REFERENCES
- Beitel, G., S. Clark, and H. R. Horvitz 1990. The Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction. Nature 348: 503–509.
- Beitel, G. J., S. Tuck, I. S. Greenwald, and R. H. Horvitz 1995. The C. elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway. Genes Dev. 9: 3149–3162.
- Brenner, S. 1974. The genetics of Caenorhabditis elegans. Genetics 77: 71–94.
- Chamberlin, H. M., and P. W. Sternberg 1994. The lin-3/let-23 pathway mediates inductive signaling during male spicule development in Caenorhabditis elegans. Development 120: 2713–2721.
- Church, D. L., K.-L. Guan, and E. J. Lambie 1995. mek-2, mpk-1/sur-1 and let-60 ras are required for meiotic cell cycle progression in C. elegans. Development 121: 2525–2535.
- Edgar, L. Personal communication.
- Feig, L. A., and G. M. Cooper 1988. Inhibition of NIH 3T3 cell proliferation by a mutant Ras protein with preferential affinity for GDP. Mol. Cell. Biol. 8: 3235–3243.
- Ferguson, E., and H. R. Horvitz 1985. Identification and characterization of 22 genes that affect the vulval cell lineages of Caenorhabditis elegans. Genetics 110: 17–72.
- Ferguson, E., and H. R. Horvitz 1989. The multivulva phenotype of certain C. elegans mutants results from defects in two functionally-redundant pathways. Genetics 123: 109–121.
- Fire, A., J. Ahnn, G. Seydoux, and S. Xu. Personal communication.
- Han, M., R. Aroian, and P. W. Sternberg 1990. The let-60 locus controls the switch between vulval and non-vulval cell types in C. elegans. Genetics 126: 899–913.
- Han, M., A. Golden, Y. Han, and P. W. Sternberg 1993. C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation. Nature 363: 133–140.
- Han, M., and P. W. Sternberg 1991. Analysis of dominant-negative mutations of the Caenorhabditis elegans let-60 ras gene. Genes Dev. 5: 2188–2198.
- Han, M., and P. W. Sternberg 1990. let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a Ras protein. Cell 63: 921–931.
- Hara, M., and M. Han 1995. Ras farnesyltransferase inhibitors suppress the phenotype resulting from an activated Ras mutation in Caenorhabditis elegans. Proc. Natl. Acad. Aci. USA 92: 3333–3337.
- Jongeward, G. D., T. R. Clandinin, and P. W. Sternberg 1995. sli-1, a negative regulator of let-23-mediated signaling in C. elegans. Genetics 139: 1553–1566.
- Jung, V., W. Wei, R. Ballester, J. Camonis, S. Mi, L. Van Aelst, M. Wigler, and D. Broek 1994. Two types of RAS mutants that dominantly interfere with activators of RAS. Mol. Cell. Biol. 14: 3707–3718.
- Khramtsov, N. V. 1996. The putative acetyl-CoA synthetase of Cryptosporidium parvum and a new conserved protein motif in acetyl-CoA sythetases. J. Parasitol. 82: 423–427.
- Kornfeld, K. 1997. Vulval development in Caenorhabditis elegans. Trends Genet. 13: 55–61.
- Kornfeld, K., D. B. Hom, and H. R. Horvitz 1995. The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in Caenorhabditis elegans. Cell 83: 902–913.
- Lee, J. G., G. Jongeward, and P. W. Sternberg 1994. The C. elegans unc-101 gene, required for development and behavior, encodes a clathrin-associated protein. Genes Dev. 8: 60–73.
- Maduro, M., and D. Pilgrim 1995. Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system. Genetics 141: 977–988.
- Mello, C. C., J. M. Kramer, D. Stinchcomb, and V. Ambros 1991. Efficient gene transfer in C. elegans after microinjection of DNA into germline cytoplasm: recombination drives the assembly of heritable transgenic structures. EMBO J. 10: 3959–3970.
- Powers, S., K. O’Neill, and M. Wigler 1989. Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae. Mol. Cell. Biol. 9: 390–395.
- Riddle, D. L., T. Blumenthal, B. J. Meyer, and J. R. Priess 1997. C. elegans II. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
- Saraste, M., P. R. Sibbald, and A. Wittinghofer 1990. The P-loop- a common motif in ATP- and GTP-binding proteins. Trends Biochem. Sci. 15: 430–434.
- Savage, C., M. Hamelin, J. G. Culotti, A. Coulson, D. G. Albertson, and M. Chalfie 1989. mec-7 is a β-tubulin gene required for te production of 15-protofilament microtubules in Caenorhabditis elegans. Genes Dev. 3: 870–881.
- Schroder, J. 1989. Protein sequence homology between plant 4-coumarate: CoA ligase and firefly luciferase. Nucleic Acids Res. 17: 460.
- Sigal, I. S., J. B. Gibbs, J. S. D’Alonzo, G. L. Temeles, B. S. Wolanski, S. H. Socher, and E. M. Scolnick 1986. Mutant ras-encoded proteins with altered nucleotide binding exert dominant biological effects. Proc. Natl. Acad. Sci. USA 83: 952–956.
- Smith, D. J., E. A. J., and G. Turner 1990. The multifunctional peptide synthetase performing the first step of penicillin biosynthesis in Penicillium chrysogenum is a 421,073 dalton protein similiar to Bacillus brevis peptide antibiotic synthetases. EMBO J. 9: 2743–2752.
- Sundaram, M., and I. Greenwald 1993. Genetic and phenotypic studies of hypomorphic lin-12 mutants in Caenorhabditis elegans. Genetics 135: 755–763.
- Sundaram, M., and M. Han 1995. The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction. Cell 83: 889–901.
- Sundaram, M., and M. Han 1996. Control and integration of cell signaling pathways during C. elegans vulval development. Bioessays 18: 473–479.
- Sundaram, M., J. Yochem, and M. Han 1996. A Ras-mediated signal transduction pathway is involved in the control of sex myoblast migration in Caenorhabditis elegans. Development 122: 2823–2833.
- Turgay, K., M. Krause, and M. A. Marahiel 1992. Four homologous domains in the primary structure of GrsB are related in a superfamily of adenylate-forming enzymes. Mol. Microbiol. 6: 529–546.
- Walker, J. E., M. Saraste, M. J. Runswick, and N. J. Gay 1982. Distantly related sequences and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO J. 1: 945–951.
- Wittinghofer, F. 1992. Three-dimensional structure of p21H-ras and its implications. Cancer Biol. 3: 189–198.
- Wu, Y., and M. Han 1994. Suppression of activated Let-60 Ras protein defines a role of Caenorhabditis elegans sur-1 MAP kinase in vulval differentiation. Genes Dev. 8: 147–159.
- Yochem, J., T. Gu, and M. Han. A new marker for mosaic analysis in C. elegans indicates a fusion between hyp6 and hyp7, two major components of the hypodermis. Genetics, in press.
- Yochem, J., M. Sundaram, and M. Han 1997. Ras is required for a limited number of cell fates and not for general proliferation in Caenorhabditis elegans. Mol. Cell. Biol. 17: 2716–2722.