Fission Yeast rad12⁺Regulates Cell Cycle Checkpoint Control and Is Homologous to the Bloom’s Syndrome Disease Gene

REFERENCES

• al-Khodairy, F., and A. M. Carr 1992. DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe. EMBO J. 11: 1343–1350.
   PubMed Web of Science ®Google Scholar
• al-Khodairy, F., E. Fotou, K. S. Sheldrick, D. J. Griffiths, A. R. Lehmann, and A. M. Carr 1994. Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast. Mol. Biol. Cell 5: 147–160.
   PubMed Web of Science ®Google Scholar
• Beach, D., L. Rodgers, and J. Gould 1985. ran1+ controls the transition from mitotic division to meiosis in fission yeast. Curr. Genet. 10: 297–311.
   PubMedGoogle Scholar
• Bentley, N. J., D. A. Holtzman, G. Flaggs, K. S. Keegan, A. DeMaggio, J. C. Ford, M. Hoekstra, and A. M. Carr 1996. The Schizosaccharomyces pombe rad3 checkpoint gene. EMBO J. 15: 6641–6651.
   PubMed Web of Science ®Google Scholar
• Cimprich, K. A., R. B. Shin, C. T. Keith, and S. L. Schreiber 1996. cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. Proc. Natl. Acad. Sci. USA 93: 2850–2855.
   PubMed Web of Science ®Google Scholar
• Darlington, G. J., R. Dutkowski, and W. T. Brown 1981. Sister chromatid exchange frequencies in progeria and Werner syndrome patients. Am. J. Hum. Genet. 33: 762–766.
   PubMedGoogle Scholar
• Davey, S., M. L. Nass, J. V. Ferrer, K. Sidik, A. Eisenberger, D. L. Mitchell, and G. A. Freyer 1997. The fission yeast UVDR DNA repair pathway is inducible. Nucleic Acids Res. 25: 1002–1008.
   PubMedGoogle Scholar
• Ellis, N. A., J. Groden, T. Z. Ye, J. Straughen, D. J. Lennon, S. Ciocci, M. Proytcheva, and J. German 1995. The Bloom’s syndrome gene product is homologous to RecQ helicases. Cell 83: 655–666.
   PubMed Web of Science ®Google Scholar
• Enoch, T., A. M. Carr, and P. Nurse 1992. Fission yeast genes involved in coupling mitosis to completion of DNA replication. Genes Dev. 6: 2035–2046.
   PubMed Web of Science ®Google Scholar
• Freyer, G. A., S. Davey, J. V. Ferrer, A. M. Martin, D. Beach, and P. W. Doetsch 1995. An alternative eukaryotic DNA excision repair pathway. Mol. Cell. Biol. 15: 4572–4577.
   PubMed Web of Science ®Google Scholar
• Gangloff, S., J. P. McDonald, C. Bendixen, L. Arthur, and R. Rothstein 1994. The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase. Mol. Cell. Biol. 14: 8391–8398.
   PubMed Web of Science ®Google Scholar
• German, J. 1995. Bloom’s syndrome. Dermatol. Clin. 13: 7–18.
   PubMed Web of Science ®Google Scholar
• Gorbalenya, A. E., E. V. Koonin, A. P. Donchenko, and V. M. Blinov 1989. Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes. Nucleic Acids Res. 17: 4713–4730.
   PubMed Web of Science ®Google Scholar
• Hartwell, L. 1992. Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells. Cell 71: 543–546.
   PubMed Web of Science ®Google Scholar
• Hawthorne, D. C., and U. Leupold 1974. Suppressor mutations in yeast. Curr. Top. Microbiol. Immunol. 64: 1–47.
   PubMedGoogle Scholar
• Hoheisel, J. D., E. Maier, R. Mott, L. McCarthy, A. V. Grigoriev, L. C. Schalkwyk, D. Nizetic, F. Francis, and H. Lehrach 1993. High resolution cosmid and P1 maps spanning the 14 Mb genome of the fission yeast S. pombe. Cell 73: 109–120.
   PubMed Web of Science ®Google Scholar
• Leupold, U. 1970. Genetical methods for Schizosaccharomyces pombe. Methods Cell Physiol. 4: 169–177.
   Google Scholar
• Lieberman, H. B., K. M. Hopkins, M. Laverty, and H. M. Chu 1992. Molecular cloning and analysis of Schizosaccharomyces pombe rad9, a gene involved in DNA repair and mutagenesis. Mol. Gen. Genet. 232: 367–376.
   PubMedGoogle Scholar
• Lieberman, H. B., K. M. Hopkins, M. Nass, D. Demetrick, and S. Davey 1996. A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene. Proc. Natl. Acad. Sci. USA 93: 13890–13895.
