14
Views
142
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Human T-Cell Leukemia Virus Type 1 Tax and Cell Cycle Progression: Role of Cyclin D-cdk and p110Rb

, , , , , & show all
Pages 3620-3632 | Received 16 Dec 1997, Accepted 24 Feb 1998, Published online: 28 Mar 2023

REFERENCES

  • Alexandre, C., P. Charnay, and B. Verrier 1991. Transactivation of Krox-20 and Krox-24 promoters by the HTLV-1 Tax protein through common regulatory elements. Oncogene 6: 1851–1857.
  • Arnold, A., H. G. Kim, R. D. Gaz, R. L. Eddy, Y. Fukushima, M. G. Byers, T. B. Shows, and H. M. Kronenberg 1989. Molecular cloning and chromosomal mapping of DNA rearranged with the parathyroid hormone gene in a parathyroid adenoma. J. Clin. Invest. 83: 2034–2040.
  • Arroyo, M., S. Bagchi, and P. Raychaudhuri 1993. Association of the human papillomavirus type 16 E7 protein with the S-phase-specific E2F-cyclin A complex. Mol. Cell. Biol. 13: 6537–6546.
  • Ballard, D. W., E. Bohnlein, J. W. Lowenthal, Y. Wano, B. R. Franza, and W. C. Greene 1988. HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene. Science 241: 1652–1655.
  • Boyer, S. N., D. E. Wazer, and V. Band 1996. E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway. Cancer Res. 56: 4620–4624.
  • Brady, J., K. T. Jeang, J. Duvall, and G. Khoury 1987. Identification of p40x-responsive regulatory sequences within the human T-cell leukemia virus type I long terminal repeat. J. Virol. 61: 2175–2181.
  • Brauweiler, A., J. E. Garrus, J. C. Reed, and J. K. Nyborg 1997. Repression of bax gene expression by the HTLV-1 Tax protein: implications for suppression of apoptosis in virally infected cells. Virology 231: 135–140.
  • Buckley, M. F., K. J. Sweeney, J. A. Hamilton, R. L. Sini, D. L. Manning, R. I. Nicholson, A. deFazio, C. K. Watts, E. A. Musgrove, and R. L. Sutherland 1993. Expression and amplification of cyclin genes in human breast cancer. Oncogene 8: 2127–2133.
  • Chan, F. K., J. Zhang, L. Cheng, D. N. Shapiro, and A. Winoto 1995. Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. Mol. Cell. Biol. 15: 2682–2688.
  • Chen, I. S., D. J. Slamon, J. D. Rosenblatt, N. P. Shah, S. G. Quan, and W. Wachsman 1985. The x gene is essential for HTLV replication. Science 229: 54–58.
  • DeCaprio, J. A., J. W. Ludlow, J. Figge, J. Y. Shew, C. M. Huang, W. H. Lee, E. Marsilio, E. Paucha, and D. M. Livingston 1988. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell 54: 275–283.
  • DeGregori, J., G. Leone, K. Ohtani, A. Miron, and J. R. Nevins 1995. E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity. Genes Dev. 9: 2873–2887.
  • Diehl, J. A., F. Zindy, and C. J. Sherr 1997. Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway. Genes Dev. 11: 957–972.
  • Dowdy, S. F., P. W. Hinds, K. Louie, S. I. Reed, A. Arnold, and R. A. Weinberg 1993. Physical interaction of the retinoblastoma protein with human D cyclins. Cell 73: 499–511.
  • Dyson, N., P. M. Howley, K. Munger, and E. Harlow 1989. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243: 934–937.
  • Earl, P. L., N. Cooper, and B. Moss 1991. Preparation of cell culture and vaccinia virus stocks Current protocols in molecular biology. In: Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl16.16.1–16.16.7Greene Publishing Associates and Wiley-Interscience, New York, N.Y.
  • Elroy-Stein, O., T. R. Fuerst, and B. Moss 1989. Cap-independent translation of mRNA conferred by encephalomyocarditis virus 5′ sequence improves the performance of the vaccinia virus/bacteriophage T7 hybrid expression system. Proc. Natl. Acad. Sci. USA 86: 6126–6130.
  • Elroy-Stein, O., and B. Moss 1991. Gene expression using vaccinia/T7 RNA polymerase hybrid system Current protocols in molecular biology. In: Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl16.19.1–16.19.9Greene Publishing Associates and Wiley-Interscience, New York, N.Y.
  • Erikson, J., J. Finan, Y. Tsujimoto, P. C. Nowell, and C. M. Croce 1984. The chromosome 14 breakpoint in neoplastic B cells with the t(11;14) translocation involves the immunoglobulin heavy chain locus. Proc. Natl. Acad. Sci. USA 81: 4144–4148.
