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DNA Dynamics and Chromosome Structure

Characterization of Interactions between the Mammalian Polycomb-Group Proteins Enx1/EZH2 and EED Suggests the Existence of Different Mammalian Polycomb-Group Protein Complexes

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Pages 3586-3595 | Received 01 Dec 1997, Accepted 24 Feb 1998, Published online: 28 Mar 2023

REFERENCES

  • Alkema, M. J., J. Wiegant, A. K. Raap, A. Berns, and M. van Lohuizen 1993. Characterization and chromosomal localization of the human proto-oncogene BMI-1. Hum. Mol. Genet. 2: 1597–1603.
  • Alkema, M. J., M. Bronk, E. Verhoeven, A. P. Otte, L. J. van’t Veer, A. Berns, and M. van Lohuizen 1997. Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian Polycomb complex. Genes Dev. 11: 226–240.
  • Bunker, C. A., and R. E. Kingston 1994. Transcriptional repression by Drosophila and mammalian Polycomb group proteins in transfected mammalian cells. Mol. Cell. Biol. 14: 1721–1732.
  • Carrington, E. A., and R. S. Jones 1996. The Drosophila Enhancer of zeste gene encodes a chromosomal protein: examination of wild-type and mutant protein distribution. Development 122: 4073–4083.
  • Chang, Y.-L., B. O. King, M. O’Connor, A. Mazo, and D.-H. Huang 1995. Functional reconstruction of trans regulation of the Ultrabithorax promoter by the products of two antagonistic genes, trithorax and Polycomb. Mol. Cell. Biol. 15: 6601–6612.
  • Chinwalla, V., E. P. Jane, and P. J. Harte 1995. The Drosophila trithorax protein binds to specific sites and is co-localized with Polycomb at many sites. EMBO J. 14: 2056–2065.
  • Denisenko, O. N., and K. Bomsztyk 1997. The product of the murine homolog of the Drosophila extra sex combs gene displays transcriptional repressor activity. Mol. Cell. Biol. 17: 4707–4717.
  • Durfee, T., K. Becherer, P.-L. Chen, S.-H. Yeh, Y. Yang, A. E. Kilburn, W.-H. Lee, and S. J. Elledge 1993. The retinoblastoma protein associates with the protein phosphatase type I catalytic subunit. Genes Dev. 7: 555–569.
  • Fields, S., and O. K. Song 1989. A novel genetic system to detect protein-protein interactions. Nature (London) 340: 245–246.
  • Franke, A., M. DeCamillis, D. Zink, N. Cheng, H. W. Brock, and R. Paro 1992. Polycomb and polyhomeotic are constituents of a multimeric protein complex in chromatin of Drosophila melanogaster. EMBO J. 11: 2941–2950.
  • Goodrich, J., P. Puangsomlee, M. Martin, D. Long, E. M. Meyerowitz, and G. Coupland 1997. A Polycomb-group gene regulates homeotic gene expression in Arabidopsis. Nature (London) 386: 44–51.
  • Gunster, M. J., D. P. E. Satijn, C. M. Hamer, J. L. den Blaauwen, D. de Bruijn, M. J. Alkema, M. van Lohuizen, R. van Driel, and A. P. Otte 1997. Identification and characterization of interactions between the vertebrate Polycomb-group protein BMI1 and human homologs of Polyhomeotic. Mol. Cell. Biol. 17: 2326–2335.
  • Farkas, G., J. Gausz, M. Galloni, G. Reuter, H. Gyurkovics, and F. Karch 1994. The trithorax-like gene encodes the Drosophila GAGA factor. Nature 371: 806–808.
  • Gutjahr, T., E. Frei, C. Spicer, S. Baumgarter, R. A. H. White, and M. Noll 1995. The Polycomb-group gene, extra sex combs, encodes a nuclear member of the WD-40 repeat family. EMBO J. 14: 4296–4306.
  • Hobert, O., B. Jalla, and A. Ullrich 1996. Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression. Mol. Cell. Biol. 16: 3066–3073.
  • Hobert, O., I. Sures, T. Ciossek, M. Fuchs, and A. Ullrich 1996. Isolation and developmental expression of Enx-1, a novel mouse Polycomb group gene. Mech. Dev. 55: 171–184.
  • Jones, R. S., and W. M. Gelbart 1993. The Drosophila Polycomb-group gene enhancer of zeste contains a region with sequence similarity to trithorax. Mol. Cell. Biol. 13: 6357–6366.
  • Jürgens, G. 1985. A group of genes controlling the spatial expression of the bithorax complex in Drosophila. Nature (London) 316: 153–155.
  • Keleher, C. A., M. J. Redd, J. Schultz, M. Carlson, and A. D. Johnson 1992. Ssn6-Tup1 is a general repressor of transcription in yeast. Cell 68: 709–719.
