11
Views
95
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Dependence of Dbl and Dbs Transformation on MEK and NF-κB Activation

, , , , , , , , & show all
Pages 7759-7770 | Received 17 Jun 1999, Accepted 21 Jul 1999, Published online: 28 Mar 2023

REFERENCES

  • Albanese, C., J. Johnson, G. Watanabe, N. Eklund, D. Vu, A. Arnold, and J. Pestell 1995. Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions. J. Biol. Chem. 270:23589–23597.
  • Baldwin, A. Unpublished observation.
  • Boguski, M. S., and J. McCormick 1993. Proteins regulating Ras and its relatives. Nature 366:643–654.
  • Bourne, H. R., D. A. Sanders, and J. McCormick 1990. The GTPase superfamily: a conserved switch for diverse cell functions. Nature 348:125–132.
  • Cerione, R. A., and J. Zheng 1996. The Dbl family of oncogenes. Curr. Opin. Cell Biol. 8:216–222.
  • Chardin, P., P. Boquet, P. Madaule, M. R. Popoff, E. J. Rubin, and J. Gill 1989. The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells. EMBO J. 8:1087–1092.
  • Clark, G. J., A. D. Cox, S. M. Graham, and J. Der 1995. Biological assays for Ras transformation. Methods Enzymol. 255:395–412.
  • Clark, G. J., J. K. Westwick, and J. Der 1997. p120 GAP modulates Ras activation of Jun kinases and transformation. J. Biol. Chem. 272:1677–1681.
  • Coso, O. A., M. Chiariello, J.-C. Yu, H. Teramoto, P. Crespo, N. Xu, T. Miki, and J. Gutkind 1995. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81:1137–1146.
  • Cowley, S., H. Paterson, P. Kemp, and J. Marshall 1994. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77:841–852.
  • Crespo, P., X. R. Bustelo, D. S. Aaronson, O. A. Coso, M. Lopez-Barahona, M. Barbacid, and J. Gutkind 1996. Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav. Oncogene 13:455–460.
  • DeSilva, D. R., E. A. Jones, M. F. Favata, B. D. Jaffee, R. L. Magolda, J. M. Trzaskos, and J. Scherle 1998. Inhibition of mitogen-activated protein kinase kinase blocks T cell proliferation but does not induce or prevent anergy. J. Immunol. 160:4175–4181.
  • Favata, M. F., K. Y. Horiuchi, E. J. Manos, A. J. Daulerio, D. A. Stradley, W. S. Feeser, D. E. Van Dyk, W. J. Pitts, R. A. Earl, F. Hobbs, R. A. Copeland, R. L. Magolda, P. A. Scherle, and J. Trzaskos 1998. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J. Biol. Chem. 273:18623–18632.
  • Finco, T. S., J. K. Westwick, J. L. Norris, A. A. Beg, C. J. Der, A. S. Baldwin Jr.. 1997. Oncogenic Ha-Ras-induced signaling activates NF-κB transcriptional activity, which is required for cellular transformation. J. Biol. Chem. 272:24113–24116.
  • Galang, C. K., J. J. García-Ramírez, P. A. Solski, J. K. Westwick, C. J. Der, N. N. Neznanov, R. G. Oshima, and J. Hauser 1996. Oncogenic Neu/ErbB-2 increases Ets, AP-1 and NF-κB-dependent gene expression, and inhibiting Ets activation blocks Neu-mediated cellular transformation. J. Biol. Chem. 271:7992–7998.
  • Glaven, J. A., I. P. Whitehead, T. Nomanbhoy, R. Kay, and J. Cerione 1996. Lfc and Lsc oncoproteins represent two new guanine nucleotide exchange factors for the Rho GTP-binding protein. J. Biol. Chem. 271:27374–27381.
  • Habets, G. G. M., E. H. M. Scholtes, D. Zuydgeest, R. A. van der Kammen, J. C. Stam, A. Berns, and J. Collard 1994. Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins. Cell 77:537–549.
