H. Dombret, P. Fenaux, and S. Castaigne. 1990. Treatment of first relapse in acute promyelocytic leukemia with all-trans retinoic acid. Lancet 336:1440–1443.
   PubMed Web of Science ®Google Scholar
• de The, H., C. Lavau, A. Marchio, C. Chomienne, L. Degos, and A. Dejean. 1991. The PML-RARa fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RARa. Cell 66:675–684.
   PubMed Web of Science ®Google Scholar
• Dong, S., J. Zhu, A. Reid, P. Strutt, F. Guidez, H. J. Zhong, Z. Y. Wang, J. Licht, S. Waxman, C. Chomienne, Z. Chen, A. Zelent, and S. J. Chen. 1996. Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukaemia zinc finger-retinoic acid receptor-a fusion protein. Proc. Natl. Acad. Sci. USA 93:3624–3629.
   PubMed Web of Science ®Google Scholar
• Dyck, J. A., G. G. Maul, W. H. Miller, Jr., J. D. Chen, A. Kakizuka, and R. Evans. 1994. A novel macromolecular structure is a target of the promyelo-cyte-retinoic acid receptor oncoprotein. Cell 76:333–343.
   PubMed Web of Science ®Google Scholar
• Ferrucci, P. F., F. Grignani, M. Fagioli, F. Griynani, I. Nicoletti, and P. G. Pelicci. Cell death induction by the acute promyelocytic leukemia specific PML/RARa fusion protein. Submitted for publication.
   Google Scholar
• Giudez, F., W. Huang, J. T. Tong, C. Dubois, N. Balitrand, J. Michaux, P. Martiat, L. Degos, S. Waxman, and C. Chomienne. 1994. Poor response to all-trans retinoic acid in a t(11;17) PLZF/RARa AML3 patient. Leukaemia 8:312–314.
   PubMedGoogle Scholar
• Grignani, F., P. F. Ferrucci, U. Testa, G. Talamo, M. Fagioli, M. Alcalay, A. Mencarelli, F. Grignani, C. Peschle, I. Nicoletti, and P. G. Pelicci. 1993. The acute promyelocytic leukaemia specific PML/RARa fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. Cell 74:423–431.
   PubMed Web of Science ®Google Scholar
• Grignani, F., M. Fagioli, M. Alcalay, L. Longo, P. P. Pandolfi, E. Donti, A. Biondi, F. Lo Coco, F. Grignani, and P. G. Pelicci. 1994. Acute promyelocytic leukaemia: from genetics to treatment. Blood 83:10–25.
   PubMed Web of Science ®Google Scholar
• Grignani, F., U. Testa, M. Fagioli, T. Barberi, R. Masciulli, G. Mariani, C. Peschle, and P. G. Pelicci. 1995. Promyelocytic leukaemia-specific PML-retinoic acid a receptor fusion protein interferes with erythroid differentiation of human erythroleukemia K562 cells. Cancer Res. 85:440–443.
   Google Scholar
• Grignani, F., U. Testa, D. Rogaia, P. F. Ferrucci, P. Samoggia, A. Pinto, D. Aldinucci, V. Gelmetti, M. Fagioli, M. Alcalay, J. Seeler, F. Grignani, I. Nicoletti, C. Peschle, and P. G. Pelicci. 1996. Effects ondifferentiationbythe promyelocytic leukaemia PML/RARa protein depend on the fusion of the PML protein-dimerization and RARa DNA binding domains. EMBO J. 15:4949–4958.
   PubMed Web of Science ®Google Scholar
• Grisolano, J. L., R. L. Wesselschmidt, P. G. Pelicci, and T. J. Ley. 1996. Early myeloid expression of PML/RARa fusion gene associated with acute pro-myelocytic leukaemia (APL) in transgenic mice alters myeloid development. Blood 86(Suppl. 1):430a.
   Google Scholar
• Horlein, A. J., A. M. Naar, T. Heinzel, J. Torchia, B. Gloss, R. Kurokawa, A. Ryan, Y. Kamei, M. Soderstrom, C. K. Glass, and M. G. Rosenfeld. 1995. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377:397–403.
   PubMed Web of Science ®Google Scholar
• Huang, M., Y. Yu-Chen, C. Shu-Rong, J. Chai, Z. Lin, J. Long, and Z. Wang. 1988. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 72:567–571.
   PubMed Web of Science ®Google Scholar
• Jetten, A. M., J. F. Grippo, and C. Nervi. 1990. Isolation and binding characteristics of nuclear retinoic acid receptors. Methods Enzymol. 189:248–255.
   PubMedGoogle Scholar
• Kakizuka, A., W. H. Miller, Jr., K. Umesono, R. P. Warrel, Jr., S. R. Frankel, V. V. V. S. Murty, E. Dmitrovsky, and R. M. Evans. 1991. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARa with a novel putative transcription factor, PML. Cell 66:663–674.