  • Kennison, J. A. 1995. The Polycomb and trithorax group proteins of Drosophila: trans-regulators of homeotic gene function. Annu. Rev. Gen. 29: 289–303.
  • Kennison, J. A., and J. W. Tamkun 1992. Trans-regulation of homeotic genes in Drosophila. New Biol. 4: 91–96.
  • Kingston, R. E., C. A. Bunker, and A. N. Imbalzano 1996. Repression and activation by multiprotein complexes that alter chromatin structure. Genes Dev. 10: 905–920.
  • Komachi, K., M. J. Redd, and A. D. Johnson 1994. The WD repeats of Tup1 interact with the homeo domain protein α2. Genes Dev. 8: 2857–2867.
  • Kuzin, B., S. Tillib, Y. Sedkov, L. Mizrokhi, and A. Mazo 1994. The Drosophila trithorax gene encodes a chromosomal protein and directly regulates the region-specific homeotic gene fork head. Genes Dev. 8: 2478–2490.
  • Laible, G., A. Wolf, R. Dorn, G. Reuter, C. Nislow, A. Lebersorger, D. Popkin, L. Pillus, and T. Junuwein 1997. Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres. EMBO J. 16: 3219–3232.
  • LaJeunesse, D., and A. Shearn 1996. E(z): a polycomb group gene or a trithorax group gene? Development 122: 2189–2197.
  • Paro, R. 1990. Imprinting a determined state into the chromatin of Drosophila. Trends Genet. 6: 416–421.
  • Pirrotta, V. 1997. PcG complexes and chromatin silencing. Curr. Opin. Genet. Dev. 7: 249–258.
  • Rastelli, L., C. S. Chan, and V. Pirotta 1993. Related chromosome binding sites for zeste, suppressors of zeste and Polycomb group proteins in Drosophila and their dependence on Enhancer of zeste function. EMBO J. 12: 1513–1522.
  • Reijnen, M. J., K. M. Hamer, J. L. den Blaauwen, C. Lambrechts, I. Schoneveld, R. van Driel, and A. P. Otte 1995. Polycomb and bmi-1 homologs are expressed in overlapping patterns in Xenopus embryos and are able to interact with each other. Mech. Dev. 53: 35–46.
  • Rogers, S., R. Wells, and M. Rechsteiner 1986. Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis. Science 234: 364–368.
  • Sathe, S., and P. J. Harte 1995. The Drosophila extra sex combs protein contains WD motifs essential for its function as repressor of homeotic genes. Mech. Dev. 52: 77–87.
  • Satijn, D. P. E., M. J. Gunster, J. van der Vlag, K. M. Hamer, W. Schul, M. J. Alkema, A. J. Saurin, P. S. Freemont, R. van Driel, and A. P. Otte 1997. RING1 is associated with the Polycomb-group protein complex and acts as a transcriptional repressor. Mol. Cell. Biol. 17: 4105–4113.
  • Satijn, D. P. E., D. J. Olson, J. van der Vlag, C. M. Hamer, A. C. Lambrechts, H. Masselink, M. J. Gunster, R. G. A. B. Sewalt, R. van Driel, and A. P. Otte 1997. Interference with the expression of a novel human Polycomb protein, hPc2, results in cellular transformation and apoptosis. Mol. Cell. Biol. 17: 6076–6086.
  • Schoorlemmer, J., C. Marcos, F. Were, R. Martinez, E. Garcia, D. P. E. Satijn, A. P. Otte, and M. Vidal 1997. RING1A is a transcriptional repressor that interacts with the Polycomb-M33 protein and is expressed at rhombomere boundaries in the mouse hindbrain. EMBO J. 16: 5930–5942.
  • Schumacher, A., C. Faust, and T. Magnuson 1996. Positional cloning of a global regulator of anterior-posterior patterning in mice. Nature (London) 383: 250–253.
  • Schumacher, A., and T. Magnuson 1997. Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond. Trends Genet. 13: 167–170.
  • Simon, J. 1995. Locking in stable states of gene expression: transcriptional control during Drosophila development. Curr. Opin. Cell Biol. 7: 376–385.
  • Simon, J., D. Bornemann, K. Lunde, and C. Schwartz 1995. The extra sex combs product contains WD40 repeats and its time of action implies a role distinct from other Polycomb group products. Mech. Dev. 53: 197–208.
  • Struhl, G., and D. Brower 1982. Early role of the esc+ gene product in the determination of segments in Drosophila. Cell 31: 285–292.
  • Strutt, H., G. Cavalli, and R. Paro 1997. Co-localization of Polycomb protein and GAGA factor on regulatory elements responsible for the maintenance of homeotic gene expression. EMBO J. 16: 3621–3632.

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