Tumor Necrosis Factor Alpha Gene Regulation: Enhancement of C/EBPβ-Induced Activation by c-Jun

REFERENCES

• Akira, S., H. Isshiki, T. Sugita, O. Tanabe, S. Kinoshita, Y. Nishio, T. Nakajima, T. Hirano, and T. Kishimoto 1990. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBPβ family. EMBO J. 9: 1897–1906.
   PubMed Web of Science ®Google Scholar
• Alani, R., P. Brown, B. Binétruy, H. Dosaka, R. Rosenberg, P. Angel, M. Karin, and M. J. Birrer 1991. The transactivating domain of the c-Jun proto-oncoprotein is required for cotransformation of rat embryo cells. Mol. Cell. Biol. 11: 6286–6295.
   PubMedGoogle Scholar
• Angel, P., M. Imagawa, R. Chiu, B. Stein, R. J. Imbra, H. J. Rahmsdorf, C. Jonat, P. Herrlich, and M. Karin 1987. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 49: 729–739.
   PubMed Web of Science ®Google Scholar
• Arias, J., A. S. Alperts, P. Brindle, F. X. Claret, T. Smeal, M. Karin, J. Feramisco, and M. Montminy 1994. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature 370: 226–229.
   PubMed Web of Science ®Google Scholar
• Bannister, A. J., T. Oehler, D. Whilhelm, P. Angel, and T. Kouzarides 1995. Stimulation of c-Jun activity by CBP:c-Jun residues Ser 63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro. Oncogene 11: 2509–2514.
   PubMed Web of Science ®Google Scholar
• Brown, P. H., R. Alani, L. H. Preis, E. Szabo, and M. J. Birrer 1992. Suppression of oncogene-induced transformation by a deletion mutant of c-jun. Oncogene 8: 877–886.
   Google Scholar
• Burk, O., S. Mink, M. Ringwald, and K. H. Klempnauer 1993. Synergistic activation of the chicken mim-1 gene by v-myb and C/EBPβ transcription factors. EMBO J. 12: 2027–2038.
   PubMed Web of Science ®Google Scholar
• Callahan, M., R. M. Lovis, C. Rammohan, Y. Lu, and R. M. Pope 1996. Autocrine regulation of collagenase gene expression by TNF-α in U937 cells. J. Leukocyte Biol. 59: 125–132.
   PubMedGoogle Scholar
• Cao, Z., R. M. Umek, and S. L. McNight 1991. Regulated expression of three C/EBPβ isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 5: 1538–1552.
   PubMed Web of Science ®Google Scholar
• Chrivia, J. C., R. P. S. Kwok, N. Lamb, M. Hagiwara, M. R. Montminy, and R. H. Goodman 1993. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365: 855–859.
   PubMed Web of Science ®Google Scholar
• Doyle, G. A. R., R. A. Pierce, and W. C. Parks 1997. Transcriptional induction of collagenase-1 in differentiated monocyte-like (U937) cells is regulated by AP-1 and an upstream C/EBP-β site. J. Biol. Chem. 272: 11840–11649.
   PubMedGoogle Scholar
• Eckner, R., M. E. Ewen, D. Newsome, M. Gerdes, J. A. DeCaprio, J. B. Lawrence, and D. M. Livingston 1994. Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev. 8: 869–884.
   PubMed Web of Science ®Google Scholar
• Economou, J. S., K. Rhoades, R. Essner, W. H. McBride, J. C. Gassonand, and D. L. Morton 1989. Genetic analysis of the human tumor necrosis factor α/cachectin promoter region in a macrophage cell line. J. Exp. Med. 170: 321–326.
   PubMed Web of Science ®Google Scholar
• Elliot, M. J., R. N. Maini, M. Feldman, J. R. Kalden, C. Antoni, J. S. Smolen, B. Leeb, F. C. Breedveld, J. D. Macfarlane, H. Bijl, and J. N. Woody 1994. Randomized double-blind comparison of chimeric monoclonal antibody to tumor necrosis factor a (cA2) versus placebo in rheumatoid arthritis. Lancet 344: 1105–1110.
   PubMed Web of Science ®Google Scholar
• Goldfeld, A. E., P. G. McCaffrey, J. L. Strominger, and A. Rao 1993. Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor α gene promoter. J. Exp. Med. 178: 1365–1379.
   PubMed Web of Science ®Google Scholar
• Gonzalez-Amaro, R., C. Garcia-Monzon, L. Garcia-Buey, R. Moreno-Otero, J. L. Alonso, E. Yague, J. P. Pivel, M. Lopez-Cabrera, E. Fernandez-Ruiz, and F. Sanchez-Madrid 1994. Induction of tumor necrosis factor alpha production by human hepatocytes in chronic viral hepatitis. J. Exp. Med. 179: 841–848.
   PubMed Web of Science ®Google Scholar
• Grove, M., and M. Plumb 1993. C/EBPβ, NF-κB, and c-Ets family members and transcriptional regulation of the cell-specific and inducible macrophage inflammatory protein 1α immediate-early gene. Mol. Cell. Biol. 13: 5276–5289.
