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Cell Growth and Development

Engagement of the Cellular Receptor for Glycoprotein B of Human Cytomegalovirus Activates the Interferon-Responsive Pathway

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Pages 3607-3613 | Received 17 Dec 1998, Accepted 02 Feb 1999, Published online: 28 Mar 2023

REFERENCES

  • Akiyama, T., J. Ishida, S. Nakagawa, H. Ogawara, S. Watanabe, N. Itoh, M. Shibuya, and J. Fukami 1987. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem. 262:5592–5595.
  • Albrecht, T., I. Boldogh, M. Fons, S. AbuBakar, and J. Deng 1990. Cell activation signals and the pathogenesis of human cytomegalovirus. Intervirology 31:68–75.
  • Albrecht, T., I. Boldogh, M. Fons, C. H. Lee, S. AbuBakar, J. M. Russell, and J. Au 1989. Cell-activation responses to cytomegalovirus infection. Relationship to the phasing of CMV replication and to the induction of cellular damage. Subcell. Biochem. 15:157–202.
  • Alford, C. A., W. J. Britt 1993. Cytomegalovirus, p. 227–255. In B. Roizman, R. J. Whitley, C. Lopex (ed.), Human herpesviruses. Raven Press, New York, N.Y.
  • Au, W. C., P. A. Moore, W. Lowther, Y. T. Juang, and J. Pitha 1995. Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes. Proc. Natl. Acad. Sci. USA 92:11657–11661.
  • Baglioni, C., M. A. Minks, and J. Maroney 1978. Interferon action may be mediated by activation of a nuclease by pppA2′p5′A2′p5′A. Nature 273:684–687.
  • Baldari, C. T., E. Milia, M. M. Di Somma, F. Baldoni, S. Valitutti, and J. Telford 1995. Distinct signaling properties identify functionally different CD4 epitopes. Eur. J. Immunol. 25:1843–1850.
  • Boldogh, I., S. AbuBakar, and J. Albrecht 1990. Activation of proto-oncogenes: an immediate early event in human cytomegalovirus infection. Science 247:561–564.
  • Boldogh, I., M. P. Fons, and J. Albrecht 1993. Increased levels of sequence-specific DNA-binding proteins in human cytomegalovirus infected cells. Biochem. Biophys. Res. Commun. 197:1505–1510.
  • Boulton, T. G., J. S. Gregory, and J. Cobb 1991. Purification and properties of extracellular signal-regulated kinase 1, and insulin-stimulated microtubule-associated protein 2 kinase. Biochemistry 30:278–286.
  • Boyle, K. A., and J. Compton 1998. Receptor binding properties of a soluble form of human cytomegalovirus glycoprotein B. J. Virol. 72:1826–1833.
  • Boyle, K. A., and T. Compton. Unpublished results.
  • Briant, L., N. Signoret, M. Gaubin, V. Robert-Hebmann, X. Zhang, R. Murali, M. I. Greene, D. Piatier-Tonneau, and J. Devaux 1997. Transduction of activation signal that follows HIV-1 binding to CD4 and CD4 dimerization involves the immunoglobulin CDR3-like region in domain 1 of CD4. J. Biol. Chem. 272:19441–19450.
  • Britt, W. J., C. A. Alford 1996. Cytomegalovirus:, p. 2493–2523. In B. N. Fields, D. M. Knipe, P. M. Howley (ed.), Virology. Lippincott-Raven Publishers, Philadelphia, Pa.
  • Britt, W. J., and J. Mach 1996. Human cytomegalovirus glycoproteins. Intervirology 39:401–412.
  • Carlson, C., W. J. Britt, and J. Compton 1997. Expression, purification and characterization of a soluble form of human cytomegalovirus glycoprotein B. Virology 239:168–205.
  • Cirone, M., A. Angeloni, G. Barile, C. Zompetta, M. Venanzoni, M. R. Torrisi, L. Frati, and J. Faggioni 1990. Epstein Barr virus internalization and infectivity are blocked by selective protein kinase C inhibitors. Int. J. Cancer 45:490–493.
  • Clemens, M. J., and J. Williams 1976. Inhibition of cell-free protein synthesis by pppA2′p5′A2′p5′A: a novel oligonucleotide synthesized by interferon treated cell extracts. Cell 13:565–572.
  • Cobb, M. H., and J. Goldsmith 1995. How MAP kinases are regulated. J. Biol. Chem. 270:14843–14846.