   PubMed Web of Science ®Google Scholar
• Kamei, Y., L. Xu, T. Heizel, J. Torchia, R. Kurokawa, B. Gloss, S. C. Lin, R. A. Heyman, D. W. Rose, C. K. Glass, and M. G. Rosenfeld. 1996. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85:403–414.
   PubMed Web of Science ®Google Scholar
• Kastner, P., A. Perez, Y. Lutz, C. Rochette-Egly, M. P. Gaub, B. Durand, M. Lanotte, R. Berger, and P. Chambon. 1992. Structure, localization and tran-scriptional properties of two classes of retinoic acid receptor a fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins. EMBO J. 11:629–642.
   PubMed Web of Science ®Google Scholar
• Kastner, P., M. Leid, and P. Chambon. 1994. The role of nuclear retinoic acid receptors in the regulation of gene expression, p. 189–238. In R. Blomhoff (ed.), Vitamin A in health and disease. Marcel Dekker, New York, N.Y.
   Google Scholar
• Kliewer, S. A., K. Umesono, D. J. Mangelsdorf, and R. M. Evans. 1991. Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling. Nature 355:446–449.
   Google Scholar
• Koken, M. H. M., F. Puvio-Dutilleul, M. C. Guillemin, A. Viron, G. Cruz-Linares, N. Stuurman, L. de Jong, C. Szostecki, F. Calvo, C. Chomienne, L. Degos, E. Puvion, and H. de The. 1994. The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion. EMBO J. 13:1073–1083.
   PubMed Web of Science ®Google Scholar
• Kurokawa, R., M. Soderstrom, A. Horlein, S. Halachmi, M. Brown, M. G. Rosenfeld, and C. K. Glass. 1995. Polarity-specific activities of retinoic acid receptors determined by a co-repressor. Nature 377:451–454.
   PubMed Web of Science ®Google Scholar
• Le Dourain, B., C. Zechel, J. M. Garnier, Y. Lutz, L. Tora, B. Pierrat, D. Heery, H. Gronemeyer, P. Chambon, and R. Losson. 1995. The N-terminal part of TIF-1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18. EMBO J. 14:2020–2033.
   PubMedGoogle Scholar
• Lee, J. W., F. Ryan, J. C. Swaffield, S. A. Johnston, and D. D. Moore. 1995. Interaction of thyroid hormone receptor with a conserved transcriptional mediator. Nature 374:91–94.
   PubMed Web of Science ®Google Scholar
• Licht, J. D., C. Chomienne, A. Goy, A. Chen, A. A. Scott, D. R. Head, J. L. Michaux, Y. Wu, A. De Blasio, W. H. Miller, Jr., A. D. Zelenetz, C. L. Willman, Z. Chen, S. J. Chen, A. Zelent, E. Macintyre, A. Veil, J. Cortes, H. Kantarjian, and S. Waxman. 1995. Clinical and molecular characterisation of a rare syndrome of acute promyelocytic leukaemia associated with translocation (11;17). Blood 85:1083–1094.
   PubMed Web of Science ®Google Scholar
• Licht, J. D., R. Shaknovich, M. A. English, A. Melnick, J.-Y. Li, J. C. Reddy, S. Dong, S. J. Chen, A. Zelent, and S. Waxman. 1996. Reduced and altered DNA-binding and transcriptional properties of the PLZF-retinoic acid receptor-a chimera generated in t(11;17)-associated acute promyelocytic leukaemia. Oncogene 12:323–336.
   PubMed Web of Science ®Google Scholar
• LoCoco, F., G. Avvisati, D. Diverio, M. C. Petti, M. Alcalay, P. P. Pandolfi, A. Biondi, A. Rambaldi, M. L. Moleti, F. Mandelli, and P. G. Pelicci. 1991. Molecular evaluation of response to all-trans retinoic acid therapy in patients with acute promyelocytic leukaemia. Blood 77:1657–1659.
   PubMedGoogle Scholar
• Mangelsdorf, D. J., and R. M. Evans. 1995. The RXR heterodimers and orphan receptors. Cell 83:841–850.
   PubMed Web of Science ®Google Scholar
• Mendelsohn, C., E. Ruberte, M. LeMeur, G. Morris-Kay, and P. Chambon. 1991. Developmental analysis of the retinoic acid-inducible RARβ2 promoter in transgenic animals. Development 113:723–734.
   PubMed Web of Science ®Google Scholar
• Minucci, S., and K. Ozato. 1996. Retinoid receptors in transcriptional regulation. Curr. Opin. Genet. Dev. 6:567–574.
   PubMedGoogle Scholar
• Mitelman, F. 1988. Catalogue of chromosome aberrations incancer, 3rd ed. Alan R. Liss, Inc., New York, N.Y.
   Google Scholar
• Nagpal, S., M. Saunders, P. Kastner, B. Durand, H. Nakshatri, and P. Chambon. 1992. Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors. Cell 70:1007–1019.
   PubMed Web of Science ®Google Scholar
• Nervi, C., C. E. Poindexter, F. Grignani, P. P. Pandolfi, F. Lo Coco, G. Avvisati, P. G. Pelicci, and A. M. Jetten. 1992. Characterisation of the PML/RARα chimeric product of the acute promyelocytic leukaemia-specific t(15;17) translocation. Cancer Res. 52:3687–3692.