   PubMedGoogle Scholar
• Lu, J., J. R. Mullen, S. J. Brill, S. Kleff, A. M. Romeo, and R. Sternglanz 1996. Human homologues of yeast helicase. Nature 383: 678–679.
   PubMed Web of Science ®Google Scholar
• Lydall, D., and T. Weinert 1995. Yeast checkpoint genes in DNA damage processing: implications for repair and arrest. Science 270: 1488–1491.
   PubMed Web of Science ®Google Scholar
• Mizukami, T., W. I. Chang, I. Garkavtsev, N. Kaplan, D. Lombardi, T. Matsumoto, O. Niwa, A. Kounosu, M. Yanagida, T. G. Marr, and D. Beach 1993. A 13 kb resolution cosmid map of the 14 Mb fission yeast genome by nonrandom sequence-tagged site mapping. Cell 73: 121–132.
   PubMed Web of Science ®Google Scholar
• Murray, J. M., H. D. Lindsay, C. A. Munday, and A. M. Carr 1997. Role of Schizosaccharomyces pombe RecQ homolog, recombination, and checkpoint genes in UV damage tolerance. Mol. Cell. Biol. 17: 6868–6875.
   PubMed Web of Science ®Google Scholar
• Nasim, A., and B. P. Smith 1975. Genetic control of radiation sensitivity in Schizosaccharomyces pombe. Genetics 79: 573–582.
   PubMed Web of Science ®Google Scholar
• Rosen, K. M., E. D. Lamperti, and L. Villa-Komaroff 1990. Optimizing the Northern blot procedure. BioTechniques 8: 398–402.
   PubMed Web of Science ®Google Scholar
• Rothstein, R., and S. Gangloff 1996. Hyper-recombination and Bloom’s syndrome: microbes again provide clues about cancer. Genome Res. 5: 258–262.
   Google Scholar
• Rowley, R., S. Subramani, and P. G. Young 1992. Checkpoint controls in Schizosaccharomyces pombe: rad1. EMBO J. 11: 1335–1342.
   PubMed Web of Science ®Google Scholar
• Salk, D., E. Bryant, K. Au, H. Hoehn, and G. M. Martin 1981. Systematic growth studies, cocultivation, and cell hybridization studies of Werner syndrome cultured skin fibroblasts. Hum. Genet. 58: 310–316.
   PubMedGoogle Scholar
• Sinclair, D. A., and L. Guarente 1997. Extrachromosomal rDNA circles—a cause of aging in yeast. Cell 91: 1033–1042.
   PubMed Web of Science ®Google Scholar
• Sinclair, D. A., K. Mills, and L. Guarente 1997. Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. Science 277: 1313–1316.
   PubMed Web of Science ®Google Scholar
• Smith, M. L., Fornace, A. J.Jr. 1995. Genomic instability and the role of p53 mutations in cancer cells. Curr. Opin. Oncol. 7: 69–75.
   PubMedGoogle Scholar
• Stewart, E., C. R. Chapman, F. al-Khodairy, A. M. Carr, and T. Enoch 1997. rqh1+, a fission yeast gene related to the Bloom’s and Werner’s syndrome genes, is required for reversible S phase arrest. EMBO J. 16: 2682–2692.
   PubMed Web of Science ®Google Scholar
• Tlsty, T. D., A. Briot, A. Gualberto, I. Hall, S. Hess, M. Hixon, D. Kuppuswamy, S. Romanov, M. Sage, and A. White 1995. Genomic instability and cancer. Mutat. Res. 337: 1–7.
   PubMed Web of Science ®Google Scholar
• Umezu, K., K. Nakayama, and H. Nakayama 1990. Escherichia coli RecQ protein is a DNA helicase. Proc. Natl. Acad. Sci. USA 87: 5363–5367.
   PubMedGoogle Scholar
• Watt, P. M., I. D. Hickson, R. H. Borts, and E. J. Louis 1996. SGS1, a homologue of the Bloom’s and Werner’s syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae. Genetics 144: 935–945.
   PubMed Web of Science ®Google Scholar
• Watt, P. M., E. J. Louis, R. H. Borts, and I. D. Hickson 1995. Sgs1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation. Cell 81: 253–260.
   PubMed Web of Science ®Google Scholar
• Yu, C. E., J. Oshima, Y. H. Fu, E. M. Wijsman, F. Hisama, R. Alisch, S. Matthews, J. Nakura, T. Miki, S. Ouais, G. M. Martin, J. Mulligan, and G. D. Schellenberg 1996. Positional cloning of the Werner’s syndrome gene. Science 272: 258–262.
   PubMed Web of Science ®Google Scholar