13
Views
60
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Role of Phosphatidylinositol 4,5-Bisphosphate in Ras/Rac-Induced Disruption of the Cortactin-Actomyosin II Complex and Malignant Transformation

, , , , , , , , & show all
Pages 3829-3837 | Received 13 Jan 1998, Accepted 08 Apr 1998, Published online: 28 Mar 2023

REFERENCES

  • Bar-Sagi, D., and J. Feramisco 1986. Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by Ras proteins. Science 233: 1061–1065.
  • Bleasby, A. J., and J. C. Wootton 1990. Construction of validated, non-redundant composite protein sequences in a protein database. Protein Eng. 3: 153–159.
  • Choi, O. H., C. S. Park, K. Itoh, R. S. Adelstein, and M. Beaven 1996. Cloning of cDNA encoding rat myosin II-A heavy chain and evidence for the absence of myosin II-B heavy chain in cultured rat mast (RBL-2H3) cells. J. Muscle Res. Cell Motil. 17: 69–77.
  • D’Abaco, G., R. Whitehead, and A. W. Burgess 1996. Synergy between APC (Min) and an activated Ras mutation is sufficient to induce colon carcinomas. Mol. Cell. Biol. 16: 884–891.
  • Eng, J. K., A. McCormack, and J. Yates 1994. An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. Am. Soc. Mass Spectrom. 5: 976–989.
  • Fernandez, J. L. R., B. Geiger, D. Salomon, I. Sabanay, M. Zoeller, and A. Ben-Ze’ev 1992. Suppression of tumorigenicity in SV40-transformed cells after transfection with vinculin cDNA. J. Cell Biol. 119: 427–438.
  • Fukami, K., K. Matsuoka, O. Nakanishi, A. Yamakawa, S. Kawai, and T. Takenawa 1988. Antibody to PIP2 inhibits oncogene induced mitogenesis. Proc. Natl. Acad. Sci. USA 85: 9057–9061.
  • Fukami, K., K. Furuhashi, M. Inagaki, T. Endo, S. Hatano, and T. Takenawa 1992. Requirement of PIP2 for alpha-actinin function. Nature 359: 150–152.
  • Fukami, K., T. Endo, M. Imamura, and T. Tekenawa 1994. Alpha-actinin and vinculin are PIP2-binding proteins involved in signaling by Tyr kinase. J. Biol. Chem. 269: 1518–1522.
  • Fukui, Y., T. Lynch, H. Brzeska, and E. D. Korn 1989. Myosin I is located at the leading edges of locomoting Dictyostelium amoeba. Nature 341: 328–331.
  • Gibbs, J. B., R. Elis, and E. M. Scolnick 1984. Autophosphorylation of v-Ha-Ras is modulated by amino acid 12. Proc. Natl. Acad. Sci. USA 81: 2674–2678.
  • Gimona, M., J. Kazzaz, and D. Helfman 1996. Forced expression of tropo -myosin2 and 3 in v-Ki-Ras-transformed fibroblasts results in distinct phenotypic effects. Proc. Natl. Acad. Sci. USA 93: 9618–9623.
  • Glueck, U., D. Kwiatkowski, and A. Ben-Ze’ev 1993. Suppression of tumorigenicity in SV40-transformed 3T3 cells transfected with alpha-actinin cDNA. Proc. Natl. Acad. Sci. USA 90: 383–387.
  • Hartwig, J., G. M. Bokoch, C. L. Carpenter, P. Janmey, L. Taylor, A. Toker, and T. Stossel 1995. Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis. Cell 82: 643–653.
  • He, H. 1997. HS1 and EMS1. Jpn. J. Cancer Chemother. 24: 1448–1453.
  • Hirao, M., N. Sato, T. Kondo, S. Yonemura, M. Monden, T. Sakaki, Y. Takai, S. Tsukita, and S. Tsukita 1996. Regulation mechanism of ERM (Ezrin/Radixin/Moesin) protein/plasma membrane association: possible involvement of PIP2 turnover and Rho-dependent signaling pathway. J. Cell Biol. 135: 37–51.
  • Huang, C., Y. Ni, T. Wang, Y. Gao, C. C. Haudenschild, and X. Zhan 1997. Down-regulation of F-actin cross-linking activity of cortactin/EMS1 by Src-mediated Tyr phosphorylation. J. Biol. Chem. 272: 13911–13915.
  • Janmey, P., and T. Stossel 1987. Modulation of gelsolin function by PIP2. Nature 325: 362–364.
