Coactivator PC4 Mediates AP-2 Transcriptional Activity and Suppresses ras-Induced Transformation Dependent on AP-2 Transcriptional Interference

REFERENCES

• Bohm, M., H. Kirch, T. Otto, H. Rubben, and J. Wieland 1997. Deletion analysis at the DEL-27, APC and MTS1 loci in bladder cancer: LOH at the DEL-27 locus on 5p13-12 is a prognostic marker of tumor progression. Int. J. Cancer 74:291–295.
   PubMedGoogle Scholar
• Bosher, J. M., T. Williams, and J. Hurst 1995. The developmentally regulated transcription factor AP-2 is involved in c-erbB-2 overexpression in human mammary carcinoma. Proc. Natl. Acad. Sci. USA 92:744–747.
   PubMed Web of Science ®Google Scholar
• Buettner, R., P. Kannan, A. Imhof, R. Bauer, S. O. Yim, R. Glockshuber, M. W. Van Dyke, and J. Tainsky 1993. An alternatively spliced mRNA from the AP-2 gene encodes a negative regulator of transcriptional activation by AP-2. Mol. Cell. Biol. 13:4174–4185.
   PubMedGoogle Scholar
• Chiang, C. M., H. Ge, Z. Wang, A. Hoffmann, and J. Roeder 1993. Unique TATA-binding protein-containing complexes and cofactors involved in transcription by RNA polymerases II and III. EMBO J. 12:2749–2762.
   PubMed Web of Science ®Google Scholar
• Chiu, R., M. Imagawa, R. J. Imbra, J. R. Bockoven, and J. Karin 1987. Multiple cis- and trans-acting elements mediate the transcriptional response to phorbol esters. Nature 329:648–651.
   PubMed Web of Science ®Google Scholar
• Dignam, J. D., R. M. Lebovitz, and J. Roeder 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475–1489.
   PubMed Web of Science ®Google Scholar
• Flanagan, P. M., R. J. D. Kelleher, M. H. Sayre, H. Tschochner, and J. Kornberg 1983. Mediator required for activation of RNA polymerase II transcription in vitro. Nature 350:436–438.
   Google Scholar
• Ge, H., and J. Roeder 1994. Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes. Cell 78:513–523.
   PubMedGoogle Scholar
• Ge, H., Y. Zhao, B. T. Chait, and J. Roeder 1994. Phosphorylation negatively regulates the function of coactivator PC4. Proc. Natl. Acad. Sci. USA 91:12691–12695.
   PubMedGoogle Scholar
• Gill, G., and J. Ptashne 1988. Negative effect of the transcriptional activator GAL4. Nature 334:721–724.
   PubMed Web of Science ®Google Scholar
• Hollywood, D. P., and J. Hurst 1993. A novel transcription factor, OB2-1, is required for overexpression of the proto-oncogene c-erbB-2 in mammary tumour lines. EMBO J. 12:2369–2375.
   PubMed Web of Science ®Google Scholar
• Hyman, S. E., M. Comb, J. Pearlberg, and J. Goodman 1989. An AP-2 element acts synergistically with the cyclic AMP- and phorbol ester-inducible enhancer of the human proenkephalin gene. Mol. Cell. Biol. 9:321–324.
   PubMedGoogle Scholar
• Imagawa, M., R. Chiu, and J. Karin 1987. Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP. Cell 51:251–260.
   PubMed Web of Science ®Google Scholar
• Kaiser, K., G. Stelzer, and J. Meisterernst 1995. The coactivator p15 (PC4) initiates transcriptional activation during TFIIA-TFIID-promoter complex formation. EMBO J. 14:3520–3527.
   PubMedGoogle Scholar
• Kannan, P., R. Buettner, P. J. Chiao, S. O. Yim, M. Sarkiss, and J. Tainsky 1994. N-ras oncogene causes AP-2 transcriptional self-interference, which leads to transformation. Genes Dev. 8:1258–1269.
   PubMedGoogle Scholar
• Kannan, P., and M. A. Tainsky. Unpublished data.
   Google Scholar
• Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680–685.
   PubMed Web of Science ®Google Scholar
• Luckow, B., and J. Schutz 1987. CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements. Nucleic Acids Res. 15:5490.
