Distinct Regulation of p53 and p73 Activity by Adenovirus E1A, E1B, and E4orf6 Proteins

REFERENCES

• Buckbinder, L., R. Talbott, S. Velasco-Miguel, I. Takenaka, B. Faha, B. R. Seizinger, and J. Kley 1995. Induction of the growth inhibitor IGF-binding protein 3 by p53. Nature 377:646–649.
   PubMed Web of Science ®Google Scholar
• Dobner, T., N. Horikoshi, S. Rubenwolf, and J. Shenk 1996. Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor. Science 272:1470–1473.
   PubMed Web of Science ®Google Scholar
• El-Deiry, W. S., T. Tokino, V. E. Velculescu, D. B. Levy, R. Parsons, J. M. Trent, D. Lin, W. E. Mercer, K. W. Kinzler, and J. Vogelstein 1993. WAF1, a potential mediator of p53 tumor suppression. Cell 75:817–825.
   PubMed Web of Science ®Google Scholar
• Friedlander, P., Y. Haupt, C. Prives, and J. Oren 1996. A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis. Mol. Cell. Biol. 16:4961–4971.
   PubMed Web of Science ®Google Scholar
• Grossman, S. R., M. Perez, A. L. Kung, M. Joseph, C. Mansur, Z. X. Xiao, S. Kumar, P. M. Howley, and J. Livingston 1998. p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Mol. Cell 2:405–415.
   PubMed Web of Science ®Google Scholar
• Gu, W., and J. Roeder 1997. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90:595–606.
   PubMed Web of Science ®Google Scholar
• Gu, W., X. L. Shi, and J. Roeder 1997. Synergistic activation of transcription by CBP and p53. Nature 387:819–823.
   PubMed Web of Science ®Google Scholar
• Haupt, Y., R. Maya, A. Kazaz, and J. Oren 1997. Mdm2 promotes the rapid degradation of p53. Nature 387:296–299.
   PubMed Web of Science ®Google Scholar
• Jost, C. A., M. C. Marin, W. G. Kaelin Jr.. 1997. p73 is a human p53-related protein that can induce apoptosis. Nature 389:191–194.
   PubMed Web of Science ®Google Scholar
• Kaghad, M., H. Bonnet, A. Yang, L. Creancier, J. C. Biscan, A. Valent, A. Minty, P. Chalon, J. M. Lelias, X. Dumont, P. Ferrara, F. McKeon, and J. Caput 1997. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 90:809–819.
   PubMed Web of Science ®Google Scholar
• Kubbutat, M. H., S. N. Jones, and J. Vousden 1997. Regulation of p53 stability by Mdm2. Nature 387:299–303.
   PubMed Web of Science ®Google Scholar
• Lill, N. L., S. R. Grossman, D. Ginsberg, J. DeCaprio, and J. Livingston 1997. Binding and modulation of p53 by p300/CBP coactivators. Nature 387:823–827.
   PubMed Web of Science ®Google Scholar
• Lin, J., J. Chen, B. Elenbaas, and J. Levine 1994. Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein. Genes Dev. 8:1235–1246.
   PubMed Web of Science ®Google Scholar
• Lowe, S. W., and J. Ruley 1993. Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis. Genes Dev. 7:535–545.
   PubMed Web of Science ®Google Scholar
• Marin, M. C., C. A. Jost, M. S. Irwin, J. A. DeCaprio, D. Caput, W. G. Kaelin Jr.. 1998. Viral oncoproteins discriminate between p53 and the p53 homolog p73. Mol. Cell. Biol. 18:6316–6324.
   PubMedGoogle Scholar
• Miyashita, T., and J. Reed 1995. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80:293–299.
   PubMed Web of Science ®Google Scholar
• Nevels, M., S. Rubenwolf, T. Spruss, H. Wolf, and J. Dobner 1997. The adenovirus E4orf6 protein can promote E1A/E1B-induced focus formation by interfering with p53 tumor suppressor function. Proc. Natl. Acad. Sci. USA 94:1206–1211.
   PubMed Web of Science ®Google Scholar
• Offringa, R., S. Gebel, H. van Dam, M. Timmers, A. Smits, R. Zwart, B. Stein, J. L. Bos, A. van der Eb, and J. Herrlich 1990. A novel function of the transforming domain of E1a: repression of AP-1 activity. Cell 62:527–538.
   PubMedGoogle Scholar
• Osada, M., M. Ohba, C. Kawahara, C. Ishioka, R. Kanamaru, I. Katoh, Y. Ikawa, Y. Nimura, A. Nakagawara, M. Obinata, and J. Ikawa 1998. Cloning and functional analysis of human p51, which structurally and functionally resembles p53. Nat. Med. 4:839–843.
   PubMed Web of Science ®Google Scholar
• Prabhu, N. S., K. Somasundaram, K. Satyamoorthy, M. Herlyn, and J. El-Deiry 1998. p73beta, unlike p53, suppresses growth and induces apoptosis of human papillomavirus E6-expressing cancer cells. Int. J. Oncol. 13:5–9.
   PubMedGoogle Scholar
• Puisieux, A., K. Galvin, F. Troalen, B. Bressac, C. Marcais, E. Galun, F. Ponchel, C. Yakicier, J. Ji, and J. Ozturk 1993. Retinoblastoma and p53 tumor suppressor genes in human hepatoma cell lines. FASEB J. 7:1407–1413.