  • Ewen, M. E., H. K. Sluss, C. J. Sherr, H. Matsushime, J. Kato, and D. M. Livingston 1993. Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 73: 487–497.
  • Faha, B., E. Harlow, and E. Lees 1993. The adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2. J. Virol. 67: 2456–2465.
  • Felber, B. K., H. Paskalis, C. Kleinman-Ewing, F. Wong-Staal, and G. N. Pavlakis 1985. The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats. Science 229: 675–679.
  • Franklin, A. A., and J. K. Nyborg 1995. Mechanisms of Tax regulation of human T cell leukemia virus type I gene expression. J. Biomed. Sci. 2: 17–29.
  • Fujii, M., T. Niki, T. Mori, T. Matsuda, M. Matsui, N. Nomura, and M. Seiki 1991. HTLV-1 Tax induces expression of various immediate early serum responsive genes. Oncogene 6: 1023–1029.
  • Fujii, M., P. Sassone-Corsi, and I. M. Verma 1988. c-fos promoter trans-activation by the tax1 protein of human T-cell leukemia virus type I. Proc. Natl. Acad. Sci. USA 85: 8526–8530.
  • Gorman, C. M., L. F. Moffat, and B. H. Howard 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2: 1044–1051.
  • Grana, X., and E. P. Reddy 1995. Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene 11: 211–219.
  • Grassmann, R., S. Berchtold, I. Radant, M. Alt, B. Fleckenstein, J. G. Sodroski, W. A. Haseltine, and U. Ramstedt 1992. Role of human T-cell leukemia virus type 1 X region proteins in immortalization of primary human lymphocytes in culture. J. Virol. 66: 4570–4575.
  • Grossman, W. J., J. T. Kimata, F. H. Wong, M. Zutter, T. J. Ley, and L. Ratner 1995. Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I. Proc. Natl. Acad. Sci. USA 92: 1057–1061.
  • Gu, W., J. W. Schneider, G. Condorelli, S. Kaushal, V. Mahdavi, and B. Nadal-Ginard 1993. Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell 72: 309–324.
  • Guan, K. L., C. W. Jenkins, Y. Li, M. A. Nichols, X. Wu, C. L. O’Keefe, A. G. Matera, and Y. Xiong 1994. Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev. 8: 2939–2952.
  • Hannon, G. J., and D. Beach 1994. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature 371: 257–261.
  • Hinds, P. W., and R. A. Weinberg 1994. Tumor suppressor genes. Curr. Opin. Genet. Dev. 4: 135–141.
  • Hirai, H., M. F. Roussel, J. Y. Kato, R. A. Ashmun, and C. J. Sherr 1995. Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol. Cell. Biol. 15: 2672–2681.
  • Hirama, T., and H. P. Koeffler 1995. Role of the cyclin-dependent kinase inhibitors in the development of cancer. Blood 86: 841–854.
  • Hollsberg, P., and D. A. Hafler 1993. Seminars in medicine of the Beth Israel Hospital, Boston. Pathogenesis of diseases induced by human lymphotropic virus type I infection. N. Engl. J. Med. 328: 1173–1182.
  • Hunter, T., and J. Pines 1994. Cyclins and cancer. II: cyclin D and CDK inhibitors come of age. Cell 79: 573–582.
  • Inoue, J., M. Seiki, T. Taniguchi, S. Tsuru, and M. Yoshida 1986. Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1. EMBO J. 5: 2883–2888.
  • Jeang, K. T., P. R. Shank, and A. Kumar 1988. Transcriptional activation of homologous viral long terminal repeats by the human immunodeficiency virus type 1 or the human T-cell leukemia virus type I tat proteins occurs in the absence of de novo protein synthesis. Proc. Natl. Acad. Sci. USA 85: 8291–8295.
  • Jeang, K. T., S. G. Widen, O. J. Semmes IV, and S. H. Wilson 1990. HTLV-I trans-activator protein, tax, is a trans-repressor of the human beta-polymerase gene. Science 247: 1082–1084.
  • Jiang, W., S. M. Kahn, N. Tomita, Y. J. Zhang, S. H. Lu, and I. B. Weinstein 1992. Amplification and expression of the human cyclin D gene in esophageal cancer. Cancer Res. 52: 2980–2983.
  • Jin, D. Y., H. Teramoto, C. Z. Giam, R. F. Chun, J. S. Gutkind, and K. T. Jeang 1997. A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha. J. Biol. Chem. 272: 25816–25823.
  • Johnson, D. G., J. K. Schwarz, W. D. Cress, and J. R. Nevins 1993. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 365: 349–352.
  • Jones, D. L., and K. Munger 1997. Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoprotein. J. Virol. 71: 2905–2912.
