REFERENCES
- Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl 1987. Current protocols in molecular biology. John Wiley & Sons, New York, N.Y.
- Bull, P. C., and D. W. Cox 1994. Wilson disease and Menkes disease: new handles on heavy metal transport. Trends Genet. Sci. 10: 248–252.
- Bull, P. C., G. R. Thomas, J. M. Rommens, J. R. Forbe, and D. W. Cox 1993. The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene. Nat. Genet. 5: 327–337.
- Butler, G., and D. J. Thiele 1991. ACE2, an activator of yeast metallothionein expression which is homologous to SWI5. Mol. Cell. Biol. 11: 476–485.
- Cousens, D. J., R. Greaves, C. R. Goding, and P. O’Hare 1989. The C-terminal 79 amino acids of the herpes simplex virus regulatory protein, Vmw65, efficiently activate transcription in yeast and mammalian cells in chimeric DNA-binding proteins. EMBO J. 8: 2337–2342.
- Cress, W. D., and S. J. Triezenberg 1991. Critical structural elements of the VP16 transcriptional activation domain. Science 251: 87–90.
- Culotta, V. C., W. R. Howard, and X. F. Liu 1994. CRS5 encodes a metallothionein-like protein in Saccharomyces cerevisiae. J. Biol. Chem. 269: 25295–25302.
- Culotta, V. C., L. W. J. Klomp, J. Strain, R. L. B. Casareno, B. Krems, and J. D. Gitlin 1997. The copper chaperone for superoxide dismutase. J. Biol. Chem. 272: 23469–23472.
- Dancis, A., D. Haile, D. S. Yuan, and R. D. Klausner 1994. The Saccharomyces cerevisiae copper transport protein (Ctr1p). J. Biol. Chem. 269: 25660–25667.
- Dancis, A., D. S. Yuan, D. Haile, C. Askwith, D. Eide, C. Moehle, J. Kaplan, and R. D. Klausner 1994. Molecular characterization of a copper transport protein in S. cerevisiae: an unexpected role for copper in iron transport. Cell 76: 393–402.
- Durnam, D. M., and R. D. Palmiter 1981. Transcriptional regulation of the mouse metallothionein-I gene by heavy metals. J. Biol. Chem. 256: 5712–5716.
- Evans, C. F., D. R. Engelke, and D. J. Thiele 1990. ACE1 transcription factor produced in Escherichia coli binds multiple regions within yeast metallothionein upstream activation sequences. Mol. Cell. Biol. 10: 426–429.
- Furst, P., S. Hu, R. Hackett, and D. Hamer 1988. Copper activates metallothionein gene transcription by altering the conformation of a specific DNA binding protein. Cell 55: 705–717.
- Georgatsou, E., L. A. Mavrogiannis, G. S. Fragiadakis, and D. Alexandraki 1997. The yeast Fre1p/Fre2p cupric reductases facilitate copper uptake and are regulated by the copper-modulated Mac1p activator. J. Biol. Chem. 272: 13786–13792.
- Glerum, D. M., A. Shtanko, and A. Tzagoloff 1996. Characterization of COX17, a yeast gene involved in copper metabolism and assembly of cytochrome oxidase. J. Biol. Chem. 271: 14504–14509.
- Graden, J. A., and D. R. Winge 1997. Copper-mediated repression of the activation domain in the yeast Mac1p transcription factor. Proc. Natl. Acad. Sci. USA 94: 5550–5555.
- Gralla, E. B., D. J. Thiele, P. Silar, and J. S. Valentine 1991. ACE1, a copper-dependent transcription factor, activates expression of the yeast copper,zinc superoxide dismutase gene. Proc. Natl. Acad. Sci. USA 88: 8558–8562.
- Halliwell, B., and J. M. C. Gutteridge 1984. Oxygen toxicity, oxygen radicals, transition metals and diseases. Biochem. J. 219: 1–4.
