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Cell Growth and Development

The Mdm2 Oncoprotein Interacts with the Cell Fate Regulator Numb

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Pages 3974-3982 | Received 17 Dec 1997, Accepted 21 Apr 1998, Published online: 28 Mar 2023

REFERENCES

  • Alexandropoulos, K., G. Cheng, and D. Baltimore 1995. Proline-rich sequences that bind to Src homology 3 domains with individual specificities. Proc. Natl. Acad. Sci. USA 92: 3110–3114.
  • Almog, N., and V. Rotter 1997. Involvement of p53 in cell differentiation and development. Biochim. Biophys. Acta 1333: F1–F27.
  • Barak, Y., E. Gottlieb, T. Juven-Gershon, and M. Oren 1994. Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential. Genes Dev. 8: 1739–1749.
  • Barak, Y., T. Juven, R. Haffner, and M. Oren 1993. mdm2 expression is induced by wild type p53 activity. EMBO J. 12: 461–468.
  • Behrens, J., J. P. von Kris, M. Kuhl, L. Bruhn, D. Wedlich, R. Grosschedl, and W. Birchmeier 1996. Functional interaction of beta-catenin with the transcription factor LEF-1. Nature 382: 638–642.
  • Blaikie, P., D. Immanuel, J. Wu, N. Li, V. Yajnik, and B. Margolis 1994. A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors. J. Biol. Chem. 269: 32031–32034.
  • Cahilly-Snyder, L., F. T. Yang, U. Francke, and D. L. George 1987. Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line. Somat. Cell Mol. Genet. 13: 235–244.
  • Chen, C. Y., J. D. Oliner, Q. Zhan, A. J. Fornace, B. Vogelstein, and M. B. Kastan 1994. Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway. Proc. Natl. Acad. Sci. USA 91: 2684–2688.
  • Chen, J., V. Marechal, and A. J. Levine 1993. Mapping of the p53 and mdm-2 interaction domains. Mol. Cell. Biol. 13: 4107–4114.
  • Chen, J., X. Wu, J. Lin, and A. J. Levine 1996. mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol. Cell. Biol. 16: 2445–2452.
  • Cordon-Cardo, C., E. Latres, M. Drobnjak, M. R. Oliva, D. Pollack, J. M. Woodruff, V. Marechal, J. Chen, M. F. Brennan, and A. J. Levine 1994. Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res. 54: 794–799.
  • Corvi, R., L. Savelyeva, S. Breit, A. Wenzel, R. Handgretinger, J. Barak, M. Oren, L. Amler, and M. Schwab 1995. Non-syntenic amplification of MDM2 and MYCN in human neuroblastoma. Oncogene 10: 1081–1086.
  • Dubs-Poterszman, M., B. Tocque, and B. Wasylyk 1995. MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest. Oncogene 11: 2445–2449.
  • Durfee, T., K. Becherer, P. L. Chen, S. H. Yeh, Y. Yang, A. E. Kilburn, W. H. Lee, and S. J. Elledge 1993. The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev. 7: 555–569.
  • Elenbaas, B., M. Dobbelstein, J. Roth, T. Shenk, and A. J. Levine 1996. The MDM2 oncoprotein binds specifically to RNA through its RING finger domain. Mol. Med. 2: 439–451.
  • Fakharzadeh, S. S., S. P. Trusko, and D. L. George 1991. Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line. EMBO J. 10: 1565–1569.
  • Fiddler, T. A., L. Smith, S. J. Tapscott, and M. J. Thayer 1996. Amplification of MDM2 inhibits MyoD-mediated myogenesis. Mol. Cell. Biol. 16: 5048–5057.
  • Finlay, C. A. 1993. The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth. Mol. Cell. Biol. 13: 301–306.
  • Freedman, D. A., C. B. Epstein, J. C. Roth, and A. J. Levine 1997. A genetic approach to mapping the p53 binding site in the MDM2 protein. Mol. Med. 3: 248–259.
  • Frise, E., J. A. Knoblich, S. S. Younger, L. Y. Jan, and Y. N. Jan 1996. The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage. Proc. Natl. Acad. Sci. USA 93: 11925–11932.
  • Guo, M., L. Y. Jan, and Y. N. Jan 1996. Control of daughter cell fates during asymmetric division: interaction of Numb and Notch. Neuron 17: 27–41.
  • Haines, D. S., J. E. Landers, L. J. Engle, and D. L. George 1994. Physical and functional interaction between wild-type p53 and mdm2 proteins. Mol. Cell. Biol. 14: 1171–1178.
