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Gene Expression

A New 34-Kilodalton Isoform of Human Fibroblast Growth Factor 2 Is Cap Dependently Synthesized by Using a Non-AUG Start Codon and Behaves as a Survival Factor

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Pages 505-514 | Received 30 Jul 1998, Accepted 15 Oct 1998, Published online: 28 Mar 2023

REFERENCES

  • Amalric, F., V. Baldin, I. Bosc-Bierne, G. Bouche, B. Bugler, B. Couderc, H. Prats, A. M. Roman 1991. Nuclear translocation of basic fibroblast growth factor. Academic Press, New York, N.Y.
  • Baldin, V., A. M. Roman, I. Bosc-Bierne, F. Amalric, and J. Bouche 1990. Translocation of bFGF to the nucleus is G1 phase cell cycle specific in bovine aortic endothelial cells. EMBO J. 9:1511–1517.
  • Bensaid, M., F. Malecaze, H. Prats, F. Bayard, and J. Tauber 1989. Autocrine regulation of bovine retinal capillary endothelial cells (BREC) proliferation by BREC derived fibroblast growth factor. Exp. Eye Res. 45:801–813.
  • Berlioz, C., and J. Darlix 1995. An internal ribosomal entry mechanism promotes translation of murine leukemia virus Gag polyprotein precursors. J. Virol. 69:2214–2222.
  • Bernstein, J., O. Sella, S. Y. Le, and J. Elroy-Stein 1997. PDGF2/c-sis mRNA leader contains a differentiation-linked internal ribosome entry site (D-IRES). J. Biol. Chem. 272:9356–9362.
  • Bieth, E. Unpublished results.
  • Bikfalvi, A., S. Klein, G. Pintucci, N. Quarto, P. Mignatti, and J. Rifkin 1995. Differential modulation of cell phenotype by different molecular weight forms of basic fibroblast growth factor: possible intracellular signaling by the high molecular weight forms. J. Cell Biol. 129:233–243.
  • Bost, L. M., and J. Hjelmeland 1993. Cell density regulates differential production of bFGF transcripts. Growth Factors 9:195–203.
  • Bouvet, P., J. J. Diaz, K. Kindbeiter, J. J. Madjar, and J. Amalric 1998. Nucleolin interacts with several ribosomal proteins through its RGG domain. J. Biol. Chem. 273:19025–19029.
  • Brigstock, D. R., J. Sasse, and J. Klagsbrun 1991. Subcellular distribution of basic fibroblast growth factor in human hepatoma cells. Growth Factors 4:189–196.
  • Bugler, B., F. Amalric, and J. Prats 1991. Alternative initiation of translation determines cytoplasmic or nuclear localization of basic fibroblast growth factor. Mol. Cell. Biol. 11:573–577.
  • Coffin, J. D., R. Z. Florkiewicz, J. Neumann, T. Mort-Hopkins, G. W. Dorn II, P. Lightfoot, R. German, P. N. Howles, A. Kier, B. A. O’Toole et al.. 1995. Abnormal bone growth and selective translational regulation in basic fibroblast growth factor (FGF-2) transgenic mice. Mol. Biol. Cell 6:1861–1973.
  • Corbin, A., A. C. Prats, J. L. Darlix, and J. Sitbon 1994. A nonstructural gag-encoded glycoprotein precursor is necessary for efficient spreading and pathogenesis of murine leukemia viruses. J. Virol. 68:3857–3867.
  • Couderc, B., H. Prats, F. Bayard, and J. Amalric 1991. Potential oncogenic effects of basic fibroblast growth factor requires cooperation between CUG and AUG-initiated forms. Cell Regul. 2:709–718.
  • Davis, M. G., M. Zhou, S. Ali, J. D. Coffin, T. Doetschman, G. W. Dorn II.. 1997. Intracrine and autocrine effects of basic fibroblast growth factor in vascular smooth muscle cells. J. Mol. Cell. Cardiol. 29:1061–1072.
  • Florkiewicz, R. Z., and J. Sommer 1989. Human basic fibroblast growth factor gene encodes four polypeptides: three initiate translation from non-AUG codons. Proc. Natl. Acad. Sci. USA 86:3978–3981.
  • Galy, B., et al. Submitted for publication.
