Reactivation of Mutant p53 through Interaction of a C-Terminal Peptide with the Core Domain

REFERENCES

• Abarzua, P., J. E. LoSardo, M. L. Subler, R. Spathis, Y.-A. Lu, A. Felix, and J. Neri 1996. Restoration of the transcription activation function to mutant p53 in human cancer cells. Oncogene 13:2477–2482.
   PubMed Web of Science ®Google Scholar
• Bakalkin, G., G. Selivanova, T. Yakovleva, E. Kiseleva, E. Kashuba, K. P. Magnusson, L. Szekely, G. Klein, L. Terenius, and J. Wiman 1995. p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain. Nucleic Acids Res. 23:362–369.
   PubMed Web of Science ®Google Scholar
• Bargonetti, J., J. J. Manfredi, X. Chen, D. R. Marshak, and J. Prives 1993. A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild type but not from oncogenic mutant p53 protein. Genes Dev. 7:2565–2574.
   PubMed Web of Science ®Google Scholar
• Cho, Y., S. Gorina, P. D. Jeffrey, and J. Pavletich 1994. Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science 265:346–355.
   PubMed Web of Science ®Google Scholar
• Clore, G. M., J. G. Omichinski, K. Sakagushi, N. Zambrano, H. Sakamoto, E. Apella, and J. Groneborn 1994. High resolution structure of the oligomerization domain of p53 by multidimensional NMR. Science 265:386–391.
   PubMedGoogle Scholar
• Gu, W., and J. Roeder 1997. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90:595–606.
   PubMed Web of Science ®Google Scholar
• Halazonetis, T. D., L. J. Davies, and J. Kandil 1993. Wild-type p53 adopts a “mutant”-like conformation when bound to DNA. EMBO J. 12:1021–1028.
   PubMed Web of Science ®Google Scholar
• Halazonetis, T. D., and J. Kandil 1993. Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants. EMBO J. 12:5057–5064.
   PubMedGoogle Scholar
• Hupp, T. R., D. W. Meek, C. A. Midgley, and J. Lane 1992. Regulation of the specific DNA binding function of p53. Cell 71:875–886.
   PubMed Web of Science ®Google Scholar
• Hupp, T. R., D. W. Meek, and J. Midgley 1993. Activation of the cryptic DNA binding function of mutant forms of p53. Nucleic Acids Res. 21:3167–3174.
   PubMed Web of Science ®Google Scholar
• Hupp, T. R., and J. Lane 1994. Allosteric activation of latent p53 tetramers. Curr. Biol. 4:865–875.
   PubMedGoogle Scholar
• Hupp, T. R., A. Sparks, and J. Lane 1995. Small peptides activate the latent sequence-specific binding function of p53. Cell 83:237–245.
   PubMed Web of Science ®Google Scholar
• Jayaraman, L., and J. Prives 1995. Activation of p53 sequence specific DNA binding by short single strands of DNA requires the p53 C-terminus. Cell 81:1021–1029.
   PubMed Web of Science ®Google Scholar
• Kern, S. E., J. A. Pietenpol, S. Thagaligam, A. Seymour, K. W. Kinzler, and J. Vogelstein 1992. Oncogenic forms of p53 inhibit p53-regulated gene expression. Science 256:827–832.
   PubMed Web of Science ®Google Scholar
• Ko, L. J., and J. Prives 1996. p53: puzzle and paradigm. Genes Dev. 10:1054–1072.
   PubMed Web of Science ®Google Scholar
• Lee, W., T. S. Harvey, Y. Yin, P. Yau, D. Litchfield, and J. Arrowsmith 1994. Solution structure of the tetrameric minimum transforming domain of p53. Nat. Struct. Biol. 1:877–890.
   PubMedGoogle Scholar
• Muller-Tiemann, B. F., T. D. Halazonetis, and J. Elting 1998. Identification of an additional negative regulatory region for p53 sequence-specific DNA binding. Proc. Natl. Acad. Sci. USA 95:6079–6084.
   PubMedGoogle Scholar
• Pavletich, N. P., K. A. Chambers, and J. Pabo 1993. The DNA binding domain of p53 contains the four conserved regions and the major mutation hot spots. Genes Dev. 7:2556–2564.
   PubMed Web of Science ®Google Scholar
• Selivanova, G., V. Iotsova, E. Kiseleva, M. Ström, G. Bakalkin, R. C. Grafström, and J. Wiman 1996. The single stranded DNA end binding site of p53 coincides with the C-terminal regulatory region. Nucleic Acids Res. 24:3560–3567.
   PubMed Web of Science ®Google Scholar
• Selivanova, G., V. Iotsova, I. Okan, M. Fritsche, M. Ström, B. Groner, R. C. Grafström, and J. Wiman 1997. Restoration of the growth suppressor function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain. Nat. Med. 3:632–638.
   PubMed Web of Science ®Google Scholar
• Selivanova, G., L. Ryabchenko, and K. G. Wiman. Unpublished data.
   Google Scholar
• Shaulian, E., A. Zauberman, D. Ginsberg, and J. Oren 1992. Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding. Mol. Cell. Biol. 12:5581–5592.
   PubMed Web of Science ®Google Scholar
• Shaw, P., J. Freeman, R. Bovey, and J. Iggo 1996. Regulation of specific DNA binding by p53: evidence for a role for O-glycosylation and charged residues at the carboxy-terminus. Oncogene 12:921–930.
   PubMed Web of Science ®Google Scholar
• Stürzbecher, H.-W., R. Brain, C. Addison, K. Rudge, M. Remm, M. Grimaldi, E. Keenan, and J. Jenkins 1992. A C-terminal alpha-helix plus basic region motif is the major structural determinant of p53 tetramerization. Oncogene 7:1513–1523.
   PubMedGoogle Scholar
• Unger, T., M. M. Nau, S. Segal, and J. Minna 1992. p53: a transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer. EMBO J. 11:1383–1390.
   PubMed Web of Science ®Google Scholar
• Wang, Y., M. Reed, P. Wang, J. E. Stenger, G. Mayr, M. E. Anderson, J. F. Schwedes, and J. Tegtmeyer 1993. p53 domains: identification and characterization of two autonomous DNA-binding regions. Genes Dev. 7:2575–2586.
   PubMedGoogle Scholar
• Waterman, J. L. F., J. L. Shenk, and J. Halazonetis 1995. The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding. EMBO J. 14:512–519.
   PubMedGoogle Scholar
• Wieczorek, A. M., J. L. F. Waterman, M. J. F. Waterman, and J. Halazonetis 1996. Structure-based rescue of common tumor-derived p53 mutants. Nat. Med. 2:1143–1146.
   PubMedGoogle Scholar