  • Harlow, E., and P. Lane 1988. Antibodies: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Harper, J. W., G. R. Adami, N. Wei, K. Keyomarsi, and S. J. Elledge 1993. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75: 805–816.
  • Haupt, Y., Y. Barak, and M. Oren 1996. Cell type-specific inhibition of p53-mediated apoptosis by mdm2. EMBO J. 15: 1596–1606.
  • Haupt, Y., R. Maya, A. Kazaz, and M. Oren 1997. Mdm2 promotes the rapid degradation of p53. Nature 387: 296–299.
  • Heffetz, D., I. Bushkin, R. Dror, and Y. Zick 1990. The insulinomimetic agents H2O2 and vanadate stimulate protein tyrosine phosphorylation in intact cells. J. Biol. Chem. 265: 2896–2902.
  • Honda, R., H. Tanaka, and H. Yasuda 1997. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett. 420: 25–27.
  • Israeli, D., E. Tessler, Y. Haupt, A. Elkeles, S. Wilder, R. Amson, A. Telerman, and M. Oren 1997. A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis. EMBO J. 16: 4384–4392.
  • Jones, S. N., A. E. Roe, L. A. Donehower, and A. Bradley 1995. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 378: 206–208.
  • Juven, T., Y. Barak, A. Zauberman, D. L. George, and M. Oren 1993. Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene. Oncogene 8: 3411–3416.
  • Kavanaugh, W. M., and L. T. Williams 1994. An alternative to SH2 domains for binding tyrosine-phosphorylated proteins. Science 266: 1862–1865.
  • Knoblich, J. A., L. Y. Jan, and Y. N. Jan 1995. Asymmetric segregation of Numb and Prospero during cell division. Nature 377: 624–627.
  • Kubbutat, M. H., S. N. Jones, and K. H. Vousden 1997. Regulation of p53 stability by Mdm2. Nature 387: 299–303.
  • Kussie, P. H., S. Gorina, V. Marechal, B. Elenbaas, J. Moreau, A. J. Levine, and N. P. Pavletich 1996. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science 274: 948–953.
  • Leach, F. S., T. Tokino, P. Meltzer, M. Burrell, J. D. Oliner, S. Smith, D. E. Hill, D. Sidransky, K. W. Kinzler, and B. Vogelstein 1993. p53 Mutation and MDM2 amplification in human soft tissue sarcomas. Cancer Res. 53: 2231–2234.
  • Li, S. C., Z. Songyang, S. J. Vincent, C. Zwahlen, S. Wiley, L. Cantley, L. E. Kay, K. J. Forman, and T. Pawson 1997. High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif. Proc. Natl. Acad. Sci. USA 94: 7204–7209.
  • Lundgren, K., R. Montes de Oca Luna, Y. B. McNeill, E. P. Emerick, B. Spencer, C. R. Barfield, G. Lozano, M. P. Rosenberg, and C. A. Finlay 1997. Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53. Genes Dev. 11: 714–725.
  • Marechal, V., B. Elenbaas, J. Piette, J. C. Nicolas, and A. J. Levine 1994. The ribosomal L5 protein is associated with mdm-2 and mdm-2–p53 complexes. Mol. Cell. Biol. 14: 7414–7420.
  • Martin, K., D. Trouche, C. Hagemeier, T. S. Sorensen, N. B. La Thangue, and T. Kouzarides 1995. Stimulation of E2F/DP1 transcriptional activity by MDM2 oncoprotein. Nature 375: 691–694.
  • Molenaar, M., M. van de Wetering, M. Oosterwegel, M. J. Peterson, S. Godsave, V. Korinek, J. Roose, O. Destree, and H. Clevers 1996. XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. Cell 86: 391–399.
  • Momand, J., and G. P. Zambetti 1997. Mdm-2: “big brother” of p53. J. Cell. Biochem. 64: 343–352.
  • Momand, J., G. P. Zambetti, D. C. Olson, D. George, and A. J. Levine 1992. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69: 1237–1245.
  • Montes de Oca Luna, R., D. S. Wagner, and G. Lozano 1995. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 378: 203–206.
  • Oliner, J. D., K. W. Kinzler, P. S. Meltzer, D. L. George, and B. Vogelstein 1992. Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 358: 80–83.
  • Oliner, J. D., J. A. Pietenpol, S. Thiagalingam, J. Gyuris, K. W. Kinzler, and B. Vogelstein 1993. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature 362: 857–860.
  • Olson, D. C., V. Marechal, J. Momand, J. Chen, C. Romocki, and A. J. Levine 1993. Identification and characterization of multiple mdm-2 proteins and mdm-2–p53 protein complexes. Oncogene 8: 2353–2360.
