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Cell Growth and Development

Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation

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Pages 2545-2552 | Received 16 Sep 1997, Accepted 30 Jan 1998, Published online: 28 Mar 2023

REFERENCES

  • Aftab, D. T., J. Kwan, and G. S. Martin 1997. Ras-independent transformation by v-Src. Proc. Natl. Acad. Sci. USA 94: 3028–3033.
  • Akira, S., Y. Nishio, M. Inoue, X.-J. Wang, S. Wei, T. Matsusaka, K. Yoshida, T. Sudo, M. Naruto, and T. Kishimoto 1994. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 77: 63–71.
  • Bowman, T., and R. Jove. Unpublished data.
  • Bromberg, J. F., C. M. Horvath, D. Besser, W. W. Lathem, Darnell J. E., Jr. 1998. Stat3 activation is required for cellular transformation by v-src. Mol. Cell. Biol. 18: 2553–2558.
  • Bromberg, J. F., C. M. Horvath, Z. Wen, R. D. Schreiber, Darnell J. E., Jr. 1996. Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma. Proc. Natl. Acad. Sci. USA 93: 7673–7678.
  • Caldenhoven, E., T. B. van Dijk, R. Solari, J. Armstrong, J. A. M. Raaijmakers, J. W. J. Lammers, L. Koenderman, and R. P. de Groot 1996. STAT3beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription. J. Biol. Chem. 271: 13221–13227.
  • Campbell, G. S., C. L. Yu, R. Jove, and C. Carter-Su 1997. Constitutive activation of JAK1 in Src-transformed cells. J. Biol. Chem. 272: 2591–2594.
  • Cao, X., A. Tay, G. R. Guy, and Y. H. Tan 1996. Activation and association of Stat3 with Src in v-Src-transformed cell lines. Mol. Cell. Biol. 16: 1595–1603.
  • Chaturvedi, P., S. Sharma, and E. P. Reddy 1997. Abrogation of interleukin-3 dependence of myeloid cells by the v-src oncogene requires SH2 and SH3 domains which specify activation of STATs. Mol. Cell. Biol. 17: 3295–3304.
  • Chen, C. A., and H. Okayama 1988. Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA. BioTechniques 6: 632–638.
  • Cressman, D. E., L. E. Greenbaum, R. A. DeAngelis, G. Ciliberto, E. E. Furth, V. Poli, and R. Taub 1996. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 274: 1379–1383.
  • Danial, N. N., A. Pernis, and P. B. Rothman 1995. Jak-STAT signaling induced by the v-abl oncogene. Science 269: 1875–1877.
  • Darnell, J. E.Jr., I. M. Kerr, and G. R. Stark 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264: 1415–1421.
  • Fukada, T., M. Hibi, Y. Yamanaka, M. Takahashi-Tezuka, Y. Fujitani, T. Yamaguchi, K. Nakajima, and T. Hirano 1996. Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of Stat3 in anti-apoptosis. Immunity 5: 449–460.
  • Garcia, R., C.-L. Yu, A. Hudnall, R. Catlett, K. L. Nelson, T. Smithgall, D. J. Fujita, S. P. Ethier, and R. Jove 1997. Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells. Cell Growth Differ. 8: 1267–1276.
  • Gouilleux-Gruart, V., F. Gouilleux, C. Desaint, J. F. Claisse, J. C. Capiod, J. Delobel, R. Weber-Nordt, I. Dusanter-Fourt, F. Dreyfus, B. Groner, and L. Prin 1996. STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients. Blood 87: 1692–1697.
  • Horvath, C. M., Darnell, J. E.Jr. 1997. The state of the STATs: recent developments in the study of signal transduction to the nucleus. Curr. Opin. Cell Biol. 9: 233–239.
  • Johnson, P. J., P. M. Coussens, A. V. Danko, and D. Shalloway 1985. Overexpressed pp60c-src can induce focus formation without complete transformation of NIH 3T3 cells. Mol. Cell. Biol. 5: 1073–1083.
  • Jove, R., and H. Hanafusa 1987. Cell transformation by the viral src oncogene. Annu. Rev. Cell Biol. 3: 31–56.
  • Kaplan, M. H., U. Schindler, S. T. Smiley, and M. J. Grusby 1996. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4: 313–319.
  • Kaplan, M. H., Y. L. Sun, T. Hoey, and M. J. Grusby 1996. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382: 174–177.
  • Leaman, D. W., S. Leung, X. Li, and G. R. Stark 1996. Regulation of STAT-dependent pathways by growth factors and cytokines. FASEB. J. 10: 1578–1588.
  • Leaman, D. W., S. Pisharody, T. W. Flickinger, M. A. Commane, J. Schlessinger, I. M. Kerr, D. E. Levy, and G. R. Stark 1996. Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor. Mol. Cell. Biol. 16: 369–375.
  • Liu, X., G. W. Robinson, and L. Hennighausen 1996. Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation. Mol. Endocrinol. 10: 1496–1506.
  • Lund, T. C., R. Garcia, M. M. Medveczky, R. Jove, and P. G. Medveczky 1997. Activation of STAT transcription factors by herpesvirus saimiri Tip-484 requires p56lck. J. Virol. 71: 6677–6682.
  • Migone, T. S., J. X. Lin, A. Cereseto, J. C. Mulloy, J. J. O’Shea, G. Franchini, and W. J. Leonard 1995. Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-1. Science 269: 79–81.