  • Janssen, R., and J. Mier 1997. Tropomyosin-2 cDNA lacking the 3′ untranslated region riboregulator induces growth inhibition of v-Ki-Ras-transformed fibroblasts. Mol. Biol. Cell 8: 897–908.
  • Kitamura, D., H. Kaneko, Y. Miyazgoe, T. Ariyasu, and T. Watanabe 1989. Isolation and characterization of a novel human gene expressed specially in the cells of hematopoietic lineage. Nucleic Acids Res. 17: 9367–9379.
  • Kumar, C. C., C. Prorock-Rogers, J. Kelley, Z. Dong, J. J. Lin, L. Armstrong, H. F. Kung, M. J. Weber, and A. Afonso 1995. SCH51344 inhibits Ras transformation by a novel mechanism. Cancer Res. 55: 5106–5117.
  • Lassing, I., and U. Lindberg 1988. Evidence that the phosphatidylinositol cycle is linked to cell motility. Exp. Cell Res. 174: 1–15.
  • Maruta, H., and E. D. Korn 1977. Acanthamoeba myosin II. J. Biol. Chem. 252: 6501–6509.
  • Maruta, H., J. Holden, A. Sizeland, and G. D’Abaco 1991. The residues of Ras and Rap proteins that determine their GAP specificities. J. Biol. Chem. 266: 11661–11668.
  • Maruta, H., and H. He 1995. Cytoskeletal SH3 proteins. Biochemistry (Tokyo) 67: 1210–1217.
  • Maruta, H. 1996. Downstream of RAS and actin-cytoskeleton Regulation of the RAS signaling network. In: Maruta, H., and A. W. Burgess139–180Springer-Verlag, Heidelberg, Germany.
  • Maruta, H. 1997. F-actin cappers. Jpn. J. Cancer Chemother. 24: 1442–1447.
  • Moritz, R. L., and R. J. Simpson 1992. Application of capillary reversed-phase high-performance liquid chromatography to high-sensitive protein sequence analysis. J. Chromatogr. 599: 119–130.
  • Moritz, R. L., J. Eddes, G. Reid, and R. J. Simpson 1996. S-pyridylethylation of intact polyacrylamide gels and in situ digestion of electrophoretically separated proteins: a rapid mass spectrometric method for identifying cysteine-containing peptides. Electrophoresis 17: 907–917.
  • Muellauer, L., H. Fujita, A. Shizaki, and N. Kuzumaki 1993. Tumor-suppressive function of mutated gelsolin in Ras-transformed cells. Oncogene 8: 2531–2536.
  • Nur-E-Kamal, M. S. A., A. Sizeland, G. D’Abaco, and H. Maruta 1992. Asn26, Glu31, Val45, and Tyr64 of Ras proteins are required for their oncogenicity. J. Biol. Chem. 267: 1415–1418.
  • Pollard, T. D., and J. A. Cooper 1986. Actin and actin-binding proteins. A critical evaluation of mechanisms and function. Annu. Rev. Biochem. 55: 987–1035.
  • Prasad, G., R. Fuldner, and H. Cooper 1993. Expression of transduced tropomyosin 1 cDNA suppresses neoplastic growth of cells transformed by the Ras oncogene. Proc. Natl. Acad. Sci. USA 90: 7039–7043.
  • Qiu, R. G., J. Che, D. Kirn, F. McCormick, and M. Symons 1995. An essential role for Rac in Ras transformation. Nature 374: 457–459.
  • Rodriguez-Viciana, P., P. Warne, A. Khwaja, B. Marte, D. Pappin, P. Das, M. Waterfield, A. Ridley, and J. Downward 1997. Role of PI-3 kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell 89: 457–467.
  • Saez, C. G., J. Myers, T. Shows, and L. Leinward 1990. Human non-muscle II heavy chain mRNA: generation of diversity through alternative polyadenylylation. Proc. Natl. Acad. Sci. USA 87: 1164–1168.
  • Saito, Y., and K. Umezawa 1997. Synthesis of echiguanine analogues and their ribofuranosyl glycosides that inhibit PI-4 kinase. Bioorg. Med. Chem. Lett. 7: 861–864.
  • Sato, N., S. Yonemura, T. Obinata, S. Tsukita, and S. Tsukita 1991. Radixin, an F-actin barbed end-capping protein, is concentrated at the cleavage furrow during cytokinesis. J. Cell Biol. 113: 321–330.