  • Colamonici, O. R., and T. Compton. Unpublished results.
  • Colamonici, O. R., H. Uyttendaele, P. Domanski, H. Yan, and J. Krolewski 1994. p135tyk2, an interferon-alpha-activated tyrosine kinase, is physically associated with an interferon-alpha receptor. J. Biol. Chem. 269:3518–3522.
  • Compton, T. 1993. An immortalized human fibroblast cell line is permissive for human cytomegalovirus infection. J. Virol. 67:3644–3648.
  • Compton, T. 1995. Towards a definition of the HCMV entry pathway. Scand. J. Infect. Dis. 99:30–32.
  • Compton, T., R. R. Nepomuceno, and J. Nowlin 1992. Human cytomegalovirus penetrates host cells by pH-independent fusion at the cell surface. Virology 191:387–395.
  • Compton, T., D. M. Nowlin, and J. Cooper 1993. Initiation of human cytomegalovirus infection requires initial interaction with cell surface heparan sulfate. Virology 193:834–841.
  • Darnell, J. E. Jr., I. M. Kerr, and J. Stark 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415–1421.
  • David, M., E. Petricoin III, C. Benjamin, R. Pine, M. J. Weber, and J. Larner 1995. Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins. Science 269:1721–1723.
  • Davignon, J. L., P. Castanie, J. A. Yorke, N. Gautier, D. Clement, and J. Davrinche 1996. Anti-human cytomegalovirus activity of cytokines produced by CD4+ T-cell clones specifically activated by IE1 peptides in vitro. J. Virol. 70:2162–2169.
  • Domanski, P., and J. Colamonici 1996. The type-I interferon receptor. The long and short of it. Cytokine Growth Factor Rev. 7:143–151.
  • Farrar, G. H., and J. Greenaway 1986. Characterization of glycoprotein complexes present in human cytomegalovirus envelopes. J. Gen. Virol. 67:1469–1473.
  • Farrar, M. A., and J. Schreiber 1993. The molecular cell biology of interferon-gamma and its receptor. Annu. Rev. Immunol. 11:571–611.
  • Fu, X.-Y., C. Schindler, T. Improta, R. Aebersold, and J. Darnell 1992. The proteins of ISGF3, the interferon a-induced transcriptional activator, define a gene family involved in signal transduction. Proc. Natl. Acad. Sci. USA 89:7840–7843.
  • Gazit, A., P. Yaish, C. Gilon, and J. Levitzki 1989. Tyrphostins. I. Synthesis and biological activity of protein tyrosine kinase inhibitors. J. Med. Chem. 32:2344–2352.
  • Gilmore, K. C., and J. Reich 1995. Signal transduction and activation of gene transcription by interferons. Gene Exp. 5:1–18.
  • Gopalakrishna, R., Z. H. Chen, and J. Gundimeda 1992. Irreversible oxidative inactivation of protein kinase C by photosensitive inhibitor calphostin C. FEBS Lett. 314:149–154.
  • Greenberg, M. E., A. L. Hermanowski, and J. Ziff 1986. Effect of protein synthesis inhibitors on growth factor activation of c-fos, c-myc, and actin gene transcription. Mol. Cell. Biol. 6:1050–1057.
  • Gretch, D. R., R. C. Gehrz, and J. Stinski 1988. Characterization of a human cytomegalovirus glycoprotein complex (gcI). J. Gen. Virol. 69:1205–1215.
  • Harel, N. Y., and J. Alwine 1998. Phosphorylation of the human cytomegalovirus 86-kilodalton immediate-early protein IE2. J. Virol. 72:5481–5492.
  • Ibanez, C. E., R. Schrier, P. Ghazal, C. Wiley, and J. Nelson 1991. Human cytomegalovirus productively infects primary differentiated macrophages. J. Virol. 65:6581–6588.
  • Kari, B., and J. Gehrz 1992. A human cytomegalovirus glycoprotein complex designated gC-II is a major heparin-binding component of the envelope. J. Virol. 66:1761–1764.
  • Kobayashi, E., H. Nakano, M. Morimoto, and J. Tamaoki 1989. Calphostin C (UCN-1028C) a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem. Biophys. Res. Commun. 159:548–553.
  • Kowalik, T. F., B. Wing, J. S. Haskill, J. C. Azizkhan, A. S. Baldwin, and J. Huang 1993. Multiple mechanisms are implicated in the regulation of NF-κB activity during human cytomegalovirus infection. Proc. Natl. Acad. Sci. USA 90:1107–1111.