- Hamer, D. H. 1986. Metallothioneins. Annu. Rev. Biochem. 55: 913–951.
- Hamer, D. H., D. J. Thiele, and J. E. Lemontt 1985. Function and autoregulation of yeast copperthionein. Science 228: 685–690.
- Hassett, R., and D. J. Kosman 1996. Evidence for Cu(II) reduction as a component of Cu uptake by Saccharomyces cerevisiae. J. Biol. Chem. 270: 128–134.
- Hu, S., P. Furst, and D. Hamer 1990. The DNA and Cu binding functions of ACE1 are interdigitated within a single domain. New Biol. 2: 544–555.
- Huibregtse, J. M., D. R. Engelke, and D. J. Thiele 1989. Copper-induced binding of cellular factors to yeast metallothionein upstream activation sequences. Proc. Natl. Acad. Sci. USA 86: 65–69.
- Jungmann, J., H. A. Reins, J. Lee, A. Romeo, R. Hassett, D. Kosman, and S. Jentsch 1993. MAC1, a nuclear regulatory protein related to Cu-dependent transcription factors is involved in Cu/Fe utilization and stress resistance in yeast. EMBO J. 12: 5051–5056.
- Knight, S. A. B., S. Labbé, L. F. Kwon, D. J. Kosman, and D. J. Thiele 1996. A widespread transposable element masks expression of a yeast copper transport gene. Genes Dev. 10: 1917–1929.
- Koch, K. A., M. M. O. Peña, and D. J. Thiele 1997. Copper-binding motifs in catalysis, transport, detoxification and signaling. Chem. Biol. 4: 549–560.
- Koch, K. A., and D. J. Thiele 1996. Autoactivation by a Candida glabrata copper metalloregulatory transcription factor requires critical minor groove interactions. Mol. Cell. Biol. 16: 724–734.
- Kohrer, K., and H. Domdey 1991. Preparation of high molecular weight RNA. Methods Enzymol. 194: 398–405.
- Labbé, S., Z. Zhu, and D. J. Thiele 1997. Copper-specific transcriptional repression of yeast genes encoding critical components in the copper transport pathway. J. Biol. Chem. 272: 15951–15958.
- Lin, C., and D. J. Kosman 1990. Copper uptake in wild type and copper metallothionein-deficient Saccharomyces cerevisiae. J. Biol. Chem. 265: 9194–9200.
- Lin, S.-J., R. A. Pufahl, A. Dancis, T. V. O’Halloran, and V. C. Culotta 1997. A role for the Saccharomyces cerevisiae ATX1 gene in copper trafficking and iron transport. J. Biol. Chem. 272: 9215–9220.
- Linder, M. C. 1991. Biochemistry of copper. Plenum Press, New York, N.Y.
- Münger, K., U. A. Germann, and K. Lerch 1987. Isolation and regulation of expression of the Neurospora crassa copper metallothionein gene. Birkhauser Verlag, Basel, Germany.
- Palmiter, R. Personal communication.
- Palmiter, R. D., T. B. Cole, and S. D. Findley 1996. ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration. EMBO J. 15: 1784–1791.
- Palmiter, R. D., and S. D. Findley 1995. Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc. EMBO J. 14: 639–649.
- Parker, R. Personal communication.
- Peña, M. M. O., and D. J. Thiele. Unpublished data.
- Predki, P. F., and B. Sarkar 1992. Effect of replacement of “zinc finger” zinc on estrogen receptor DNA interactions. J. Biol. Chem. 267: 5842–5846.
- Rymond, B. C., R. S. Zitomer, D. Schumperli, and M. Rosenberg 1983. The expression in yeast of the Escherichia coli galk gene on CYC1::galk fusion plasmids. Gene 25: 249–262.
- Sherman, F., G. R. Fink, and J. Hicks 1986. Methods in yeast genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
- Szczypka, M. S., and D. J. Thiele 1989. A cysteine-rich nuclear protein activates yeast metallothionein gene transcription. Mol. Cell. Biol. 9: 421–429.