   PubMed Web of Science ®Google Scholar
• Grant, S., A. J. Freemerman, M. J. Birrer, H. A. Martin, A. J. Turner, E. Szabo, J. Chelliah, and W. D. Jarvis 1996. Effect of 1-β-d-arabinofuranosylcytosine on apoptosis and differentiation in human monocytic leukemia cells (U937) expressing c-Jun dominant-negative mutant protein (TAM67). Cell Growth Differ. 7: 603–610.
   PubMedGoogle Scholar
• Hotamisligil, G. S., P. Arner, J. F. Caro, R. L. Atkinson, and B. M. Spiegelman 1995. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J. Clin. Invest. 95: 2409–2415.
   PubMed Web of Science ®Google Scholar
• Hotamisligil, G. S., N. S. Shargill, and B. M. Spiegelman 1993. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259: 87–91.
   PubMed Web of Science ®Google Scholar
• Hsu, W., T. K. Kerpolla, P.-L. Chen, T. Curran, and S. Chen-Kiang 1994. Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region. Mol. Cell. Biol. 14: 268–276.
   PubMed Web of Science ®Google Scholar
• Kern, P. A., M. Saghizadeh, J. M. Ong, R. J. Bosch, and R. Deem 1995. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J. Clin. Invest. 95: 2111–2119.
   PubMed Web of Science ®Google Scholar
• Klampfer, L., T. H. Lee, W. Hsu, J. Vilcek, and S. Chen-Kiang 1994. NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor necrosis factor alpha and interleukin-1. Mol. Cell. Biol. 14: 6561–6569.
   PubMedGoogle Scholar
• Kowenz-Leutz, E., G. Twamley, S. Ansieau, and A. Leutz 1994. Novel mechanism of C/EBPβ (NF-M) transcriptional control: activation through derepression. Genes Dev. 8: 2781–2791.
   PubMed Web of Science ®Google Scholar
• Kramer, B., K. Wiegmann, and M. Kronke 1995. Regulation of the human TNFα promoter by the transcription factor Ets. J. Biol. Chem. 270: 6577–6583.
   PubMed Web of Science ®Google Scholar
• LeClair, K. P., M. A. Blanar, and P. A. Sharp 1992. The p50 subunit of NF-κB associates with the NF-IL6 transcription factor. Proc. Natl. Acad. Sci. USA 89: 8145–8149.
   PubMedGoogle Scholar
• MacNaul, K. L., N. I. Hutchinson, J. N. Parson, E. K. Bayne, and M. J. Tocci 1990. Analysis of IL-1 and TNFα-gene expression in human rheumatoid synoviocytes and normal monocytes by in situ hybridization. J. Immunol. 145: 4154–4166.
   PubMed Web of Science ®Google Scholar
• Metcalf, J. P. 1996. Adenovirus E1A 13S gene product upregulates tumor necrosis factor gene. Am. J. Physiol. 270: L535–L540.
   PubMedGoogle Scholar
• Mink, S., B. Haenig, and K. H. Klempnauer 1997. Interaction and functional collaboration of p300 and C/EBPβ. Mol. Cell. Biol. 17: 6609–6617.
   PubMed Web of Science ®Google Scholar
• Miyazaki, Y., K. Araki, C. Vesin, I. Garcia, Y. Kapanci, J. A. Whitsett, P. F. Piguet, and P. Vassalli 1995. Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis. J. Clin. Invest. 96: 250–259.
   PubMed Web of Science ®Google Scholar
• Nakajima, T., S. Kinoshita, T. Sasagawa, K. Sasaki, M. Naruto, T. Kishimoto, and S. Akira 1993. Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc. Natl. Acad. Sci. USA 90: 2207–2211.
   PubMed Web of Science ®Google Scholar
• Natsuka, S., S. Akira, Y. Nishio, S. Hashimoto, T. Sugita, H. Isshiki, and T. Kishimoto 1991. Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6. Blood 79: 460–466.
   Google Scholar
• Ness, S. A., E. Kowenz-Leutz, T. Casini, T. Graf, and A. Leutz 1993. Myb and MF-M: combinatorial activators of myeloid genes in heterologous cell types. Genes Dev. 7: 749–759.
   PubMedGoogle Scholar
• Newell, C. L., A. B. Deisseroth, and G. Lopez-Berestein 1994. Interaction of nuclear proteins with an AP-1/CRE-like promoter sequence in the human TNFα gene. J. Leukocyte Biol. 56: 27–35.
   PubMed Web of Science ®Google Scholar
• Nguyen, D. T., M. K. Eskandari, L. E. DeFore, C. L. Raiford, R. M. Strieter, S. L. Kunkel, and D. G. Remick 1990. Cyclosporin A modulation of tumor necrosis factor gene expression and effects in vitro and in vivo. J. Immunol. 144: 3822–3828.
   PubMedGoogle Scholar
• Nishio, Y., H. Isshiki, T. Kishimoto, and S. Akira 1993. A nuclear factor for interleukin-6 expression (NF-IL6) and the glucocorticoid receptor synergistically activate transcription of the rat 1-acid glycoprotein gene via direct protein-protein interaction. Mol. Cell. Biol. 13: 1854–1862.
