Coactivator OBF-1 Makes Selective Contacts with Both the POU-Specific Domain and the POU Homeodomain and Acts as a Molecular Clamp on DNA

REFERENCES

• Assa-Munt, N., R. J. Mortishire-Smith, R. Aurora, W. Herr, and P. E. Wright 1993. The solution structure of the Oct-1 POU-specific domain reveals a striking similarity to the bacteriophage lambda repressor DNA-binding domain. Cell 73: 193–205.
   PubMedGoogle Scholar
• Aurora, R., and W. Herr 1992. Segments of the POU domain influence one another’s DNA-binding specificity. Mol. Cell. Biol. 12: 455–467.
   PubMedGoogle Scholar
• Babb, R., M. A. Cleary, and W. Herr 1997. OCA-B is a functional analog of VP16 but targets a separate surface of the Oct-1 POU domain. Mol. Cell. Biol. 17: 7295–7305.
   PubMedGoogle Scholar
• Cepek, K. L., D. I. Chasman, and P. A. Sharp 1996. Sequence-specific DNA binding of the B-cell-specific coactivator OCA-B. Genes Dev. 10: 2079–2088.
   PubMedGoogle Scholar
• Clark, M. E., and P. L. Mellon 1995. The POU homeodomain transcription factor Oct-1 is essential for activity of the gonadotropin-releasing hormone neuron-specific enhancer. Mol. Cell. Biol. 15: 6169–6177.
   PubMedGoogle Scholar
• Dekker, N., M. Cox, R. Boelens, C. P. Verrijzer, P. C. van der Vliet, and R. Kaptein 1993. Solution structure of the POU-specific DNA-binding domain of Oct-1. Nature 362: 852–855.
   PubMedGoogle Scholar
• Gerster, T., C. G. Balmaceda, and R. G. Roeder 1990. The cell type-specific octamer transcription factor OTF-2 has two domains required for the activation of transcription. EMBO J. 9: 1635–1643.
   PubMedGoogle Scholar
• Gstaiger, M., O. Georgiev, H. van Leeuwen, P. van der Vliet, and W. Schaffner 1996. The B cell coactivator Bob1 shows DNA sequence-dependent complex formation with Oct-1/Oct-2 factors, leading to differential promoter activation. EMBO J. 15: 2781–2790.
   PubMedGoogle Scholar
• Gstaiger, M., L. Knoepfel, O. Georgiev, W. Schaffner, and C. M. Hovens 1995. A B-cell coactivator of octamer-binding transcription factors. Nature 373: 360–362.
   PubMed Web of Science ®Google Scholar
• Hauptmann, G., and T. Gerster 1995. Pou-2—a zebra fish gene active during cleavage stages and in the early hindbrain. Mech. Dev. 51: 127–138.
   PubMedGoogle Scholar
• Herr, W., and M. A. Cleary 1995. The POU domain: versatility in transcriptional regulation by a flexible two-in-one DNA-binding domain. Genes Dev. 9: 1679–1693.
   PubMed Web of Science ®Google Scholar
• Herr, W., R. A. Sturm, R. G. Clerc, L. M. Corcoran, D. Baltimore, P. A. Sharp, H. A. Ingraham, M. G. Rosenfeld, M. Finney, G. Ruvkun, and H. R. Horvitz 1988. The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2 and Caenorhabditis elegans unc-86 gene products. Genes Dev. 2: 1513–1516.
   PubMed Web of Science ®Google Scholar
• Jacobson, E. M., P. Li, A. Leon-del-Rio, M. G. Rosenfeld, and A. K. Aggarwal 1997. Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility. Genes Dev. 11: 198–212.
   PubMed Web of Science ®Google Scholar
• Kim, U., X. F. Qin, S. Gong, S. Stevens, Y. Luo, M. Nussenzweig, and R. G. Roeder 1996. The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes. Nature 383: 542–547.
   PubMed Web of Science ®Google Scholar
• Kissinger, C. R., B. S. Liu, E. Martin-Blanco, T. B. Kornberg, and C. O. Pabo 1990. Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: a framework for understanding homeodomain-DNA interactions. Cell 63: 579–590.
   PubMed Web of Science ®Google Scholar
• Klemm, J. D., M. A. Rould, R. Aurora, W. Herr, and C. O. Pabo 1994. Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules. Cell 77: 21–32.
   PubMed Web of Science ®Google Scholar
• Kristie, T. M., and P. A. Sharp 1993. Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16). J. Biol. Chem. 268: 6525–6534.
   PubMedGoogle Scholar
• Lai, J. S., M. A. Cleary, and W. Herr 1992. A single amino acid exchange transfers VP16-induced positive control from the Oct-1 to the Oct-2 homeo-domain. Genes Dev. 6: 2058–2065.
   PubMedGoogle Scholar
• Luo, Y., H. Fujii, T. Gerster, and R. G. Roeder 1992. A novel B cell-derived coactivator potentiates the activation of immunoglobulin promoters by octamer-binding transcription factors. Cell 71: 231–241.
   PubMed Web of Science ®Google Scholar
• Luo, Y., and R. G. Roeder 1995. Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B. Mol. Cell. Biol. 15: 4115–4124.
   PubMed Web of Science ®Google Scholar
• Mittal, V., M. A. Cleary, W. Herr, and N. Hernandez 1996. The Oct-1 POU-specific domain can stimulate small nuclear RNA gene transcription by stabilizing the basal transcription complex SNAPc. Mol. Cell. Biol. 16: 1955–1965.
