Protein Kinase C-δ Is an Important Signaling Molecule in Insulin-Like Growth Factor I Receptor-Mediated Cell Transformation

REFERENCES

• Arteaga, C. L. 1992. Interference of the IGF system as a strategy to inhibit breast cancer growth. Breast Cancer Res. Treat. 22: 101–106.
   PubMed Web of Science ®Google Scholar
• Baker, J., J. P. Liu, E. J. Robertson, and A. Efstraitiadis 1993. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 79: 927–930.
   Google Scholar
• Baserga, R. 1995. The insulin-like growth factor I receptor: a key to tumor growth. Cancer Res. 55: 249–252.
   PubMed Web of Science ®Google Scholar
• Baserga, R. 1994. Oncogenes and the strategy of growth factors. Cell 79: 927–930.
   PubMed Web of Science ®Google Scholar
• Baserga, R., A. Hongo, M. Rubini, M. Prisco, and B. Valentinis 1997. The IGF-I receptor in cell growth, transformation and apoptosis. Biochim. Biophys. Acta 1332: F105–F126.
   PubMed Web of Science ®Google Scholar
• Coppola, D., A. Ferver, M. Miura, C. Sell, C. D’Ambrosio, R. Rubin, and R. Baserga 1994. A functional IGF-I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor. Mol. Cell. Biol. 14: 4588–4595.
   PubMed Web of Science ®Google Scholar
• DeAngelis, T., A. Ferber, and R. Baserga 1995. Insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the platelet-derived growth factor receptor. J. Cell. Physiol. 164: 214–221.
   PubMedGoogle Scholar
• Denning, M. F., A. Dlugosz, D. W. Threadgill, T. Magnuson, and S. H. Yuspa 1996. Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C δ. J. Biol. Chem. 271: 26079–26081.
   Google Scholar
• Denning, M. F., A. A. Dlugosz, M. K. Howett, and S. H. Yuspa 1993. Expression of an oncogenic rasHa gene in murine keratinocytes induces tyrosine phosphorylation and reduced activity of protein kinase C δ. J. Biol. Chem. 268: 26079–26081.
   PubMed Web of Science ®Google Scholar
• Ettinger, S. L., R. W. Lauener, and V. Duronio 1996. Protein kinase C δ specifically associates with phosphatidylinositol 3-kinase following cytokine stimulation. J. Biol. Chem. 271: 14514–14518.
   PubMed Web of Science ®Google Scholar
• Gschwendt, M., K. Kielbassa, W. Kittstein, and F. Marks 1994. Tyrosine phosphorylation and stimulation of protein kinase Cδ from porcine spleen by src in vitro: dependence on the activated state of protein kinase Cδ. FEBS Lett. 347: 85–89.
   PubMed Web of Science ®Google Scholar
• Hernandez-Sanchez, C., V. Blakesley, T. Kalebic, L. Helman, and D. LeRoith 1995. The role of the tyrosine kinase domain of the insulin-like growth factor-I receptor in intracellular signaling, cellular proliferation, and tomorigenesis. J. Biol. Chem. 270: 29176–29181.
   PubMed Web of Science ®Google Scholar
• Hirai, S., Y. Izumi, K. Higa, K. Kaibuchi, K. Mizuno, S. Osada, K. Suzuki, and S. Ohno 1994. Ras-dependent signal transduction is indispensable but not sufficient for the activation of AP1/Jun by PKCδ. EMBO J. 13: 2331–2340.
   PubMed Web of Science ®Google Scholar
• Jaken, S. Personal communication.
   Google Scholar
• Jiang, Y., J. L.-K. Chan, C. S. Zong, and L.-H. Wang 1996. Effect of tyrosine mutations on the kinase activity and transforming potential of an oncogenic human insulin-like growth factor I receptor. J. Biol. Chem. 271: 160–167.
   PubMedGoogle Scholar
• Jiang, Y.-X., and L.-H. Wang. Unpublished observations.
   Google Scholar
• Kalebic, T., M. Tsokos, and L. J. Helman 1994. In vivo treatment with antibody against the IGF-I receptor suppresses growth of human rhabdomyosarcoma and down regulates p34/cdc2. Cancer Res. 54: 5531–5534.
   PubMed Web of Science ®Google Scholar
• Konishi, H., M. Tanaka, Y. Takemura, H. Matsuzaki, Y. Ono, U. Kikkawa, and Y. Nishizuka 1997. Activation of protein kinase C by tyrosine phosphorylation in response to H2O2. Proc. Natl. Acad. Sci. USA 94: 11233–11237.
   PubMed Web of Science ®Google Scholar
• Lee, C.-T., S. Wu, D. Gabrilovich, H. Chen, N. Nadaf-Rahrov, I. F. Ciernik, and D. P. Carbone 1996. Antitumor effects of an adenovirus expressing antisense insulin-like growth factor I receptor on human lung cancer cell lines. Cancer Res. 56: 3038–3041.
   PubMedGoogle Scholar
• Li, S., A. Ferber, M. Miura, and R. Baserga 1994. Mitogenicity and transforming activity of the insulin-like growth factor I receptor with mutations in the tyrosine kinase domain. J. Biol. Chem. 269: 32558–32564.