  • Gan, W., and J. Rhoads 1996. Internal initiation of translation directed by the 5′ untranslated region of the mRNA for eIF4G, a factor involved in the picornavirus-induced switch from cap-dependent to internal initiation. J. Biol. Chem. 271:623–626.
  • Görlich, D. 1998. Transport into and out of the cell nucleus. EMBO J. 17:2721–2727.
  • Hann, S. R., M. Dixit, R. C. Sears, and J. Sealy 1994. The alternatively initiated c-Myc proteins differentially regulate transcription through a noncanonical DNA-binding site. Genes Dev. 8:2441–2452.
  • Hann, S. R., M. W. King, D. L. Bentley, C. W. Anderson, and J. Eisenman 1988. A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt’s lymphomas. Cell 52:185–195.
  • Harlow, E., D. Lane 1988. Antibodies, a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Henderson, B. R., and J. Percipalle 1997. Interactions between HIV Rev and nuclear import and export factors: the rev nuclear localisation signal mediates specific binding to human importin β. J. Mol. Biol. 274:693–707.
  • Hoshikawa, M., N. Ohbayashi, A. Yonamine, M. Konishi, K. Ozaki, S. Fukui, and J. Itoh 1998. Structure and expression of a novel fibroblast growth factor, FGF-17, preferentially expressed in the embryonic brain. Biochem. Biophys. Res. Commun. 244:187–191.
  • Jackson, R. J. 1991. Initiation without an end. Nature (London) 353:14–15.
  • Kalderon, D., B. L. Roberts, W. D. Richardson, and J. Smith 1984. A short amino acid sequence able to specify nuclear location. Cell 39:499–509.
  • Kandel, J., E. Bossy-Wetzel, F. Radvanyi, M. Klagsbrun, J. Folkman, and J. Hanahan 1991. Neovascularisation is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma. Cell 66:1095–1104.
  • Kerekatte, V., K. Smiley, B. Hu, A. Smith, F. Gelder, and J. Benedetti 1995. The proto-oncogene/translation factor eIF-4E: a survey of its expression in breast carcinomas. Int. J. Cancer 64:27–31.
  • Kevil, C., P. Carter, B. Hu, and J. DeBenedetti 1995. Translational enhancement of FGF-2 by eIF-4 factors, and alternate utilization of CUG and AUG codons for translation initiation. Oncogene 11:2239–2348.
  • Kozak, M. 1987. Effects of intercistronic length on the efficiency of reinitiation by eucaryotic ribosomes. Mol. Cell. Biol. 7:3438–3445.
  • Kozak, M. 1989. The scanning model for translation: an update. J. Cell Biol. 108:229–241.
  • Macejak, D. J., and J. Sarnow 1991. Internal initiation of translation mediated by the 5′ leader of a cellular mRNA. Nature (London) 353:90–94.
  • Maret, A., B. Galy, E. Arnaud, F. Bayard, and J. Prats 1995. Inhibition of fibroblast growth factor 2 expression by antisense RNA induced a loss of the transformed phenotype in a human hepatoma cell line. Cancer Res. 55:5075–5079.
  • Mason, I. J. 1994. The ins and outs of fibroblast growth factors. Cell 78:547–552.
  • Mignatti, P., T. Morimoto, and J. Rifkin 1991. Basic fibroblast growth factor (bFGF) released by single isolated cells stimulates their migration in an autocrine manner. Proc. Natl. Acad. Sci. USA 88:11007–11011.
  • Mignatti, P., T. Morimoto, and J. Rifkin 1992. Basic fibroblast growth factor, a protein devoid of secretory signal sequence, is released by cells via a pathway independent of the endoplasmic reticulum-Golgi complex. J. Cell. Physiol. 151:81–93.
  • Miyake, A., M. Konishi, F. Martin, N. Hernday, K. Ozaki, S. Yamamoto, T. Mikami, T. Arakawa, and J. Itoh 1998. Structure and expression of a novel member, FGF-16, of the fibroblast growth factor family. Biochem. Biophys. Res. Commun. 243:148–152.
  • Nanbru, C., I. Lafon, S. Audigier, M. C. Gensac, S. Vagner, G. Huez, and J. Prats 1997. Alternative translation of the proto-oncogene c-myc by an internal ribosome entry site (IRES). J. Biol. Chem. 272:32061–32066.