  • Schuuring, E., E. Verhoeven, S. Litvinov, and R. Michalides 1993. The product of the EMS1 gene, amplified in human carcinomas, is homologous to a Src substrate and is localized in cell-substratum contact sites. Mol. Cell. Biol. 13: 2891–2898.
  • Simons, M., M. Wang, O. McBride, S. Kawamoto, K. Yamakawa, D. Gdula, R. S. Adelstein, and L. Weir 1991. Human non-muscle myosin II heavy chains are encoded by two genes located on different chromosomes. Circ. Res. 69: 530–539.
  • Spudich, J. A., and S. Watt 1971. The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of tropomyosin-troponin complex with actin and proteolytic fragments of myosin. J. Biol. Chem. 246: 4866–4871.
  • Takemoto, Y., M. Furuta, X. K. Li, J. Strong-Sparks, and Y. Hashimoto 1995. LchBP/HS1, expressed in hematopoietic lineage cells, directly associates with the SH3 domain of Lck. EMBO J. 14: 3403–3414.
  • Tikoo, A., V. Ramesh, J. Gusella, and H. Maruta 1994. Anti-Ras function of neurofibromatosis type 2 gene product (NF2/Merlin). J. Biol. Chem. 269: 23387–23390.
  • Toothaker, L. E., D. Gonalez, N. Tung, R. Lemons, M. Lebeau, M. Arnaout, L. Clayton, and T. Tenen 1991. Cellular myosin II heavy chain in human leukocytes: isolation of 5′ cDNA clones, characterization of protein, chromosomal localization, and up-regulation during myeloid differentiation. Blood 78: 1826–1833.
  • van Damme, H., V. van Buuren, and E. Schuuring. Unpublished observation.
  • Vandekerckhove, J., G. Bauw, A. Vancompernolle, B. Honore, and J. Celis 1990. Gelsolin as one of the most prominent down-regulated markers of transformed human fibroblast and epithelial cells. J. Cell Biol. 111: 95–102.
  • Walsh, A. B., M. Dhanasekaran, D. Bar-Sagi, and C. C. Kumar 1997. SCH51344-induced reversal of RAS-transformation is accompanied by the specific inhibition of the RAS and RAC-dependent cell morphology pathway. Oncogene 15: 2553–2560.
  • Wang, D. Z. M., M. S. A. Nur-E-Kamal, A. Tikoo, W. Montague, and H. Maruta 1997. The GTPase and Rho GAP domains of p190-A, a tumor suppressor protein that binds the Ras GAP of 120 kDa, independently function as anti-Ras tumor suppressors. Cancer Res. 57: 2478–2484.
  • Weber, K., E. Lazarides, R. Goldman, A. Vogel, and R. Pollack 1974. Localization and distribution of actin fibers in normal, transformed and revertant cells. Cold Spring Harbor Symp. Quant. Biol. 39: 363–369.
  • Wu, H., and T. Parsons 1993. Cortactin, a Src substrate of 80/85 kDa, is an F-actin binding protein enriched in the cell cortex. J. Cell Biol. 120: 1417–1426.
  • Yahara, I., F. Harada, S. Sekita, K. Yoshihira, and S. Natori 1982. Correlation between effects of 24 different cytochalasins on cellular structures and events and those on actin in vitro. J. Cell Biol. 92: 69–78.
  • Yamanashi, Y., M. Okada, T. Semba, T. Yamori, H. Umemori, S. Tsunasawa, K. Toyoshima, D. Kitamura, T. Watanabe, and T. Yamamoto 1993. Identification of HS1 as a major substrate of Tyr kinase(s) upon B-cell antigen receptor-mediated signaling. Proc. Natl. Acad. Sci. USA 90: 3631–3635.
  • Yamanashi, Y., T. Fukuda, H. Nishizumi, T. Ianazu, K. Higashi, D. Kitamura, T. Ishida, H. Yamamura, T. Watanabe, and T. Yamamoto 1997. Role of Tyr phosphorylation of HS1 in B-cell antigen receptor-mediated apoptosis. J. Exp. Med. 185: 1387–1392.
  • Yonezawa, N., Y. Homma, I. Yahara, H. Sakai, and E. Nishida 1991. A short sequence responsible for both PIP2 binding and actin binding activities of cofilin. J. Biol. Chem. 266: 17218–17221.
  • Yu, F. X., H. Q. Sun, P. Janmey, and H. L. Yin 1992. Identification of a PIP2-binding sequence in a G-actin binding domain of gelsolin. J. Biol. Chem. 267: 14616–14621.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.