   PubMed Web of Science ®Google Scholar
• Querido, E., R. C. Marcellus, A. Lai, R. Charbonneau, J. G. Teodoro, G. Ketner, and J. Branton 1997. Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells. J. Virol. 71:3788–3798.
   PubMed Web of Science ®Google Scholar
• Roth, J., C. Konig, S. Wienzek, S. Weigel, S. Ristea, and J. Dobbelstein 1998. Inactivation of p53 but not p73 by adenovirus type 5 E1B 55-kilodalton and E4 34-kilodalton oncoproteins. J. Virol. 72:8510–8516.
   PubMedGoogle Scholar
• Sabbatini, P., S. K. Chiou, L. Rao, and J. White 1995. Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein. Mol. Cell. Biol. 15:1060–1070.
   PubMedGoogle Scholar
• Schmale, H., and J. Bamberger 1997. A novel protein with strong homology to the tumor suppressor p53. Oncogene 15:1363–1367.
   PubMed Web of Science ®Google Scholar
• Shen, Y., and J. Shenk 1994. Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 protein. Proc. Natl. Acad. Sci. USA 91:8940–8944.
   PubMedGoogle Scholar
• Somasundaram, K., and J. El-Deiry 1997. Inhibition of p53-mediated transactivation and cell cycle arrest by E1A through its p300/CBP-interacting region. Oncogene 14:1047–1057.
   PubMed Web of Science ®Google Scholar
• Steegenga, W. T., N. Riteco, A. G. Jochemsen, F. J. Fallaux, and J. Bos 1998. The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus infected cells. Oncogene 16:349–357.
   PubMed Web of Science ®Google Scholar
• Steegenga, W. T., A. Shvarts, T. van Laar, A. J. van der Eb, and J. Jochemsen 1995. Altered phosphorylation and oligomerization of p53 in adenovirus type 12-transformed cells. Oncogene 11:49–57.
   PubMedGoogle Scholar
• Steegenga, W. T., T. van Laar, N. Riteco, A. Mandarino, A. Shvarts, A. J. van der Eb, and J. Jochemsen 1996. Adenovirus E1A proteins inhibit activation of transcription by p53. Mol. Cell. Biol. 16:2101–2109.
   PubMedGoogle Scholar
• Steegenga, W. T., T. Van Laar, A. Shvarts, C. Terleth, A. J. Van der Eb, and J. Jochemsen 1995. Distinct modulation of p53 activity in transcription and cell-cycle regulation by the large (54 kDa) and small (21 kDa) adenovirus E1B proteins. Virology 212:543–554.
   PubMedGoogle Scholar
• Trink, B., K. Okami, L. Wu, V. Sriuranpong, J. Jen, and J. Sidransky 1998. A new human p53 homologue. Nat. Med. 4:747–748 (Letter.)
   PubMed Web of Science ®Google Scholar
• Vaessen, R. T., A. Houweling, A. Israel, P. Kourilsky, and J. van der Eb 1986. Adenovirus E1A-mediated regulation of class I MHC expression. EMBO J. 5:335–341.
   PubMedGoogle Scholar
• Van den Heuvel, S. J., T. van Laar, I. The, and J. van der Eb 1993. Large E1B proteins of adenovirus types 5 and 12 have different effects on p53 and distinct roles in cell transformation. J. Virol. 67:5226–5234.
   PubMedGoogle Scholar
• Van der Eb, A. J., and J. Graham 1980. Assay of transforming activity of tumor virus DNA. Methods Enzymol. 65:826–839.
   PubMedGoogle Scholar
• Weissman, B. E., P. J. Saxon, S. R. Pasquale, G. R. Jones, A. G. Geiser, and J. Stanbridge 1987. Introduction of a normal human chromosome 11 into a Wilms’ tumor cell line controls its tumorigenic expression. Science 236:175–180.
   PubMed Web of Science ®Google Scholar
• Yang, A., M. Kaghad, Y. Wang, E. Gillett, M. D. Fleming, V. Dotsch, N. C. Andrews, D. Caput, and J. McKeon 1998. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol. Cell 3:305–316.
   Google Scholar
• Yew, P. R., and J. Berk 1992. Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein. Nature 357:82–85.
   PubMed Web of Science ®Google Scholar
• Yew, P. R., X. Liu, and J. Berk 1994. Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53. Genes Dev. 8:190–202.
   PubMed Web of Science ®Google Scholar
• Zantema, A., J. A. Fransen, A. Davis-Olivier, F. C. Ramaekers, G. P. Vooijs, B. DeLeys, and J. Van der Eb 1985. Localization of the E1B proteins of adenovirus 5 in transformed cells, as revealed by interaction with monoclonal antibodies. Virology 142:44–58.
   PubMedGoogle Scholar
• Zantema, A., P. I. Schrier, A. Davis-Olivier, T. van Laar, R. T. Vaessen, and J. van der Eb 1985. Adenovirus serotype determines association and localization of the large E1B tumor antigen with cellular tumor antigen p53 in transformed cells. Mol. Cell. Biol. 5:3084–3091.
   PubMedGoogle Scholar
• Zauberman, A., A. Lupo, and J. Oren 1995. Identification of p53 target genes through immune selection of genomic DNA: the cyclin G gene contains two distinct p53 binding sites. Oncogene 10:2361–2366.
   PubMedGoogle Scholar