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Transcriptional Regulation

Inhibition of Cyclin D1 Kinase Activity Is Associated with E2F-Mediated Inhibition of Cyclin D1 Promoter Activity through E2F and Sp1

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Pages 3212-3222 | Received 17 Sep 1997, Accepted 06 Mar 1998, Published online: 28 Mar 2023

REFERENCES

  • Albanese, C., J. Johnson, G. Watanabe, N. Eklund, D. Vu, A. Arnold, and R. G. Pestell 1995. Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions. J. Biol. Chem. 270: 23589–23597.
  • Asano, M., J. R. Nevins, and R. P. Wharton 1996. Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs. Genes Dev. 10: 1422–1432.
  • Bandara, L. R., V. M. Buck, M. Zamanian, L. H. Johnston, and N. B. La Thangue 1993. Functional synergy between DP-1 and E2F-1 in the cell cycle-regulatory transcription factor DRTF1/E2F. EMBO J. 12: 4317–4324.
  • Bartkova, J., J. Lukas, H. Muller, D. Lutzhoft, M. Strauss, and J. Bartek 1994. Cyclin D1 protein expression and function in human breast cancer. Int. J. Cancer 57: 351–361.
  • Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248–254.
  • Buchou, T., O. Kranenburg, H. van Dam, D. Roelen, A. Zantema, F. L. Hall, and A. J. van der Eb 1993. Increased cyclin A and decreased cyclin D levels in adenovirus 5 E1A-transformed rodent cell lines. Oncogene 8: 1765–1773.
  • Caceres, A., L. I. Binder, M. R. Payne, P. Bender, L. Rebhun, and O. Steward 1983. Differential subcellular localization of tubulin and the microtubule-associated protein MAP2 in brain tissue as revealed by immunocytochemistry with monoclonal hybridoma antibodies. J. Neurosci. 4: 394–410.
  • Cress, W. D., D. G. Johnson, and J. R. Nevins 1993. A genetic analysis of the E2F1 gene distinguishes regulation by Rb, p107, and adenovirus E4. Mol. Cell. Biol. 13: 6314–6325.
  • DeCaprio, J. A., J. W. Ludlow, J. Figge, J. Y. Shew, C. M. Huang, W. H. Lee, E. Marsilio, E. Paucha, and D. M. Livingston 1992. The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression. Proc. Natl. Acad. Sci. USA 89: 1795–1798.
  • DeGregori, J., T. Kowalik, and J. R. Nevins 1995. Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes. Mol. Cell. Biol. 15: 4215–4224.
  • DeGregori, J., G. Leone, K. Ohtani, A. Mirone, and J. R. Nevins 1995. E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity. Genes Dev. 9: 2873–2887.
  • Ewen, M. E., H. K. Sluss, C. J. Sherr, D. M. Livingston, and H. Matsushime 1993. Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 73: 487–497.
  • Field, S. J., F.-Y. Tsai, F. Kuo, A. M. Zubiaga, W. G. J. Kaelin, D. M. Livingston, S. H. Orkin, and M. E. Greenberg 1996. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 85: 549–561.
  • Flemington, E. K., S. H. Speck, and W. G. J. Kaelin 1993. E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product. Proc. Natl. Acad. Sci. USA 90: 6914–6918.
  • Ginsberg, D., G. Vairo, T. Chittenden, Z.-X. Xiao, G. Xu, K. L. Wydner, J. A. DeCaprio, J. B. Lawrence, and D. M. Livingston 1994. E2F4, a new member of the E2F transcription family, interacts with p107. Genes Dev. 8: 2665–2679.
  • Goodrich, D. W., N. P. Wang, Y.-W. Quian, E. Y.-H. P. Lee, and W. H. Lee 1991. The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle. Cell 67: 293–302.
  • Han, E. K.-H., M. Begeman, A. Sgambato, J.-W. Soh, Y. Doki, W.-Q. Xing, W. Liu, and I. B. Weinstein 1996. Increased expression of cyclin D1 in a murine mammary epithelial cell line induces p27kip1, inhibits growth and enhances apoptosis. Cell Growth Differ. 7: 699–710.
  • Helin, K., E. Harlow, and A. Fattaey 1993. Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein. Mol. Cell. Biol. 13: 6501–6508.
  • Helin, K., J. A. Lees, M. Vidal, N. Dyson, E. Harlow, and A. Fattaey 1992. A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell 70: 337–350.
  • Henglein, B. Unpublished data.