  • Kato, J., H. Matsushime, S. W. Hiebert, M. E. Ewen, and C. J. Sherr 1993. Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev. 7: 331–342.
  • Kato, J. Y., and C. J. Sherr 1993. Inhibition of granulocyte differentiation by G1 cyclins D2 and D3 but not D1. Proc. Natl. Acad. Sci. USA 90: 11513–11517.
  • Khatib, Z. A., H. Matsushime, M. Valentine, D. N. Shapiro, C. J. Sherr, and A. T. Look 1993. Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas. Cancer Res. 53: 5535–5541.
  • Lammie, G. A., and G. Peters 1991. Chromosome 11q13 abnormalities in human cancer. Cancer Cells 3: 413–420.
  • Low, K. G., L. F. Dorner, D. B. Fernando, J. Grossman, K. T. Jeang, and M. J. Comb 1997. Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a. J. Virol. 71: 1956–1962.
  • Martelli, F., C. Cenciarelli, G. Santarelli, B. Polikar, A. Felsani, and M. Caruso 1994. MyoD induces retinoblastoma gene expression during myogenic differentiation. Oncogene 9: 3579–3590.
  • Matsushime, H., D. E. Quelle, S. A. Shurtleff, M. Shibuya, C. J. Sherr, and J. Y. Kato 1994. D-type cyclin-dependent kinase activity in mammalian cells. Mol. Cell. Biol. 14: 2066–2076.
  • Matsushime, H., M. F. Roussel, R. A. Ashmun, and C. J. Sherr 1991. Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell 65: 701–713.
  • McIntyre, M. C., M. N. Ruesch, and L. A. Laimins 1996. Human papillomavirus E7 oncoproteins bind a single form of cyclin E in a complex with cdk2 and p107. Virology 215: 73–82.
  • Miyatake, S., M. Seiki, M. Yoshida, and K. Arai 1988. T-cell activation signals and human T-cell leukemia virus type I-encoded p40x protein activate the mouse granulocyte-macrophage colony-stimulating factor gene through a common DNA element. Mol. Cell. Biol. 8: 5581–5587.
  • Morgan, D. O. 1995. Principles of CDK regulation. Nature 374: 131–134.
  • Moss, B., O. Elroy-Stein, T. Mizukami, W. A. Alexander, and T. R. Fuerst 1990. Product review. New mammalian expression vectors. Nature 348: 91–92.
  • Motokura, T., T. Bloom, H. G. Kim, H. Juppner, J. V. Ruderman, H. M. Kronenberg, and A. Arnold 1991. A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature 350: 512–515.
  • Murray, A. 1994. Cell cycle checkpoints. Curr. Opin. Cell. Biol. 6: 872–876.
  • Nerenberg, M., S. H. Hinrichs, R. K. Reynolds, G. Khoury, and G. Jay 1987. The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice. Science 237: 1324–1329.
  • Neuveut, C. Unpublished data.
  • Neuveut, C., D. Y. Jin, O. J. Semmes, F. Diella, R. Callahan, and K. T. Jeang 1997. Divergent subcellular locations of HTLV-1 Tax and INT-6: a contrast between in vitro protein-protein binding and intracellular protein colocalization. J. Biomed. Sci. 4: 229–234.
  • Nevins, J. R. 1992. E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258: 424–429.
  • Ohtani, K., M. Nakamura, S. Saito, K. Nagata, K. Sugamura, and Y. Hinuma 1989. Electroporation: application to human lymphoid cell lines for stable introduction of a transactivator gene of human T-cell leukemia virus type I. Nucleic Acids Res. 17: 1589–1604.
  • Peter, M., and I. Herskowitz 1994. Joining the complex: cyclin-dependent kinase inhibitory proteins and the cell cycle. Cell 79: 181–184.
  • Peters, G. 1994. The D-type cyclins and their role in tumorigenesis. J. Cell. Sci. Suppl. 18: 89–96.
  • Pozzatti, R., J. Vogel, and G. Jay 1990. The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells. Mol. Cell. Biol. 10: 413–417.
  • Qin, X. Q., D. M. Livingston, Kaelin W., Jr., and P. D. Adams 1994. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. USA 91: 10918–10922.
  • Rao, S. S., C. Chu, and D. S. Kohtz 1994. Ectopic expression of cyclin D1 prevents activation of gene transcription by myogenic basic helix-loop-helix regulators. Mol. Cell. Biol. 14: 5259–5267.
  • Resnitzky, D., M. Gossen, H. Bujard, and S. I. Reed 1994. Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol. Cell. Biol. 14: 1669–1679.
  • Ruben, S., H. Poteat, T. H. Tan, K. Kawakami, R. Roeder, W. Haseltine, and C. A. Rosen 1988. Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-I tax gene product. Science 241: 89–92.