  • Hall, A. 1993. Ras-related proteins. Curr. Biol. 5:265–268.
  • Han, J., K. Luby-Phelps, B. Das, X. Shu, Y. Xia, R. D. Mosteller, U. M. Krishna, J. R. Falck, M. A. White, and J. Broek 1998. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science 279:558–560.
  • Hart, M. J., A. Eva, T. Evans, S. A. Aaronson, and J. Cerione 1991. Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product. Nature 354:311–314.
  • Hauser, C. A., J. K. Westwick, and J. Quilliam 1995. Ras-mediated transcription activation: analysis by transient cotransfection assays. Methods Enzymol. 255:412–426.
  • Hill, C. S., J. Wynne, and J. Treisman 1995. The Rho family GTPases RhoA, Rac1 and Cdc42Hs regulate transcriptional activation by SRF. Cell 81:1159–1170.
  • Horii, Y., J. F. Beeler, K. Sakaguchi, M. Tachibana, and J. Miki 1994. A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways. EMBO J. 13:4776–4786.
  • Kahn, R. A., C. J. Der, and J. Bokoch 1992. The Ras superfamily of GTP-binding proteins: guidelines on nomenclature. FASEB J. 6:2512–2513.
  • Khosravi-Far, R., M. Chrzanowska-Wodnicka, P. A. Solski, A. Eva, K. Burridge, and J. Der 1994. Vav and Dbl mediate transformation via Ras-independent mitogen activated protein kinase activation. Mol. Cell. Biol. 14:6848–6857.
  • Khosravi-Far, R., P. A. Solski, M. S. Kinch, K. Burridge, and J. Der 1995. Activation of Rac and Rho, and mitogen activated protein kinases, are required for Ras transformation. Mol. Cell. Biol. 15:6443–6453.
  • Khosravi-Far, R., M. A. White, J. K. Westwick, P. A. Solski, M. Chrzanowska-Wodnicka, L. Van Aelst, M. H. Wigler, and J. Der 1996. Oncogenic Ras activation of Raf/MAP kinase-independent pathways is sufficient to cause tumorigenic transformation. Mol. Cell. Biol. 16:3923–3933.
  • Kolch, W., G. Heidecker, P. Lloyd, and J. Rapp 1991. Raf-1 protein kinase is required for growth of induced NIH/3T3 cells. Nature 349:426–428.
  • Lin, R., S. Bagrodia, R. Cerione, and J. Manor 1997. A novel Cdc42Hs mutant induces cellular transformation. Curr. Biol. 7:794–797.
  • Liu, X., H. Wang, M. Eberstadt, A. Schnuchel, E. T. Olejniczak, R. P. Meadows, J. M. Schkeryantz, D. A. Janowick, J. E. Harlan, E. A. Harris, D. E. Staunton, and J. Fesik 1998. NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio. Cell 95:269–277.
  • Maniatis, T., E. F. Fritsch, J. Sambrook 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
  • Mansour, S. J., W. T. Matten, A. S. Hermann, J. M. Candia, S. Rong, K. Fukasawa, G. F. Vande Woude, and J. Ahn 1994. Transformation of mammalian cells by constitutively active MAP kinase kinase. Science 265:966–970.
  • Marais, R., J. Wynne, and J. Treisman 1993. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 73:381–393.
  • Mayo, M. W., C.-Y. Wang, P. C. Cogswell, K. S. Rogers-Graham, S. W. Lowe, C. J. Der, A. S. Baldwin Jr.. 1997. Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras. Science 278:1812–1815.
  • Michiels, F., J. C. Stam, P. L. Hordijk, R. A. van der Kammen, L. Ruuls-Van Stalle, C. A. Feltkamp, and J. Collard 1997. Regulated membrane localization of TIAM1, mediated by the N-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and JNK activation. J. Cell. Biol. 137:1–12.
  • Miki, T., C. L. Smith, J. E. Long, A. Eva, and J. Fleming 1993. Oncogene ect2 is related to regulators of small GTP-binding proteins. Nature 362:462–465.