- Thiele, D. J. 1988. ACE1 regulates expression of the Saccharomyces cerevisiae metallothionein gene. Mol. Cell. Biol. 8: 2745–2752.
- Thiele, D. J. 1992. Metal-regulated transcription in eukaryotes. Nucleic Acids Res. 20: 1183–1191.
- Thorvaldsen, J. L., A. K. Sewell, A. M. Tanner, J. M. Peltier, I. J. Pickering, G. N. George, and D. R. Winge 1994. Mixed Cu+ and Zn2+ coordination in the DNA-binding domain of the AMT1 transcription factor from Candida glabrata. Biochemistry 33: 9566–9577.
- Vulpe, C., B. Levinson, S. Whitney, S. Packman, and J. Gitschier 1993. Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper transporting ATPase. Nat. Genet. 3: 7–13.
- Wach, A., A. Brachat, R. Pohlmann, and P. Philippsen 1994. New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae. Yeast 10: 1793–1808.
- Welch, J., S. Fogel, C. Buchman, and M. Karin 1989. The CUP2 gene product regulates the expression of the CUP1 gene coding for yeast metallothionein. EMBO J. 8: 255–260.
- Wright, C. F., D. H. Hamer, and K. McKenney 1988. Autoregulation of the yeast copper metallothionein gene depends on metal binding. J. Biol. Chem. 263: 1570–1574.
- Yamaguchi, Y., M. E. Heiny, and J. D. Gitlin 1993. Isolation and characterization of a human liver cDNA as a candidate gene for Wilson disease. Biochem. Biophys. Res. Commun. 197: 271–277.
- Yamaguchi-Iwai, Y., M. Serpe, D. Haile, W. Yang, D. J. Kosman, R. D. Klausner, and A. Dancis 1997. Homeostatic regulation of copper uptake in yeast via direct binding of MAC1 protein to upstream regulatory sequences of FRE1 and CTR1. J. Biol. Chem. 272: 17711–17718.
- Yuan, D. S., R. Stearman, A. Dancis, T. Dunn, T. Beeler, and R. D. Klausner 1995. The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake. Proc. Natl. Acad. Sci. USA 92: 2632–2636.
- Zeng, J., R. Heuchel, W. Schaffner, and J. H. R. Kagi 1991. Thionein (apometallothionein) can modulate DNA binding and transcription by zinc finger containing factor Sp1. FEBS Lett. 279: 310–312.
- Zeng, J., B. Vallee, and J. H. R. Kagi 1991. Zinc transfer from transcription factor IIIA fingers to thionein clusters. Proc. Natl. Acad. Sci. USA 88: 9984–9988.
- Zhao, H., and D. J. Eide 1997. Zap1p, a metalloregulatory protein involved in zinc-responsive transcriptional regulation in Saccharomyces cerevisiae. Mol. Cell. Biol. 17: 5044–5052.
- Zhou, P., and D. J. Thiele 1993. Copper and gene regulation in yeast. BioFactors 4: 105–115.
- Zhou, P., and D. J. Thiele 1993. Rapid transcriptional autoregulation of a yeast metalloregulatory factor is essential for high-level copper detoxification. Genes Dev. 7: 1824–1835.
- Zhou, P., and D. J. Thiele 1991. Isolation of a metal-activated transcription factor gene from Candida glabrata by complementation in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 88: 6112–6116.
- Zhu, Z., S. Labbé, M. M. O. Peña, and D. J. Thiele 1998. Copper differentially regulates the activity and degradation of yeast Mac1 transcription factor. J. Biol. Chem. 273: 1277–1288.
- Zhu, Z., and D. J. Thiele 1996. A specialized nucleosome modulates transcription factor access to a C. glabrata metal responsive promoter. Cell 87: 459–470.