   PubMedGoogle Scholar
• Müller-Immergluck, M. M., W. Schaffner, and P. Matthias 1990. Transcription factor Oct-2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non-lymphoid (HeLa) cells. EMBO J. 9: 1625–1634.
   PubMedGoogle Scholar
• Murphy, S., J. B. Yoon, T. Gerster, and R. G. Roeder 1992. Oct-1 and Oct-2 potentiate functional interactions of a transcription factor with the proximal sequence element of small nuclear RNA genes. Mol. Cell. Biol. 12: 3247–3261.
   PubMed Web of Science ®Google Scholar
• Nielsen, P. J., O. Georgiev, B. Lorenz, and W. Schaffner 1996. B lymphocytes are impaired in mice lacking the transcriptional co-activator Bob1/OCA-B/OBF1. Eur. J. Immunol. 26: 3214–3218.
   PubMed Web of Science ®Google Scholar
• Otting, G., Y. Q. Qian, M. Billeter, M. Muller, M. Affolter, W. J. Gehring, and K. Wuthrich 1990. Protein-DNA contacts in the structure of a homeodomain-DNA complex determined by nuclear magnetic resonance spectroscopy in solution. EMBO J. 9: 3085–3092.
   PubMed Web of Science ®Google Scholar
• Pabo, C. O., A. K. Aggarwal, S. R. Jordan, L. J. Beamer, U. R. Obeysekare, and S. C. Harrison 1990. Conserved residues make similar contacts in two repressor-operator complexes. Science 247: 1210–1213.
   PubMedGoogle Scholar
• Pfisterer, P., S. Zwilling, J. Hess, and T. Wirth 1995. Functional characterization of the murine homolog of the B cell-specific coactivator BOB.1/OBF.1. J. Biol. Chem. 270: 29870–29880.
   PubMedGoogle Scholar
• Pomerantz, J. L., T. M. Kristie, and P. A. Sharp 1992. Recognition of the surface of a homeo domain protein. Genes Dev. 6: 2047–2057.
   PubMedGoogle Scholar
• Sauter, P., and P. Matthias 1997. The B cell-specific coactivator OBF-1 (OCA-B, Bob-1) is inducible in T cells and its expression is dispensable for IL-2 gene induction. Immunobiology 197: 293–302.
   Google Scholar
• Schubart, D. B., A. Rolink, M. H. Kosco-Vilbois, F. Botteri, and P. Matthias 1996. B-cell-specific coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation. Nature 383: 538–542.
   PubMed Web of Science ®Google Scholar
• Schubart, D. B., P. Sauter, S. Massa, E. M. Friedl, H. Schwarzenbach, and P. Matthias 1996. Gene structure and characterization of the murine homologue of the B cell-specific transcriptional coactivator OBF-1. Nucleic Acids Res. 24: 1913–1920.
   PubMedGoogle Scholar
• Schwarzenbach, H., J. W. Newell, and P. Matthias 1995. Involvement of the Ets family factor PU.1 in the activation of immunoglobulin promoters. J. Biol. Chem. 270: 898–907.
   PubMedGoogle Scholar
• Sivaraja, M., M. C. Botfield, M. Mueller, A. Jancso, and M. A. Weiss 1994. Solution structure of a POU-specific homeodomain: 3D-NMR studies of human B-cell transcription factor Oct-2. Biochemistry 33: 9845–9855.
   PubMedGoogle Scholar
• Strubin, M., J. W. Newell, and P. Matthias 1995. OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins. Cell 80: 497–506.
   PubMed Web of Science ®Google Scholar
• Tanaka, M., and W. Herr 1990. Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation. Cell 60: 375–386.
   PubMedGoogle Scholar
• Tanaka, M., J. S. Lai, and W. Herr 1992. Promoter-selective activation domains in Oct-1 and Oct-2 direct differential activation of an snRNA and mRNA promoter. Cell 68: 755–767.
   PubMed Web of Science ®Google Scholar
• Verrijzer, C. P., M. J. Alkema, W. W. van Weperen, H. C. Van Leeuwen, M. J. Strating, and P. C. van der Vliet 1992. The DNA binding specificity of the bipartite POU domain and its subdomains. EMBO J. 11: 4993–5003.
   PubMedGoogle Scholar
• Verrijzer, C. P., and P. C. Van der Vliet 1993. POU domain transcription factors. Biochim. Biophys. Acta 1173: 1–21.
   PubMedGoogle Scholar
• Verrijzer, C. P., J. A. van Oosterhout, W. W. van Weperen, and P. C. van der Vliet 1991. POU proteins bend DNA via the POU-specific domain. EMBO J. 10: 3007–3014.
   PubMedGoogle Scholar
• Wilson, A. C., K. LaMarco, M. G. Peterson, and W. Herr 1993. The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein. Cell 74: 115–125.
   PubMed Web of Science ®Google Scholar
• Wong, M. W., R. W. Henry, B. Ma, R. Kobayashi, N. Klages, P. Matthias, M. Strubin, and N. Hernandez 1998. The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1. Mol. Cell. Biol. 18: 368–377.
   PubMedGoogle Scholar
• Zwilling, S., A. Dieckmann, P. Pfisterer, P. Angel, and T. Wirth 1997. Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells. Science 277: 221–225.
   PubMed Web of Science ®Google Scholar