  • Lathey, J. L., and J. Spector 1991. Unrestricted replication of human cytomegalovirus in hydrocortisone-treated macrophages. J. Virol. 65:6371–6375.
  • Levy, D. E., D. S. Kessler, R. Pine, J. E. Darnell Jr.. 1989. Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro. Genes Dev. 3:1362–1371.
  • Levy, D. E., D. J. Lew, D. S. Kessler, and J. Darnell 1990. Synergistic interaction between interferon-α and interferon-γ through induced synthesis of one subunit of the transcription factor ISGF3. EMBO J. 9:1105–1111.
  • Liu, B., and J. Stinski 1992. Human cytomegalovirus contains a tegument protein that enhances transcription from promoters with upstream ATF and AP-1 cis-acting elements. J. Virol. 66:4434–4444.
  • Luxembourg, A. T., and J. Cooper 1994. Modulation of signaling via the B cell antigen receptor by CD21, the receptor for C3dg and EBV. J. Immunol. 153:4448–4457.
  • Meier, J. L., and J. Stinski 1996. Regulation of human cytomegalovirus immediate-early gene expression. Intervirology 39:331–42.
  • Miller, D. M., B. M. Rahill, J. M. Boss, M. D. Lairmore, J. E. Durbin, J. W. Waldman, and J. Sedmak 1998. Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathway. J. Exp. Med. 187:675–683.
  • Minton, E. J., C. Tysoe, J. H. Sinclair, and J. Sissons 1994. Human cytomegalovirus infection of the monocyte/macrophage lineage in bone marrow. J. Virol. 68:4017–4021.
  • Navarro, D., P. Paz, S. Tugizov, K. Topp, J. La Vail, and J. Pereira 1993. Glycoprotein B of human cytomegalovirus promotes virion penetration into cells, transmission of infection from cell to cell, and fusion of infected cells. Virology 197:143–158.
  • Navarro, L., K. Mowen, S. Rodems, B. Weaver, N. Reich, D. Spector, and J. David 1998. Cytomegalovirus activates interferon immediate-early response gene expression and an interferon regulatory factor 3-containing interferon-stimulated response element-binding complex. Mol. Cell. Biol. 18:3796–3802.
  • Nemerow, G. R., and J. Cooper 1984. Early events in the infection of human B lymphocytes by Epstein-Barr virus: the internalization process. Virology 132:186–198.
  • Neyts, J., R. Shoeck, D. Schols, J. Balzarini, J. D. Esko, S. A. Van, and J. De 1992. Sulfated polymers inhibit the interaction of human cytomegalovirus with cell surface heparan sulfate. Virology 189:48–58.
  • Pereira, L. 1994. Function of glycoprotein B homologues of the family Herpesviridae. Infect. Agents Dis. 3:9–28.
  • Rapraeger, A. C., A. Krufka, and J. Olwin 1991. Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation. Science 252:1705–1708.
  • Ratner, L., R. C. Wiegand, P. J. Farrell, G. C. Sen, and J. Lengyel 1978. Interferon, double stranded RNA and RNA degradation. Fractionation of the endonuclease INT system into two macromolecular components: role of a small molecule in nuclease activation. Biochem. Biophys. Res. Commun. 81:947–954.
  • Roberts, M. L., A. T. Luxembourg, and J. Cooper 1996. Epstein-Barr virus binding to CD21, the virus receptor, activates resting B cells via an intracellular pathway that is linked to B cell infection. J. Gen. Virol. 77Pt. 123077–3085.
  • Rossi, D., L. Del Giacco, L. Doneda, U. Nicolini, B. Acaia, D. Brioschi, and J. Larizza 1996. Expression pattern of c-sis, c-fos, and c-jun in human placenta and embryofetal organs. Gynecol. Obstetr. Investig. 42:1–7.
  • Sambucetti, L. C., J. M. Cherrington, G. W. G. Wilkenson, and J. Mocarski 1989. NF-κB activation of the cytomegalovirus enhancer is mediated by a viral transactivator and by T cell stimulation. EMBO J. 8:4251–4258.
  • Segar, R., and J. Krebs 1995. The MAPK signaling cascade. FASEB J. 9:726–735.