  • Henglein, B., X. Chenivesse, J. Wang, D. Eick, and C. Brechot 1994. Structure and cell cycle-regulated transcription of the human cyclin A gene. Proc. Natl. Acad. Sci. USA 91: 5490–5494.
  • Hinds, P. W., S. Mittnacht, V. Dulic, A. Arnold, S. I. Reed, and R. A. Weinberg 1992. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70: 993–1006.
  • Hofmann, F., and D. M. Livingston 1996. Differential effects of cdk2 and cdk3 on the control of pRB and E2F function during G1 exit. Genes Dev. 10: 851–861.
  • Hsieh, J.-K., S. Frersdorf, T. Kouzarides, K. Martin, and X. Lu 1997. E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction. Genes Dev. 11: 1840–1852.
  • Ivey-Hoyle, M., R. Conroy, H. E. Huber, P. J. Goodhart, A. Oliff, and D. C. Heimbrook 1993. Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F. Mol. Cell. Biol. 13: 7802–7812.
  • Johnson, D. G., K. Ohtani, and J. Nevins 1994. Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Genes Dev. 8: 1514–1525.
  • Johnson, D. G., J. K. Schwarz, W. D. Cress, and J. R. Nevins 1993. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 365: 349–352.
  • Karlseder, J., H. Rotheneder, and E. Wintersberger 1996. Interaction of Sp1 with growth- and cell cycle-regulated transcription factor E2F. Mol. Cell. Biol. 16: 1659–1667.
  • Khleif, S. N., J. DeGregori, C. L. Yee, G. A. Otterson, F. J. Kaye, J. R. Nevins, and P. M. Howley 1996. Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. Proc. Natl. Acad. Sci. USA 93: 4350–4354.
  • Khochbin, S., A. Chabanas, P. Albert, J. Albert, and J. J. Lawrence 1988. Application of bromodeoxyuridine incorporation measurements to the determination of cell distribution within the S phase of the cell cycle. Cytometry 9: 499–503.
  • Kim, S.-J., U. S. Onwuta, Y. I. Lee, R. Li, M. R. Botchan, and P. D. Robbins 1992. The retinoblastoma gene product regulates Sp1-mediated transcription. Mol. Cell. Biol. 12: 2455–2463.
  • Kowalik, T. F., J. DeGregori, J. K. Schwarz, and J. R. Nevins 1995. E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J. Virol. 69: 2491–2500.
  • Kranenburg, O., A. J. van der Eb, and A. Zantema 1996. Cyclin D1 is an essential mediator of apoptotic neuronal cell death. EMBO J. 15: 46–54.
  • Lahti, J. M., H. Li, and V. J. Kidd 1997. Elimination of cyclin D1 in vertebrate cells leads to an altered cell cycle phenotype which is rescued by overexpression of murine cyclins D1, D2, or D3 but not by a mutant cyclin D1. J. Biol. Chem. 272: 10859–10869.
  • Lam, E. W.-F., and R. J. Watson 1993. An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription. EMBO J. 12: 2705–2713.
  • La Thangue, N. B. 1996. E2F and the molecular mechanisms of early cell-cycle control. Biochem. Soc. Trans. 24: 54–59.
  • Lin, S.-Y., A. R. Black, D. Kostic, S. Pajovic, C. N. Hoover, and J. C. Azizkhan 1996. Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction. Mol. Cell. Biol. 16: 1668–1675.
  • Lukas, J., J. Bartkova, M. Rohde, M. Strauss, and J. Bartek 1995. Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity. Mol. Cell. Biol. 15: 2600–2611.
  • Lukas, J., M. Pagano, Z. Staskova, G. Draetta, and J. Bartek 1994. Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumor cell lines. Oncogene 9: 707–718.
  • Lukas, J., B. O. Petersen, K. Holm, J. Bartek, and K. Helin 1996. Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression. Mol. Cell. Biol. 16: 1047–1057.
  • Lybarger, L., D. Dempsey, K. J. Franek, and R. Chervenak 1996. Rapid generation and flow cytometric analysis of stable GFP-expressing cells. Cytometry 25: 211–220.
  • Macleod, K., Y. Hu, and T. Jacks 1996. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. EMBO J. 15: 6178–6188.
  • Marhin, W. W., Y.-J. Hei, S. Chen, Z. Jiang, B. L. Gallie, R. A. Phillips, and L. Z. Penn 1996. Loss of pRb and Myc activation co-operate to suppress cyclin D1 and contribute to transformation. Oncogene 12: 43–52.