  • Minden, A., and J. Karin 1997. Regulation and function of the JNK subgroup of MAP kinases. Biochim. Biophys. Acta 1333:85–104.
  • Minden, A., A. Lin, F.-X. Claret, A. Abo, and J. Karin 1995. Selective activation of the JNK signaling cascade and Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81:1147–1157.
  • Montaner, S., R. Perona, L. Saniger, and J. Lacal 1998. Multiple signalling pathways lead to the activation of the nuclear factor kappaB by the Rho family of GTPases. J. Biol. Chem. 273:12779–12785.
  • Murphy, G. A., P. A. Solski, S. A. Jillian, P. Perez de la Ossa, P. D’Eustachio, C. J. Der, and J. Rush 1999. Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction, and cell growth. Oncogene 15:3831–3845.
  • Nimnual, A. S., B. A. Yatsula, and J. Bar-Sagi 1998. Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos. Science 279:560–563.
  • Olson, M. F., A. Ashworth, and J. Hall 1995. An essential role for Rho, Rac and Cdc42 GTPases in cell cycle progression through G1. Science 269:1270–1272.
  • Olson, M. F., N. G. Pasteris, J. L. Gorski, and J. Hall 1996. Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases. Curr. Biol. 6:1628–1633.
  • Perona, R., S. Montaner, L. Saniger, I. Sánchez-Pérez, R. Bravo, and J. Lacal 1997. Activation of the nuclear factor-κB by Rho, CDC42, and Rac-1 proteins. Genes Dev. 11:463–475.
  • Prendergast, G. C., R. Khosravi-Far, P. A. Solski, H. Kurzawa, P. F. Lebowitz, and J. Der 1995. Critical role of RhoB in cell transformation by oncogenic Ras. Oncogene 10:2289–2296.
  • Qiu, R.-G., A. Abo, F. McCormick, and J. Symons 1997. Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation. Mol. Cell. Biol. 17:3449–3458.
  • Qiu, R.-G., J. Chen, D. Kirn, F. McCormick, and J. Symons 1995. An essential role for Rac in Ras transformation. Nature 374:457–459.
  • Qiu, R.-G., J. Chen, F. McCormick, and J. Symons 1995. A role for Rho in Ras transformation. Proc. Natl. Acad. Sci. USA 92:11781–11785.
  • Raitano, A. B., J. R. Halpern, T. M. Hambuch, and J. Sawyers 1995. The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation. Proc. Natl. Acad. Sci. USA 92:11746–11750.
  • Reuther, J. Y., G. W. Reuther, D. Cortez, A. M. Pendergast, A. S. Baldwin Jr.. 1998. A requirement for NF-kappaB activation in Bcr-Abl-mediated transformation. Genes Dev. 12:1–14.
  • Rodrigues, G. A., M. Park, and J. Schlessinger 1997. Activation of the JNK pathway is essential for transformation by the Met oncogene. EMBO J. 16:2634–2645.
  • Ron, D., M. Zannini, M. Lewis, R. B. Wickner, L. T. Hunt, G. Graziani, S. R. Tronick, S. A. Aaronson, and J. Eva 1991. A region of Proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr. New Biol. 3:372–379.
  • Sahai, E., A. S. Alberts, and J. Treisman 1998. RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation. EMBO J. 17:1350–1361.
  • Sanchez, I., R. T. Hughes, B. J. Mayer, K. Yee, J. R. Woodgett, J. Avruch, J. M. Kyriakis, and J. Zon 1994. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor Jun. Nature 372:794.
  • Settleman, J., C. F. Albright, L. C. Foster, and J. Weinberg 1992. Association between GTPase activators for Rho and Ras families. Nature 359:153–154.
  • Shou, C., C. L. Farnsworth, B. G. Neel, and J. Feig 1992. Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21. Nature 358:351–354.