  • Sinclair, J. H., J. Baillie, L. A. Bryant, J. A. Taylor-Wiedeman, and J. Sissons 1992. Repression of human cytomegalovirus major immediate early gene expression in a monocytic cell line. J. Gen. Virol. 73Pt. 2433–435.
  • Soderberg-Naucler, C., K. N. Fish, and J. Nelson 1997. Interferon-gamma and tumor necrosis factor-alpha specifically induce formation of cytomegalovirus-permissive monocyte-derived macrophages that are refractory to the antiviral activity of these cytokines. J. Clin. Investig. 100:3154–3163.
  • Soderberg-Naucler, C., K. N. Fish, and J. Nelson 1997. Reactivation of latent human cytomegalovirus by allogeneic stimulation of blood cells from healthy donors. Cell 91:119–126.
  • Spear, P. G. 1993. Entry of alphaherpesviruses into cells. Semin. Virol. 4:167–180.
  • Stein, B. S., S. D. Gowda, J. D. Lifson, R. C. Penhallow, K. G. Bensch, and J. Engleman 1987. pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane. Cell 49:659–668.
  • Stenberg, R. M., and J. Kerry 1995. Cytomegalovirus genes: their structure and function. Scand. J. Infect. Dis. Suppl. 99:3–6.
  • Sugano, N., W. Chen, M. L. Roberts, and J. Cooper 1997. Epstein-Barr virus binding to CD21 activates the initial viral promoter via NF-kappaB induction. J. Exp. Med. 186:731–737.
  • Takahashi, I., E. Kobayashi, H. Nakano, C. Murakata, H. Saitoh, K. Suzuki, and J. Tamaoki 1990. Potent selective inhibition of 7-O-methyl UCN-01 against protein kinase C. J. Pharmacol. Exp. Ther. 255:1218–1221.
  • Taylor-Wiedeman, J., J. G. Sissons, L. K. Borysiewicz, and J. Sinclair 1991. Monocytes are a major site of persistence of human cytomegalovirus in peripheral blood mononuclear cells. J. Gen. Virol. 72Pt. 92059–2064.
  • Taylor-Wiedeman, J., P. Sissons, and J. Sinclair 1994. Induction of endogenous human cytomegalovirus gene expression after differentiation of monocytes from healthy carriers. J. Virol. 68:1597–1604.
  • Torigoe, S., D. E. Campbell, and J. Starr 1997. Cytokines released by human peripheral blood mononuclear cells inhibit the production of early and late cytomegalovirus proteins. Microbiol. Immunol. 41:403–413.
  • Tugizov, S., D. Navarro, P. Paz, Y. Wang, I. Qadri, and J. Pereira 1994. Function of human cytomegalovirus glycoprotein B: syncytium formation in cells constitutively expressing gB is blocked by virus-neutralizing antibodies. Virology 201:263–276.
  • Valy-Nagy, T., Z. Bandi, I. Boldogh, and J. Albrecht 1988. Hydrolysis of inositol lipids: an early signal of human cytomegalovirus infection. Arch. Virol. 101:199–207.
  • Weissman, D., R. L. Rabin, J. Arthos, A. Rubbert, M. Dybul, R. Swofford, S. Venkatesan, J. M. Farber, and J. Fauci 1997. Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor. Nature 389:981–985.
  • Yamamoto, N., K. Shimokata, K. Maeno, and J. Nishiyama 1987. Effect of recombinant human interferon-gamma against human cytomegalovirus. Arch. Virol. 94:323–329.
  • Yurochko, A. D., E. Hwang, L. Rasmussen, S. Keay, L. Pereira, and J. Huang 1997. The human cytomegalovirus UL55 (gB) and UL75 (gH) glycoprotein ligands initiate the rapid activation of Sp1 and NF-κB during infection. J. Virol. 71:5051–5059.
  • Yurochko, A. D., T. F. Kowalik, S. Huong, and J. Huang 1995. Human cytomegalovirus upregulates NF-κB activity by transactivating the NF-κB p105/p50 and p65 promoters. J. Virol. 69:5391–5400.
  • Yurochko, A. D., M. W. Mayo, E. E. Poma, A. S. Baldwin, and J. Huang 1997. Induction of the transcription factor Sp1 during human cytomegalovirus infection mediates upregulation of the p65 and p105/p50 NF-κB promoters. J. Virol. 71:4638–4648.
  • Zhu, H., J. Cong, and J. Shenk 1997. Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: Induction of interferon-responsive RNAs. Proc. Natl. Acad. Sci. USA 94:13985–13990.

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