   PubMed Web of Science ®Google Scholar
• Li, S., M. Resnicoff, and R. Baserga 1996. Effect of mutations at serines 1280–1283 on the mitogenic and transforming activities of the insulin-like growth factor I receptor. J. Biol. Chem. 271: 12254–12260.
   PubMed Web of Science ®Google Scholar
• Li, W., W. Li, X.-H. Chen, C. A. Kelley, M. Alimandi, J. Zhang, Q. Chen, D. P. Bottaro, and J. H. Pierce 1996. Identification of tyrosine 187 as a protein kinase C-δ phosphorylation site. J. Biol. Chem. 271: 26404–26409.
   PubMedGoogle Scholar
• Li, W., P. Michieli, M. Alimandi, M. V. Lorenzi, Y. Wu, L.-H. Wang, M. A. Heidaran, and J. H. Pierce 1996. Expression of an ATP binding mutant of PKC-δ inhibits Sis-induced transformation of NIH3T3 cells. Oncogene 13: 731–737.
   PubMedGoogle Scholar
• Li, W., H. Mischak, J.-C. Yu, L.-M. Wang, J. F. Mushinski, M. A. Heidaran, and J. H. Pierce 1994. Tyrosine phosphorylation of protein kinase C-δ in response to its activation. J. Biol. Chem. 269: 2349–2352.
   PubMed Web of Science ®Google Scholar
• Li, W., and J. H. Pierce 1996. Protein kinase C-δ, an important signaling molecule in the platelet-derived growth factor-β receptor pathway. Cur. Top. Microbiol. Immunol. 211: 55–65.
   PubMedGoogle Scholar
• Li, W., J.-C. Yu, P. Michieli, J. F. Beeler, N. Ellmore, M. A. Heidaran, and J. H. Pierce 1994. Stimulation of the platelet-derived growth factor β receptor signaling pathway activates protein kinase C-δ. Mol. Cell. Biol. 14: 6727–6735.
   PubMedGoogle Scholar
• Li, W., J.-C. Yu, D.-Y. Shin, and J. H. Pierce 1995. Characterization of a protein kinase C-δ (PKC-δ) ATP binding mutant: an inactive enzyme that competitively inhibits wild type PKC-δ enzymatic activity. J. Biol. Chem. 270: 8311–8318.
   PubMedGoogle Scholar
• Liao, L., K. Ramsey, and S. Jaken 1994. Protein kinase C isozyme in progressively transformed rat fibroblasts. Cell Growth Differ. 5: 1185–1194.
   PubMedGoogle Scholar
• Liu, D., W. J. Rutter, and L.-H. Wang 1992. Enhancement of transforming potential of human insulin-like growth factor I receptor N-terminal truncation and fusion to avian sarcoma virus. J. Virol. 66: 374–385.
   PubMedGoogle Scholar
• Liu, D., W. Rutter, and L.-H. Wang 1993. Modulatory effects of the extracellular sequence of the human insulin-like growth I receptor on its transforming and tumorigenic potential. J. Virol. 67: 9–18.
   PubMedGoogle Scholar
• Liu, J. P., J. Baker, A. S. Perkins, E. J. Robertson, and A. Efstratiadis 1993. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75: 59–72.
   PubMed Web of Science ®Google Scholar
• Lu, Z., A. Hornia, Y.-W. Jiang, Q. Zang, S. Ohno, and D. A. Foster 1997. Tumor promotion by depleting cells of protein kinase Cδ. Mol. Cell. Biol. 17: 3418–3428.
   PubMed Web of Science ®Google Scholar
• Mischak, H., J. H. Pierce, J. Goodnight, M. G. Kazanietz, P. M. Blumberg, and J. F. Mushinski 1993. Phorbol ester-induced myeloid differentiation is mediated by protein kinase C-α and -δ and not protein kinase C-βII, -γ, -ζ, and -η. J. Biol. Chem. 268: 20110–20115.
   PubMed Web of Science ®Google Scholar
• Miura, M., E. Surmacz, J.-L. Burgaud, and R. Baserga 1995. Different effects on mitogenesis and transformation of a mutation at tyrosine 1251 of the insulin-like growth factor I receptor. J. Biol. Chem. 270: 22639–22644.
   PubMedGoogle Scholar
• Morrione, A., T. DeAngelis, and R. Baserga 1995. Failure of the bovine papillomavirus to transform mouse embryo fibroblasts with a targeted disruption of the insulin-like growth factor I receptor genes. J. Virol. 69: 5300–5303.
   PubMed Web of Science ®Google Scholar
• Neuenschwander, S., J. C. T. Roberts, and D. LeRoith 1995. Growth inhibition of MCF-7 breast cancer cells by stable expression of an insulin-like growth factor 1 receptor antisense ribonucleic acid. Endocrinology 136: 4298–4303.
   PubMed Web of Science ®Google Scholar
• O’Connor, R., A. Kauffmann-Zeh, Y. Liu, S. Lehar, G. I. Evan, R. Baserga, and W. A. Blatter 1997. Identification of domains of the insulin-like growth factor I receptor that are required for protection from apoptosis. Mol. Cell. Biol. 17: 427–435.