   PubMed Web of Science ®Google Scholar
• Olsson, I. L., and R. T. Breitman. 1982. Induction of differentiation of the human histiocytic lymphoma cell line U-937 by retinoic acid and cyclic adenosine 3′:5′-monophosphate-inducing agents. Cancer Res. 42:3924–3927.
   PubMed Web of Science ®Google Scholar
• Onate, S. A., S. Y. Tsai, M. J. Tsai, and B. W. O’Malley. 1995. Sequence and characterisation of a coactivator for the steroid hormone receptor superfamily. Science 270:1354–1357.
   PubMed Web of Science ®Google Scholar
• Pandolfi, P. P., F. Grignani, M. Alcalay, A. Mencarelli, A. Biondi, F. Lo Coco, F. Grignani, and P. G. Pelicci. 1991. Structure and originofthe acute promyelocytic leukemia myl/RARa cDNA and characterization of its retin-oid-binding and transactivation properties. Oncogene 6:1285–1292.
   PubMed Web of Science ®Google Scholar
• Pandolfi, P. P., M. Alcalay, M. Fagioli, D. Zangrilli, A. Mencarelli, D. Diverio, A. Biondi, F. Lo Coco, A. Rambaldi, F. Grignani, C. Rochette-Egly, M. P. Gaube, P. Chambon, and P. G. Pelicci. 1992. Genomic variability and alternative splicing generate multiple PML-RARα transcripts that encode aberrant PML proteins and PML/RARα isoforms in acute promyelocytic leukaemia. EMBO J. 11:1397–1407.
   PubMed Web of Science ®Google Scholar
• Perez, A., P. Kastner, S. Sethi, Y. Lutz, C. Reibel, and P. Chambon. 1993. PMLRARα homodimers: distinct DNA binding properties and hetero-dimeric interaction with RXR. EMBO J. 12:3171–3182.
   PubMed Web of Science ®Google Scholar
• Robertson, K. A., B. Emami, and S. J. Collins. 1992. Retinoic acid-resistant HL-60R cells harbour a point mutation in the retinoic acid receptor ligandbinding domain that confers dominant negative activity. Blood 80:1885–1889.
   PubMed Web of Science ®Google Scholar
• Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
   Google Scholar
• Smith, N. C., H. Nakshatri, P. Leroy, J. Rees, and P. Chambon. 1991. A reinoic acid response element is present in the mouse cellular retinol binding protein I (mCRABP I) promoter EMBO J. 10:2223–2230.
   PubMed Web of Science ®Google Scholar
• Testa, U., F. Grignani, T. Barberi, M. Fagioli, R. Masciulli, P. F. Ferrucci, D. Seripa, A. Camagna, M. Alcalay, P. G. Pelicci, and C. Peschle. 1994. PML/RARα+ U937 mutant and NB4 cell lines: retinoic acid restores the monocytic differentiation response to vitamin D3. Cancer Res. 54:4508–4515.
   PubMed Web of Science ®Google Scholar
• Von Baur, E., C. Zechel, D. Heery, M. J. S. Heine, J. M. Garnier, V. Vivat, B. Le Dourain, H. Gronemeyer, P. Chambon, and R. Losson. 1996. Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1. EMBO J. 15:110–124.
   PubMedGoogle Scholar
• Warrel, R. P., Jr., S. R. Frankel, W. H. Miller, D. A. Scheinberg, L. M. Itri, W. N. Hittelman, R. Vyas, M. Andreeff, A. Tafuri, A. Jakubowski, J. Gabrilove, M. S. Gordon, and E. Dmitrovsky. 1991. Differentiation therapy of acute promyelocytic leukaemia with tretinoin (all-trans retinoic acid). N. Engl. J. Med. 324:1358–1393.
   PubMedGoogle Scholar
• Warrel, R. P., Jr., H. de The, Z. Y. Wang, and L. Degos. 1993. Acute promyelocytic leukemia. N. Engl. J. Med. 329:177–189.
   PubMed Web of Science ®Google Scholar
• Weis, K., S. Rambaud, C. Lavau, J. Jansen, T. Carcalho, M. Carmo-Fonseca, A. Lamond, and A. Dejean. 1994. Retinoic acid regulates aberrant nuclear localisation of PML-RARα in acute promyelocytic leukaemia cells. Cell 76:345–358.
   PubMed Web of Science ®Google Scholar
• Yu, V. C., C. Delsert, B. Andersen, J. M. Holloway, O. V. Devary, A. M. Naar, S. Y. Kim, J. M. Boutin, C. K. Glass, and M. G. Rosenfeld. 1991. RXRβ:a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell 67:1251–1266.
   PubMed Web of Science ®Google Scholar
• Zhang, X. K., B. Hoffmann, P. B. V. Tran, G. Graupner, and M. Pfahl. 1992. Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors. Nature 355:441–446.
   PubMed Web of Science ®Google Scholar