  • Matsushime, H., D. E. Quelle, S. A. Shurtleff, M. Shibuya, C. J. Sherr, and J.-Y. Kato 1994. D-type cyclin-dependent kinase activity in mammalian cells. Mol. Cell. Biol. 14: 2066–2076.
  • Matsushime, H., M. F. Roussel, R. A. Ashmun, and C. J. Sherr 1991. Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell 65: 701–713.
  • Melillo, R. M., K. Helin, D. R. Lowy, and J. T. Schiller 1994. Positive and negative regulation of cell proliferation by E2F-1: influence of protein level and human papillomavirus oncoproteins. Mol. Cell. Biol. 14: 8241–8249.
  • Mittnacht, S., J. A. Lees, D. Desai, D. O. Morgan, and R. A. Weinberg 1994. Distinct subpopulations of the retinoblastoma protein show a distinct pattern of phosphorylation. EMBO J. 13: 118–127.
  • Moberg, K., M. A. Starz, and J. A. Lees 1996. E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry. Mol. Cell. Biol. 16: 1436–1449.
  • Motokura, T., and A. Arnold 1993. The PRAD1/cyclin D1 proto-oncogene: genomic organization, 5′ DNA sequence, and sequence of a tumor-specific rearrangement breakpoint. Genes Chromosomes Cancer 7: 89–95.
  • Motokura, T., T. Bloom, H. G. Kim, H. Juppner, J. V. Ruderman, H. M. Kronenberg, and A. Arnold 1991. A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature 350: 512–515.
  • Muller, H., J. Lukas, A. Schneider, P. Warthoe, J. Bartek, M. Eilers, and M. Strauss 1994. Cyclin D1 expression is regulated by the retinoblastoma protein. Proc. Natl. Acad. Sci. USA 91: 2945–2949.
  • Pagano, M., R. Pepperkok, F. Verde, W. Ansorge, and G. Draetta 1992. Cyclin A is required at two points in the human cell-cycle. EMBO J. 11: 961–971.
  • Paulus, W., I. Baur, F. M. Boyce, X. O. Breakefield, and S. A. Reeves 1996. Self-contained, tetracycline-regulated retroviral vector system for gene delivery to mammalian cells. J. Virol. 70: 62–67.
  • Pestell, R. G., C. Albanese, A. Hollenberg, and J. L. Jameson 1994. Transcription of the human chorionic gonadotropin α and β genes is negatively regulated by c-jun. J. Biol. Chem. 269: 31090–31096.
  • Pestell, R. G., C. Albanese, R. J. Lee, G. Watanabe, E. Moran, J. Johnson, and J. L. Jameson 1996. A potential role for cell-cycle control proteins in regulation of the cAMP-responsive glycoprotein hormone α-subunit gene. Cell Growth Differ. 7: 1337–1344.
  • Pestell, R. G., C. Albanese, G. Watanabe, J. Johnson, N. Eklund, P. Lastowiecki, and J. L. Jameson 1995. Epidermal growth factor and c-Jun act via a common DNA regulatory element to stimulate transcription of the ovine P-450 cholesterol side chain cleavage (CYP11A1) promoter. J. Biol. Chem. 270: 18301–18308.
  • Philipp, A., A. Schneider, I. Väsrik, K. Finke, Y. Xiong, D. Beach, K. Alitalo, and M. Eilers 1994. Repression of cyclin D1: a novel function of MYC. Mol. Cell. Biol. 14: 4032–4043.
  • Phillips, A. C., S. Bates, K. M. Ryan, K. Helin, and K. H. Vousden 1997. Induction of DNA synthesis and apoptosis are separable functions of E2F-1. Genes Dev. 11: 1853–1863.
  • Qin, X., D. M. Livingston, Kaelin W. G., Jr., and P. D. Adams 1994. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. USA 91: 10918–10922.
  • Resnitzky, D., M. Gossen, H. Bujard, and S. I. Reed 1994. Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol. Cell. Biol. 14: 1669–1679.
  • Resnitzky, D., and S. I. Reed 1995. Different roles for cyclins D1 and E in regulation of the G1-to-S transition. Mol. Cell. Biol. 15: 3463–3469.
  • Sardet, C., M. Vidal, D. Cobrinik, Y. Geng, C. Onufryk, A. Chen, and R. A. Weinberg 1995. E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Proc. Natl. Acad. Sci. USA 92: 2403–2407.