  • Solski, P. A., L. A. Quilliam, S. G. Coats, C. J. Der, and J. Buss 1995. Targeting proteins to membranes using signal sequences for lipid modification. Methods Enzymol. 250:435–454.
  • Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and J. Ben-Neriah 1994. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77:727–736.
  • Sulciner, D. J., K. Irani, Z.-X. Yu, V. J. Ferrans, P. Goldschmidt-Clermont, and J. Finkel 1996. rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-κB activation. Mol. Cell. Biol. 16:7115–7121.
  • Treisman, R. 1996. Regulation of transcription by MAP kinase cascades. Curr. Opin. Cell Biol. 8:205–215.
  • Valencia, A., P. Chardin, A. Wittinghofer, and J. Sander 1991. The ras protein family: evolutionary tree and role of conserved amino acids. Biochemistry 30:4637–4648.
  • Verheij, M., R. Bose, X. H. Lin, B. Yao, W. D. Jarvis, S. Grant, M. J. Birrer, E. Szabo, L. I. Zon, J. M. Kyriakis, A. Haimovitz-Friedman, Z. Fuks, and J. Kolesnick 1996. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 380:75–79.
  • Westwick, J. K., and J. Brenner 1995. Methods for analyzing c-Jun kinase. Methods Enzymol. 255:342–360.
  • Westwick, J. K., Q. T. Lambert, G. J. Clark, M. Symons, L. Van Aelst, R. G. Pestell, and J. Der 1997. Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways. Mol. Cell. Biol. 17:1324–1335.
  • Westwick, J. K., R. J. Lee, Q. T. Lambert, M. Symons, R. G. Pestell, C. J. Der, and J. Whitehead 1998. Transforming potential of Dbl family proteins correlates with transcription from the cyclin D1 promoter but not with activation of Jun NH2-terminal kinase, p38/Mpk2, serum response factor or c-Jun. J. Biol. Chem. 273:16739–16747.
  • Whitehead, I. P., K. Abe, J. L. Gorski, and J. Der 1998. CDC42 and FGD1 cause distinct signaling and transforming activities. Mol. Cell. Biol. 18:4689–4697.
  • Whitehead, I. P., S. Campbell, K. L. Rossman, and J. Der 1997. Dbl family proteins. Biochem. Biophys. Acta 1332:F1–F23.
  • Whitehead, I. P., R. Khosravi-Far, H. Kirk, G. Trigo-Gonzalez, C. J. Der, and J. Kay 1996. Expression cloning of Isc, a novel oncogene with structural similarities to the Dbl family of guanine nucleotide exchange factors. J. Biol. Chem. 271:18643–18650.
  • Whitehead, I. P., H. Kirk, and J. Kay 1995. Retroviral transduction and oncogenic selection of a cDNA encoding Dbs, a homolog of the Dbl guanine nucleotide exchange factor. Oncogene 10:713–721.
  • Whitehead, I. P., H. Kirk, C. Tognon, G. Trigo-Gonzalez, and J. Kay 1995. Expression cloning of lfc, a novel oncogene with structural similarities to guanine nucleotide exchange factors and to the regulatory region of protein kinase C. J. Biol. Chem. 271:18388–18395.
  • Whitmarsh, A. J., S.-H. Yang, M. S. S. Su, A. D. Sharrocks, and J. Davis 1997. Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors. Mol. Cell. Biol. 17:2360–2371.
  • Zhang, S., J. Han, M. A. Sells, J. Chernoff, U. G. Knaus, R. J. Ulevitch, and J. Bokoch 1995. Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J. Biol. Chem. 270:23934–23936.
  • Zheng, Y., D. Zangrilli, R. A. Cerione, and J. Eva 1996. The pleckstrin homology domain mediates transformation by oncogenic Dbl through specific intracellular targeting. J. Biol. Chem. 271:19017–19020.
  • Zohn, I. E., S. L. Campbell, R. Khosravi-Far, K. L. Rossman, and J. Der 1998. Rho family proteins and Ras transformation: the RHOad less traveled gets congested. Oncogene 17:1415–1438.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.