   PubMed Web of Science ®Google Scholar
• Luscher, B., P. J. Mitchell, T. Williams, and J. Tjian 1989. Regulation of transcription factor AP-2 by the morphogen retinoic acid and by second messengers. Genes Dev. 3:1507–1517.
   PubMedGoogle Scholar
• Malik, S., M. Guermah, and J. Roeder 1998. A dynamic model for PC4 coactivator function in RNA polymerase II transcription. Proc. Natl. Acad. Sci. USA 95:2192–2197.
   PubMedGoogle Scholar
• McPherson, L. A., V. R. Baichwal, and J. Weigel 1997. Identification of ERF-1 as a member of the AP2 transcription factor family. Proc. Natl. Acad. Sci. USA 94:4342–4347.
   PubMedGoogle Scholar
• Meyer, M. E., H. Gronemeyer, B. Turcotte, M. T. Bocquel, D. Tasset, and J. Chambon 1989. Steroid hormone receptors compete for factors that mediate their enhancer function. Cell 57:433–442.
   PubMed Web of Science ®Google Scholar
• Mitchell, P. J., P. M. Timmons, J. M. Hebert, P. W. Rigby, and J. Tjian 1991. Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis. Genes Dev. 5:105–119.
   PubMed Web of Science ®Google Scholar
• Prywes, R., and J. Zhu 1992. In vitro squelching of activated transcription by serum response factor: evidence for a common coactivator used by multiple transcriptional activators. Nucleic Acids Res. 20:513–520.
   PubMedGoogle Scholar
• Ptashne, M. 1988. How eukaryotic transcriptional activators work. Nature 335:683–689.
   PubMed Web of Science ®Google Scholar
• Sadowski, I., J. Ma, S. Triezenberg, and J. Ptashne 1988. GAL4-VP16 is an unusually potent transcriptional activator. Nature 335:563–564.
   PubMed Web of Science ®Google Scholar
• Sawardogo, M., and J. Roeder 1985. Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region. Cell 43:165–175.
   PubMedGoogle Scholar
• Smith, D. B., and J. Concoran 1991. Unit 16-7 Current protocols in molecular biology In F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidmen, J. A. Smith, K. Struhl (ed.), 2:1–8 Green Publishing Associates and Wiley Interscience, New York, N.Y.
   Google Scholar
• Tainsky, M. A., D. B. Krizman, P. J. Chiao, S. O. Yim, and J. Giovanella 1988. PA-1, a human cell model for multistage carcinogenesis: oncogenes and other factors. Anticancer Res. 8:899–913.
   PubMedGoogle Scholar
• Tainsky, M. A., C. S. Cooper, B. C. Giovanella, and J. Vande Woude 1984. An activated rasN gene: detected in late but not early passage human PA1 teratocarcinoma cells. Science 225:643–645.
   PubMedGoogle Scholar
• Wang, J. C., and J. Van Dyke 1994. Sp1, USF, and GAL4 activate transcription independently of TFIID-downstream promoter interactions. Biochim. Biophys. Acta 1218:308–314.
   PubMedGoogle Scholar
• Wieland, I., M. Bohm, K. C. Arden, T. Ammermuller, S. Bogatz, C. S. Viars, and J. Rajewsky 1996. Allelic deletion mapping on chromosome 5 in human carcinomas. Oncogene 12:97–102.
   PubMed Web of Science ®Google Scholar
• Williams, T., A. Admon, B. Luscher, and J. Tjian 1988. Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements. Genes Dev. 2:1557–1569.
   PubMed Web of Science ®Google Scholar
• Williams, T., and J. Tjian 1991. Analysis of the DNA-binding and activation properties of the human transcription factor AP-2. Genes Dev. 5:670–682.
   PubMed Web of Science ®Google Scholar
• Zeuthen, J., J. D. R. Norgaard, P. Avner, M. Fellows, J. Wartiovaara, A. Vaheri, J. Rosen, and J. Giovanella 1980. Characterization of a human ovarian teratocarcinoma-derived cell line. Int. J. Cancer 25:19–32.
   PubMedGoogle Scholar
• Zhu, H., V. Joliot, and J. Prywes 1994. Role of transcription factor TFIIF in serum response factor-activated transcription. J. Biol. Chem. 269:3489–3497.
   PubMedGoogle Scholar