  • Patry, V., E. Arnaud, F. Amalric, and J. Prats 1994. Involvement of basic fibroblast growth factor NH2 terminus in nuclear accumulation. Growth Factors 11:163–174.
  • Patry, V., B. Bugler, F. Amalric, J. C. Promé, and J. Prats 1994. Purification and characterization of the 210-amino acid recombinant basic fibroblast growth factor form (FGF-2). FEBS Lett. 349:23–28.
  • Prats, A. C., G. De Billy, P. Wang, and J. Darlix 1989. CUG initiation codon used for the synthesis of a cell surface antigen coded by the murine leukemia virus. J. Mol. Biol. 205:363–372.
  • Prats, A. C., S. Vagner, H. Prats, and J. Amalric 1992. cis-acting elements involved in the alternative translation initiation process of human basic fibroblast growth factor. Mol. Cell. Biol. 12:4796–4805.
  • Prats, H., M. Kaghad, A. C. Prats, M. Klagsbrun, J. M. Lélias, P. Liauzun, P. Chalon, J. P. Tauber, F. Amalric, J. A. Smith, and J. Caput 1989. High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons. Proc. Natl. Acad. Sci. USA 86:1836–1840.
  • Quarto, N., D. Talarico, R. Florkiewicz, and J. Rifkin 1991. Selective expression of high molecular weight basic fibroblast growth factor confers a unique phenotype to NIH 3T3 cells. Cell Regul. 2:699–708.
  • Ramackers, A. Unpublished results.
  • Seed, B., and J. Sheen 1988. A simple phase-extraction assay for chloramphenicol acyltransferase activity. Gene 67:271–277.
  • Shibata, F., A. Baird, and J. Florkiewicz 1991. Functional characterization of the human basic fibroblast growth factor gene promoter. Growth Factors 4:277–287.
  • Smallwood, P. M., I. Munoz-Sanjuan, P. Tong, J. P. Macke, S. H. C. Hendry, D. J. Gilbert, N. G. Copeland, N. A. Jenkins, and J. Nathans 1996. Fibroblast growth factor (FGF) homologous factors: new members of the FGF family in nervous system development. Proc. Natl. Acad. Sci. USA 93:9850–9857.
  • Teerink, H., H. O. Voorma, and J. Thomas 1995. The human insulin-like growth factor II leader 1 contains an internal ribosomal entry site. Biochim. Biophys. Acta 1264:403–408.
  • Touriol, C. Unpublished results.
  • Vagner, S., M. C. Gensac, A. Maret, F. Bayard, F. Amalric, H. Prats, and J. Prats 1995. Alternative translation of human fibroblast growth factor 2 mRNA occurs by internal entry of ribosomes. Mol. Cell. Biol. 15:35–44.
  • Vagner, S., C. Touriol, B. Galy, S. Audigier, M. C. Gensac, F. Amalric, F. Bayard, H. Prats, and J. Prats 1996. Translation of CUG- but not AUG-initiated forms of human fibroblast growth factor 2 is activated in transformed and stressed cells. J. Cell Biol. 135:1391–1402.
  • Vagner, S., A. Waysbort, M. Marenda, M. C. Gensac, F. Amalric, and J. Prats 1995. Alternative translation initiation of the Moloney murine leukemia virus mRNA controlled by internal ribosome entry involving the p57/PTB splicing factor. J. Biol. Chem. 270:20376–20383.
  • Wagner, J. A. 1991. The fibroblasts growth factors: an emerging family of neural growth factors. Curr. Top. Microbiol. Immunol. 165:95–118.
  • Weich, H. A., N. Iberg, M. Klagsbrun, and J. Folkman 1990. Expression of acidic and basic fibroblast growth factors in human and bovine vascular smooth muscle cells. Growth Factors 2:313–320.
  • Yamaguchi, T. P., and J. Rossant 1995. Fibroblast growth factors in mammalian development. Curr. Opin. Genet. Dev. 5:485–491.
  • Yanagisawa-Miwa, A., Y. Uchida, F. Nakamura, T. Tomaru, H. Kido, T. Kamijo, T. Sugimoto, K. Kaji, M. Utsuyama, C. Kurashima, and J. Ito 1992. Salvage of infarcted myocardium by angiogenic action of basic fibroblast growth factor. Science 257:1401–1403.
  • Yayon, A., M. Klagsbrun, J. D. Esko, P. Leder, and J. Ornitz 1991. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell 64:841–848.

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