  • Schulze, A., K. Zerfass, D. Spitkovsky, J. Berges, S. Middendorp, P. Jansen-Durr, and B. Henglein 1995. Cell cycle regulation of cyclin A gene transcription is mediated by a variant E2F binding site. Proc. Natl. Acad. Sci. USA 92: 11264–11268.
  • Sellers, W., B. G. Novitch, S. Miyake, A. Heith, G. A. Otterson, F. J. Kaye, A. B. Lassar, and W. G. Kaelin 1997. Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation and suppress tumor cell growth. Genes Dev. 12: 95–106.
  • Shin, E. K., S. G. Tevosian, and A. S. Yee 1996. The N-terminal region of E2F-1 is required for transcriptional activation of a new class of target promoter. J. Biol. Chem. 271: 12261–12268.
  • Singh, P., S. H. Wong, and W. Hong 1994. Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation. EMBO J. 13: 3329–3338.
  • Slansky, J., Y. Li, W. G. Kaelin, and P. J. Farnham 1993. A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter. Mol. Cell. Biol. 13: 1610–1618.
  • Spitkovsky, D., P. Steiner, J. Lukas, E. Lees, M. Pagano, A. Schulze, S. Joswig, D. Picard, M. Tommasino, M. Eilers, and P. Jansen-Durr 1994. Modulation of cyclin gene expression by adenovirus E1A in a cell line with E1A-dependent conditional proliferation. J. Virol. 68: 2206–2214.
  • Taya, Y. 1997. RB kinases and RB-binding proteins: new points of view. Trends Biochem. Sci. 22: 14–17.
  • Vairo, G., D. M. Livingston, and D. Ginsberg 1995. Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different RB family members. Genes Dev. 9: 869–881.
  • Watanabe, G., A. Howe, R. J. Lee, C. Albanese, I.-W. Shu, A. Karnezis, L. Zon, J. Kyriakis, K. Rundell, and R. G. Pestell 1996. Induction of cyclin D1 by simian virus 40 small tumor antigen. Proc. Natl. Acad. Sci. USA 93: 12861–12866.
  • Watanabe, G., R. J. Lee, C. Albanese, W. E. Rainey, D. Batlle, and R. G. Pestell 1996. Angiotensin II (AII) activation of cyclin D1-dependent kinase activity. J. Biol. Chem. 271: 22570–22577.
  • Watanabe, G., and R. G. Pestell. Unpublished data.
  • Weinberg, R. A. 1995. The retinoblastoma protein and cell cycle control. Cell 81: 323–330.
  • Weintraub, S. J., C. A. Prater, and D. C. Dean 1992. Retinoblastoma protein switches the E2F site from positive to negative element. Nature 358: 259–261.
  • Welch, P. J., and J. Y. J. Wang 1995. Disruption of retinoblastoma protein function by coexpression of its C pocket fragment. Genes Dev. 9: 31–46.
  • Wu, X., and A. J. Levine 1994. p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl. Acad. Sci. USA 91: 3802–3806.
  • Xu, G., D. M. Livingston, and W. Krek 1995. Multiple members of the E2F transcription factor family are the products of oncogenes. Proc. Natl. Acad. Sci. USA 92: 1357–1361.
  • Yamasaki, L., T. Jacks, R. Bronson, E. Goillot, E. Harlow, and N. J. Dyson 1996. Tumor induction and tissue atrophy in mice lacking E2F-1. Cell 85: 537–548.
  • Zerfass-Thome, K., A. Schulze, W. Zwerschke, B. Vogt, K. Helin, J. Bartek, B. Henglein, and P. Jansen-Durr 1997. p27KIP1 blocks cyclin E-dependent transactivation of cyclin A gene expression. Mol. Cell. Biol. 17: 407–415.
  • Zhou, P., W. Jiang, C. M. Weghorst, and I. B. Weinstein 1996. Overexpression of cyclin D1 enhances gene amplification. Cancer Res. 56: 36–39.
  • Zhu, L., S. van der Heuvel, K. Helin, A. Fattaey, M. Ewen, D. Livingston, N. Dyson, and E. Harlow 1993. Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev. 7: 1111–1125.
  • Zwicker, J., N. Liu, K. Engeland, F. C. Lucibello, and R. Muller 1996. Cell cycle regulation of E2F site occupation in vivo. Science 271: 1595–1597.
  • Zwicker, J., F. C. Lucibello, L. A. Wolfraim, C. Gross, M. Truss, K. Engeland, and R. Muller 1995. Cell-cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression. EMBO J. 14: 4514–4522.

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