  • Schmitt, V. I., O. Rosin, P. Rohwer, M. Gossen, and R. Grassmann 1998. Stimulation of cyclin-dependent kinase activity and G1-to-S-phase transition in human lymphocytes by the human T-cell leukemia/lymphotropic virus type 1 Tax protein. J. Virol. 72: 633–640.
  • Schneider, J. W., W. Gu, L. Zhu, V. Mahdavi, and B. Nadal-Ginard 1994. Reversal of terminal differentiation mediated by p107 in Rb−/− muscle cells. Science 264: 1467–1471.
  • Semmes, O. J., J. F. Barret, C. V. Dang, and K. T. Jeang 1996. Human T-cell leukemia virus type I tax masks c-Myc function through a cAMP-dependent pathway. J. Biol. Chem. 271: 9730–9738.
  • Sherr, C. J. 1994. G1 phase progression: cycling on cue. Cell 79: 551–555.
  • Sherr, C. J. 1995. D-type cyclins. Trends Biochem. Sci. 20: 187–190.
  • Sherr, C. J., and J. M. Roberts 1995. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9: 1149–1163.
  • Siekevitz, M., M. B. Feinberg, N. Holbrook, F. Wong-Staal, and W. C. Greene 1987. Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I. Proc. Natl. Acad. Sci. USA 84: 5389–5393.
  • Skapek, S. X., J. Rhee, D. B. Spicer, and A. B. Lassar 1995. Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase. Science 267: 1022–1024.
  • Slansky, J. E., and P. J. Farnham 1996. Introduction to the E2F family: protein structure and gene regulation. Curr. Top. Microbiol. Immunol. 208: 1–30.
  • Sodroski, J., C. Rosen, W. C. Goh, and W. Haseltine 1985. A transcriptional activator protein encoded by the x-lor region of the human T-cell leukemia virus. Science 228: 1430–1434.
  • Steiner, P., A. Philipp, J. Lukas, D. Godden-Kent, M. Pagano, S. Mittnacht, J. Bartek, and M. Eilers 1995. Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes. EMBO J. 14: 4814–4826.
  • Sugamora, K. Personal communication.
  • Suzuki, T., S. Kitao, H. Matsushime, and M. Yoshida 1996. HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4. EMBO J. 15: 1607–1614.
  • Tam, S. W., A. M. Theodoras, J. W. Shay, G. F. Draetta, and M. Pagano 1994. Differential expression and regulation of cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for cyclin D1 function in G1 progression. Oncogene 9: 2663–2674.
  • Tommasino, M., J. P. Adamczewski, F. Carlotti, C. F. Barth, R. Manetti, M. Contorni, F. Cavalieri, T. Hunt, and L. Crawford 1993. HPV16 E7 protein associates with the protein kinase p33CDK2 and cyclin A. Oncogene 8: 195–202.
  • Trihn, D., K. T. Jeang, and O. J. Semmes 1997. HTLV-1 Tax and cytokeratin-Tax-expressing cells show morphological changes in keratin-containing cytoskeletal networks. J. Biomed. Sci. 4: 47–53.
  • Tsujimoto, Y., J. Yunis, L. Onorato-Showe, J. Erikson, P. C. Nowell, and C. M. Croce 1984. Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation. Science 224: 1403–1406.
  • Uittenbogaard, M. N., H. A. Giebler, D. Reisman, and J. K. Nyborg 1995. Transcriptional repression of p53 by human T-cell leukemia virus type I Tax protein. J. Biol. Chem. 270: 28503–28506.
  • Wang, J., and B. Nadal-Ginard 1995. Regulation of cyclins and p34CDC2 expression during terminal differentiation of C2C12 myocytes. Biochem. Biophys. Res. Commun. 206: 82–88.
  • Weber, F., E. Meinl, K. Drexler, A. Czlonkowska, S. Huber, H. Fickenscher, I. Muller-Fleckenstein, B. Fleckenstein, H. Wekerle, and R. Hohlfeld 1993. Transformation of human T-cell clones by herpesvirus saimiri: intact antigen recognition by autonomously growing myelin basic protein-specific T cells. Proc. Natl. Acad. Sci. USA 90: 11049–11053.
  • Weinberg, R. A. 1996. E2F and cell proliferation: a world turned upside down. Cell 85: 457–459.
  • Whyte, P., K. J. Buchkovich, J. M. Horowitz, S. H. Friend, M. Raybuck, R. A. Weinberg, and E. Harlow 1988. Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product. Nature 334: 124–129.
  • Yoshida, M. 1993. HTLV-1 Tax: regulation of gene expression and disease. Trends Microbiol. 1: 131–135.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.