   PubMed Web of Science ®Google Scholar
• Petrak, D., S. A. Memon, M. J. Birrer, J. D. Ashwell, and C. M. Zacharchuk 1994. Dominant negative mutant of c-jun inhibits NF-AT transcriptional activity and prevents IL-2 gene transcription. J. Immunol. 153: 2046–2051.
   PubMedGoogle Scholar
• Plevy, S. E., J. H. Gemberling, S. Hsu, A. J. Dorner, and S. T. Smale 1997. Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins. Mol. Cell. Biol. 17: 4572–4588.
   PubMed Web of Science ®Google Scholar
• Pope, R. M., A. Leutz, and S. Ness 1994. C/EBPβ regulation of the tumor necrosis factor alpha gene. J. Clin. Invest. 94: 1449–1455.
   PubMed Web of Science ®Google Scholar
• Rhoads, K. L., S. H. Golub, and J. S. Economou 1992. The regulation of the human tumor necrosis factor a promoter region in macrophage, T cell and B cell lines. J. Biol. Chem. 267: 22102–22107.
   PubMedGoogle Scholar
• Saisanit, S., and X.-H. Sun 1997. Regulation of the pro-B-cell-specific enhancer of the Idl gene involves the C/EBP family of proteins. Mol. Cell. Biol. 17: 844–850.
   PubMedGoogle Scholar
• Sears, R. C., and L. Sealy 1994. Multiple forms of C/EBPβ bind the EFII enhancer sequence in the Rous sarcoma virus long terminal repeat. Mol. Cell. Biol. 14: 4855–4871.
   PubMed Web of Science ®Google Scholar
• Stein, B., P. C. Cogswell, Baldwin A. S., Jr. 1993. Functional and physical associations between NF-κB and C/EBPβ family members: a Rel domain-bZip interaction. Mol. Cell. Biol. 13: 3964–3974.
   PubMed Web of Science ®Google Scholar
• Sterneck, E., M. Christine, S. Katz, and A. Leutz 1992. Autocrine growth induced by kinase type oncogenes in myeloid cells requires AP-1 and NF-M, a myeloid specific, C/EBPβ-like factor. EMBO J. 11: 115–126.
   PubMedGoogle Scholar
• Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and Y. Ben-Neriah 1994. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77: 727–736.
   PubMed Web of Science ®Google Scholar
• Szabo, E., L. H. Preis, and M. J. Birrer 1994. Constitutive cJun expression induces partial macrophage differentiation in U-937 cells. Cell Growth Differ. 5: 439–446.
   PubMedGoogle Scholar
• Trautwein, C., C. Caelles, P. van der Geer, T. Hunter, M. Karin, and M. Chojkier 1993. Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain. Nature 364: 544–547.
   PubMedGoogle Scholar
• Trautwein, C., P. van der Geer, M. Karin, T. Hunter, and M. Chojkier 1994. Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA recognition elements. J. Clin. Invest. 93: 2554–2561.
   PubMedGoogle Scholar
• Tsai, E. Y., J. Jain, P. A. Pesavento, A. Rao, and A. F. Goldfeld 1996. Tumor necrosis factor alpha gene regulation in activated T cells involves ATF-2/Jun and NFATp. Mol. Cell. Biol. 16: 459–467.
   PubMedGoogle Scholar
• Vassalli, P. 1992. The pathophysiology of tumor necrosis factors. Annu. Rev. Immunol. 10: 411–452.
   PubMed Web of Science ®Google Scholar
• Wedel, A., G. Sulski, and H. W. L. Ziegler-Heitbrock 1996. CCAAT/enhanced binding protein is involved in the expression of the tumor necrosis factor gene in human monocytes. Cytokine 8: 335–341.
   PubMedGoogle Scholar
• Wegner, M., Z. Cao, and M. G. Rosenfeld 1992. Calcium-regulated phosphorylation within the leucine zipper of C/EBPβ. Science 256: 370–373.
   PubMed Web of Science ®Google Scholar
• Williams, S. C., M. Baer, A. J. Dillner, and P. F. Johnson 1995. CRP2 (C/EBPβ) contains a bipartite regulatory domain that controls transcriptional activation, DNA binding and cell specificity. EMBO J. 14: 3170–3183.
   PubMed Web of Science ®Google Scholar
• Yang, X. D., R. Tisch, S. M. Singer, Z. A. Cao, R. S. Liblau, R. D. Schreiber, and H. O. McDevitt 1994. Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process. J. Exp. Med. 180: 995–1004.
   PubMed Web of Science ®Google Scholar
• Zhang, Y., T. C. Lee, B. Guillemin, M. C. Yu, and W. N. Rom 1993. Enhanced IL-1 beta and tumor necrosis factor-alpha release and messenger RNA expression in macrophages from idiopathic pulmonary fibrosis or after asbestos exposure. J. Immunol. 150: 4188–4196.
   PubMed Web of Science ®Google Scholar