  • Muli, A. L., H. Wakao, T. Kinoshita, T. Kitamura, and A. Miyajima 1996. Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation. EMBO J. 15: 2425–2433.
  • Nakajima, K., Y. Yamanaka, K. Nakae, H. Kojima, M. Ichiba, N. Kiuchi, T. Kitaoka, T. Fukada, M. Hibi, and T. Hirano 1996. A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells. EMBO J. 15: 3651–3658.
  • Parada, L. F., C. J. Tabin, C. Shih, and R. A. Weinberg 1982. Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature 297: 474–478.
  • Planas, A. M., M. Berruezo, C. Justicia, S. Barron, and I. Ferrer 1997. Stat3 is present in the developing and adult rat cerebellum and participates in the formation of transcription complexes binding DNA at the sis-inducible element. J. Neurochem. 68: 1345–1351.
  • Pumiglia, K., Y. H. Chow, J. Fabian, D. Morrison, S. Decker, and R. Jove 1995. Raf-1 N-terminal sequences necessary for Ras-Raf interaction and signal transduction. Mol. Cell. Biol. 15: 398–406.
  • Ruff-Jamison, S., K. Chen, and S. Cohen 1993. Induction by EGF and interferon-gamma of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei. Science 261: 1733–1736.
  • Sartor, C. I., M. L. Dziubinski, C. L. Yu, R. Jove, and S. P. Ethier 1997. Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells. Cancer Res. 57: 978–987.
  • Sasse, J., U. Hemmann, C. Schwartz, U. Schniertshauer, B. Heesel, C. Landgraf, J. Schneider-Mergener, P. C. Heinrich, and F. Horn 1997. Mutational analysis of acute-phase response factor/Stat3 activation and dimerization. Mol. Cell. Biol. 17: 4677–4686.
  • Schaefer, T. S., L. K. Sanders, and D. Nathans 1995. Cooperative transcriptional activity of Jun and Stat3beta, a short form of Stat3. Proc. Natl. Acad. Sci. USA 92: 9097–9101.
  • Schindler, C., Darnell, J. E.Jr. 1995. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu. Rev. Biochem. 64: 621–651.
  • Seidel, H. M., L. H. Milocco, P. Lamb, J. E. Darnell, R. B. Stein, and J. Rosen 1995. Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity. Proc. Natl. Acad. Sci. USA 92: 3041–3045.
  • Stephens, J. M., R. F. Morrison, and P. F. Pilch 1996. The expression and regulation of STATs during 3T3-L1 adipocyte differentiation. J. Biol. Chem. 271: 10441–10444.
  • Stofega, M. R., C. L. Yu, J. Wu, and R. Jove 1997. Activation of extracellular signal-regulated kinase (ERK) by mitogenic stimuli is repressed in v-Src-transformed cells. Cell Growth Differ. 8: 113–119.
  • Takeda, K., K. Noguchi, W. Shi, T. Tanaka, M. Matsumoto, N. Yoshida, T. Kishimoto, and S. Akira 1997. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc. Natl. Acad. Sci. USA 94: 3801–3804.
  • Vignais, M. L., H. B. Sadowski, D. Watling, N. C. Rogers, and M. Gilman 1996. Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins. Mol. Cell. Biol. 16: 1759–1769.
  • Wagner, B. J., T. E. Hayes, C. J. Hoban, and B. H. Cochran 1990. The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter. EMBO J. 9: 4477–4484.
  • Watson, C. J., and W. R. Miller 1995. Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts. Br. J. Cancer 71: 840–844.
  • Weber-Nordt, R. M., C. Egen, J. Wehinger, W. Ludwig, V. Gouilleux-Gruart, R. Mertelsmann, and J. Finke 1996. Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines. Blood 88: 809–816.
  • Wen, Z., Darnell, J. E.Jr. 1997. Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3. Nucleic Acids Res. 25: 2062–2067.
  • Wen, Z., Z. Zhong, Darnell J. E., Jr. 1995. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82: 241–250.
  • Yamauchi, K., K. Holt, and J. E. Pessin 1993. Phosphatidylinositol 3-kinase functions upstream of Ras and Raf in mediating insulin stimulation of c-fos transcription. J. Biol. Chem. 268: 14597–14600.
  • Yu, C. L., D. J. Meyer, G. S. Campbell, A. C. Larner, C. Carter-Su, J. Schwartz, and R. Jove 1995. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science 269: 81–83.
  • Zhang, D., M. Sun, D. Samols, and I. Kushner 1996. STAT3 participates in transcriptional activation of the C-reactive protein gene by interleukin-6. J. Biol. Chem. 271: 9503–9509.
  • Zhang, Q., I. Nowak, E. C. Vonderheid, A. H. Rook, M. E. Kadin, P. C. Nowell, L. M. Shaw, and M. A. Wasik 1996. Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome. Proc. Natl. Acad. Sci. USA 93: 9148–9153.
  • Zhong, Z., Z. Wen, Darnell J. E., Jr. 1994. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 264: 95–98.
  • Zong, C., R. Yan, A. August, J. E. Darnell, and H. Hanafusa 1996. Unique signal transduction of Eyk: constitutive stimulation of the JAK-STAT pathway by an oncogenic receptor-type tyrosine kinase. EMBO J. 15: 4515–4525.

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