  • Otto, A., and W. Deppert 1993. Upregulation of mdm-2 expression in Meth A tumor cells tolerating wild-type p53. Oncogene 8: 2591–2603.
  • Perry, M. E., J. Piette, J. A. Zawadzki, D. Harvey, and A. J. Levine 1993. The mdm-2 gene is induced in response to UV light in a p53-dependent manner. Proc. Natl. Acad. Sci. USA 90: 11623–11627.
  • Picksley, S. M., and D. P. Lane 1993. The p53-mdm2 autoregulatory feedback loop: a paradigm for the regulation of growth control by p53? Bioessays 15: 689–690.
  • Picksley, S. M., B. Vojtesek, A. Sparks, and D. P. Lane 1994. Immunochemical analysis of the interaction of p53 with MDM2;--fine mapping of the MDM2 binding site on p53 using synthetic peptides. Oncogene 9: 2523–2529.
  • Piette, J., H. Neel, and V. Marechal 1997. Mdm2: keeping p53 under control. Oncogene 15: 1001–1010.
  • Pomerantz, J., N. Schreiber-Agus, N. Liegeois, A. Silverman, L. Alland, L. Chin, J. Potes, K. Chen, I. Orlow, H.-W. Lee, C. Cordon-Cardo, and R. A. DePinho 1998. The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2’s inhibition of p53. Cell 92: 713–723.
  • Reifenberger, G., L. Liu, K. Ichimura, E. E. Schmidt, and V. P. Collins 1993. Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res. 53: 2736–2739.
  • Rhyu, M. S., L. Y. Jan, and Y. N. Jan 1994. Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells. Cell 76: 477–491.
  • Roth, J., M. Dobbelstein, D. A. Freedman, and A. J. Levine 1998. Nucleocytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein. EMBO J. 17: 554–564.
  • Salcini, A. E., S. Confalonieri, M. Doria, E. Santolini, E. Tassi, O. Minenkova, G. Cesareni, P. G. Pelicci, and F. P. Di 1997. Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. Genes Dev. 11: 2239–2249.
  • Shaulian, E., D. Reznitzky, O. Shifman, G. Blandino, A. Amsterdam, A. Yayon, and M. Oren 1997. Induction of Mdm2 and enhancement of cell survival by bFGF. Oncogene 15: 2717–2725.
  • Sherrington, R., E. I. Rogaev, Y. Liang, E. A. Rogaeva, G. Levesque, M. Ikeda, H. Chi, C. Lin, G. Li, K. Holman, et al. 1995. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer’s disease. Nature 375: 754–760.
  • Shifman, O., T. Juven-Gershon, and M. Oren. Unpublished results.
  • Sigalas, I., A. H. Calvert, J. J. Anderson, D. E. Neal, and J. Lunec 1996. Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer. Nat. Med. 2: 912–917.
  • Songyang, Z., B. Margolis, M. Chaudhuri, S. E. Shoelson, and L. C. Cantley 1995. The phosphotyrosine interaction domain of SHC recognizes tyrosine phosphorylated NPXY motif. J. Biol. Chem. 270: 14863–14866.
  • Thut, C. J., J. A. Goodrich, and R. Tjian 1997. Repression of p53-mediated transcription by MDM2: a dual mechanism. Genes Dev. 11: 1974–1986.
  • Uemura, T., S. Shepherd, L. Ackerman, L. Y. Jan, and Y. N. Jan 1989. numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos. Cell 58: 349–360.
  • Verdi, J. M., R. Schmandt, A. Bashirullah, S. Jacob, R. Salvino, C. G. Craig, A. E. Program, H. D. Lipshitz, and C. J. McGlade 1996. Mammalian NUMB is an evolutionarily conserved signaling adapter protein that specifies cell fate. Curr. Biol. 6: 1134–1145.
  • Wu, X., J. H. Bayle, D. Olson, and A. J. Levine 1993. The p53-mdm-2 autoregulatory feedback loop. Genes Dev. 7: 1126–1132.
  • Xiao, Z., J. Chen, A. J. Levine, N. Modjtahedi, J. Xing, W. R. Sellers, and D. M. Livingston 1995. Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature 375: 694–698.
  • Zauberman, A., D. Flusberg, Y. Haupt, Y. Barak, and M. Oren 1995. A functional p53-responsive intronic promoter is contained within the human mdm2 gene. Nucleic Acids Res. 23: 2584–2592.
  • Zhang, Y., Y. Xiong, and W. G. Yarbrough 1998. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92: 725–734.
  • Zhong, W., J. N. Feder, M. Jiang, L. Y. Jan, and Y. N. Jan 1996. Assymetric localization of a mammalian Numb homolog during mouse cortical neurogenesis. Neuron 17: 43–53.

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