   PubMed Web of Science ®Google Scholar
• Pass, H. I., D. J. W. Mew, M. Carbone, W. A. Matthews, J. S. Donington, R. Baserga, C. L. Walker, M. Resnicoff, and S. M. Steinberg 1996. Inhibition of hamster mesothelioma tumorigenesis by an antisense expression plasmid to the insulin-like growth factor I receptor. Cancer Res. 56: 4044–4048.
   PubMedGoogle Scholar
• Pawson, T. 1995. Protein modules and signalling networks. Nature 373: 573–580.
   PubMed Web of Science ®Google Scholar
• Poon, B., D. Dixon, L. Ellis, R. A. Roth, W. J. Rutter, and L.-H. Wang 1991. Molecular basis of the activation of the tumorigenic potential of Gag-insulin receptor chimeras. Proc. Natl. Acad. Sci. USA 88: 877–881.
   PubMedGoogle Scholar
• Prager, D., H. L. Li, S. Asa, and S. Melmed 1994. Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor-I receptor mutant. Proc. Natl. Acad. Sci. USA 91: 2181–2185.
   PubMedGoogle Scholar
• Resnicoff, M., D. Coppola, C. Sell, R. Rubin, S. Ferrone, and R. Baserga 1994. Growth inhibition of human melanoma cells in nude mice by antisense strategies to the type 1 insulin-like growth factor receptor. Cancer Res. 54: 4848–4850.
   PubMed Web of Science ®Google Scholar
• Sell, C., G. Dumenil, C. Devaud, M. Miura, D. Coppola, T. DeAngelis, R. Rubin, A. Efstratiadis, and R. Baserga 1994. Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts. Mol. Cell. Biol. 14: 3604–3612.
   PubMed Web of Science ®Google Scholar
• Sell, C., M. Rubini, R. Rubin, J. P. Liu, A. Efstratiadis, and R. Baserga 1993. Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type I IGF receptor. Proc. Natl. Acad. Sci. USA 90: 11217–11221.
   PubMed Web of Science ®Google Scholar
• Shapiro, D. N., B. G. Jones, L. H. Shapiro, P. Dias, and P. J. Houghton 1994. Antisense-mediated reduction in insulin-like growth factor I receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma. J. Clin. Invest. 94: 1235–1242.
   PubMedGoogle Scholar
• Smith, H., E.-Y. Chang, Z. Szallasi, P. M. Blumberg, and J. Rivera 1995. Tyrosine phosphorylation of protein kinase C-δ in response to the activation of the high-affinity receptor for immunoglobulin E modifies its substrate recognition. Proc. Natl. Acad. Sci. USA 92: 9112–9116.
   PubMedGoogle Scholar
• Soltoff, S. P., and A. Toker 1995. Carbachol, substance P, and phorbol ester promote the tyrosine phosphorylation of protein kinase C delta in salivary gland epithelial cells. J. Biol. Chem. 270: 13490–13495.
   PubMedGoogle Scholar
• Standaert, M., G. Bandyopadhyay, X. Zhou, L. Galloway, and R. Farese 1996. Insulin stimulates phospholipase D-dependent phosphatidylcholine hydrolysis, Rho translocation, de novo phospholipid synthesis, and diacylglycerol/protein kinase C signaling in L6 myotubes. Endocrinology 137: 3014–3020.
   PubMedGoogle Scholar
• Standaert, M., K. Musunuru, K. Yamada, D. Cooper, and R. Farese 1994. Insulin-stimulated phosphatidylcholine hydrolysis, diacylglycerol/protein kinase C signalling, and hexose transport in pertussis toxin-treated BC3H-1 myocytes. Cell Signal 6: 707–716.
   PubMedGoogle Scholar
• Trojan, J., T. R. Johnson, S. D. Rudin, J. Ilan, M. L. Tykocinski, and I. Ilan 1993. Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin-like growth factor I RNA. Science 256: 94–97.
   Google Scholar
• Ullrich, A., A. Gray, R. W. Tam, T. Yang-Feng, M. Tsubokawa, C. Collins, W. Henzel, T. Le Bon, S. Kathuria, E. Chen, S. Jacobs, U. Franke, J. Ramachandran, and Y. Fujita-Yamaguchi 1986. Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J. 5: 2503–2512.
   PubMed Web of Science ®Google Scholar
• Ullrich, A., and J. Schlessinger 1990. Signal transduction by receptors with tyrosine kinase activity. Cell 61: 203–211.
   PubMed Web of Science ®Google Scholar
• Zang, Q., Z. Lu, M. Curto, N. Barile, D. Shalloway, and D. A. Foster 1997. Interaction between v-Src and protein kinase C δ in v-Src-transformed fibroblasts. J. Biol. Chem. 272: 13275–13280.
   PubMedGoogle Scholar
• Zong, C. S., J. L. K. Chan, S. K. Yang, and L.-H. Wang 1997. Mutation of Ros differentially effecting signal transduction pathways leading to cell growth versus transformation. J. Biol. Chem. 272: 1500–1506.
   PubMedGoogle Scholar